General information for g11019.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as RAC serine/threonine-protein kinase.
Parent gene
- The parent gene g11019 is located on chr_1: 13430427..13431038 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11019 | g11019.t1 | isoform | g11019.t1 | 13427539 | 13430427 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon1 | 13427539 | 13427912 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS1 | 13427539 | 13427912 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon2 | 13428410 | 13428566 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS2 | 13428410 | 13428566 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon3 | 13428631 | 13428828 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS3 | 13428631 | 13428828 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon4 | 13428892 | 13428942 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS4 | 13428892 | 13428942 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon5 | 13429013 | 13429113 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS5 | 13429013 | 13429113 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon6 | 13429531 | 13429673 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS6 | 13429531 | 13429673 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon7 | 13429757 | 13429778 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS7 | 13429757 | 13429778 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon8 | 13429848 | 13430301 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS8 | 13429848 | 13430301 |
| chr_1 | g11019 | g11019.t1 | exon | g11019.t1.exon9 | 13430368 | 13430427 |
| chr_1 | g11019 | g11019.t1 | cds | g11019.t1.CDS9 | 13430368 | 13430427 |
| chr_1 | g11019 | g11019.t1 | TTS | g11019.t1 | 13430463 | 13430463 |
| chr_1 | g11019 | g11019.t1 | TSS | g11019.t1 | NA | NA |
Sequences
>g11019.t1 Gene=g11019 Length=1560
ATGTCACTTGCATCAACATCAATTGATTCAGGACAATTGCCTGATCTTGTATCACATAAT
ATTGACGTCAACTCGCGTCAAATCATTAAAGAAGGATGGTTATTTAAACGTGGTGAACAT
ATAAAAAATTGGAGATCGCGCTATTTTATTTTACGATCAGACGGCTCACTTGTAGGCTAT
AAGAATCGACCAGACGCTCAAATTCCAACTGAGCCGTCCAATAATTTTACTGTTGCACGA
TGTCAAATCATGTCAGTTGATCGACCAAGACCTTATACATTTATAATCAGAGGCCTACAA
TGGACCACTGTCATCGAGCGAATGTTTTATGTCGAGACAGAGCATGAGAGAACCCAATGG
GTTGAAGCTATACGGAGTGTTGCAAATCGTCTGAGTGAAATTGATCAACAAAAACAGGCT
CAAGCTAATGAAGACATTGAAATGGTACCGATTGCTGAAGATGCCTTACTTAATGAAAAA
TTCTCACTTCAAGGTACATCAACAGGAAAAGTTAGTGGAAGAAAAAAAGTGACATTGGAA
AATTTTGAATTTTTAAAAGTATTGGGAAAAGGCACTTTTGGAAAAGTAATTTTATGTCGT
GAAAAAATCACAGCAAAATTATATGCTATTAAAATTCTTAAAAAAGAAGTTATTATTCAA
AAAGATGAAGTAAAACACACAATGGCTGAAAATCGTGTACTTCAAAGAACAAATCATCCC
TTTTTAATTTCGCTTAAATATTCATTTCAAACAAATGAACGTTTATGTTTTGTCATGGAG
TATGTCAACGGCGGTGAATTGTTCTTTCATTTAAGCCGTGACAGAATATTTTCAGAGGAA
CGTACTCGATTTTACGGAGCTGAAATAATATCTGCCCTCGGATATTTGCATTCGCACAAC
ATTATTTATCGTGACTTAAAATTAGAAAATCTCTTACTTGATAAAGATGGTCATATAAAA
ATTGCAGATTTTGGTTTATGTAAGGAAGATATTACATATGGTAGAACAACGAAAACTTTT
TGTGGAACACCCGAATATTTAGCACCAGAAGTGCTTGAAGACAACGATTACGGACGTGCA
