Gene loci information

Transcript annotation

  • This transcript has been annotated as Insulin-degrading enzyme.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g11339 g11339.t1 TSS g11339.t1 15723555 15723555
chr_1 g11339 g11339.t1 isoform g11339.t1 15723622 15727486
chr_1 g11339 g11339.t1 exon g11339.t1.exon1 15723622 15723674
chr_1 g11339 g11339.t1 cds g11339.t1.CDS1 15723622 15723674
chr_1 g11339 g11339.t1 exon g11339.t1.exon2 15723838 15724822
chr_1 g11339 g11339.t1 cds g11339.t1.CDS2 15723838 15724822
chr_1 g11339 g11339.t1 exon g11339.t1.exon3 15724893 15726021
chr_1 g11339 g11339.t1 cds g11339.t1.CDS3 15724893 15726021
chr_1 g11339 g11339.t1 exon g11339.t1.exon4 15726084 15726287
chr_1 g11339 g11339.t1 cds g11339.t1.CDS4 15726084 15726287
chr_1 g11339 g11339.t1 exon g11339.t1.exon5 15726697 15726742
chr_1 g11339 g11339.t1 cds g11339.t1.CDS5 15726697 15726742
chr_1 g11339 g11339.t1 exon g11339.t1.exon6 15726798 15726939
chr_1 g11339 g11339.t1 cds g11339.t1.CDS6 15726798 15726939
chr_1 g11339 g11339.t1 exon g11339.t1.exon7 15726994 15727203
chr_1 g11339 g11339.t1 cds g11339.t1.CDS7 15726994 15727203
chr_1 g11339 g11339.t1 exon g11339.t1.exon8 15727262 15727486
chr_1 g11339 g11339.t1 cds g11339.t1.CDS8 15727262 15727486
chr_1 g11339 g11339.t1 TTS g11339.t1 15727528 15727528

