General information for g11347.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Arylsulfatase B.
Parent gene
- The parent gene g11347 is located on chr_1: 15740135..15742966 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11347 | g11347.t1 | TSS | g11347.t1 | 15739088 | 15739088 |
| chr_1 | g11347 | g11347.t1 | isoform | g11347.t1 | 15739155 | 15742966 |
| chr_1 | g11347 | g11347.t1 | exon | g11347.t1.exon1 | 15739155 | 15739348 |
| chr_1 | g11347 | g11347.t1 | cds | g11347.t1.CDS1 | 15739155 | 15739348 |
| chr_1 | g11347 | g11347.t1 | exon | g11347.t1.exon2 | 15739412 | 15739482 |
| chr_1 | g11347 | g11347.t1 | cds | g11347.t1.CDS2 | 15739412 | 15739482 |
| chr_1 | g11347 | g11347.t1 | exon | g11347.t1.exon3 | 15739560 | 15740138 |
| chr_1 | g11347 | g11347.t1 | cds | g11347.t1.CDS3 | 15739560 | 15740138 |
| chr_1 | g11347 | g11347.t1 | exon | g11347.t1.exon4 | 15740202 | 15740259 |
| chr_1 | g11347 | g11347.t1 | cds | g11347.t1.CDS4 | 15740202 | 15740259 |
| chr_1 | g11347 | g11347.t1 | exon | g11347.t1.exon5 | 15742108 | 15742966 |
| chr_1 | g11347 | g11347.t1 | cds | g11347.t1.CDS5 | 15742108 | 15742966 |
| chr_1 | g11347 | g11347.t1 | TTS | g11347.t1 | 15742990 | 15742990 |
Sequences
>g11347.t1 Gene=g11347 Length=1761
ATGATTACTAAAGTATCAAATTTTTTCTTATTTATAAGTTATTTGCTGTTCAGTGTTATC
AAGTGTGAGAAACCAAACATTGTTATAATACTAGCTGATGATTTAGGCTATAATGATGTG
AGCTTTCATGGCAGTTCAGAAATTCCCACACCGAATTTGGATGCTCTTTGCTATAATGGA
GTTATCCTTAACAGATTTTATACAACGCCTCTATGTACACCTTCGCGAAGTTCATTAATG
ACAGGAAAATACAGTACAAAATTAGGCATGAACCATTACGTGATACCAAGTGATGAGCCA
TGGGGACTTCCCTTGAATGAAAAAATCATTCCAGAATATTTTAAAGAAGCTGGTTATAAA
ACTGCACTTATTGGCAAATGGCATCTTGGATTTTTCAAAAAATCTTATACGCCTCTTATG
CGAGGTTTTGATTATCATTATGGTTATCTTGGTCCATATATTGGTTATTATGACCATTCA
CTCATCATGCTTGATAGAAATTATTCACGTGGATTTGATATGCGAAATAATTTTGAAGTT
GAAAATGTTAGAGGAAAATATGCGACAGATGTATTCACCGATGAAGCTGTTAATTTAATT
AAGAGACATAACACAAGCGATCCTCTTTTTTTGCTTTTATCACATTTAGCACCACATGCT
GGCAATGAAGATAAGCCACTTGAAGCATCTGAAGAAGTTATAAATAAGTTCGCTTATATA
AAAAACGAACAGAGAAGAACGTTGGCGGCAATGATTAATATTATGGATGACGGAATTGGT
AGGGTTGTGGAGGCATTGAACGAAAAAGGCATCATGAACAATACGATAATTATGTTTCTA
TCAGATAACGGTGGACCAACTTTTGGAATTCACTCAACAGAAGCATCAAATTCTCCTTTA
AGAGGACAAAAGGGAAGTGTATGGGAAGGTGGCACTCGAGTACCAGCTTGTATCTACAGC
CCTTTGATTAAGAATAAAAATAGAGTCACGAATGAGTTTATGTATATTACAGACATTCTC
CCAACTATGGCTGCAGCTGCAAATATATCAATTACAAATAATATTGATGGAATCAATCAA
TTTGAAACAATCTCAAATAGCAAAATAACTGAAAGAAAAGATATACTTTATAATATTGAG
TCAGTGTTTGGATTTAGCGCTATCATGAGCAATGGTTTTAAATTGGTTAATGGAAGTGAA
AATATGAAATATTCGGGCTGGTTTGGTAGCTCTGGTGATTATGCTGCAACAAGTTTAGAA
GAATACTTTCAAAACATTATCAATTCAATTACATATAAAAATTTGCCGATGATTGATATA
GATATAGTAAAGAAAATGCGAGAAGAATCAAAAACTGTTTGTGATAATAGTATATCAACA
ACAAAATGCAATCCAATACAAGCACCATGTTTGTTTGACATTATAAATGACCCATGCGAA
