General information for g11186.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Adenosylhomocysteinase-like 1.
Parent gene
- The parent gene g11186 is located on chr_1: 14476826..14479399 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11186 | g11186.t1 | TTS | g11186.t1 | 14472515 | 14472515 |
| chr_1 | g11186 | g11186.t1 | isoform | g11186.t1 | 14473269 | 14477988 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon1 | 14473269 | 14473396 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS1 | 14473269 | 14473396 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon2 | 14473478 | 14473750 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS2 | 14473478 | 14473750 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon3 | 14473852 | 14474127 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS3 | 14473852 | 14474127 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon4 | 14474224 | 14474626 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS4 | 14474224 | 14474626 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon5 | 14474893 | 14475029 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS5 | 14474893 | 14475029 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon6 | 14475098 | 14475244 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS6 | 14475098 | 14475244 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon7 | 14476077 | 14476179 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS7 | 14476077 | 14476179 |
| chr_1 | g11186 | g11186.t1 | exon | g11186.t1.exon8 | 14477827 | 14477988 |
| chr_1 | g11186 | g11186.t1 | cds | g11186.t1.CDS8 | 14477827 | 14477988 |
| chr_1 | g11186 | g11186.t1 | TSS | g11186.t1 | 14478233 | 14478233 |
Sequences
>g11186.t1 Gene=g11186 Length=1629
ATGTCTAACGAAAATCTACAGATGCACCAAATAAATTCCACCTCGACAATTGGAGAGTCA
AATCTCTCGCATAATCCAAGCAATGCTTCGATGGCACCAAAATCAGCAACCGTTCAATTT
GTGAGTGACTCTCCCATAACCGATCCAGGACAGACTACCAAGGAAAAGGATAAAGATGTG
AAAAACATTTCTAGTGCCCTTAAAAAGTCAAGTCGCTATCGTAGTCGCAGTCTTTCAGCA
AGTTCAACTGACTCATATAGCTCTGCATCATATACAGGAAGTTCAAGCGAGGACGATGAT
GCATCACCTCGTGAAAAAATTCAAAGCAATTCGAAAGGATTTGCGGACTTTTGTGTAAGA
AATATTCAACAACATGCGTTTGGCCGGCGTGAAATTGAAATTGCCGAGCAAGAGATGCCA
GGAATTATGGCATTAAGGAAACGTGCTTCCGAAGATAAGCCCCTTAAGAATGCTAAAATT
GTTGGATGCACACATGTTAATGCGCAAACGGCTGTTCTTATTGAAACTTTAGCAGCACTC
GGAGCTTCTGTTCGTTGGGCAGCCTGCAACATTTATTCAACACAAAATGAAGTGGCCGCA
GCTCTAGCCGAAAGTGGATTTAGTGTATTTGCGTGGCGCGGCGAGACGGAAGAAGATTTC
TGGTGGTGTATTGATAAATGTGTTAATGCAGAAAATTGGCAACCAAACCTGATACTCGAT
GATGGTGGTGATGCAACGCATTTAATGTTGAAAAAATATCCAGCCATGTTTAAAATGGTG
AAGGGTATCGTTGAAGAGAGTGTCACAGGCGTACATCGACTTTATCAATTGTCTAAAAGT
GGCAAACTGACAGTTCCTGCGATGAATGTCCATGATTCTGTTATCAAGACTAAATTTGAT
AATTTCTATAGTTGCAAAGAGAGCATAATTGATAGTTTAAAACGTTCGACTGACATTATG
TTTTCGGGAAAACAAGTCGCACTATGTGGATATGGTGAAGTCGGTAAAGGTTGTTCGCAA
GCTTTAAAAGCACTCGGATGCATCGTCTACGTCACCGAAATCGATCCTATTTGTGCGCTA
CAAGCAAGCGTTGATGGCTTTCGTGTTGTTAAGCTAAATGAGATAATTCGAAATGTTGAT
ATCGTAATCACGACTACTGGCAATAAAAGCGTAGTTACTCGAGAGCACATGGAGAAAATG
AAGAATGGCTGCATTGTATGCAATATGGGCCATTCAAACACAGAAATCGATGTTAAAGAT
