General information for g11186.t6
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Adenosylhomocysteinase-like 1.
Parent gene
- The parent gene g11186 is located on chr_1: 14476826..14479399 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11186 | g11186.t6 | TTS | g11186.t6 | 14472515 | 14472515 |
| chr_1 | g11186 | g11186.t6 | isoform | g11186.t6 | 14472936 | 14475244 |
| chr_1 | g11186 | g11186.t6 | exon | g11186.t6.exon1 | 14472936 | 14473396 |
| chr_1 | g11186 | g11186.t6 | cds | g11186.t6.CDS1 | 14473269 | 14473396 |
| chr_1 | g11186 | g11186.t6 | exon | g11186.t6.exon2 | 14473478 | 14473750 |
| chr_1 | g11186 | g11186.t6 | cds | g11186.t6.CDS2 | 14473478 | 14473750 |
| chr_1 | g11186 | g11186.t6 | exon | g11186.t6.exon3 | 14473852 | 14474127 |
| chr_1 | g11186 | g11186.t6 | cds | g11186.t6.CDS3 | 14473852 | 14474127 |
| chr_1 | g11186 | g11186.t6 | exon | g11186.t6.exon4 | 14474224 | 14474626 |
| chr_1 | g11186 | g11186.t6 | cds | g11186.t6.CDS4 | 14474224 | 14474626 |
| chr_1 | g11186 | g11186.t6 | exon | g11186.t6.exon5 | 14474893 | 14475029 |
| chr_1 | g11186 | g11186.t6 | cds | g11186.t6.CDS5 | 14474893 | 14475027 |
| chr_1 | g11186 | g11186.t6 | exon | g11186.t6.exon6 | 14475098 | 14475244 |
| chr_1 | g11186 | g11186.t6 | TSS | g11186.t6 | 14475396 | 14475396 |
Sequences
>g11186.t6 Gene=g11186 Length=1697
CATCATATACAGGAAGTTCAAGCGAGGACGATGATGCATCACCTCGTGAAAAAATTCAAA
GCAATTCGAAAGGATTTGCGGACTTTTGTGTAAGAAATATTCAACAACATGCGTTTGGCC
GGCGTGAAATTGAAATTGCCGAGCAAGAGATGCCAGGAATTATGGCATTAAGGAAACGTG
CTTCCGAAGATAAGCCCCTTAAGAATGCTAAAATTGTTGGATGCACACATGTTAATGCGC
AAACGGCTGTTCTTATTGAAACTTTAGCAGCACTCGGAGCTTCTGTTCGTTGGGCAGCCT
GCAACATTTATTCAACACAAAATGAAGTGGCCGCAGCTCTAGCCGAAAGTGGATTTAGTG
TATTTGCGTGGCGCGGCGAGACGGAAGAAGATTTCTGGTGGTGTATTGATAAATGTGTTA
ATGCAGAAAATTGGCAACCAAACCTGATACTCGATGATGGTGGTGATGCAACGCATTTAA
TGTTGAAAAAATATCCAGCCATGTTTAAAATGGTGAAGGGTATCGTTGAAGAGAGTGTCA
CAGGCGTACATCGACTTTATCAATTGTCTAAAAGTGGCAAACTGACAGTTCCTGCGATGA
ATGTCCATGATTCTGTTATCAAGACTAAATTTGATAATTTCTATAGTTGCAAAGAGAGCA
TAATTGATAGTTTAAAACGTTCGACTGACATTATGTTTTCGGGAAAACAAGTCGCACTAT
GTGGATATGGTGAAGTCGGTAAAGGTTGTTCGCAAGCTTTAAAAGCACTCGGATGCATCG
TCTACGTCACCGAAATCGATCCTATTTGTGCGCTACAAGCAAGCGTTGATGGCTTTCGTG
TTGTTAAGCTAAATGAGATAATTCGAAATGTTGATATCGTAATCACGACTACTGGCAATA
AAAGCGTAGTTACTCGAGAGCACATGGAGAAAATGAAGAATGGCTGCATTGTATGCAATA
TGGGCCATTCAAACACAGAAATCGATGTTAAAGATCTCCGCACGCCAGATTTGACATGGG
AAAAAGTTCGTTCACAGGTCGATCATATCATTTTTCCTGATGGAAAGCGAATAGTTTTAT
TAGCTGAAGGACGTTTGGTTAATCTTTCTTGCTCAAGTGTTCCATCATTTTGTGCTAGTA
TCACATCTGCAACGCAAGCATTAGCTTTAATTGAACTTTATAATGCACAGGCAGGTCGCT
ATAAATGCGACGTTTATTTATTATCAAGAAAAATGGACGAGTATGTCGCGATTTTACATT
TACCAACATTTGATGCACATTTAACAGAGCTTACAGATGAGCAAGCTAAATACATGGGTC
TCAGCAAAGCTGGTCCTTTTAAGCCCAACTATTATCGTTATTAAAGAAAAAAAAAAATCA
CAAATTATGGCGCTCCAAGAAAAAAGAAGAATACCTGTAATGAATGAAAAGAATATTTTT
ATCAACTAATAACGATGATGACGATTCTTAACAAAATTTGACGAATTTTTATTTTTATGA
TGTTCTTAATAAAAGTTAAACTTACTTATGTACTTCCCATCGTTGACGACAGATAGGCGA
TAAAATTAAGTGAAAAAAATGTAATCTTAATTTCGCGAGCATTGCATAGAAAATATTTAG
AAAGAAATGCTGAAAAAATGTTAAATCAATTTTTTTCAATCAACATCACACTTTAATTGT
GTATTAATACCCATACA
>g11186.t6 Gene=g11186 Length=404
MPGIMALRKRASEDKPLKNAKIVGCTHVNAQTAVLIETLAALGASVRWAACNIYSTQNEV
AAALAESGFSVFAWRGETEEDFWWCIDKCVNAENWQPNLILDDGGDATHLMLKKYPAMFK
MVKGIVEESVTGVHRLYQLSKSGKLTVPAMNVHDSVIKTKFDNFYSCKESIIDSLKRSTD
IMFSGKQVALCGYGEVGKGCSQALKALGCIVYVTEIDPICALQASVDGFRVVKLNEIIRN
VDIVITTTGNKSVVTREHMEKMKNGCIVCNMGHSNTEIDVKDLRTPDLTWEKVRSQVDHI
IFPDGKRIVLLAEGRLVNLSCSSVPSFCASITSATQALALIELYNAQAGRYKCDVYLLSR
KMDEYVAILHLPTFDAHLTELTDEQAKYMGLSKAGPFKPNYYRY
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g11186.t6 | CDD | cd00401 | SAHH | 1 | 391 | 0.0 |
| 9 | g11186.t6 | Gene3D | G3DSA:3.40.50.1480 | - | 1 | 169 | 1.3E-76 |
| 7 | g11186.t6 | Gene3D | G3DSA:3.40.50.720 | - | 170 | 322 | 1.1E-70 |
| 8 | g11186.t6 | Gene3D | G3DSA:3.40.50.1480 | - | 323 | 404 | 2.2E-28 |
| 3 | g11186.t6 | PANTHER | PTHR23420 | ADENOSYLHOMOCYSTEINASE | 1 | 404 | 8.6E-258 |
| 4 | g11186.t6 | PANTHER | PTHR23420:SF2 | ADENOSYLHOMOCYSTEINASE 3 | 1 | 404 | 8.6E-258 |
| 10 | g11186.t6 | PIRSF | PIRSF001109 | SAHH | 1 | 404 | 8.2E-173 |
| 1 | g11186.t6 | Pfam | PF05221 | S-adenosyl-L-homocysteine hydrolase | 1 | 113 | 7.8E-54 |
| 2 | g11186.t6 | Pfam | PF00670 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain | 163 | 323 | 2.3E-77 |
| 13 | g11186.t6 | ProSitePatterns | PS00738 | S-adenosyl-L-homocysteine hydrolase signature 1. | 50 | 64 | - |
| 12 | g11186.t6 | ProSitePatterns | PS00739 | S-adenosyl-L-homocysteine hydrolase signature 2. | 185 | 201 | - |
| 15 | g11186.t6 | SMART | SM00996 | AdoHcyase_2 | 1 | 403 | 3.4E-226 |
| 14 | g11186.t6 | SMART | SM00997 | AdoHcyase_NAD_2 | 163 | 324 | 2.3E-97 |
| 6 | g11186.t6 | SUPERFAMILY | SSF52283 | Formate/glycerate dehydrogenase catalytic domain-like | 1 | 404 | 1.02E-93 |
| 5 | g11186.t6 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 163 | 322 | 1.01E-62 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004013 | adenosylhomocysteinase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
