General information for g11155.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aurora kinase A-A.
Parent gene
- The parent gene g11155 is located on chr_1: 14357770..14358513 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11155 | g11155.t1 | TTS | g11155.t1 | 14356263 | 14356263 |
| chr_1 | g11155 | g11155.t1 | isoform | g11155.t1 | 14357183 | 14358513 |
| chr_1 | g11155 | g11155.t1 | exon | g11155.t1.exon1 | 14357183 | 14357385 |
| chr_1 | g11155 | g11155.t1 | cds | g11155.t1.CDS1 | 14357183 | 14357385 |
| chr_1 | g11155 | g11155.t1 | exon | g11155.t1.exon2 | 14357458 | 14357604 |
| chr_1 | g11155 | g11155.t1 | cds | g11155.t1.CDS2 | 14357458 | 14357604 |
| chr_1 | g11155 | g11155.t1 | exon | g11155.t1.exon3 | 14357661 | 14357703 |
| chr_1 | g11155 | g11155.t1 | cds | g11155.t1.CDS3 | 14357661 | 14357703 |
| chr_1 | g11155 | g11155.t1 | exon | g11155.t1.exon4 | 14357770 | 14357906 |
| chr_1 | g11155 | g11155.t1 | cds | g11155.t1.CDS4 | 14357770 | 14357906 |
| chr_1 | g11155 | g11155.t1 | exon | g11155.t1.exon5 | 14357979 | 14358513 |
| chr_1 | g11155 | g11155.t1 | cds | g11155.t1.CDS5 | 14357979 | 14358513 |
| chr_1 | g11155 | g11155.t1 | TSS | g11155.t1 | 14358623 | 14358623 |
Sequences
>g11155.t1 Gene=g11155 Length=1065
ATGAATAGTCACGCAATTAAACAGAATGGAAAGGAAAACTGTTTATATAACGAGAAAAAG
AATAGACAAATTTATACTCATCAACAGCAACCAAAATCAGTTTTATCGTCATCAACTACA
ATTAACAATACTGTGAATGATAATGCAATTAAGAATCCTAATCTTCTCAATATAAAGCCT
ATCACGCAAAAACCTCAAATTTCATCTTCGAATGCTCCTGGATCTTCTTCCTCAAACAAT
CAACAGCAGCAGCACCAACAATCTAGAAAATCTTGGTCTTTAGTTAATTTTGATATAGGC
CGTCCTTTGGGTCGTGGAAAATTTGGAAATGTGTACTTGGCGAGAGAAAAGGAGACTAAA
TTTGTTATTGCCCTTAAGGTTCTTTTTAAGAAACAAGTCGCTGAGCAAGGAATTGAACAT
CAAGTTCGTCGAGAAATTGAAATTCAAAGTCATTTAAGACATCCAAATATTCTTCGTATG
TATGGATTCTTTCATGATGAAGCACGCATTTATTTGATTTTGGAATATGCTCCAGGAGGA
ACATTATTCAATGCATTGAAAAATCAACCTAACAATCGTTTTAACGAACAAAAGTCAGCA
AAGTATATTAAATGTTTAGTATCTGCACTCTCATATTTGCACGAAAAGAATGTGATTCAT
CGAGACATTAAGCCTGAAAATTTGTTACTTGGACATGACGATCAATTAAAAATTGCTGAT
TTTGGATGGTCAGTTCATGAACCAAATTCGCAACGTACAACTCTATGTGGCACATTTGAT
TATCTTAGTCCTGAAATGGTTCAAGGAAATCCTCATTCAAAGACTGTTGACTTATGGAGT
ATTGGTGTTTTAGCTTATGAATTAATTGTTGGTTCAGCTCCATTCCATCATGATGAATAT
GACATTACTTATAGAAGGATTATGAATGTTCAATATACAGTGCCCAATTTCGTTTCTAAG
CCAGCTGTACACTTTATAGGAAGTCTTTTGGTATTCGATCCTAAGAAACGCATGCCATTA
TCGCAACTCATCAATCATCCTTGGCTCAAATTTGATGCAAAGTAG
>g11155.t1 Gene=g11155 Length=354
MNSHAIKQNGKENCLYNEKKNRQIYTHQQQPKSVLSSSTTINNTVNDNAIKNPNLLNIKP
ITQKPQISSSNAPGSSSSNNQQQQHQQSRKSWSLVNFDIGRPLGRGKFGNVYLAREKETK
FVIALKVLFKKQVAEQGIEHQVRREIEIQSHLRHPNILRMYGFFHDEARIYLILEYAPGG
TLFNALKNQPNNRFNEQKSAKYIKCLVSALSYLHEKNVIHRDIKPENLLLGHDDQLKIAD
FGWSVHEPNSQRTTLCGTFDYLSPEMVQGNPHSKTVDLWSIGVLAYELIVGSAPFHHDEY
DITYRRIMNVQYTVPNFVSKPAVHFIGSLLVFDPKKRMPLSQLINHPWLKFDAK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g11155.t1 | CDD | cd14007 | STKc_Aurora | 96 | 350 | 7.39457E-162 |
| 5 | g11155.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 84 | 180 | 2.4E-35 |
| 6 | g11155.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 183 | 352 | 3.4E-59 |
| 11 | g11155.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 65 | 91 | - |
| 2 | g11155.t1 | PANTHER | PTHR24350:SF0 | AURORA A | 22 | 350 | 5.7E-145 |
| 3 | g11155.t1 | PANTHER | PTHR24350 | SERINE/THREONINE-PROTEIN KINASE IAL-RELATED | 22 | 350 | 5.7E-145 |
| 1 | g11155.t1 | Pfam | PF00069 | Protein kinase domain | 99 | 349 | 7.2E-72 |
| 9 | g11155.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 103 | 126 | - |
| 8 | g11155.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 218 | 230 | - |
| 12 | g11155.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 97 | 349 | 50.548 |
| 10 | g11155.t1 | SMART | SM00220 | serkin_6 | 97 | 349 | 2.1E-99 |
| 4 | g11155.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 84 | 350 | 7.42E-88 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K11481 (aurora kinase A)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
