General information for g10580.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Axin.
Parent gene
- The parent gene g10580 is located on chr_1: 10519596..10522743 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10580 | g10580.t1 | isoform | g10580.t1 | 10519596 | 10522743 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon1 | 10519596 | 10519722 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS1 | 10519596 | 10519722 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon2 | 10519816 | 10520088 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS2 | 10519816 | 10520088 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon3 | 10520151 | 10520327 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS3 | 10520151 | 10520327 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon4 | 10520410 | 10520497 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS4 | 10520410 | 10520497 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon5 | 10520569 | 10520785 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS5 | 10520569 | 10520785 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon6 | 10520846 | 10520986 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS6 | 10520846 | 10520986 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon7 | 10521058 | 10521154 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS7 | 10521058 | 10521154 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon8 | 10521252 | 10521363 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS8 | 10521252 | 10521363 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon9 | 10521849 | 10521872 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS9 | 10521849 | 10521872 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon10 | 10521934 | 10522600 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS10 | 10521934 | 10522600 |
| chr_1 | g10580 | g10580.t1 | exon | g10580.t1.exon11 | 10522666 | 10522743 |
| chr_1 | g10580 | g10580.t1 | cds | g10580.t1.CDS11 | 10522666 | 10522743 |
| chr_1 | g10580 | g10580.t1 | TSS | g10580.t1 | NA | NA |
| chr_1 | g10580 | g10580.t1 | TTS | g10580.t1 | NA | NA |
Sequences
>g10580.t1 Gene=g10580 Length=2001
ATGCATCAAAATTTCAATGAGAATGACAATATTGGAAAAAGACCGCCAATTCCAGGAGAG
GAAACAAAATATATTAAGATGACAGATAGTACTCAAAGTGAATTACTTTCATACATGACG
ACACCATCATCATCTTCGTCTCAATCTTCATCGCCATCATGTTTAAAGTGGGCTTGTACA
CTTAATCGCTTACTTGAAGATCGCGAAGGCGTTGAATTATTTAAAAAATATGCAGAAGCA
GAAGGTGGCATTCATCATGATCGTTTAAGATTTTATTTCGCTGTCGAAGGATTAAAGCAA
CAGGGCGATCTAAGCAAAATCAAACTGATTGTTGGGGCAATTTATAGATTTCTTAAAAAA
ACTGAACTTGTAGTGCCTGAAGACATTAAAAGAACGATAAAAGCAGGACTAAAAGATGAC
TCGTATGTTTTTAAACCAGATATATACGACAAAATGCAAAAAAGTGTCGAAAAAATTATC
AATGAAACGACTTATCCTAATTTTTTACAATCAGATATGTATTTGCAATATGTGCATAAT
GCTCAAAGTGCCAATGAACGAAATCTAATTTCTCAAGAAAATTCAACTGCAGCTAGTTCA
ATGAGTATTTCTGATTCATCTCTGAAACTTCTTTCAAGGAGCTCTACACTGCCAACGCTC
ATGGAAGAAACTGCAGATGGTTCCACTGGTGATTTAAACGAAGCTTCCGGCGGTTTTTCT
GAAATAACTAATCGTGTGCCAATAAGCGGCTCGAAATGCGACCACAAGGTTTACAACAAC
TATGCTCCTTATAATCCCGTTTCGAGACGAGATTCTGAATTAGCAAGTTTAAGCTCAGGG
CGAACAGACTCCGATACAATGTCAATTTCTAGTATGTCAACAGATGGTAGACCACAAAGG
AGACATCATCATCATAGCCATCGTCAGGAACGACGAATAATCAACGAAAATGTTACAATT
AATACAAATAATGAACCATTTATACCTCGAACTCAACGACCAGATGGTATACCAAAAAAT
TTATCACCTGATGAATTTCTAAGAATTTTAATACCAAAATTGGAAGCAGTTAAGAAACAT
