General information for g11456.t82
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Hsp90 co-chaperone Cdc37.
Parent gene
- The parent gene g11456 is located on chr_1: 16359059..16361209 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11456 | g11456.t82 | isoform | g11456.t82 | 16358064 | 16359529 |
| chr_1 | g11456 | g11456.t82 | exon | g11456.t82.exon1 | 16358064 | 16358200 |
| chr_1 | g11456 | g11456.t82 | TTS | g11456.t82 | 16358079 | 16358079 |
| chr_1 | g11456 | g11456.t82 | cds | g11456.t82.CDS1 | 16358114 | 16358200 |
| chr_1 | g11456 | g11456.t82 | exon | g11456.t82.exon2 | 16358275 | 16358439 |
| chr_1 | g11456 | g11456.t82 | cds | g11456.t82.CDS2 | 16358275 | 16358439 |
| chr_1 | g11456 | g11456.t82 | exon | g11456.t82.exon3 | 16358577 | 16359424 |
| chr_1 | g11456 | g11456.t82 | cds | g11456.t82.CDS3 | 16358577 | 16359424 |
| chr_1 | g11456 | g11456.t82 | exon | g11456.t82.exon4 | 16359478 | 16359529 |
| chr_1 | g11456 | g11456.t82 | cds | g11456.t82.CDS4 | 16359478 | 16359529 |
| chr_1 | g11456 | g11456.t82 | TSS | g11456.t82 | 16359617 | 16359617 |
Sequences
>g11456.t82 Gene=g11456 Length=1202
ATGGTCGATTACTCAAAGTGGAAGAATATTGAAGTATCTGATGATGAAGATGATACTCAT
CCAAATATCGATACACCAAGTCTTTTTCGTTGGAGGCATCAGGCAAGAATTGAACGTATG
GAAGAAATGGAACAGCAAAAAAAGCAATTGGAATCAGCAATTAAAGAGAATGAAAAGTTG
CTAAATGATTTGAAGGAAAAATTAAAAATATCACCCGAGGACAAAAAACTTACAGATGAA
ATTAAAAAACAAGAAGCCGAAAGAATTAAATTAATGGATGTTCAGAAAGATCTTAAGAAG
AAAGAACAATTGGCTCCATGGAATGTTGACACATTATCTCAACCCAAATTTTCAAAAACA
GTTATCAATAAAAAGGATGAGAGAAATTATGAAGAAATGACAGATGAAGAAAAGGAACAG
CACATGAAAAAGTTTGTTAAAGAAAATGAAGCACTTATGAAACAATTTGGAATGTTGCGC
AAATTCGATGATTCTAAAACTTTCTTAATGAAACATACCTCTTTGGTACACGAAGATACT
GCAAATTATCTCGTTATTTGGTGCATTAATTTAGAAATGGAAGAGAAGCATGAACTGATG
ACACATGTTGCTCATCAATGCATTTGTATGCAATACATGCTTGAACTTTCTAAACAACTT
AAAATTGATCCTCGAGCATGTATTGCTCCATTTTTTGAGAGAATTCAAACTGCTGATGTT
GAGTACAAACGTCAATTTGAAGATGAAATTGCTGCATTTATCGGTCGTATTGAGAGACGA
GCAAAGGAGAAAATTGCAGAAGCTCTTAAAGAACAAGAGGAAGAAGAAAAACGCGAGAGA
CTTGCACGACTTGGACCTGGCGGTTTGGATCCAGCTGAAGTTTTTGAAACATTGCCCAAG
GATCTTCAAGTTTGTTTTGAAACTCGTGATACAGAAATGCTAAAGGAAGTAATTTCAAAA
ATGCCAGAAGATGAAGCAAAATATCACATGAAGCGTTGTGTAGATTCTGGTTTATGGGTA
CCTGATGCAAGTCAACTACCATCATCTGAAAATGAGGAAGAAAATCATCAAATCCATTTT
TATTTAATAATCCAGCTGAATTTCGCTATCTCTTCTTGTATTATTATTATTGATGTCAAA
AAATGTGTATAAAATAAAACTTTACTTTACTTTAGCGTTTTCACTTTAAATGATTTTGAT
TT
>g11456.t82 Gene=g11456 Length=383
MVDYSKWKNIEVSDDEDDTHPNIDTPSLFRWRHQARIERMEEMEQQKKQLESAIKENEKL
LNDLKEKLKISPEDKKLTDEIKKQEAERIKLMDVQKDLKKKEQLAPWNVDTLSQPKFSKT
VINKKDERNYEEMTDEEKEQHMKKFVKENEALMKQFGMLRKFDDSKTFLMKHTSLVHEDT
ANYLVIWCINLEMEEKHELMTHVAHQCICMQYMLELSKQLKIDPRACIAPFFERIQTADV
EYKRQFEDEIAAFIGRIERRAKEKIAEALKEQEEEEKRERLARLGPGGLDPAEVFETLPK
DLQVCFETRDTEMLKEVISKMPEDEAKYHMKRCVDSGLWVPDASQLPSSENEEENHQIHF
YLIIQLNFAISSCIIIIDVKKCV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g11456.t82 | Coils | Coil | Coil | 33 | 70 | - |
| 8 | g11456.t82 | Coils | Coil | Coil | 81 | 101 | - |
| 9 | g11456.t82 | Coils | Coil | Coil | 258 | 282 | - |
| 7 | g11456.t82 | Gene3D | G3DSA:1.20.58.610 | - | 141 | 270 | 1.3E-56 |
| 17 | g11456.t82 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 26 | - |
| 18 | g11456.t82 | MobiDBLite | mobidb-lite | consensus disorder prediction | 8 | 23 | - |
| 4 | g11456.t82 | PANTHER | PTHR12800:SF3 | HSP90 CO-CHAPERONE CDC37 | 1 | 356 | 4.9E-124 |
| 5 | g11456.t82 | PANTHER | PTHR12800 | CDC37-RELATED | 1 | 356 | 4.9E-124 |
| 1 | g11456.t82 | Pfam | PF03234 | Cdc37 N terminal kinase binding | 1 | 134 | 6.4E-12 |
| 2 | g11456.t82 | Pfam | PF08565 | Cdc37 Hsp90 binding domain | 156 | 267 | 7.6E-23 |
| 3 | g11456.t82 | Pfam | PF08564 | Cdc37 C terminal domain | 288 | 355 | 8.2E-14 |
| 12 | g11456.t82 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 357 | - |
| 13 | g11456.t82 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 358 | 377 | - |
| 11 | g11456.t82 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 378 | 383 | - |
| 16 | g11456.t82 | SMART | SM01071 | CDC37_N_2 | 1 | 120 | 1.4E-40 |
| 15 | g11456.t82 | SMART | SM01070 | CDC37_M_2 | 118 | 276 | 8.6E-59 |
| 14 | g11456.t82 | SMART | SM01069 | CDC37_C_2 | 283 | 357 | 2.0E-31 |
| 6 | g11456.t82 | SUPERFAMILY | SSF101391 | Hsp90 co-chaperone CDC37 | 142 | 343 | 3.92E-70 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0019901 | protein kinase binding | MF |
KEGG
Orthology
- This transcript has been annotated with K09554 (cell division cycle protein 37)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