AAAGATAATCTCGCTGAAATTTATCCAGACAAAGTTAAAATGTTGATTGAAAAATTAAAT
ATTGAAATTCAATTAATGGTTCCAACAATTCGAGTTAAATCAGATCCATTATGTGATCCA
AAGCTTCATAACTGGACTTGGACGTGGTGGAGGCAAGATGATGACCAATCTGCAAACGTT
AATAAGGAAGATGATGATTTTTCTTCGCGAACTACCTTAATTTTTGTAATTTGTTTCATT
TTCATAATAATTCAATTTTTCATATTCTTCATTAAATGTAAAAAGAATTCTGAAAATTTT
ACGATTTTCCGCCTTCAATAA
>g11347.t1 Gene=g11347 Length=586
MITKVSNFFLFISYLLFSVIKCEKPNIVIILADDLGYNDVSFHGSSEIPTPNLDALCYNG
VILNRFYTTPLCTPSRSSLMTGKYSTKLGMNHYVIPSDEPWGLPLNEKIIPEYFKEAGYK
TALIGKWHLGFFKKSYTPLMRGFDYHYGYLGPYIGYYDHSLIMLDRNYSRGFDMRNNFEV
ENVRGKYATDVFTDEAVNLIKRHNTSDPLFLLLSHLAPHAGNEDKPLEASEEVINKFAYI
KNEQRRTLAAMINIMDDGIGRVVEALNEKGIMNNTIIMFLSDNGGPTFGIHSTEASNSPL
RGQKGSVWEGGTRVPACIYSPLIKNKNRVTNEFMYITDILPTMAAAANISITNNIDGINQ
FETISNSKITERKDILYNIESVFGFSAIMSNGFKLVNGSENMKYSGWFGSSGDYAATSLE
EYFQNIINSITYKNLPMIDIDIVKKMREESKTVCDNSISTTKCNPIQAPCLFDIINDPCE
KDNLAEIYPDKVKMLIEKLNIEIQLMVPTIRVKSDPLCDPKLHNWTWTWWRQDDDQSANV
NKEDDDFSSRTTLIFVICFIFIIIQFFIFFIKCKKNSENFTIFRLQ
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g11347.t1 | CDD | cd16029 | 4-S | 25 | 398 | 0.0 |
| 6 | g11347.t1 | Gene3D | G3DSA:3.40.720.10 | Alkaline Phosphatase | 25 | 372 | 1.7E-140 |
| 7 | g11347.t1 | Gene3D | G3DSA:3.30.1120.10 | - | 373 | 500 | 1.7E-140 |
| 2 | g11347.t1 | PANTHER | PTHR10342 | ARYLSULFATASE | 21 | 542 | 8.5E-204 |
| 3 | g11347.t1 | PANTHER | PTHR10342:SF264 | MIP05773P | 21 | 542 | 8.5E-204 |
| 1 | g11347.t1 | Pfam | PF00884 | Sulfatase | 25 | 349 | 8.0E-72 |
| 10 | g11347.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 22 | - |
| 11 | g11347.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 7 | - |
| 12 | g11347.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 8 | 17 | - |
| 14 | g11347.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 18 | 22 | - |
| 9 | g11347.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 23 | 551 | - |
| 13 | g11347.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 552 | 571 | - |
| 8 | g11347.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 572 | 586 | - |
| 17 | g11347.t1 | ProSitePatterns | PS00523 | Sulfatases signature 1. | 70 | 82 | - |
| 18 | g11347.t1 | ProSitePatterns | PS00149 | Sulfatases signature 2. | 118 | 128 | - |
| 4 | g11347.t1 | SUPERFAMILY | SSF53649 | Alkaline phosphatase-like | 23 | 530 | 1.89E-124 |
| 5 | g11347.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 22 | - |
| 16 | g11347.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 552 | 571 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008484 | sulfuric ester hydrolase activity | MF |
| GO:0003824 | catalytic activity | MF |
KEGG
Orthology
- This transcript has been annotated with K01135 (arylsulfatase B)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
