General information for g10630.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Toll-like receptor Tollo.
Parent gene
- The parent gene g10630 is located on chr_1: 10869654..10871666 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10630 | g10630.t1 | isoform | g10630.t1 | 10869654 | 10871666 |
| chr_1 | g10630 | g10630.t1 | exon | g10630.t1.exon1 | 10869654 | 10871666 |
| chr_1 | g10630 | g10630.t1 | cds | g10630.t1.CDS1 | 10869654 | 10871666 |
| chr_1 | g10630 | g10630.t1 | TSS | g10630.t1 | NA | NA |
| chr_1 | g10630 | g10630.t1 | TTS | g10630.t1 | NA | NA |
Sequences
>g10630.t1 Gene=g10630 Length=2013
ATGTTCAAAAATAATGATGATGGTAATAATGATGATGATAATGGCAGTGATGAGGAAGAA
GCAGAATGCAAATGTAAAATGACTTGTCCAGATCAATGCTCATGTTATCATGACAACACA
TGGAATAAAAATATTGTTGATTGTGGAAATGCCAATATGCAAACATTTCCACATCGTGTG
CCAATTGATGTGACCACTTTCTATCTCGATGGCAATAATCTTACACATTTATCGCATCAT
CAATTTGTAGGCAAAAATAGACTTGAAGTTTTATACTTAAATGATAGCAACATTCATACA
ATTGCTAATGGAACATTTGATGAACTTAAAAGTCTTCGAGTTTTACATTTAAATCGTAAT
CAATTGAAAAGACTTCATGGAAATGAATTTAAAGAATTGCAATTACTAAATGAGCTCTAT
TTGGATCATAATAAACTCACACATATTGGTGATAATGCATTTAGTCATATGAAATTTCTT
CGTACAATTGATTTAAGTGACAATCGTTTGGTTGATTTCAATCCGATAACACAATTGTCA
ACAGCAAGTCGTAGTGGAATGTTGTCACAAGTATATTTAGATGGTGATAATAAATGGAAT
TGTGATTGCAAGAGTTTAGTCCAGTTAATCGAATGGATCAAAAATCGCTCAAATAATTTC
AATGTTCAACGAATGCTCTGCAATGATAATCGAATTGTTGGCGATGTACTCAACAATTGC
CATCTCATCATGAACACAAACATCTTTGGTAACGAATTTGCAACTCCACCATCATCGTTG
AACTCACTTCAACAACAGCATTCGACCATCAACGCCAACAATGTTCATCGTCATCATCCA
TTCAGCAATGTCGGTAGTGGTGGATATATTCCACTTTTTGCAGCTATTCTTGTCACTGTC
ATCACTTCAGCATTATTGATTGCACTCGTATGTATCTTCAGACAGGATGTCAAGTTATGG
GCATTCTCAAAATATGGCATTCGTTTTGGTGGCGATGGAACAAGCAAAAATAGTGGAAAT
GGCAAGAAACAAATTTTGAATCATCATCGCTATAATGCAAATGCAGCAACAACAGCAGCA
GATGAAGAATATTATGCAGAAAAAATTTATGATGCATATTGCATTTATTCAATCAATGAC
ACAGACTTGTTGACTCAAATTTTATTACCAGAAATGCAAAATCTTGGCTATAATGTTTCA
CTTTTTAATCATCATAATAAACCAATTATGGCAAGAGATAATTTTCAAGTGACCAACTAT
TTAATCGATACACTCAAGACTGGAACAGATGCATCGCATAAACTTGTAATAGTTTTGTCT
TTCAACTTCTTGCAGACTGAATGGTGCGATAATAATTTCCGTTGTGCTATGCAAGCACTC
ATCGACTCAATGATGAATCAACGAACTAACAAAAATATCATTCTCATTCTTACTGTGCCA
GTTCAAATAATTCAAATGGATCCACTTCTTCAACTTCTAATACGCACATGCACCATCATA
TGTTGGGGTGAAAAACGTTTCTGGACTAAATTACGCTATGCATTGCCGGATGTCTCGAAT
GATAAGAAATATATAAATACAAGTTATGCTGATGGCACAATGACACATCGATATTCAGTC
GCACCAACGTCCACCCTTCAATCAACACGAGCGACACATGCTCCCATGATGATGCAATAT
AACAACAACATGAATGGACAGCCGGTCAGCTGGCCTTATAATTCATCGCCTGTCGTGTGC
AGTGGCTATTCTATGCCCATCAATCAGTATGAAAACGAGAATGAGCCATGCCATGAATAT
GAACAGCCAGTTTACTCGACAATTCCCGAGACACCTCCACTCTCATCCTCATCAAATGCT
TCATCGTCACCTTCACTTTCGCACAATGGTGGTGAACGAGTACATCGACAGACACATGGT
CGTAATCGCATGAATGAGCAACAACAACAACACTGTGATTTTCCTGGCATCAGCAACAAC
AACAATAATGGTAACAACGATCATTTTGTTTGA
>g10630.t1 Gene=g10630 Length=670
MFKNNDDGNNDDDNGSDEEEAECKCKMTCPDQCSCYHDNTWNKNIVDCGNANMQTFPHRV
PIDVTTFYLDGNNLTHLSHHQFVGKNRLEVLYLNDSNIHTIANGTFDELKSLRVLHLNRN
QLKRLHGNEFKELQLLNELYLDHNKLTHIGDNAFSHMKFLRTIDLSDNRLVDFNPITQLS
TASRSGMLSQVYLDGDNKWNCDCKSLVQLIEWIKNRSNNFNVQRMLCNDNRIVGDVLNNC
HLIMNTNIFGNEFATPPSSLNSLQQQHSTINANNVHRHHPFSNVGSGGYIPLFAAILVTV
ITSALLIALVCIFRQDVKLWAFSKYGIRFGGDGTSKNSGNGKKQILNHHRYNANAATTAA
DEEYYAEKIYDAYCIYSINDTDLLTQILLPEMQNLGYNVSLFNHHNKPIMARDNFQVTNY
LIDTLKTGTDASHKLVIVLSFNFLQTEWCDNNFRCAMQALIDSMMNQRTNKNIILILTVP
VQIIQMDPLLQLLIRTCTIICWGEKRFWTKLRYALPDVSNDKKYINTSYADGTMTHRYSV
APTSTLQSTRATHAPMMMQYNNNMNGQPVSWPYNSSPVVCSGYSMPINQYENENEPCHEY
EQPVYSTIPETPPLSSSSNASSSPSLSHNGGERVHRQTHGRNRMNEQQQQHCDFPGISNN
NNNGNNDHFV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g10630.t1 | Gene3D | G3DSA:3.80.10.10 | Ribonuclease Inhibitor | 20 | 236 | 2.3E-41 |
| 6 | g10630.t1 | Gene3D | G3DSA:3.40.50.10140 | - | 365 | 516 | 5.2E-27 |
| 18 | g10630.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 610 | 670 | - |
| 19 | g10630.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 610 | 631 | - |
| 17 | g10630.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 643 | 670 | - |
| 2 | g10630.t1 | PANTHER | PTHR45836:SF8 | TOLL-LIKE RECEPTOR 6 | 22 | 629 | 1.5E-101 |
| 3 | g10630.t1 | PANTHER | PTHR45836 | SLIT HOMOLOG | 22 | 629 | 1.5E-101 |
| 1 | g10630.t1 | Pfam | PF13855 | Leucine rich repeat | 111 | 170 | 2.9E-12 |
| 10 | g10630.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 288 | - |
| 11 | g10630.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 289 | 313 | - |
| 8 | g10630.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 314 | 472 | - |
| 12 | g10630.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 473 | 494 | - |
| 9 | g10630.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 495 | 670 | - |
| 22 | g10630.t1 | ProSiteProfiles | PS51450 | Leucine-rich repeat profile. | 63 | 84 | 5.055 |
| 24 | g10630.t1 | ProSiteProfiles | PS51450 | Leucine-rich repeat profile. | 87 | 108 | 5.44 |
| 21 | g10630.t1 | ProSiteProfiles | PS51450 | Leucine-rich repeat profile. | 111 | 132 | 6.819 |
| 20 | g10630.t1 | ProSiteProfiles | PS51450 | Leucine-rich repeat profile. | 135 | 156 | 7.227 |
| 23 | g10630.t1 | ProSiteProfiles | PS51450 | Leucine-rich repeat profile. | 159 | 180 | 7.327 |
| 25 | g10630.t1 | ProSiteProfiles | PS50104 | TIR domain profile. | 368 | 518 | 18.329 |
| 16 | g10630.t1 | SMART | SM00369 | LRR_typ_2 | 87 | 108 | 140.0 |
| 15 | g10630.t1 | SMART | SM00369 | LRR_typ_2 | 109 | 132 | 0.032 |
| 14 | g10630.t1 | SMART | SM00369 | LRR_typ_2 | 133 | 156 | 0.0021 |
| 5 | g10630.t1 | SUPERFAMILY | SSF52058 | L domain-like | 44 | 218 | 3.49E-27 |
| 4 | g10630.t1 | SUPERFAMILY | SSF52200 | Toll/Interleukin receptor TIR domain | 361 | 520 | 2.09E-21 |
| 13 | g10630.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 291 | 313 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0007165 | signal transduction | BP |
| GO:0005515 | protein binding | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
