General information for g10880.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Serine/threonine-protein kinase STK11.
Parent gene
- The parent gene g10880 is located on chr_1: 12423125..12424491 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g10880 | g10880.t1 | TSS | g10880.t1 | 12422869 | 12422869 |
| chr_1 | g10880 | g10880.t1 | isoform | g10880.t1 | 12423125 | 12424491 |
| chr_1 | g10880 | g10880.t1 | exon | g10880.t1.exon1 | 12423125 | 12424103 |
| chr_1 | g10880 | g10880.t1 | cds | g10880.t1.CDS1 | 12423125 | 12424103 |
| chr_1 | g10880 | g10880.t1 | exon | g10880.t1.exon2 | 12424166 | 12424491 |
| chr_1 | g10880 | g10880.t1 | cds | g10880.t1.CDS2 | 12424166 | 12424491 |
| chr_1 | g10880 | g10880.t1 | TTS | g10880.t1 | 12424760 | 12424760 |
Sequences
>g10880.t1 Gene=g10880 Length=1305
ATGGAAGAGGATGACAACGTTCCTCTAGATCCACAGCCAGTTGTTGAATGGCTCGATGAC
GATGAAATTGCACAACTGGATTTGCAAACAATATCAAATTCCTTACAATTTAATCGAGTC
TCATCACAGGACATCATTTATCAAAAGAAACAAAAGTGTAAAATGGTCGGTCGTTATGTT
ATGGGAGATAAATTGGGTGAAGGATCTTATGGTAAAGTTAAAGAAGTACTTGACAGCGAA
TCCCTCACACGTAGAGCTGTAAAAATTCTTGCTAAACGAAAACTAAGGCGAATTCCAAAT
GGTGAAATGAATGTTCGCAATGAAATTCTCTTTTTACGTTCCCTTAAGCATAAAAATGTC
GTTGAATTAATTGATGTACTATATAATGAAGAGAAACAGAAAATGTATCTTGTTATGGAA
TATTGTGTGTGTGTTCTGCAAGAGCTTTTAGCATCTGCCCCTGAATCAAAATTACCATTA
TTTCAAGCGCATAAATATTTTGTTCAGCTTATCGATGGACTTCAATATTTACACGGACAA
GGTGTAATTCATAGTGATATAAAGCCAGGAAATTTATTACTTACGCTCGATGACACGCTA
AAAATATCAGATTTTGGTGTGACAGAAAAATTAGACCCTTTTGCGCCTGATGACACATGT
ACTAAAGGTCAAGGTTCGCCTGCTTTTCAACCGCCAGAAATTGCCAATGGACATGACTCA
TTTTCTGGTTTCAAAGCTGATATATGGAGTACAGGTGTTACACTATTTAATATCACGACT
GGTGCGTATCCATTCGAAGGTGATAACATTTATCGGCTGTTGGAGAACATTGGCAAGGGT
GTATGGTCTGTTCCCGAAGGCTTAGACCCCTTGCTGTCTGATTTACTAGTTAATATGCTA
AGATTCGATTCAAAAGAACGATATACAATTCAACAAATTCGTAATCACACGTGGTTTATG
TCTTCACCAATTAATACAGGAGATAGTGTTCCTATTCCACCTCTACAAGGAAATGCTTTG
AGAAGTTCGACAGTGCTGCCTTATTTAGAATCTTATCACTATGAAAGTCGACAAAACAAT
GTATACTTCACAGAGCATGACCTGAATGAAGCTGAAGAAATGGCACGACAACAAGAGACA
TCATCATCATCTCAAAATATGAGAATTAGTAAAAATAATAGTATTACTAACGAGGAAGCG
TTTACAACAAGAGCATCGTCTGACTTAAACAAAAAACGACGGACGAAAAAGAAATTTATA
TCGTGTATTAGTGTGAAAAAATTAACTCATTGTCGTCAATCTTAA
>g10880.t1 Gene=g10880 Length=434
MEEDDNVPLDPQPVVEWLDDDEIAQLDLQTISNSLQFNRVSSQDIIYQKKQKCKMVGRYV
MGDKLGEGSYGKVKEVLDSESLTRRAVKILAKRKLRRIPNGEMNVRNEILFLRSLKHKNV
VELIDVLYNEEKQKMYLVMEYCVCVLQELLASAPESKLPLFQAHKYFVQLIDGLQYLHGQ
GVIHSDIKPGNLLLTLDDTLKISDFGVTEKLDPFAPDDTCTKGQGSPAFQPPEIANGHDS
FSGFKADIWSTGVTLFNITTGAYPFEGDNIYRLLENIGKGVWSVPEGLDPLLSDLLVNML
RFDSKERYTIQQIRNHTWFMSSPINTGDSVPIPPLQGNALRSSTVLPYLESYHYESRQNN
VYFTEHDLNEAEEMARQQETSSSSQNMRISKNNSITNEEAFTTRASSDLNKKRRTKKKFI
SCISVKKLTHCRQS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g10880.t1 | CDD | cd14119 | STKc_LKB1 | 65 | 319 | 4.19249E-168 |
| 5 | g10880.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 64 | 141 | 5.4E-86 |
| 6 | g10880.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 142 | 319 | 5.4E-86 |
| 11 | g10880.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 376 | 404 | - |
| 12 | g10880.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 376 | 409 | - |
| 2 | g10880.t1 | PANTHER | PTHR44167 | OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED | 20 | 434 | 7.4E-171 |
| 3 | g10880.t1 | PANTHER | PTHR44167:SF10 | SERINE/THREONINE KINASE 11 | 20 | 434 | 7.4E-171 |
| 1 | g10880.t1 | Pfam | PF00069 | Protein kinase domain | 60 | 319 | 4.1E-55 |
| 9 | g10880.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 65 | 88 | - |
| 8 | g10880.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 182 | 194 | - |
| 13 | g10880.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 59 | 319 | 42.958 |
| 10 | g10880.t1 | SMART | SM00220 | serkin_6 | 59 | 319 | 4.2E-73 |
| 4 | g10880.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 50 | 336 | 7.55E-72 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0001558 | regulation of cell growth | BP |
| GO:0005524 | ATP binding | MF |
| GO:0030295 | protein kinase activator activity | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0042593 | glucose homeostasis | BP |
| GO:0030010 | establishment of cell polarity | BP |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K07298 (serine/threonine-protein kinase 11)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
