General information for g11233.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Monocarboxylate transporter 10.
Parent gene
- The parent gene g11233 is located on chr_1: 14836143..14838469 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11233 | g11233.t1 | TTS | g11233.t1 | 14834674 | 14834674 |
| chr_1 | g11233 | g11233.t1 | isoform | g11233.t1 | 14834832 | 14838127 |
| chr_1 | g11233 | g11233.t1 | exon | g11233.t1.exon1 | 14834832 | 14834839 |
| chr_1 | g11233 | g11233.t1 | cds | g11233.t1.CDS1 | 14834832 | 14834839 |
| chr_1 | g11233 | g11233.t1 | exon | g11233.t1.exon2 | 14835403 | 14835450 |
| chr_1 | g11233 | g11233.t1 | cds | g11233.t1.CDS2 | 14835403 | 14835450 |
| chr_1 | g11233 | g11233.t1 | exon | g11233.t1.exon3 | 14835504 | 14836075 |
| chr_1 | g11233 | g11233.t1 | cds | g11233.t1.CDS3 | 14835504 | 14836075 |
| chr_1 | g11233 | g11233.t1 | exon | g11233.t1.exon4 | 14836139 | 14836534 |
| chr_1 | g11233 | g11233.t1 | cds | g11233.t1.CDS4 | 14836139 | 14836534 |
| chr_1 | g11233 | g11233.t1 | exon | g11233.t1.exon5 | 14836596 | 14836779 |
| chr_1 | g11233 | g11233.t1 | cds | g11233.t1.CDS5 | 14836596 | 14836779 |
| chr_1 | g11233 | g11233.t1 | exon | g11233.t1.exon6 | 14837863 | 14838127 |
| chr_1 | g11233 | g11233.t1 | cds | g11233.t1.CDS6 | 14837863 | 14838127 |
| chr_1 | g11233 | g11233.t1 | TSS | g11233.t1 | 14838469 | 14838469 |
Sequences
>g11233.t1 Gene=g11233 Length=1473
ATGACTTCAGAATCGCTAATAAATAATAATAATAATGTAATAATAGTATCAGCTGATAAA
AATATAGTTAAAGAGGAAGATACCAGAAAAGTTGTTGAACATGAGCCTCCTGATTCAGGC
TTTCGTGCTTACATAGTTGCAATATGTGCTTTTCTCTGTAATGGAATAATTTTTGGCATT
ATAAATACTTATTCAGTTATTTATCTGAGTTTACAAAAACAACTCGTTGCAAGTGGAGAT
GATGCAAATGCATCGTCAAAAGCTGCACTTGTAGGCTCGTTGACAATTGGCGCTACATTT
TTCTTTTCACCAGTATCTGGTATCTTAGTTGACAAGTTAGGGTTAAGAAGAACAACATTT
CTTGGCGGTATTTTAACAACATGCGGTATGATGCTTTCTGCGTATCACACAGATGATCCT
TTTCAGCCAGAAAAGGTTACTGTTCTCTGTTTTACTTATGGCTTACTTTTTGGAACTGGT
GCAGCTTTGGCATATACTCCCACATTAGCAATATTGGGACATTATTTTAAAAAGAAGCTG
GGAATCGTTAATGGTTTTGTGACAGCTGGTAGCAATGTTTTTACATTCATTTTACCACAA
TTCTTGACTCATATTGAGGAACATTATGGTTTAAAAAACTGCTTACGAGTGATGATGATC
ATGTCAAGTTTCATCATTGTTTGTGCTCTTATTTACAAACCTTTGCAGCCACCTCCACCA
AAAAAGCAACAGAAAGCCAATCGATCAAGTTTCTACAATTTTCTTCGATCGATAATTAAC
TTTGATAACTGGAAAAAGAAGAAATATGTCGTGTGGGCAATATCGATTCCCGTAGCTTTA
TTCGGATACTTTGTACCTTATGTTCATATTGGAAAATTCATAGAAGAAAAATTTCCTGAT
GAAAATAAAAATTTGCCACTTATGTGTATTGGAATAACTTCAGGCTTAGGTCGTATAATT
TTTGGATGGATCTCAGACTTGCCAAATGTCAATCGTATATTTCTTCAACAAATTTCATTC
TATTTTATTGGTCTCATGACAATATTTGTTCCACTTACTGACAATTATATATTTTTATTG
TTTATTGTCCTTGCCCTCGGATTATTTGATGGTTGCTTTATCTCATTACTTGGTCCTATT
GCTTATGAGTTATGTGGCAGTCATGGAGCAGCGCAAGCAATTGGATTTTTACTTGGGTTA
TGTTCTTTTGGATTAACTGCAGGTCCACCAATAGCAGGAGAAATATACGATAGTACAAAA
TCATATACCCTGCCATTTATACTTGCTGGCATTCCCCCGTTGGTCGGAGCTTCACTTATG
TTCATTATTAGAGCTCTAAAGGATGAGCGCAAAATTTCTAATGATGTTATTGAAGCTCAA
CCTCTTCAGACAATGCCACAAATTGCTTGGGATAAAGAAAATAAACAACCAATTGAAGAA
CGTAGAGCAACTCTAGCAGAACCAGATGAATAA
>g11233.t1 Gene=g11233 Length=490
MTSESLINNNNNVIIVSADKNIVKEEDTRKVVEHEPPDSGFRAYIVAICAFLCNGIIFGI
INTYSVIYLSLQKQLVASGDDANASSKAALVGSLTIGATFFFSPVSGILVDKLGLRRTTF
LGGILTTCGMMLSAYHTDDPFQPEKVTVLCFTYGLLFGTGAALAYTPTLAILGHYFKKKL
GIVNGFVTAGSNVFTFILPQFLTHIEEHYGLKNCLRVMMIMSSFIIVCALIYKPLQPPPP
KKQQKANRSSFYNFLRSIINFDNWKKKKYVVWAISIPVALFGYFVPYVHIGKFIEEKFPD
ENKNLPLMCIGITSGLGRIIFGWISDLPNVNRIFLQQISFYFIGLMTIFVPLTDNYIFLL
FIVLALGLFDGCFISLLGPIAYELCGSHGAAQAIGFLLGLCSFGLTAGPPIAGEIYDSTK
SYTLPFILAGIPPLVGASLMFIIRALKDERKISNDVIEAQPLQTMPQIAWDKENKQPIEE
RRATLAEPDE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 17 | g11233.t1 | Gene3D | G3DSA:1.20.1250.20 | MFS general substrate transporter like domains | 25 | 452 | 1.9E-44 |
| 2 | g11233.t1 | PANTHER | PTHR11360:SF119 | MONOCARBOXYLATE TRANSPORTER 10 | 27 | 452 | 3.5E-118 |
| 3 | g11233.t1 | PANTHER | PTHR11360 | MONOCARBOXYLATE TRANSPORTER | 27 | 452 | 3.5E-118 |
| 1 | g11233.t1 | Pfam | PF07690 | Major Facilitator Superfamily | 48 | 401 | 5.0E-26 |
| 23 | g11233.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 42 | - |
| 32 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 43 | 68 | - |
| 31 | g11233.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 69 | 87 | - |
| 40 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 88 | 110 | - |
| 22 | g11233.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 111 | 116 | - |
| 41 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 117 | 135 | - |
| 30 | g11233.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 136 | 154 | - |
| 34 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 155 | 176 | - |
| 21 | g11233.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 177 | 182 | - |
| 33 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 183 | 203 | - |
| 29 | g11233.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 204 | 214 | - |
| 43 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 215 | 235 | - |
| 20 | g11233.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 236 | 268 | - |
| 36 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 269 | 285 | - |
| 27 | g11233.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 286 | 304 | - |
| 37 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 305 | 321 | - |
| 24 | g11233.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 322 | 332 | - |
| 35 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 333 | 350 | - |
| 26 | g11233.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 351 | 355 | - |
| 39 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 356 | 382 | - |
| 19 | g11233.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 383 | 393 | - |
| 42 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 394 | 412 | - |
| 28 | g11233.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 413 | 423 | - |
| 38 | g11233.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 424 | 443 | - |
| 25 | g11233.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 444 | 490 | - |
| 18 | g11233.t1 | ProSiteProfiles | PS50850 | Major facilitator superfamily (MFS) profile. | 43 | 448 | 10.931 |
| 16 | g11233.t1 | SUPERFAMILY | SSF103473 | MFS general substrate transporter | 32 | 448 | 5.75E-49 |
| 10 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 46 | 68 | - |
| 12 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 88 | 110 | - |
| 13 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 119 | 136 | - |
| 8 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 151 | 173 | - |
| 9 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 180 | 202 | - |
| 15 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 217 | 235 | - |
| 5 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 269 | 291 | - |
| 4 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 306 | 325 | - |
| 6 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 330 | 352 | - |
| 14 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 356 | 378 | - |
| 11 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 385 | 407 | - |
| 7 | g11233.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 422 | 444 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0055085 | transmembrane transport | BP |
| GO:0015349 | thyroid hormone transmembrane transporter activity | MF |
| GO:0005887 | integral component of plasma membrane | CC |
| GO:0015173 | aromatic amino acid transmembrane transporter activity | MF |
| GO:0022857 | transmembrane transporter activity | MF |
KEGG
Orthology
- This transcript has been annotated with K08187 (MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 10)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