CAAGAAACAACAGAATTACTCGGCAAAAAACTCGCAGAGGTTGATAAATCAAACAAATTG
TTTGTGGATGCAATTAATGCTAAATTAATGTTGGGTGATGATAAAGATGATCAAGATATT
TTAGATCAGCATGTATCAAGAGTTTGGTCTGATCGAACGCCCCTTCGTTCTCCGGGCAAT
ATGTCACCATGCAATACATCAAATCAATTTCAACGAACAAAACAATACGAGACTGTATTA
AGTTGTGGAAGTAGTAGCATACATTCATCAATGAGGTCTTCAAAATCAATGCCAGATTCA
AATATGCGTAAATTTTCAAAATGGGGTAGCATTAATACGGATAGTGGTATCAGCTTATTT
TCATCTGATACGATGACAATTAAGCATAAGGATGCAATGAGTATATCAAGTGGTAGCAGT
AGTAGCACATCAAAATCTAGAACAATCGTGGCAAGTGAAGTAGGTTCAAGTATTAACTCT
CATAACAAATTAACGCCGCAGCAAATAGAAGAACTGAGAAGATCAAAACGATATCAGCAA
CAACAACCACCAGCTTTGCCAGTTAAAAATGTTATACCTCCACCATTACCTGCCAAAAAT
TTACCTCAATTACCACAACAACAGCAATTACATCAAACTCAACCTTCCTCAGTTGTTGCT
CCACCAGAACATACAACAACTGTTGTTTGTTCATTTTGCGACGAAGACGTTCCATATCGT
ATTAAAATCCCAGGTAAAAGTCCATTAACTTTAAAGCAGTTCAAGGAATCATTACCGAAG
AAAGGAAACTATAGATTTTTCTTTAAAACTCGTTGTGAAGATGAAGATAATCCTATAATT
CAAGAAGAAGTTGTAAATGATTCAGATGTGCTACCGCTTTTTGATGATAAAGTGATGGCA
ACAGTGAAATTGGCCTCTTAA
>g10580.t1 Gene=g10580 Length=666
MHQNFNENDNIGKRPPIPGEETKYIKMTDSTQSELLSYMTTPSSSSSQSSSPSCLKWACT
LNRLLEDREGVELFKKYAEAEGGIHHDRLRFYFAVEGLKQQGDLSKIKLIVGAIYRFLKK
TELVVPEDIKRTIKAGLKDDSYVFKPDIYDKMQKSVEKIINETTYPNFLQSDMYLQYVHN
AQSANERNLISQENSTAASSMSISDSSLKLLSRSSTLPTLMEETADGSTGDLNEASGGFS
EITNRVPISGSKCDHKVYNNYAPYNPVSRRDSELASLSSGRTDSDTMSISSMSTDGRPQR
RHHHHSHRQERRIINENVTINTNNEPFIPRTQRPDGIPKNLSPDEFLRILIPKLEAVKKH
QETTELLGKKLAEVDKSNKLFVDAINAKLMLGDDKDDQDILDQHVSRVWSDRTPLRSPGN
MSPCNTSNQFQRTKQYETVLSCGSSSIHSSMRSSKSMPDSNMRKFSKWGSINTDSGISLF
SSDTMTIKHKDAMSISSGSSSSTSKSRTIVASEVGSSINSHNKLTPQQIEELRRSKRYQQ
QQPPALPVKNVIPPPLPAKNLPQLPQQQQLHQTQPSSVVAPPEHTTTVVCSFCDEDVPYR
IKIPGKSPLTLKQFKESLPKKGNYRFFFKTRCEDEDNPIIQEEVVNDSDVLPLFDDKVMA
TVKLAS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g10580.t1 | Gene3D | G3DSA:1.10.196.10 | - | 56 | 176 | 4.4E-23 |
| 14 | g10580.t1 | Gene3D | G3DSA:1.10.167.10 | - | 82 | 163 | 4.4E-23 |
| 13 | g10580.t1 | Gene3D | G3DSA:3.10.20.380 | - | 582 | 666 | 5.4E-29 |
| 10 | g10580.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 20 | - |
| 12 | g10580.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 269 | 311 | - |
| 11 | g10580.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 271 | 295 | - |
| 4 | g10580.t1 | PANTHER | PTHR46102 | AXIN | 8 | 664 | 4.9E-141 |
| 5 | g10580.t1 | PANTHER | PTHR46102:SF2 | AXIN | 8 | 664 | 4.9E-141 |
| 3 | g10580.t1 | Pfam | PF00615 | Regulator of G protein signaling domain | 61 | 177 | 7.7E-14 |
| 1 | g10580.t1 | Pfam | PF08833 | Axin beta-catenin binding motif | 396 | 423 | 4.9E-10 |
| 2 | g10580.t1 | Pfam | PF00778 | DIX domain | 585 | 663 | 2.1E-29 |
| 17 | g10580.t1 | ProSiteProfiles | PS50132 | RGS domain profile. | 60 | 178 | 15.58 |
| 16 | g10580.t1 | ProSiteProfiles | PS50841 | DIX domain profile. | 583 | 666 | 21.673 |
| 8 | g10580.t1 | SMART | SM00315 | RGS_3 | 60 | 178 | 6.8E-17 |
| 9 | g10580.t1 | SMART | SM00021 | dax_2 | 583 | 666 | 1.2E-15 |
| 7 | g10580.t1 | SUPERFAMILY | SSF48097 | Regulator of G-protein signaling, RGS | 47 | 180 | 1.77E-18 |
| 6 | g10580.t1 | SUPERFAMILY | SSF54236 | Ubiquitin-like | 585 | 664 | 3.41E-24 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | BP |
KEGG
Orthology
- This transcript has been annotated with K02157 (axin 1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
