General information for g10026.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1.
Parent gene
- The parent gene g10026 is located on chr_1: 6798067..6798782 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10026 | g10026.t3 | TSS | g10026.t3 | 6793820 | 6793820 |
| chr_1 | g10026 | g10026.t3 | isoform | g10026.t3 | 6794108 | 6796271 |
| chr_1 | g10026 | g10026.t3 | exon | g10026.t3.exon1 | 6794108 | 6794637 |
| chr_1 | g10026 | g10026.t3 | cds | g10026.t3.CDS1 | 6794108 | 6794637 |
| chr_1 | g10026 | g10026.t3 | exon | g10026.t3.exon2 | 6794779 | 6795864 |
| chr_1 | g10026 | g10026.t3 | cds | g10026.t3.CDS2 | 6794779 | 6795864 |
| chr_1 | g10026 | g10026.t3 | exon | g10026.t3.exon3 | 6795950 | 6796090 |
| chr_1 | g10026 | g10026.t3 | cds | g10026.t3.CDS3 | 6795950 | 6796090 |
| chr_1 | g10026 | g10026.t3 | exon | g10026.t3.exon4 | 6796155 | 6796271 |
| chr_1 | g10026 | g10026.t3 | cds | g10026.t3.CDS4 | 6796155 | 6796269 |
| chr_1 | g10026 | g10026.t3 | TTS | g10026.t3 | NA | NA |
Sequences
>g10026.t3 Gene=g10026 Length=1874
ATGATGTCAGTAATGAATGTTCCAAGTTTGGGTGAGAATGAGCAAATATGCAATTATTTA
GAACGAGGAACGTTGATCACAAAGTATTATCTAAAGAAGCGACCCGAGAAGAAATATTTA
AGTTTAAGACGAGAAACGAGACAAATTCTTGTAAGTCAATTATCTGCTGCATCAACGTCA
TCAAATGCATCATCATCATTGTCGACAAGTGGCAATGCAACTCGTAACAATTATGATTTT
GCCCTTGAGTTGAGAGAAGTCAAAGAGATTCGTTTCGGAAAGAATTCGAAAGATTTTGAT
AAATGGGAAGAGAGCAAGAAAGTCGACCATCAGAAATGTTTTGTAATTCTTTATGGCAAT
GAATTCAAGCTAAAAACCTTTTCTGTCGTTGCGCATTCTGAGAAGGAGTGCGAAATGTGG
ATAAAAGGCATAAAATATATGTTGAATGATACAATTTTCTCACCATATCCGCTTCAAGTT
GAGCGTTGGCTTCGTAAAGAATTCTATGGAATGGAAAATGCCAATAAAGCCGTTACGTTG
AAAGAAGTGAAGGCCTTTCTACCGAAAATCAATTTCAAAATATCGACATCGGAACTCAAT
AGACATTTTCAAATTGTCGACACAAGAAAACGAAATGAAATTGGCTTTGATGATTTTACT
CGTCTCTATCAAAATTTAATTAATGTTCCGACATTCCTCTTTGAATGTTTCAACAGTAAA
ATGCCCTATTCGGAAGGAGAAACTGTCACATTAAAAGAATTTCAAAAATTTCTTCTAACA
GAACAGGGTGATGAAAAGGCCAATGATGACCAAACAATATCAGCTTTCATACGTGATTTT
GTGCAAGATACACAACGTGAAGTGCAAGAGCCTTATTTTACTGTCAATGAATTTGTTGAT
TATTTGTTCTCTAAACAAAATGAAATATGGGATAGCAAATGTAATCGTGTATATCATGAT
ATGACAAAGCCACTTTGTGATTATTGGATTTCATCTTCACATAATACATATCTCTTTGGT
GATCAATTTTCAAGTGAATCTTCCACAGAAGCATACATTCGTGCACTTCGAATGGGCTGC
CGTTGCATTGAACTGGATTGTTGGGATGGTCCAGATTCGCCACTAATTTTTCATGGTCAT
ACATTTACTTCCAAAATAAAGTTCAAAGATGTCATCAAAACAATTAAAGAACACGCTTTC
GTAACATCCCAATTTCCATTGATTCTCTCAATCGAACAAAATTGTTCTCTCGTGCAGCAA
AGAAAAATGGCACAATTGATGCTAGAAGTTTTCGGTGATATGTTACTAACACAACCAATT
GAGAAAAATGAAACAAAATTGCCATCGCCATATGCGTTAAGACGTAAAATAATTTTAAAG
CACAAAAAGTTGATCTATTATGAGGGTGCTAGTCACAATGCCTTTTTCGTAGATGATTCT
AGTGACAGTTTAACAAGAAGCGATAGTCTCATGAGACAAGATGACAATGAGCTAGATATT
CGTAATACTGTTAAAAATGGCATTCTCTATCTGGAAGATCCTGTCGATAAAGTTTGGAAT
CCGCACTTTTTCGTTCTGACACCAAACAATAAAATCTTTTATACTGACAGTTATCGATTG
GATCGCGATGACGCACGCGATGAAGAGGTTGAAAATATTCTAACTCGCCCAAAAGAACAA
ACATCAAATGATGAACTTCATTTTGGTGAAAATTGGTTTCATGGAAAATTATCTGGTGGC
AGAGAAGAAGCTGAAAGTTTGTTACGTCAGTACTCTCATTTGGGTGATGGAACATTTTTA
GTGCGTGAATCTGTCACATTTGTCGGCGACTATTGCTTATCGTTTTGGAGAAAAGGCAAA
CCAAATCATTGCAG
>g10026.t3 Gene=g10026 Length=624
MMSVMNVPSLGENEQICNYLERGTLITKYYLKKRPEKKYLSLRRETRQILVSQLSAASTS
SNASSSLSTSGNATRNNYDFALELREVKEIRFGKNSKDFDKWEESKKVDHQKCFVILYGN
