General information for g10793.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Guanylate cyclase soluble subunit beta-1.
Parent gene
- The parent gene g10793 is located on chr_1: 12005411..12017813 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10793 | g10793.t1 | isoform | g10793.t1 | 12005411 | 12017813 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon1 | 12005411 | 12005492 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS1 | 12005411 | 12005492 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon2 | 12011020 | 12011138 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS2 | 12011020 | 12011138 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon3 | 12013740 | 12013892 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS3 | 12013740 | 12013892 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon4 | 12013949 | 12014150 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS4 | 12013949 | 12014150 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon5 | 12014397 | 12014902 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS5 | 12014397 | 12014902 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon6 | 12014959 | 12015041 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS6 | 12014959 | 12015041 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon7 | 12016105 | 12016507 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS7 | 12016105 | 12016507 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon8 | 12016604 | 12016741 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS8 | 12016604 | 12016741 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon9 | 12016814 | 12016878 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS9 | 12016814 | 12016878 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon10 | 12016956 | 12017048 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS10 | 12016956 | 12017048 |
| chr_1 | g10793 | g10793.t1 | exon | g10793.t1.exon11 | 12017645 | 12017813 |
| chr_1 | g10793 | g10793.t1 | cds | g10793.t1.CDS11 | 12017645 | 12017813 |
| chr_1 | g10793 | g10793.t1 | TSS | g10793.t1 | NA | NA |
| chr_1 | g10793 | g10793.t1 | TTS | g10793.t1 | NA | NA |
Sequences
>g10793.t1 Gene=g10793 Length=2013
ATGGAAGGACAATTTTTAGTAAGACAAATTTACGATGATGAGATCACGTACAATCTTATT
GGTGCTGCTGTGGAAGTTTTAAACATCCCAGCAGACGCAATTTTAGAATTATTCGGTGTC
ACATTTTTCGATTACTGCCAAGATTCAGGATATGACAAAATTCTACAAGTTTTAGGAAGT
TGCACAAAAGATTTTCTTCAGAATCTTGATGCTCTTCACGATCATCTAGGCCTTCTATAT
CCCGGTATGAGAGCCCCGTCATTTCGATGCACTGAAGAACCCGATGGGTCACTTATTCTT
CATTATTATTCGGATCGTGGTGGTCTTGAATATATTGTCATCGGAATTGTAAAGGCTGTC
GCATCTAAACTACATGGCGTTGAGGTTGATATAAAAATAATTAAACGCAAAGGGGATCCA
ATTATGTTAGTGGCAGCTCGTGATGCTGAAAATAACTGTACGCTTGGAGACAATGACAGT
AAGACTCTCTGCAATGTCACAAATAAATATGACTCGAATAATATCAACAATAATGGCGAG
ATACGATGTGAACAAACGTTCTTTAACAACGAAACAAAAATAAAAAAAGCTGCAAATGGT
AACCTGAAATGTCCTCACAATAACAATAATGAGAATGACACTCAAACACTACAAACAACA
TCAGATCACATTCAATTTTTAATCACTGAAGTTGGCCCGAAAACTCCAAAATACCCTAAA
ACGACAATTGACGATTACGACAATATGAATGAAAAGGAAATGTTCGATGATTTTGAATTG
GTGGCAGAGGAACCATTAGTTTCACCGCAAATCTTCTGTCAAGTCTTTCCATTTCATCTA
ATGTTTGACCGACAAATGAAAATTGTGCAAGCAGGCAAGTCGGTTTCACGTGTAATACCA
AAAATAAATGAAAACCATTGCAATCTACTTGACATTCTCGAAGCCATTCGACCACATATT
GAATTATCATTTCAGTCCATTCTTGCTCATATCAGTACAATTTATGTACTAAAGACAAAA
GCATGCGTGATGCTCGAGCCAGATATGTTCATGAGACTAAAGGGTCAAATGATGTACATT
GAGGAAACTGATCTGATTATGTTTCAATGCTATCCAAGTGTAATGAATTTGGACGATTTG
ACAAAAAAGGGCTTGTGTATATCTGATGTTCCACTACATGATGCAACTAGAGATCTTGTT