Sequences

>g11339.t1 Gene=g11339 Length=2994
ATGTATAGTGTTCGGATTATTTCCTGTGCGCTTGTAGAGAGACATATTGTGAAAAAGAAA
AACTGGTTTGGATTAAGTAGGAGATTCTTATCATCATCTACATTATCAAATAATACTCTT
GTAATGAAAACAGCAGAAAAAGGAAAATCAAATATCTCTGGATCTATTTTATCAAGCGTA
CAAAATATGGAAATAATCAGATATGAGAATATTGTAAAAAGTGAAGAGGACAAGCGTTTG
TATAGAGGACTTAAACTAGAAAATGGTATCAAAGTGCTCCTTATATCTGATCCTGAAACT
GATAAAAGTGCTGCATGCATGTCGATTGAAATCGGGCATATGTCTGATCCAATATCATTA
CCGGGCTTAGCTCATTTCGTAGAACATATGCTCTTTTTAGGAACTAAAAAATATCCAAAT
GAAAATGAATATAGCAGTTTTTTGAGCAAAAATAGTGGCACTTCAAATGCTGCAACGTAT
CCAGATTTGACTAAATATTACTTTGATGTCATGCCTGAGAAACTTGAGGGCGCCATTGAT
CGATTTTCTCAATTTTTTACAAGTCCTTTATTCACTGAAAGTGCAACATTGAGAGAAATT
AATGCAGTTCATTCTGAGCACGAAAAAAACTTGGCAACAGATGTATGGCGAATTAGACAA
GTTCAAAAATCACTTGCTAATAAAAATCATCCTTATTCAAAATTCGGCACTGGTAATAAA
GATACACTTTTAGATATTCCAAAGAAAAATGGCGTGGACACTCGTACAGAACTTATTAAA
TTTCATGACAAATACTATTCATCAAACCTCATGACACTTGCAATTTTTGGAAAAGAATCT
CTTGATGAACTTGAAGTTTTAGCAACGAAATATTTCTCTAATATAGAGAATAAAAATGTT
CCACTTCCAAAATGGGGTGATGATGTCTATTTAGACGATCAAATAAGAACAAAACTTTAT
ATTGTACCTGTAAAAGATACAAGAACTTTGTCGATGTCTTTTCAAATTCCTGATATGGAC
GAATATTTTAGAAGTGGACCTGAACATTACATTTCTCATTTAGTAGGTCATGAAGGTAAA
GGTTCAATTTTATCCGAATTAAAGAAACGTGGATGGTGCAATAATTTGATAGGAGGAGCT
AGTTCCTCTGCAAAAGGTTTTGGGTTCTTTGAAATTACTGTAGATTTGACAGAGGAAGGA
TTTGAACATATTGACGACATTTGCAAACTTATATTTCAATATCTAAATTTATTAAGAAAA
GAGGGTCCACAACAATGGATTTTTGATGAATATCGAAAACTTAGTGAAATGCAATTTCGC
TTCAAAGATAAAGAAAACCCAATAAACCTTGTATCTAACATTGTTCACCAAATGATGATT
TATCCCCTTTCTGATGTTCTTTCCGCTAACTATCTTCTTACTGAATGGCGGCCTGATTTA
ATTAATGATGTCCTGACACGTTTGAATCCACAAAATTGTCGAATAACTATAGTCGGTCAA
AAAGTTAGTGATAAATGTAAAGAGGAAGAAAAATGGTATAAAACTAATTATCATTGTGAG
AAAATCGAACAATCAGTACTTGATGAATGGTCGAATTGTGGAATAAATGAAAATCTTCAT
TTACCGGAACCAAATTTATTCATACCATCTGACTTTAATCTATTACCACTTGAAACTACC
GAAAAAATTCATCCGATGATTATTGAAGATACACCATGGATGCGAATTTGGTATAAACAA
GACGATGAGTTTTTTAAGCCTAAAATGTTCATTGGAATCGACTTTTCTAATCCAATTGTA
TATACAGATCCTCTCAATTGTAATTTGACTCATCTTTTTGTGTCACTTTTCAAAGATAGT
ATTAACGAATTCCTTTATGCTGCCGAATTAGCTGGATTACGTTTTAATATTAACAATACA
ACAAATGGTATAAGCATGCTTATCAGTGGTTATTCTGATAAGCAACATAAATTTTTAGAA
ACCATTTTAGACAAATTGTTTTCTTATGAGATTGACGAAAAGCGTTTTGAAATTATGTAT
GAACAATATTTGAGGGGACTTAAAAATTTTGATGCAGAACAGCCTTATCAGTTAGCAATT
TATCATTTAGCAGTCATTTTAACCGAACAAGCATGGACTAAGCGAGAATTGATTGATGCC
ATGCAATTGGTTACAGTAGATAGATTAAATGATTTTATTAAAGAGATATTGTCTCGAATT
CACGCTGAAGTTTTTATTTATGGAAATGTAAATAAAGAAAAATCGTTGAAGATTTCCAAA
TTAATAGATAATAAACTGAAAGAAACATCTAAAATTCTTCCTATCCTGAGTCGTCAGTTA
TTACTCAAACGTGAATATAAGCTTGTGGAAGATTTGGTAGCACAGATTTTGTCTGAGCCA
TGTTATAATGTTTTGAGAACACAAGATCAATTAGGGTATATTGTATTTTCTGGCGTTAGA
AAAGCTAATGGTGCAAAAGGAATGCGAATAATTGTACAATCTGCAAAGAATTTAGATTAT
GTTGATCAGCGGATTGAGAAATTTTTGGAATCTATGATTTCAGAAATAGAGAAAATGTCA
GAAGAAGAGTTCGAGAGACATAAAAATTCGTTAAGAGCTGCAAAAATTGAAAAACCTAAA
AGATTATCGGCTTCTTATTCGGTCTTAATAAATGAAATTGCTTTGCAACAGTATCACTTT
GATCGTTCTGAGAAAGAAGTTGAAATACTTCAAGGCATTACTAAATCGCAGTTATTAGAT
TATTACAATCATTTTATTGCACCGAATGCTCCAGCACGTCAGTCGCTATTAATTCATATT
GTGTCAAAACCTGAAAATGTCGAGCATGTTGAGATGCTTGAAGAAGAAGCAAAATCTTTG
AAAGAATACCAGAAAATATCTGATTTAGCTACATTTAAATCATCAAAGCAGCTGTATCCA
TTAGCGAAAAGCTATATTGATATTGTACCAAAAGGTGCAAAAAGTAAATTGTAA

>g11339.t1 Gene=g11339 Length=997
MYSVRIISCALVERHIVKKKNWFGLSRRFLSSSTLSNNTLVMKTAEKGKSNISGSILSSV
QNMEIIRYENIVKSEEDKRLYRGLKLENGIKVLLISDPETDKSAACMSIEIGHMSDPISL
PGLAHFVEHMLFLGTKKYPNENEYSSFLSKNSGTSNAATYPDLTKYYFDVMPEKLEGAID
RFSQFFTSPLFTESATLREINAVHSEHEKNLATDVWRIRQVQKSLANKNHPYSKFGTGNK
DTLLDIPKKNGVDTRTELIKFHDKYYSSNLMTLAIFGKESLDELEVLATKYFSNIENKNV
PLPKWGDDVYLDDQIRTKLYIVPVKDTRTLSMSFQIPDMDEYFRSGPEHYISHLVGHEGK
GSILSELKKRGWCNNLIGGASSSAKGFGFFEITVDLTEEGFEHIDDICKLIFQYLNLLRK
EGPQQWIFDEYRKLSEMQFRFKDKENPINLVSNIVHQMMIYPLSDVLSANYLLTEWRPDL
INDVLTRLNPQNCRITIVGQKVSDKCKEEEKWYKTNYHCEKIEQSVLDEWSNCGINENLH
LPEPNLFIPSDFNLLPLETTEKIHPMIIEDTPWMRIWYKQDDEFFKPKMFIGIDFSNPIV
YTDPLNCNLTHLFVSLFKDSINEFLYAAELAGLRFNINNTTNGISMLISGYSDKQHKFLE
TILDKLFSYEIDEKRFEIMYEQYLRGLKNFDAEQPYQLAIYHLAVILTEQAWTKRELIDA
MQLVTVDRLNDFIKEILSRIHAEVFIYGNVNKEKSLKISKLIDNKLKETSKILPILSRQL
LLKREYKLVEDLVAQILSEPCYNVLRTQDQLGYIVFSGVRKANGAKGMRIIVQSAKNLDY
VDQRIEKFLESMISEIEKMSEEEFERHKNSLRAAKIEKPKRLSASYSVLINEIALQQYHF
DRSEKEVEILQGITKSQLLDYYNHFIAPNAPARQSLLIHIVSKPENVEHVEMLEEEAKSL
KEYQKISDLATFKSSKQLYPLAKSYIDIVPKGAKSKL

Protein features from InterProScan

Transcript Database ID Name Start End E.value
12 g11339.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 54 302 4.9E-93
15 g11339.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 303 532 1.8E-90
14 g11339.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 561 783 3.4E-72
13 g11339.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 784 991 1.2E-63
5 g11339.t1 PANTHER PTHR43690:SF18 INSULIN-DEGRADING ENZYME-RELATED 68 981 0.0
6 g11339.t1 PANTHER PTHR43690 NARDILYSIN 68 981 0.0
1 g11339.t1 Pfam PF00675 Insulinase (Peptidase family M16) 91 227 1.0E-36
3 g11339.t1 Pfam PF05193 Peptidase M16 inactive domain 254 433 2.4E-24
2 g11339.t1 Pfam PF16187 Middle or third domain of peptidase_M16 439 720 3.2E-100
4 g11339.t1 Pfam PF05193 Peptidase M16 inactive domain 791 871 2.2E-6
11 g11339.t1 ProSitePatterns PS00143 Insulinase family, zinc-binding region signature. 112 135 -
9 g11339.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 70 303 9.6E-60
7 g11339.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 306 544 9.43E-82
8 g11339.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 545 770 2.0E-54
10 g11339.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 790 979 3.67E-39

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0046872 metal ion binding MF
GO:0006508 proteolysis BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values