General information for g11339.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Insulin-degrading enzyme.
Parent gene
- The parent gene g11339 is located on chr_1: 15727486..15735873 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11339 | g11339.t2 | TSS | g11339.t2 | 15723555 | 15723555 |
| chr_1 | g11339 | g11339.t2 | isoform | g11339.t2 | 15723622 | 15724822 |
| chr_1 | g11339 | g11339.t2 | exon | g11339.t2.exon1 | 15723622 | 15724822 |
| chr_1 | g11339 | g11339.t2 | cds | g11339.t2.CDS1 | 15723908 | 15724822 |
| chr_1 | g11339 | g11339.t2 | TTS | g11339.t2 | NA | NA |
Sequences
>g11339.t2 Gene=g11339 Length=1201
ATGTATAGTGTTCGGATTATTTCCTGTGCGCTTGTAGAGAGACATATTGTGAAGTATGTT
TTAAAAATATAATTGAAGTTCTAGGACTTTATTTCTAAGTTTAATTTCATCTTTTTTTGA
AATTAAAAAAAAATATATTGACATCATCAATACTAAACATTAACTTGATGACTTGACTAA
ATTTTAATTCCTTTCTTTACACTATTAACAATGCAGAAAGAAAAACTGGTTTGGATTAAG
TAGGAGATTCTTATCATCATCTACATTATCAAATAATACTCTTGTAATGAAAACAGCAGA
AAAAGGAAAATCAAATATCTCTGGATCTATTTTATCAAGCGTACAAAATATGGAAATAAT
CAGATATGAGAATATTGTAAAAAGTGAAGAGGACAAGCGTTTGTATAGAGGACTTAAACT
AGAAAATGGTATCAAAGTGCTCCTTATATCTGATCCTGAAACTGATAAAAGTGCTGCATG
CATGTCGATTGAAATCGGGCATATGTCTGATCCAATATCATTACCGGGCTTAGCTCATTT
CGTAGAACATATGCTCTTTTTAGGAACTAAAAAATATCCAAATGAAAATGAATATAGCAG
TTTTTTGAGCAAAAATAGTGGCACTTCAAATGCTGCAACGTATCCAGATTTGACTAAATA
TTACTTTGATGTCATGCCTGAGAAACTTGAGGGCGCCATTGATCGATTTTCTCAATTTTT
TACAAGTCCTTTATTCACTGAAAGTGCAACATTGAGAGAAATTAATGCAGTTCATTCTGA
GCACGAAAAAAACTTGGCAACAGATGTATGGCGAATTAGACAAGTTCAAAAATCACTTGC
TAATAAAAATCATCCTTATTCAAAATTCGGCACTGGTAATAAAGATACACTTTTAGATAT
TCCAAAGAAAAATGGCGTGGACACTCGTACAGAACTTATTAAATTTCATGACAAATACTA
TTCATCAAACCTCATGACACTTGCAATTTTTGGAAAAGAATCTCTTGATGAACTTGAAGT
TTTAGCAACGAAATATTTCTCTAATATAGAGAATAAAAATGTTCCACTTCCAAAATGGGG
TGATGATGTCTATTTAGACGATCAAATAAGAACAAAACTTTATATTGTACCTGTAAAAGA
TACAAGAACTTTGTCGATGTCTTTTCAAATTCCTGATATGGACGAATATTTTAGAAGTGG
A
>g11339.t2 Gene=g11339 Length=305
MKTAEKGKSNISGSILSSVQNMEIIRYENIVKSEEDKRLYRGLKLENGIKVLLISDPETD
KSAACMSIEIGHMSDPISLPGLAHFVEHMLFLGTKKYPNENEYSSFLSKNSGTSNAATYP
DLTKYYFDVMPEKLEGAIDRFSQFFTSPLFTESATLREINAVHSEHEKNLATDVWRIRQV
QKSLANKNHPYSKFGTGNKDTLLDIPKKNGVDTRTELIKFHDKYYSSNLMTLAIFGKESL
DELEVLATKYFSNIENKNVPLPKWGDDVYLDDQIRTKLYIVPVKDTRTLSMSFQIPDMDE
YFRSG
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g11339.t2 | Gene3D | G3DSA:3.30.830.10 | Cytochrome Bc1 Complex; Chain A | 13 | 261 | 2.8E-94 |
| 3 | g11339.t2 | PANTHER | PTHR43690:SF18 | INSULIN-DEGRADING ENZYME-RELATED | 27 | 303 | 8.5E-122 |
| 4 | g11339.t2 | PANTHER | PTHR43690 | NARDILYSIN | 27 | 303 | 8.5E-122 |
| 1 | g11339.t2 | Pfam | PF00675 | Insulinase (Peptidase family M16) | 50 | 186 | 1.2E-37 |
| 2 | g11339.t2 | Pfam | PF05193 | Peptidase M16 inactive domain | 213 | 298 | 4.0E-10 |
| 6 | g11339.t2 | ProSitePatterns | PS00143 | Insulinase family, zinc-binding region signature. | 71 | 94 | - |
| 5 | g11339.t2 | SUPERFAMILY | SSF63411 | LuxS/MPP-like metallohydrolase | 29 | 262 | 5.87E-61 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0046872 | metal ion binding | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
