General information for g10468.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Alkaline phosphatase 4.
Parent gene
- The parent gene g10468 is located on chr_1: 10025997..10027632 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10468 | g10468.t1 | isoform | g10468.t1 | 10025997 | 10027632 |
| chr_1 | g10468 | g10468.t1 | exon | g10468.t1.exon1 | 10025997 | 10026082 |
| chr_1 | g10468 | g10468.t1 | cds | g10468.t1.CDS1 | 10025997 | 10026082 |
| chr_1 | g10468 | g10468.t1 | exon | g10468.t1.exon2 | 10026138 | 10026947 |
| chr_1 | g10468 | g10468.t1 | cds | g10468.t1.CDS2 | 10026138 | 10026947 |
| chr_1 | g10468 | g10468.t1 | exon | g10468.t1.exon3 | 10027005 | 10027075 |
| chr_1 | g10468 | g10468.t1 | cds | g10468.t1.CDS3 | 10027005 | 10027075 |
| chr_1 | g10468 | g10468.t1 | exon | g10468.t1.exon4 | 10027142 | 10027632 |
| chr_1 | g10468 | g10468.t1 | cds | g10468.t1.CDS4 | 10027142 | 10027632 |
| chr_1 | g10468 | g10468.t1 | TSS | g10468.t1 | NA | NA |
| chr_1 | g10468 | g10468.t1 | TTS | g10468.t1 | NA | NA |
Sequences
>g10468.t1 Gene=g10468 Length=1458
ATGAAGGCACTTTTCTTATTATTGGGAATAATTTCCTTAGGAAGTTGTATAGTTTTTGAT
CCACCAAATAAAGGAGAAACAAAATATTGGCATGATTACAACATGAAATTTCTCAAAAAA
GTTCTCAACTCACAAAAACCTTTAAAAGTAGCCAAAAATGTGATTTTATTTGTTGGTGAT
GGAATGTCATTTGCAACAATTACAGCTGGTAGAATTTTAAAAGGACAAATGGAAGGAAAA
TCGGGTGAAGAATCAGAATTTATTTTTGAAGACTTTCCTCATATTGGACTAGCTAAAACT
TATGGTACAAATGTACAAATTACTGATTCTGCTTTAACTGCAACTGCAATATTTTCGGGA
ATTAAAACGTCATTTTTTGCTATTGGTGCGAATAATCCGACACAAAATGTTCAAGAAAAA
GATAGATTGAAGAATATTATTGATTGGGCTCAAGAAAAGGGAAAAAGGACTGGAGTTGTA
ACTAATACAAAAATTACTGATGCAACGCCAGCATCTGCTTACGCTTACAGTTTTTCAAGA
TTATATGAATGTGATTCAAGAATTCCTGAGAACGTTAAATCAATAGGTTTCAAAAATATT
GCAAAACAATTGGTTGAAAATGAGCCAGGAAATAAATTAAACGTGATATTTGGAGGAGGT
CGTGATTATTTAGGTGTTGGAAGTGGAAAATTTTGCAATAACAATTTGGTTACAAAATAT
TTGAATCAATTTGATAATGAGAAAAATGTAAAATTTGTGAAAAATACAGGTGAATTGCGT
GCAGTTGATTTTTCTGATGTCGATCATATAATGGGACTTTTTGCTGATGATCACATGGAT
TATGAGAGCCTTCGTAAAAAAGATCTTTATGGACAGCCTTCATTGAGTGAAATGACACAA
TCAGCAATTCAAATCTTGAATAACAAATATAATGAGAATGGTTTTGTTTTGATTATTGAA
GGAGGTTTGATTGATAAAGCACATCATTTCAATCAAGCAAAATTTGCACTTGAAGAGCTT
GTTGAAATGGAAAAAGCAATACAGATAGCAAAAAATATGACATCGTCCGAAGATACTTTG
ATAATAGTCACAGCTGATCATGCACATAGCATGTTATTTCATGGTTATCCTAGTCGTGGT
AATGATATTTTAGGCTTTGCAAATGAAGGTACTAATGTTCCATTATTTGAGACACTTGTT
TATGGAAATGGACCAGGCTATAGATACCATTTAATCAAAGGATCTCAAACACAATTTATG
CCAATGGAAAATTATACAGTTCAACAAAGAAAAGATCCGTCTTACATGTACAAATCTATG
ATTCCATTAGATTATTCAACTCATTCTGGTGAAGATGTTGGTGTTTATGCAGATGGTCCT