GTCGATTGGTGGGGCACGGGTGTCGTCATGTACGAAATGATTTGTGGTCGATTACCTTTT
TACAATCGTGATCACGAAGTGCTTTTTACTTTGATCATGGTCGAAGATGTGAAATTTCCA
CGTAACATTTCTAGTGAAGCGAGATCACTTTTAACTGGATTTCTTGAAAAAAGTCCCCAA
AAGCGCCTCGGTGGTGGACCAGATGATGTTCGAGAAATAATGGTGCATCCTTTCTTTGCT
AGCATCAATTGGTATGATTTAGTGAATAAGAAAATTATTCCACCGTTCAAGCCGCAAGTT
ACCTCAGATACTGATACACGCTATTTCGATTCTGAATTTACGGGTGAGAGTGTCGAATTG
ACACCGCCTGATCCAGCTGTTCAATTACAATCAATTCAGGAAGAACCTCATTTTTCACAA
TTCAGCTATCAAGATTTAAATTCGTACATGAGCAGTTCTACACTTGCATCATTACAATAG
>g11019.t1 Gene=g11019 Length=519
MSLASTSIDSGQLPDLVSHNIDVNSRQIIKEGWLFKRGEHIKNWRSRYFILRSDGSLVGY
KNRPDAQIPTEPSNNFTVARCQIMSVDRPRPYTFIIRGLQWTTVIERMFYVETEHERTQW
VEAIRSVANRLSEIDQQKQAQANEDIEMVPIAEDALLNEKFSLQGTSTGKVSGRKKVTLE
NFEFLKVLGKGTFGKVILCREKITAKLYAIKILKKEVIIQKDEVKHTMAENRVLQRTNHP
FLISLKYSFQTNERLCFVMEYVNGGELFFHLSRDRIFSEERTRFYGAEIISALGYLHSHN
IIYRDLKLENLLLDKDGHIKIADFGLCKEDITYGRTTKTFCGTPEYLAPEVLEDNDYGRA
VDWWGTGVVMYEMICGRLPFYNRDHEVLFTLIMVEDVKFPRNISSEARSLLTGFLEKSPQ
KRLGGGPDDVREIMVHPFFASINWYDLVNKKIIPPFKPQVTSDTDTRYFDSEFTGESVEL
TPPDPAVQLQSIQEEPHFSQFSYQDLNSYMSSSTLASLQ
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g11019.t1 | CDD | cd01241 | PH_PKB | 26 | 131 | 5.71385E-61 |
| 12 | g11019.t1 | CDD | cd05571 | STKc_PKB | 186 | 504 | 0.0 |
| 9 | g11019.t1 | Gene3D | G3DSA:2.30.29.30 | - | 22 | 143 | 2.6E-32 |
| 8 | g11019.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 180 | 476 | 9.3E-135 |
| 10 | g11019.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 266 | 460 | 9.3E-135 |
| 4 | g11019.t1 | PANTHER | PTHR24351:SF209 | NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE | 29 | 496 | 4.7E-253 |
| 5 | g11019.t1 | PANTHER | PTHR24351 | RIBOSOMAL PROTEIN S6 KINASE | 29 | 496 | 4.7E-253 |
| 2 | g11019.t1 | Pfam | PF00169 | PH domain | 29 | 127 | 1.1E-15 |
| 3 | g11019.t1 | Pfam | PF00069 | Protein kinase domain | 182 | 439 | 1.5E-75 |
| 1 | g11019.t1 | Pfam | PF00433 | Protein kinase C terminal domain | 460 | 503 | 2.9E-8 |
| 14 | g11019.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 188 | 211 | - |
| 13 | g11019.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 301 | 313 | - |
| 20 | g11019.t1 | ProSiteProfiles | PS50003 | PH domain profile. | 27 | 129 | 17.002 |
| 19 | g11019.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 182 | 439 | 49.078 |
| 18 | g11019.t1 | ProSiteProfiles | PS51285 | AGC-kinase C-terminal domain profile. | 440 | 513 | 15.824 |
| 16 | g11019.t1 | SMART | SM00233 | PH_update | 28 | 131 | 5.5E-16 |
| 17 | g11019.t1 | SMART | SM00220 | serkin_6 | 182 | 439 | 7.7E-107 |
| 15 | g11019.t1 | SMART | SM00133 | pkinase_C_6 | 440 | 505 | 7.4E-19 |
| 6 | g11019.t1 | SUPERFAMILY | SSF50729 | PH domain-like | 24 | 134 | 1.21E-23 |
| 7 | g11019.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 177 | 505 | 1.75E-99 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004674 | protein serine/threonine kinase activity | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K04456 (RAC serine/threonine-protein kinase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
