General information for g10691.t8
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as AP-2 complex subunit mu.
Parent gene
- The parent gene g10691 is located on chr_1: 11338501..11339776 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10691 | g10691.t8 | TSS | g10691.t8 | 11337279 | 11337279 |
| chr_1 | g10691 | g10691.t8 | isoform | g10691.t8 | 11338162 | 11339776 |
| chr_1 | g10691 | g10691.t8 | exon | g10691.t8.exon1 | 11338162 | 11338438 |
| chr_1 | g10691 | g10691.t8 | cds | g10691.t8.CDS1 | 11338369 | 11338438 |
| chr_1 | g10691 | g10691.t8 | exon | g10691.t8.exon2 | 11338495 | 11339087 |
| chr_1 | g10691 | g10691.t8 | cds | g10691.t8.CDS2 | 11338495 | 11339087 |
| chr_1 | g10691 | g10691.t8 | exon | g10691.t8.exon3 | 11339144 | 11339776 |
| chr_1 | g10691 | g10691.t8 | cds | g10691.t8.CDS3 | 11339144 | 11339251 |
| chr_1 | g10691 | g10691.t8 | TTS | g10691.t8 | NA | NA |
Sequences
>g10691.t8 Gene=g10691 Length=1503
GAAATTCTTGATTTTGGTTACCCACAAAATTCTGATACTGGAGTTTTAAAGACATTTATA
ACGCAACAAGGTATTAAATCAGCAACAAAAGAAGAGCAGGCGCAAATAACATCTCAAGTC
ACTGGTCAAATTGGTTGGCGTAGAGAAGGAATTAAATACAGACGCAATGAACTATTTTTG
GATGTTTTGGAATATGTTAATTTGCTCATGAGTCCCCAAGGACAAGTATTATCAGCTCAT
GTCGCTGGGAAAGTTGTTATGAAATCATTTTTATCAGGTATGCCGGAATGTAAATTTGGT
ATTAATGATAAAATCGTTATGGAAGCCAAGGGTCGTGGAGGTATATCTGGAAATACTGAA
GCAGAAACATCACGATCAGGCAAACCTGTAGTCGTTATTGATGATTGCCAATTTCATCAG
TGCGTTAAATTGAGCAAATTTGAAACAGAACATTCTATAAGCTTCATTCCACCTGATGGT
GAATTTGAATTGATGCGTTATCGTACAACAAAAGATATATCATTGCCATTCCGTGTTATT
CCATTGGTGCGTGAAGTCGGTCGAACAAAAATGGAGGTCAAAGTTGTTTTAAAATCTAAC
TTCAAACCTTCACTACTTGGGCAGAAGATTGAAGTGAAAATTCCAACACCACTCAATACA
TCTGGTGTGCAGCTTATTTGTTTGAAAGGAAAAGCCAAATATAAGGCTTCGGAGAACGCA
ATCGTTTGGAAAATTAAAAGAATGGCTGGTATGAAGGAAACTCAATTATCAGCAGAAATT
GAATTGCTAGAAACGGACACGAAGAAGAAATGGACTCGACCACCAATTTCGATGAACTTT
GAAGTTCCATTTGCTCCATCTGGCTTTAAGGTTCGTTATTTGAAAGTTTTTGAACCTAAA
CTCAACTATTCTGATCATGATGTCATTAAATGGGTTCGCTATATTGGTCGAAGTGGGCTA
TATGAAACAAGATGCTAAGTTGCTGCTATCTAATATTGATATTGAATCTTTTCTAATTGT
TCTTTTGTTCTCTTGAGCAATTATAATGTGACAAGAAATGACATTTAAATTATATATGAA
TATTGCATGTTTGAATATAGCAAATTTGCAAACAGTGTAGTAAAACAAAATTCTTTGCAT
GAAATATATACATTCATTACTATTATTATTCTGATTATTATTCTTTTAAGAATTTGAAAA
CATAATACTACATATACGTTAAAGATTTGCATGAAAATCTCCTATCTTAGATACATAAGG
AAGCTATTGTATCGTATAAAATTTATTGCTTCATTAATCAAATAAAATAAATAATAGTAA
ATTGAAAATGTTTATATGATTTTTAAGTTAAAACTGAGGAAACTTAGAGATAATGCACTT
TATATTTAGTGCTGAACACATAATATTTATCGTTGCGGTACTTAAAATTGAACACTTAAT
ACGGTGCGTCAAAATAATAAAAGAAATACTATTCAAGATTAAACGTTTCATAACACTAAA
AAT
>g10691.t8 Gene=g10691 Length=256
MSPQGQVLSAHVAGKVVMKSFLSGMPECKFGINDKIVMEAKGRGGISGNTEAETSRSGKP
VVVIDDCQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRT
KMEVKVVLKSNFKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMA
GMKETQLSAEIELLETDTKKKWTRPPISMNFEVPFAPSGFKVRYLKVFEPKLNYSDHDVI
KWVRYIGRSGLYETRC
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g10691.t8 | CDD | cd09251 | AP-2_Mu2_Cterm | 1 | 255 | 1.08207E-159 |
| 9 | g10691.t8 | Gene3D | G3DSA:2.60.40.1170 | - | 1 | 59 | 4.6E-11 |
| 10 | g10691.t8 | Gene3D | G3DSA:2.60.40.1170 | - | 73 | 249 | 2.3E-85 |
| 8 | g10691.t8 | Gene3D | G3DSA:2.60.40.1170 | - | 106 | 256 | 2.3E-85 |
| 2 | g10691.t8 | PANTHER | PTHR10529 | AP COMPLEX SUBUNIT MU | 1 | 256 | 2.4E-101 |
| 3 | g10691.t8 | PANTHER | PTHR10529:SF236 | AP-2 COMPLEX SUBUNIT MU | 1 | 256 | 2.4E-101 |
| 4 | g10691.t8 | PRINTS | PR00314 | Clathrin coat assembly protein signature | 64 | 91 | 3.9E-22 |
| 5 | g10691.t8 | PRINTS | PR00314 | Clathrin coat assembly protein signature | 133 | 148 | 3.9E-22 |
| 6 | g10691.t8 | PRINTS | PR00314 | Clathrin coat assembly protein signature | 173 | 184 | 3.9E-22 |
| 1 | g10691.t8 | Pfam | PF00928 | Adaptor complexes medium subunit family | 1 | 256 | 7.7E-67 |
| 12 | g10691.t8 | ProSitePatterns | PS00991 | Clathrin adaptor complexes medium chain signature 2. | 84 | 98 | - |
| 13 | g10691.t8 | ProSiteProfiles | PS51072 | Mu homology domain (MHD) profile. | 1 | 255 | 40.726 |
| 7 | g10691.t8 | SUPERFAMILY | SSF49447 | Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 1 | 255 | 3.92E-77 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006886 | intracellular protein transport | BP |
| GO:0030131 | clathrin adaptor complex | CC |
| GO:0016192 | vesicle-mediated transport | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