GGATCATTTTTAATTCAAAGAGTTTTTGAACAATGTTACATAGGCTATGCAATTTCTGTG
GCAAGTTGTATTGGGTAA
>g10468.t1 Gene=g10468 Length=485
MKALFLLLGIISLGSCIVFDPPNKGETKYWHDYNMKFLKKVLNSQKPLKVAKNVILFVGD
GMSFATITAGRILKGQMEGKSGEESEFIFEDFPHIGLAKTYGTNVQITDSALTATAIFSG
IKTSFFAIGANNPTQNVQEKDRLKNIIDWAQEKGKRTGVVTNTKITDATPASAYAYSFSR
LYECDSRIPENVKSIGFKNIAKQLVENEPGNKLNVIFGGGRDYLGVGSGKFCNNNLVTKY
LNQFDNEKNVKFVKNTGELRAVDFSDVDHIMGLFADDHMDYESLRKKDLYGQPSLSEMTQ
SAIQILNNKYNENGFVLIIEGGLIDKAHHFNQAKFALEELVEMEKAIQIAKNMTSSEDTL
IIVTADHAHSMLFHGYPSRGNDILGFANEGTNVPLFETLVYGNGPGYRYHLIKGSQTQFM
PMENYTVQQRKDPSYMYKSMIPLDYSTHSGEDVGVYADGPGSFLIQRVFEQCYIGYAISV
ASCIG
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 18 | g10468.t1 | CDD | cd16012 | ALP | 52 | 483 | 1.02761E-105 |
| 12 | g10468.t1 | Coils | Coil | Coil | 333 | 353 | - |
| 11 | g10468.t1 | Gene3D | G3DSA:3.40.720.10 | Alkaline Phosphatase | 25 | 485 | 6.9E-146 |
| 2 | g10468.t1 | PANTHER | PTHR11596 | ALKALINE PHOSPHATASE | 18 | 485 | 1.2E-154 |
| 3 | g10468.t1 | PANTHER | PTHR11596:SF83 | ALKALINE PHOSPHATASE 4 | 18 | 485 | 1.2E-154 |
| 4 | g10468.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 51 | 71 | 4.1E-34 |
| 6 | g10468.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 107 | 122 | 4.1E-34 |
| 8 | g10468.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 150 | 170 | 4.1E-34 |
| 5 | g10468.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 212 | 222 | 4.1E-34 |
| 7 | g10468.t1 | PRINTS | PR00113 | Alkaline phosphatase signature | 296 | 325 | 4.1E-34 |
| 1 | g10468.t1 | Pfam | PF00245 | Alkaline phosphatase | 51 | 483 | 1.1E-106 |
| 14 | g10468.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 16 | - |
| 15 | g10468.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 2 | - |
| 16 | g10468.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 3 | 11 | - |
| 17 | g10468.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 12 | 16 | - |
| 13 | g10468.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 17 | 485 | - |
| 20 | g10468.t1 | ProSiteProfiles | PS51257 | Prokaryotic membrane lipoprotein lipid attachment site profile. | 1 | 16 | 5.0 |
| 19 | g10468.t1 | SMART | SM00098 | alk_phosph_2 | 52 | 485 | 9.0E-136 |
| 9 | g10468.t1 | SUPERFAMILY | SSF53649 | Alkaline phosphatase-like | 27 | 485 | 9.49E-122 |
| 10 | g10468.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 16 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0003824 | catalytic activity | MF |
| GO:0016791 | phosphatase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed