General information for g10557.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as NAD-dependent protein deacetylase Sirt7.
Parent gene
- The parent gene g10557 is located on chr_1: 10460586..10461348 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10557 | g10557.t1 | isoform | g10557.t1 | 10457847 | 10460586 |
| chr_1 | g10557 | g10557.t1 | exon | g10557.t1.exon1 | 10457847 | 10457942 |
| chr_1 | g10557 | g10557.t1 | cds | g10557.t1.CDS1 | 10457847 | 10457942 |
| chr_1 | g10557 | g10557.t1 | exon | g10557.t1.exon2 | 10458004 | 10458280 |
| chr_1 | g10557 | g10557.t1 | cds | g10557.t1.CDS2 | 10458004 | 10458280 |
| chr_1 | g10557 | g10557.t1 | exon | g10557.t1.exon3 | 10458337 | 10460469 |
| chr_1 | g10557 | g10557.t1 | cds | g10557.t1.CDS3 | 10458337 | 10460469 |
| chr_1 | g10557 | g10557.t1 | exon | g10557.t1.exon4 | 10460537 | 10460586 |
| chr_1 | g10557 | g10557.t1 | cds | g10557.t1.CDS4 | 10460537 | 10460586 |
| chr_1 | g10557 | g10557.t1 | TTS | g10557.t1 | 10460766 | 10460766 |
| chr_1 | g10557 | g10557.t1 | TSS | g10557.t1 | NA | NA |
Sequences
>g10557.t1 Gene=g10557 Length=2556
ATGGAAGAATTTTTTTCCACTCGGCTCACTCGCAAAAAAGAAGTTCAAGAATGTCCTATT
GCCAAGAAACGAGAGAAAGCATTTAAGAAAAGAAAGATTTCTGCTATTCTGAAAAAATCT
GAGACAAGTAGAACATCAGAAGAGACTCGGTATATTGAAGAACATTTGGAAATAGTTAAG
GAAGTATCTGAAAGAAAGAAGAGAGTAGAAAAGTACAAAGATAGAGCACTCGAAAAAGAA
GATAAACCTGATATTATTGAAGAGAAGGCAAAGAAACTGGCTTCTGTTATTAAGAATGCT
AAACATTTAATAGTATATTCAGGAGCTGGTATAAGTACATCTGCTAAAATTCCTGATTAT
CGTGGTCCTCAAGGAATTTGGACTTTACTTCAGAGAGGTGAAGAGATTGGCCACCATGAT
TTATCACTTGCAGAGCCCACTTATACGCACATGTCCTTGTATGAATTACATAAGCGCAAA
ATATTGAAATATGTAGTTTCTCAAAATTGTGATGGTCTTCATTTGCGCTCAGGACTTCCA
CGATTTTCACTTTCTGAAGTACATGGTAATATGTATATTGAAGTATGCAAGCATTGTAAA
CCAGCACTTGAGTATTGGAGAATTTTCGATACAACTCCATTAACATCTAGATTTCAACAT
AAGACTAATAGACGATGTAGGTATTGTGCAAATCCTCTTATTGATACCATTGTACATTTC
GGTGAAAGAGGTTCGCTTAAATGGCCGCTAAATTGGAATGGAGCAACAAAAAATGTAGAG
AAGGCTGATGTCATTTTATGCTTAGGTTCAAGTCTAAAAGTGCTTAAAAAATATCCTTGG
CTTTGGGCTCTAGATAAACCTCAAAAACAGCGTCCAAAAATATATATTGTAAATTTGCAA
TGGACTCCCAAAGATTCGATAGCATCGATCAAAATTAATGGAAGGTGTGATGAAGTTATG
AAGACTGTTATGAAACATTTAAATATTGAGGTGCCCAAATATGATCGCGAAAATGATCCC
ATATTTCATCACGCATCTTTATTGAAAGAGGAAGAATTACATACTGCTTCACAGCCAATG
TTAAAGAGATTTGTCATTAAGGATGAAGACGATCAGAATTTTAATGAAAATGATGAATCG
ACGAATAGCATTACAATGAGTTCTGATAAGCAGACAGAATCAGAAGATCATTCTCAATCA
ACAGAATCGGCAGAAAATTTTATTAACAAGATAAAAAGTGATTTAAGCAATGATCAATCA
AATGAAATTCAAACCAATAGTGAACAAAACGATAATAAAATGACTGAAATTAAATTAAAA
CTTGAAACGCCTAAAAAAGAGAATAATGCAAAGGAAATTTTCGATTTAACTGTCGATGAA
TGTGACGATCAAAAAAATAATGTTTGTGAAACTAAGAATGAAGTAATAGATTTTGAAGAA
TTAATTGATAATTTAGATTCAAAAGTTGTAAATAATGAGAACAAAGAACCATCATCACAA
ATAATTATATGTGAAGAAAAAGAAGACAAAGAGAACCAACAGATTATAGTAAAAAGTGAA
ACAGATGAGCAACGTTCTAAAGTTGCAGATATAATTATGCAACAAAATCAAAATCTCATT
GATATGGCTCTTCTTAACAATAGTCTTTTAACAGCATCTCTTGCTTTTGCACCTGCGGGA
ACAACTTCTAAAGAAGCACTTACAGCAACCGCATTGATTCTTAATTATAATAATCAAATT
ATTAGCACGCTGACAAACAATCTTAACATGTTGCCTTATACAACAAACACTAGCGTCGCA
AATGGTTCGATACAAACCAACAACAATTCTTCCTCCTCTGCACATGTTAGATCAATCTGT
GATAAAAATAACGTAATTAAAAGTGAAAACTTTGAAAATGATATTGAAATGGTTGAAGAT
GAAGCTAGTGATGATGATAATACTGATGAAGAGTCATCGAATAGTGTTTTCAATAAATGT
ATTGATGAAGACACTTCATCATCGTCAAATCTTAATCCTGAGCAGTATTATAAGCAATTA
TTTGCCAATTATTGTAAGGCAATCAATGATAATCTTCCTCAATGGAGTGACGTAAATTAT
GCTTATTCGGGACTTCATACGATAGTAAATCCTGAGCCGGAGAATGCTAATTTGTGGAGA
AACAATAGTGATGATGAGAATCAAAAAGCAAAAAAATTGCGGAGTTCAACAGCTGCTGAA
AGAAAAGCAGCAAAAGCTGAATGCAAATTTTGTTATGATAAATATGAAATGATGGAATGT
CAATTCTATAAGCCAATAAACCGAGAGTTTAAGATCACTACCTATCGTAATGGAAAAACA
ATAGTTTGTGAATGTTGCGATTATACAGAAGAGGAGGAAGATGAGGTTGAAGCAGAACAA
AATAACGACGATGATGATATTAATATTTCAAAATCAATTAGCGATGAAAAGGATAGAGAA
AAGTCTTCAAATAATATAAGAACTAAGGCTGGGTGGTTTGGTAAAGGATATCGAAAAATT
CAGAAGAAAAGAAAGAAAGTAAATGTATCTGCATAG
>g10557.t1 Gene=g10557 Length=851
MEEFFSTRLTRKKEVQECPIAKKREKAFKKRKISAILKKSETSRTSEETRYIEEHLEIVK
EVSERKKRVEKYKDRALEKEDKPDIIEEKAKKLASVIKNAKHLIVYSGAGISTSAKIPDY
RGPQGIWTLLQRGEEIGHHDLSLAEPTYTHMSLYELHKRKILKYVVSQNCDGLHLRSGLP
RFSLSEVHGNMYIEVCKHCKPALEYWRIFDTTPLTSRFQHKTNRRCRYCANPLIDTIVHF
GERGSLKWPLNWNGATKNVEKADVILCLGSSLKVLKKYPWLWALDKPQKQRPKIYIVNLQ
WTPKDSIASIKINGRCDEVMKTVMKHLNIEVPKYDRENDPIFHHASLLKEEELHTASQPM
LKRFVIKDEDDQNFNENDESTNSITMSSDKQTESEDHSQSTESAENFINKIKSDLSNDQS
NEIQTNSEQNDNKMTEIKLKLETPKKENNAKEIFDLTVDECDDQKNNVCETKNEVIDFEE
LIDNLDSKVVNNENKEPSSQIIICEEKEDKENQQIIVKSETDEQRSKVADIIMQQNQNLI
DMALLNNSLLTASLAFAPAGTTSKEALTATALILNYNNQIISTLTNNLNMLPYTTNTSVA
NGSIQTNNNSSSSAHVRSICDKNNVIKSENFENDIEMVEDEASDDDNTDEESSNSVFNKC
IDEDTSSSSNLNPEQYYKQLFANYCKAINDNLPQWSDVNYAYSGLHTIVNPEPENANLWR
NNSDDENQKAKKLRSSTAAERKAAKAECKFCYDKYEMMECQFYKPINREFKITTYRNGKT
IVCECCDYTEEEEDEVEAEQNNDDDDINISKSISDEKDREKSSNNIRTKAGWFGKGYRKI
QKKRKKVNVSA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g10557.t1 | CDD | cd01410 | SIRT7 | 101 | 315 | 4.21738E-99 |
| 7 | g10557.t1 | Coils | Coil | Coil | 59 | 79 | - |
| 5 | g10557.t1 | Gene3D | G3DSA:3.40.50.1220 | - | 93 | 327 | 4.6E-76 |
| 6 | g10557.t1 | Gene3D | G3DSA:2.20.28.200 | - | 189 | 241 | 4.6E-76 |
| 11 | g10557.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 366 | 434 | - |
| 9 | g10557.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 401 | 432 | - |
| 10 | g10557.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 794 | 827 | - |
| 12 | g10557.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 804 | 825 | - |
| 2 | g10557.t1 | PANTHER | PTHR45853 | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-(6/7) FAMILY MEMBER | 64 | 466 | 9.0E-120 |
| 3 | g10557.t1 | PANTHER | PTHR45853:SF4 | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7 | 64 | 466 | 9.0E-120 |
| 1 | g10557.t1 | Pfam | PF02146 | Sir2 family | 144 | 275 | 6.1E-18 |
| 13 | g10557.t1 | ProSiteProfiles | PS50305 | Sirtuin catalytic domain profile. | 91 | 332 | 39.563 |
| 4 | g10557.t1 | SUPERFAMILY | SSF52467 | DHS-like NAD/FAD-binding domain | 67 | 358 | 6.72E-67 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0070403 | NAD+ binding | MF |
KEGG
Orthology
- This transcript has been annotated with K11417 (NAD+-dependent protein deacetylase sirtuin 7)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