TTATTATCTGAACATTTTGAAGCCGAATATAAGTTGACAAGAAATCTGGAAATTCTAACT
GATAAATTGCAACAAACCTATCGTGAACTTGAGAGTGAGAAGAAGATGACGGATGTCTTG
CTTTATTCCGTTTTACCGAAATCAGTTGCAAATGAACTTCGCCATCAACGACCTGTTGCA
CCAAAACGATACGATTGTGTCACTTTACTATTCTCTGGTATTGTTGGATTTAGTCAATAT
TGTGCTGCAAATACAAGCACTGAAGGCGCAATGAAAATTGTAAAGATGCTCAATGAACTC
TACACGACATTTGACTCATTGACTGATTCATATCCCAATATTTACAAAGTTGAAACCGTA
GGCGATAAATATATGGCCGTTTCAGGTTTACCGGATGAATGTGAAAACCACGCTGTCTCG
ATTGCGCGTTTAGCACTCGATATGATTGATAAAGCTGTAAGCGTAAAAATGGGAAACCAA
CCAATTCAAGTCACGGTTGGTATTCATAGTGGGGAAGTCGTCACAGGTGTTATAGGACAT
AGAATGCCAAGATTTTGTTTATTTGGTAATTCTGTAAATTTAACAAGTCGTACAGAAACA
ACAGGGATTAAAGGCAAAATTAATGTCAGTGAGGAAACATACAATTTGCTTTGTGATAAG
GTGAATTATGATCCAACAATGCATCTTGAATATCGTGGACCAGTTACAATGAAAGGAAAA
CCGGAACCAATGAAATGCTGGTTGCTTTCGAGAAAATCAATTGACTCAACTCAGGAACAA
ATAAAGCCACAGCAACAAGTAACGCCTGTATAG
>g10793.t1 Gene=g10793 Length=670
MEGQFLVRQIYDDEITYNLIGAAVEVLNIPADAILELFGVTFFDYCQDSGYDKILQVLGS
CTKDFLQNLDALHDHLGLLYPGMRAPSFRCTEEPDGSLILHYYSDRGGLEYIVIGIVKAV
ASKLHGVEVDIKIIKRKGDPIMLVAARDAENNCTLGDNDSKTLCNVTNKYDSNNINNNGE
IRCEQTFFNNETKIKKAANGNLKCPHNNNNENDTQTLQTTSDHIQFLITEVGPKTPKYPK
TTIDDYDNMNEKEMFDDFELVAEEPLVSPQIFCQVFPFHLMFDRQMKIVQAGKSVSRVIP
KINENHCNLLDILEAIRPHIELSFQSILAHISTIYVLKTKACVMLEPDMFMRLKGQMMYI
EETDLIMFQCYPSVMNLDDLTKKGLCISDVPLHDATRDLVLLSEHFEAEYKLTRNLEILT
DKLQQTYRELESEKKMTDVLLYSVLPKSVANELRHQRPVAPKRYDCVTLLFSGIVGFSQY
CAANTSTEGAMKIVKMLNELYTTFDSLTDSYPNIYKVETVGDKYMAVSGLPDECENHAVS
IARLALDMIDKAVSVKMGNQPIQVTVGIHSGEVVTGVIGHRMPRFCLFGNSVNLTSRTET
TGIKGKINVSEETYNLLCDKVNYDPTMHLEYRGPVTMKGKPEPMKCWLLSRKSIDSTQEQ
IKPQQQVTPV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g10793.t1 | CDD | cd07302 | CHD | 467 | 649 | 1.50627E-58 |
| 11 | g10793.t1 | Coils | Coil | Coil | 413 | 436 | - |
| 10 | g10793.t1 | Gene3D | G3DSA:3.90.1520.10 | - | 1 | 151 | 3.6E-49 |
| 9 | g10793.t1 | Gene3D | G3DSA:3.30.450.260 | - | 267 | 390 | 4.4E-40 |
| 8 | g10793.t1 | Gene3D | G3DSA:3.30.70.1230 | Adenylyl Cyclase | 455 | 653 | 1.1E-72 |
| 4 | g10793.t1 | PANTHER | PTHR45655:SF2 | GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 | 2 | 658 | 2.0E-276 |
| 5 | g10793.t1 | PANTHER | PTHR45655 | GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 | 2 | 658 | 2.0E-276 |
| 1 | g10793.t1 | Pfam | PF07700 | Haem-NO-binding | 3 | 133 | 2.4E-42 |
| 2 | g10793.t1 | Pfam | PF07701 | Heme NO binding associated | 267 | 453 | 2.4E-47 |
| 3 | g10793.t1 | Pfam | PF00211 | Adenylate and Guanylate cyclase catalytic domain | 461 | 649 | 5.7E-58 |
| 13 | g10793.t1 | ProSitePatterns | PS00452 | Guanylate cyclase signature. | 576 | 599 | - |
| 15 | g10793.t1 | ProSiteProfiles | PS50125 | Guanylate cyclase domain profile. | 468 | 599 | 41.729 |
| 14 | g10793.t1 | SMART | SM00044 | cyc_6 | 432 | 625 | 8.4E-77 |
| 6 | g10793.t1 | SUPERFAMILY | SSF111126 | Ligand-binding domain in the NO signalling and Golgi transport | 2 | 138 | 3.82E-37 |
| 7 | g10793.t1 | SUPERFAMILY | SSF55073 | Nucleotide cyclase | 462 | 649 | 4.4E-51 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006182 | cGMP biosynthetic process | BP |
| GO:0020037 | heme binding | MF |
| GO:0016849 | phosphorus-oxygen lyase activity | MF |
| GO:0009190 | cyclic nucleotide biosynthetic process | BP |
| GO:0035556 | intracellular signal transduction | BP |
| GO:0004383 | guanylate cyclase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K12319 (guanylate cyclase soluble subunit beta)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