CTCCGCACGCCAGATTTGACATGGGAAAAAGTTCGTTCACAGGTCGATCATATCATTTTT
CCTGATGGAAAGCGAATAGTTTTATTAGCTGAAGGACGTTTGGTTAATCTTTCTTGCTCA
AGTGTTCCATCATTTTGTGCTAGTATCACATCTGCAACGCAAGCATTAGCTTTAATTGAA
CTTTATAATGCACAGGCAGGTCGCTATAAATGCGACGTTTATTTATTATCAAGAAAAATG
GACGAGTATGTCGCGATTTTACATTTACCAACATTTGATGCACATTTAACAGAGCTTACA
GATGAGCAAGCTAAATACATGGGTCTCAGCAAAGCTGGTCCTTTTAAGCCCAACTATTAT
CGTTATTAA
>g11186.t1 Gene=g11186 Length=542
MSNENLQMHQINSTSTIGESNLSHNPSNASMAPKSATVQFVSDSPITDPGQTTKEKDKDV
KNISSALKKSSRYRSRSLSASSTDSYSSASYTGSSSEDDDASPREKIQSNSKGFADFCVR
NIQQHAFGRREIEIAEQEMPGIMALRKRASEDKPLKNAKIVGCTHVNAQTAVLIETLAAL
GASVRWAACNIYSTQNEVAAALAESGFSVFAWRGETEEDFWWCIDKCVNAENWQPNLILD
DGGDATHLMLKKYPAMFKMVKGIVEESVTGVHRLYQLSKSGKLTVPAMNVHDSVIKTKFD
NFYSCKESIIDSLKRSTDIMFSGKQVALCGYGEVGKGCSQALKALGCIVYVTEIDPICAL
QASVDGFRVVKLNEIIRNVDIVITTTGNKSVVTREHMEKMKNGCIVCNMGHSNTEIDVKD
LRTPDLTWEKVRSQVDHIIFPDGKRIVLLAEGRLVNLSCSSVPSFCASITSATQALALIE
LYNAQAGRYKCDVYLLSRKMDEYVAILHLPTFDAHLTELTDEQAKYMGLSKAGPFKPNYY
RY
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g11186.t1 | CDD | cd00401 | SAHH | 126 | 529 | 0.0 |
| 9 | g11186.t1 | Gene3D | G3DSA:3.40.50.1480 | - | 99 | 251 | 3.7E-67 |
| 8 | g11186.t1 | Gene3D | G3DSA:3.40.50.1480 | - | 252 | 307 | 1.7E-18 |
| 7 | g11186.t1 | Gene3D | G3DSA:3.40.50.720 | - | 308 | 460 | 2.0E-70 |
| 10 | g11186.t1 | Gene3D | G3DSA:3.40.50.1480 | - | 461 | 542 | 3.5E-28 |
| 18 | g11186.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 109 | - |
| 20 | g11186.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 49 | - |
| 17 | g11186.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 50 | 65 | - |
| 19 | g11186.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 66 | 97 | - |
| 3 | g11186.t1 | PANTHER | PTHR23420 | ADENOSYLHOMOCYSTEINASE | 63 | 542 | 1.8E-277 |
| 4 | g11186.t1 | PANTHER | PTHR23420:SF2 | ADENOSYLHOMOCYSTEINASE 3 | 63 | 542 | 1.8E-277 |
| 11 | g11186.t1 | PIRSF | PIRSF001109 | SAHH | 103 | 542 | 8.5E-182 |
| 1 | g11186.t1 | Pfam | PF05221 | S-adenosyl-L-homocysteine hydrolase | 116 | 251 | 6.1E-65 |
| 2 | g11186.t1 | Pfam | PF00670 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | 301 | 461 | 4.2E-77 |
| 14 | g11186.t1 | ProSitePatterns | PS00738 | S-adenosyl-L-homocysteine hydrolase signature 1. | 188 | 202 | - |
| 13 | g11186.t1 | ProSitePatterns | PS00739 | S-adenosyl-L-homocysteine hydrolase signature 2. | 323 | 339 | - |
| 16 | g11186.t1 | SMART | SM00996 | AdoHcyase_2 | 116 | 541 | 1.5E-249 |
| 15 | g11186.t1 | SMART | SM00997 | AdoHcyase_NAD_2 | 301 | 462 | 2.3E-97 |
| 6 | g11186.t1 | SUPERFAMILY | SSF52283 | Formate/glycerate dehydrogenase catalytic domain-like | 114 | 542 | 1.3E-102 |
| 5 | g11186.t1 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 301 | 460 | 1.86E-62 |
| 21 | g11186.t1 | TIGRFAM | TIGR00936 | ahcY: adenosylhomocysteinase | 117 | 534 | 1.3E-153 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004013 | adenosylhomocysteinase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K01251 (adenosylhomocysteinase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