EFKLKTFSVVAHSEKECEMWIKGIKYMLNDTIFSPYPLQVERWLRKEFYGMENANKAVTL
KEVKAFLPKINFKISTSELNRHFQIVDTRKRNEIGFDDFTRLYQNLINVPTFLFECFNSK
MPYSEGETVTLKEFQKFLLTEQGDEKANDDQTISAFIRDFVQDTQREVQEPYFTVNEFVD
YLFSKQNEIWDSKCNRVYHDMTKPLCDYWISSSHNTYLFGDQFSSESSTEAYIRALRMGC
RCIELDCWDGPDSPLIFHGHTFTSKIKFKDVIKTIKEHAFVTSQFPLILSIEQNCSLVQQ
RKMAQLMLEVFGDMLLTQPIEKNETKLPSPYALRRKIILKHKKLIYYEGASHNAFFVDDS
SDSLTRSDSLMRQDDNELDIRNTVKNGILYLEDPVDKVWNPHFFVLTPNNKIFYTDSYRL
DRDDARDEEVENILTRPKEQTSNDELHFGENWFHGKLSGGREEAESLLRQYSHLGDGTFL
VRESVTFVGDYCLSFWRKGKPNHC
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 17 | g10026.t3 | CDD | cd13362 | PH_PLC_gamma | 20 | 158 | 0.0000000 |
| 16 | g10026.t3 | CDD | cd16201 | EFh_PI-PLCgamma | 163 | 306 | 0.0000000 |
| 18 | g10026.t3 | CDD | cd08592 | PI-PLCc_gamma | 319 | 471 | 0.0000000 |
| 14 | g10026.t3 | Gene3D | G3DSA:2.30.29.30 | - | 9 | 152 | 0.0000000 |
| 15 | g10026.t3 | Gene3D | G3DSA:1.10.238.10 | - | 169 | 318 | 0.0000001 |
| 12 | g10026.t3 | Gene3D | G3DSA:3.20.20.190 | Phosphatidylinositol (PI) phosphodiesterase | 319 | 504 | 0.0000000 |
| 13 | g10026.t3 | Gene3D | G3DSA:2.30.29.30 | - | 505 | 608 | 0.0000000 |
| 3 | g10026.t3 | PANTHER | PTHR10336:SF173 | 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1 | 14 | 613 | 0.0000000 |
| 4 | g10026.t3 | PANTHER | PTHR10336 | PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN | 14 | 613 | 0.0000000 |
| 5 | g10026.t3 | PRINTS | PR00390 | Phospholipase C signature | 324 | 342 | 0.0000000 |
| 7 | g10026.t3 | PRINTS | PR00390 | Phospholipase C signature | 350 | 370 | 0.0000000 |
| 6 | g10026.t3 | PRINTS | PR00390 | Phospholipase C signature | 446 | 463 | 0.0000000 |
| 1 | g10026.t3 | Pfam | PF00388 | Phosphatidylinositol-specific phospholipase C, X domain | 321 | 463 | 0.0000000 |
| 2 | g10026.t3 | Pfam | PF00017 | SH2 domain | 572 | 624 | 0.0000000 |
| 23 | g10026.t3 | ProSiteProfiles | PS50003 | PH domain profile. | 18 | 149 | 10.2600000 |
| 21 | g10026.t3 | ProSiteProfiles | PS50007 | Phosphatidylinositol-specific phospholipase X-box domain profile. | 319 | 462 | 56.3920000 |
| 22 | g10026.t3 | ProSiteProfiles | PS50001 | Src homology 2 (SH2) domain profile. | 572 | 624 | 15.4170000 |
| 20 | g10026.t3 | SMART | SM00233 | PH_update | 19 | 151 | 0.0000300 |
| 19 | g10026.t3 | SMART | SM00148 | plcx_3 | 319 | 462 | 0.0000000 |
| 8 | g10026.t3 | SUPERFAMILY | SSF50729 | PH domain-like | 14 | 147 | 0.0000000 |
| 11 | g10026.t3 | SUPERFAMILY | SSF47473 | EF-hand | 178 | 321 | 0.0000000 |
| 10 | g10026.t3 | SUPERFAMILY | SSF51695 | PLC-like phosphodiesterases | 319 | 490 | 0.0000000 |
| 9 | g10026.t3 | SUPERFAMILY | SSF55550 | SH2 domain | 557 | 624 | 0.0000000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008081 | phosphoric diester hydrolase activity | MF |
| GO:0007165 | signal transduction | BP |
| GO:0004435 | phosphatidylinositol phospholipase C activity | MF |
| GO:0035556 | intracellular signal transduction | BP |
| GO:0006629 | lipid metabolic process | BP |
KEGG
Orthology
- This transcript has been annotated with K05857 (phosphatidylinositol phospholipase C, delta)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed