Gene loci information

Transcript annotation

  • This transcript has been annotated as Very low-density lipoprotein receptor.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g10914 g10914.t1 isoform g10914.t1 12607114 12643690
chr_1 g10914 g10914.t1 exon g10914.t1.exon1 12607114 12607423
chr_1 g10914 g10914.t1 cds g10914.t1.CDS1 12607114 12607423
chr_1 g10914 g10914.t1 exon g10914.t1.exon2 12620248 12620382
chr_1 g10914 g10914.t1 cds g10914.t1.CDS2 12620248 12620382
chr_1 g10914 g10914.t1 exon g10914.t1.exon3 12630141 12630260
chr_1 g10914 g10914.t1 cds g10914.t1.CDS3 12630141 12630260
chr_1 g10914 g10914.t1 exon g10914.t1.exon4 12632257 12632379
chr_1 g10914 g10914.t1 cds g10914.t1.CDS4 12632257 12632379
chr_1 g10914 g10914.t1 exon g10914.t1.exon5 12636086 12636312
chr_1 g10914 g10914.t1 cds g10914.t1.CDS5 12636086 12636312
chr_1 g10914 g10914.t1 exon g10914.t1.exon6 12636840 12637104
chr_1 g10914 g10914.t1 cds g10914.t1.CDS6 12636840 12637104
chr_1 g10914 g10914.t1 exon g10914.t1.exon7 12637205 12637527
chr_1 g10914 g10914.t1 cds g10914.t1.CDS7 12637205 12637527
chr_1 g10914 g10914.t1 exon g10914.t1.exon8 12637597 12637829
chr_1 g10914 g10914.t1 cds g10914.t1.CDS8 12637597 12637829
chr_1 g10914 g10914.t1 exon g10914.t1.exon9 12637991 12638354
chr_1 g10914 g10914.t1 cds g10914.t1.CDS9 12637991 12638354
chr_1 g10914 g10914.t1 exon g10914.t1.exon10 12638422 12638631
chr_1 g10914 g10914.t1 cds g10914.t1.CDS10 12638422 12638631
chr_1 g10914 g10914.t1 exon g10914.t1.exon11 12638822 12639020
chr_1 g10914 g10914.t1 cds g10914.t1.CDS11 12638822 12639020
chr_1 g10914 g10914.t1 exon g10914.t1.exon12 12639640 12639783
chr_1 g10914 g10914.t1 cds g10914.t1.CDS12 12639640 12639783
chr_1 g10914 g10914.t1 exon g10914.t1.exon13 12643151 12643266
chr_1 g10914 g10914.t1 cds g10914.t1.CDS13 12643151 12643266
chr_1 g10914 g10914.t1 exon g10914.t1.exon14 12643508 12643690
chr_1 g10914 g10914.t1 cds g10914.t1.CDS14 12643508 12643690
chr_1 g10914 g10914.t1 TTS g10914.t1 12644154 12644154
chr_1 g10914 g10914.t1 TSS g10914.t1 NA NA

Sequences

>g10914.t1 Gene=g10914 Length=2952
ATGGTGATCACTGTGTTAAGCGCTAAAAAAGCGAAAATTTTTTGTTTGTTCTGGTTTTTA
TTTATCGTCTCATTTGCAAATGGCCAAAACGATAGCATCAATAATAGCAATGTTCAGCAG
CATCATCAACAACTTTATAAATATAATTCAATCAATAATAGAAGTGTGACAAATGGAGAA
AGTTTAAAAACACCTCCTGCAATTAGTAAAGATAAGCTAGCATCAAAATCAAATATAAAT
AGCAAATATGAAACACAATCTACAGTGACTTCGGCTATTGCTATTGGTCTTTTTCCTGGT
TCTAAAAAAATGCGTCAAAGAAAATGTACAGAACGACAGTTTCAATGTAACAATGGTGAA
TGCATCCCTATGAAATACCTTTGTGATGGTGAACCAGATTGCCAAGATAAAAGTGATGAA
GATCAAACAGAATGTTCTCATAAACAAAACGAATGTAGTCAAGATCAATTTAGATGTAAT
AATGGACGATGTATACCAAAAAGATGGACCTGTGATCAGGAGAAAGATTGTAGCGATGGA
TCTGATGAAGATGCAAGCCATTGTCAAATAAAAATGTGTTCGTCCGAGGACTTTACGTGC
AGGAGCAACAATGGTGAATGCATTCCACTTTCGTGGATGTGTGATGGCAACAAAGATTGT
ACAGATGGATCTGATGAAGCATCATGTAACGATACTTGTCGTTCCGATGAGTTTACATGT
AATAATGGTAGATGTATTCAAAGTCGGTGGGTTTGTGATCGTGACGATGATTGTGGTGAT
GGATCTGATGAAGCCAAGTGTACTCCTACGAAATGTGATCCAATTAAACAATTTCAATGC
TCAGAGAAGTATTGTATTACATCGAAATGGCGTTGTGACGGCGAACAAGATTGTCCTGAT
GGTTCCGATGAAAAAGATTGTTCGATTATAATTCGACGTGAATCCTCATGTGTACAAGCA
GAGTATCAATGTAAAGATGGTATAACATGCATTCATCGTTCATGGGTTTGTGATGGTGAG
AAAGATTGCCCAGGAGGCGATGACGAGCAACCACCGCTCTGCCAAAATGTCACATGTCGA
GCAGATCAATTTCAATGTGCAGATAAGACATGCATTCATGGTCGTTTCCACTGTTCAGGC
AAAGCTGAATGTAAGGATGGAAGTGATGAACTAAATTGCCCTGTTCCAAAGAAATCATGT
GATCGCAAAACGGAATTTGATTGTGGTGATGGAATGTGCATACCTCTTTCAAAAGTATGT
GATAAGCACCAAGATTGTCCGGATGCAGAGGACGAACCAGTAGGAAAATGTGGACGTGAT
GAATGCAAATCAAATAATGGAGGCTGTTCACAATTATGCGTTGATACGCAAGCCGGCTAC
TATTGTGAATGTCGTCAAGGCTATAAATTATCTAGTGACAATCGTACGTGTGAGGACATT
AATGAATGTGAAATTCCTGGTTCATGTTCTCAATTATGTACAAATGAACGTGGCGGTTTT
AAATGCGAATGTGTTTCTGGCTTTTTGAGAGATCCTCGAGACCACACTAAATGCAAAGCC
ACAGAAGGACATGCATCGTTGCTTTTTGCACGTCGTCATGACATCAGAAAGATTTCACTT
GACCATCGTGAGATGACTTCAATTGTTAATGAAACAAAGTCGGCTACAGCATTAGACTAT
GTATTCAGAACTGGCATGATATTTTGGAGTGACGTAACGGAACAAAGAATTTATAAAGCA
CCAATTGATGAAGGTACAGAGCAAATTGTTGTACTGCAGGATAAGACAGTGACATCAGAT
GGACTTGCGGTTGATTGGATTTACAATCACATCTACTTTACTGATACAAAGCGTTATACA
ATTGAGATAATGAATTTTGACGGAAACATGGGAAAGGTGCTGATTAAAGATAATTTAGAG
ATACCACGTGCCATTGCAGTTAATCCTCTCGATGGATGGATGTTCTGGAGTGATTGGGGT
TCAAGTCCAAGAATAGAACGTGCTGGTATGGACGGTACACATCGTCAAACAATCGTCAGC
TATGACGTAAAATGGCCTAACGGATTAACACTTGATCTCGTGCAAAAACGCGTCTATTGG
GTTGATGCTAAATTAAATGTAATTTCATCATGTAATTTCGATGGCTCTGGTCGTAATTTA
GTGCTTCATTCAACCGATTCACTTCGACATCCATTTTCAATTACAACATTCGAGGATTAT
GTATATTGGACGGACTGGGATAAAGAGGCGGTTTTCCGTGCAAATAAATTCAATGGCAAT
GATGTTGAACCTGTCACTGCATTACATATGCTTCAACATCCGATGACAATTCATGTATAT
CATCCATACCGACAGCCAGATGGTGAAAATCATTGTCAAGCAGTGAATGGACATTGTTCA
CATTTGTGCTTGCCAGCTCCAAGAATCAACGCTCAAAGTGCACGAATCTCGTGTGCCTGT
CCAACAGGATTAAAACTTATGGATGATGGTCTGATGTGTGTTGAAGACGAAACTCATACA
ACAACAGGAAAAACAGAAACAGCAACGAATCATCATTCGCATCATTTGGAAACAACAACA
AAAATATCGAAAGGAATTGAACATCATTCGTCCAATATTTATGATAGTGATGTTGATGTT
ATTAAAAGCCACATTGGATTATATAATAATGAAACACAAGCAAGTGTACTAGCTGACGGT
CCTGACAATGGAATGGTTGCAATCATAACGATTGTTGTAGCCACATTGCTGGTTCTTGTG
CTAACAGTCCTGGCTGTACTCGTCTACCGACATTATGTTCACAAAAATCTAACGTCCATA
AACTTTGATAATCCTGTGTATCGTAAAACAACGGAGGATCAAGTGCGTTTGAAGAAATCG
CTTTCGCCTATAATTTATCCAAGCACGGTTGGAGAGGAGTTACGCGCTTTAGCACAAGAT
TGTCCGATTTAA

>g10914.t1 Gene=g10914 Length=983
MVITVLSAKKAKIFCLFWFLFIVSFANGQNDSINNSNVQQHHQQLYKYNSINNRSVTNGE
SLKTPPAISKDKLASKSNINSKYETQSTVTSAIAIGLFPGSKKMRQRKCTERQFQCNNGE
CIPMKYLCDGEPDCQDKSDEDQTECSHKQNECSQDQFRCNNGRCIPKRWTCDQEKDCSDG
SDEDASHCQIKMCSSEDFTCRSNNGECIPLSWMCDGNKDCTDGSDEASCNDTCRSDEFTC
NNGRCIQSRWVCDRDDDCGDGSDEAKCTPTKCDPIKQFQCSEKYCITSKWRCDGEQDCPD
GSDEKDCSIIIRRESSCVQAEYQCKDGITCIHRSWVCDGEKDCPGGDDEQPPLCQNVTCR
ADQFQCADKTCIHGRFHCSGKAECKDGSDELNCPVPKKSCDRKTEFDCGDGMCIPLSKVC
DKHQDCPDAEDEPVGKCGRDECKSNNGGCSQLCVDTQAGYYCECRQGYKLSSDNRTCEDI
NECEIPGSCSQLCTNERGGFKCECVSGFLRDPRDHTKCKATEGHASLLFARRHDIRKISL
DHREMTSIVNETKSATALDYVFRTGMIFWSDVTEQRIYKAPIDEGTEQIVVLQDKTVTSD
GLAVDWIYNHIYFTDTKRYTIEIMNFDGNMGKVLIKDNLEIPRAIAVNPLDGWMFWSDWG
SSPRIERAGMDGTHRQTIVSYDVKWPNGLTLDLVQKRVYWVDAKLNVISSCNFDGSGRNL
VLHSTDSLRHPFSITTFEDYVYWTDWDKEAVFRANKFNGNDVEPVTALHMLQHPMTIHVY
HPYRQPDGENHCQAVNGHCSHLCLPAPRINAQSARISCACPTGLKLMDDGLMCVEDETHT
TTGKTETATNHHSHHLETTTKISKGIEHHSSNIYDSDVDVIKSHIGLYNNETQASVLADG
PDNGMVAIITIVVATLLVLVLTVLAVLVYRHYVHKNLTSINFDNPVYRKTTEDQVRLKKS
LSPIIYPSTVGEELRALAQDCPI

Protein features from InterProScan

Transcript Database ID Name Start End E.value
59 g10914.t1 CDD cd00112 LDLa 109 141 2.71629E-10
56 g10914.t1 CDD cd00112 LDLa 152 184 2.70381E-11
58 g10914.t1 CDD cd00112 LDLa 193 229 5.88214E-10
55 g10914.t1 CDD cd00112 LDLa 277 307 1.79429E-9
57 g10914.t1 CDD cd00112 LDLa 317 350 3.99763E-7
53 g10914.t1 CDD cd00112 LDLa 359 393 1.63916E-8
54 g10914.t1 CDD cd00112 LDLa 404 432 9.56809E-7
60 g10914.t1 CDD cd00054 EGF_CA 479 508 3.91916E-4
39 g10914.t1 Gene3D G3DSA:4.10.400.10 - 103 147 3.2E-15
45 g10914.t1 Gene3D G3DSA:4.10.400.10 - 148 191 3.4E-15
41 g10914.t1 Gene3D G3DSA:4.10.400.10 - 192 229 2.0E-13
42 g10914.t1 Gene3D G3DSA:4.10.400.10 - 230 271 4.6E-15
40 g10914.t1 Gene3D G3DSA:4.10.400.10 - 272 309 2.3E-12
38 g10914.t1 Gene3D G3DSA:4.10.400.10 - 312 357 5.1E-12
43 g10914.t1 Gene3D G3DSA:4.10.400.10 - 358 396 1.0E-11
44 g10914.t1 Gene3D G3DSA:4.10.400.10 - 397 432 3.8E-10
34 g10914.t1 Gene3D G3DSA:2.10.25.10 Laminin 442 483 4.2E-16
36 g10914.t1 Gene3D G3DSA:2.10.25.10 Laminin 484 521 7.0E-10
37 g10914.t1 Gene3D G3DSA:2.120.10.30 TolB 525 783 8.3E-98
35 g10914.t1 Gene3D G3DSA:2.10.25.10 Laminin 785 835 1.1E-18
14 g10914.t1 PANTHER PTHR24270 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED 104 956 1.2E-232
15 g10914.t1 PANTHER PTHR24270:SF16 VERY LOW-DENSITY LIPOPROTEIN RECEPTOR 104 956 1.2E-232
19 g10914.t1 PRINTS PR00261 Low density lipoprotein (LDL) receptor signature 119 140 5.1E-52
17 g10914.t1 PRINTS PR00261 Low density lipoprotein (LDL) receptor signature 162 183 5.1E-52
21 g10914.t1 PRINTS PR00261 Low density lipoprotein (LDL) receptor signature 205 226 5.1E-52
16 g10914.t1 PRINTS PR00261 Low density lipoprotein (LDL) receptor signature 243 264 5.1E-52
20 g10914.t1 PRINTS PR00261 Low density lipoprotein (LDL) receptor signature 283 304 5.1E-52
18 g10914.t1 PRINTS PR00261 Low density lipoprotein (LDL) receptor signature 328 349 5.1E-52
2 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 108 145 1.9E-12
4 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 151 188 1.3E-11
5 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 192 229 3.2E-11
6 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 232 267 1.2E-12
1 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 271 307 2.0E-11
7 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 316 350 1.3E-9
3 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 358 393 2.2E-11
8 g10914.t1 Pfam PF00057 Low-density lipoprotein receptor domain class A 399 437 2.2E-7
10 g10914.t1 Pfam PF14670 Coagulation Factor Xa inhibitory site 442 477 6.6E-13
9 g10914.t1 Pfam PF07645 Calcium-binding EGF domain 479 518 2.2E-6
13 g10914.t1 Pfam PF00058 Low-density lipoprotein receptor repeat class B 654 692 1.5E-11
12 g10914.t1 Pfam PF00058 Low-density lipoprotein receptor repeat class B 697 735 2.6E-4
11 g10914.t1 Pfam PF14670 Coagulation Factor Xa inhibitory site 792 833 2.9E-9
48 g10914.t1 Phobius SIGNAL_PEPTIDE Signal peptide region 1 28 -
49 g10914.t1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide. 1 12 -
50 g10914.t1 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide. 13 23 -
52 g10914.t1 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide. 24 28 -
47 g10914.t1 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. 29 904 -
51 g10914.t1 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane. 905 929 -
46 g10914.t1 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. 930 983 -
89 g10914.t1 ProSitePatterns PS01209 LDL-receptor class A (LDLRA) domain signature. 164 188 -
87 g10914.t1 ProSitePatterns PS01209 LDL-receptor class A (LDLRA) domain signature. 207 229 -
85 g10914.t1 ProSitePatterns PS01209 LDL-receptor class A (LDLRA) domain signature. 245 267 -
86 g10914.t1 ProSitePatterns PS01209 LDL-receptor class A (LDLRA) domain signature. 285 307 -
88 g10914.t1 ProSitePatterns PS01209 LDL-receptor class A (LDLRA) domain signature. 413 437 -
91 g10914.t1 ProSitePatterns PS00010 Aspartic acid and asparagine hydroxylation site. 453 464 -
84 g10914.t1 ProSitePatterns PS01186 EGF-like domain signature 2. 462 477 -
90 g10914.t1 ProSitePatterns PS01187 Calcium-binding EGF-like domain signature. 479 502 -
98 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 108 146 14.05
101 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 151 189 14.35
97 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 192 230 14.55
99 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 232 268 14.6
103 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 271 308 13.887
100 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 316 355 11.7
104 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 358 394 12.463
102 g10914.t1 ProSiteProfiles PS50068 LDL-receptor class A (LDLRA) domain profile. 399 438 12.262
93 g10914.t1 ProSiteProfiles PS51120 LDL-receptor class B (LDLRB) repeat profile. 565 608 11.85
96 g10914.t1 ProSiteProfiles PS51120 LDL-receptor class B (LDLRB) repeat profile. 609 651 12.871
92 g10914.t1 ProSiteProfiles PS51120 LDL-receptor class B (LDLRB) repeat profile. 652 695 15.354
94 g10914.t1 ProSiteProfiles PS51120 LDL-receptor class B (LDLRB) repeat profile. 696 740 12.43
95 g10914.t1 ProSiteProfiles PS51120 LDL-receptor class B (LDLRB) repeat profile. 741 783 6.536
69 g10914.t1 SMART SM00192 LDLa_2 108 147 1.2E-14
67 g10914.t1 SMART SM00192 LDLa_2 151 190 1.8E-14
83 g10914.t1 SMART SM00181 egf_5 151 189 35.0
64 g10914.t1 SMART SM00192 LDLa_2 192 231 4.6E-13
80 g10914.t1 SMART SM00181 egf_5 192 230 150.0
63 g10914.t1 SMART SM00192 LDLa_2 232 269 4.7E-16
81 g10914.t1 SMART SM00181 egf_5 232 268 240.0
70 g10914.t1 SMART SM00192 LDLa_2 271 309 1.7E-11
68 g10914.t1 SMART SM00192 LDLa_2 316 356 8.6E-11
66 g10914.t1 SMART SM00192 LDLa_2 358 395 6.4E-12
65 g10914.t1 SMART SM00192 LDLa_2 399 439 8.8E-10
72 g10914.t1 SMART SM00179 egfca_6 438 478 4.0E-4
79 g10914.t1 SMART SM00181 egf_5 441 478 3.5E-5
71 g10914.t1 SMART SM00179 egfca_6 479 519 2.0E-7
78 g10914.t1 SMART SM00181 egf_5 482 519 0.29
74 g10914.t1 SMART SM00135 LY_2 545 587 4.1
73 g10914.t1 SMART SM00135 LY_2 589 631 3.5E-8
77 g10914.t1 SMART SM00135 LY_2 632 675 1.1E-14
75 g10914.t1 SMART SM00135 LY_2 676 718 8.5E-15
76 g10914.t1 SMART SM00135 LY_2 720 762 6.9E-6
82 g10914.t1 SMART SM00181 egf_5 791 834 7.2
27 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 106 143 1.1E-10
23 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 150 188 7.2E-11
30 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 185 229 2.62E-10
24 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 232 267 5.76E-11
28 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 271 308 2.23E-10
29 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 315 353 2.23E-8
25 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 353 394 4.97E-10
26 g10914.t1 SUPERFAMILY SSF57424 LDL receptor-like module 400 433 8.12E-8
31 g10914.t1 SUPERFAMILY SSF57184 Growth factor receptor domain 439 835 1.15E-19
22 g10914.t1 SUPERFAMILY SSF63825 YWTD domain 527 787 1.57E-51
33 g10914.t1 SignalP_EUK SignalP-noTM SignalP-noTM 1 28 -
61 g10914.t1 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM 1 28 -
32 g10914.t1 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM 1 25 -
62 g10914.t1 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane. 906 928 -

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0030229 very-low-density lipoprotein particle receptor activity MF
GO:0005515 protein binding MF
GO:0005509 calcium ion binding MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values