General information for g11582.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Mitogen-activated protein kinase kinase kinase.
Parent gene
- The parent gene g11582 is located on chr_1: 17322310..17322697 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11582 | g11582.t1 | isoform | g11582.t1 | 17315993 | 17322697 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon1 | 17315993 | 17316951 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS1 | 17315993 | 17316951 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon2 | 17317019 | 17317329 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS2 | 17317019 | 17317329 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon3 | 17317392 | 17317773 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS3 | 17317392 | 17317773 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon4 | 17318938 | 17319945 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS4 | 17318938 | 17319945 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon5 | 17320516 | 17320666 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS5 | 17320516 | 17320666 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon6 | 17320732 | 17320926 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS6 | 17320732 | 17320926 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon7 | 17321241 | 17321416 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS7 | 17321241 | 17321416 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon8 | 17321482 | 17321648 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS8 | 17321482 | 17321648 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon9 | 17321714 | 17322242 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS9 | 17321714 | 17322242 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon10 | 17322307 | 17322497 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS10 | 17322307 | 17322497 |
| chr_1 | g11582 | g11582.t1 | exon | g11582.t1.exon11 | 17322567 | 17322697 |
| chr_1 | g11582 | g11582.t1 | cds | g11582.t1.CDS11 | 17322567 | 17322697 |
| chr_1 | g11582 | g11582.t1 | TSS | g11582.t1 | 17323103 | 17323103 |
| chr_1 | g11582 | g11582.t1 | TTS | g11582.t1 | NA | NA |
Sequences
>g11582.t1 Gene=g11582 Length=4200
ATGTCCGAAATAAATAATGAACTAGTTTATGGAAACTATTCGCTTCTTGACAATCATCAA
GAGTCACCTCTCTATACTGCGAAATATGACTATTCAGCACAAGGTGAAGATGAATTGGAT
TTAAAAGTCGGTCAAATTGTATGGGTTTTATCAAAAGATGAATCAATATCAGGAGATTAT
GGTTGGTGGACTGGAAAAATTGGTGATCGAGTTGGAATATTTCCTGCAAATTATGTTACA
AATGACGATTTAATGCTAAAAGATGCACATCCTAGTGAAATCGATTACGATGAATTGGAT
GTAAAAGAAGTTATTGGAGCTGGGGGTTTTGGTGAAGTAAAGAGAGCTTTTTTTGCTGAT
GATTTAGTTGCTGTTAAAGAAGCTCGTCATAATCCGGAACTTGATTATAATGTAACACGA
CAAAATGTTTTACAAGAAGCAAAGCTTTTTTGGACTCTTAAACATCCAAATATTGTAACA
CTTCGTGGAGTTTGTCTGAAACCTCCAAAATTTTGTCTTGTCATGGAATATGCAAGAGGT
GGATCTTTAAATAGAATACTGTCGTCTAGTAGAAGAATTCCACCTGATGTTCTTATTGAT
TGGGCTATACAAATCTGTCGAGGAATGACTTATCTTCATAATGGCGCACCTATATCTGTA
ATTCATCGCGATTTAAAAAGTTCAAATGTACTAATAAGTGAATCAATTGATGACGGTGAT
TTACGAGGAAAAACATTAAAAATAACCGATTTTGGTTTAGCTAGAGAAGCATATAACACA
ACCAGAATGTCAGCAGCCGGAACTTATGCTTGGATGCCTCCTGAAGTTATTAAAGCTGGC
ACATATTCTAAAGCATCTGATGTTTGGAGTTATGGTGTGCTTTTATGGGAGCTTTTAACG
GGAGAGATTCCCTATAAAGGATTCGATTCACTTTCCGTAGCATATGGTGTAGCTATCAAT
ACTTTGTCGCTTCCAATTCCAAAAACATGTCCTCAGGCATGGGGAAATTTGATGAAATCA
TGCTGGGAAATAGATTCACACAAAAGGCCACAATTCAAATCAATTTTAAGGGATTTAGAA
GTTATTGCTGAATCTGGATTCAAACAGACTCCACATGAGTCTTTTCACAATATGCAAGAC
TGTTGGAAAAAAGAAATTGCAGAAGTTCTTCATGAGTTACGCTTAAAAGAAAAGGAACTG
CGTTGCAAAGAAGAAGAACTTACACGTGTACAGCAGCAGCAAAAAAGAGAGCAAGAAAAC
CTTATGAAATTAGCACAAGAATTGAAAAATAGAGAACTTGATTTGTTAGGACGAGAGTTA
AAAATTATAATGAGTAATGCACCAACACCCCATAAGAGACGCAACAAAATAGGAACTTCC
AAATTAAAACTTCTCAAAAAGGCTCCATGTCAAATATCTTTTCCATTGGATTTTAAACAT
AAAATAACAGTAATGCATACTGGAACAGCAGACGAAGTGAATTTACAAAAAGATACACCA
CCCGCATCGCCTGCTCCTACACGCTTAAGAGCTATTGCACTTCCATCTGATGATGAAAGA
GATACATCATCGTCAACGACAACCAAAGGAAAAACTTGGGGTCCTTCATCTATGTCGTCA
CAACGAGAACGTGGCTTCTTACCAGCCGGGAATTTATTTCGACCTGAACGCTTACACAAT
TTAGTTAAATCTGCACCAAATCTTGATAACAAATCGCGTTCATCGACATCTACATCGGAT
AATAATATTGTTTTAGGTAACAACTCTGATTTTTGTGATAGTATGACTGTTAAAAATAGT
ACAGCATCTATCAATAGCCATCACTATACTAACACAAATTATCATTCAATATACTATGAA
CGAGATCTCATGAAGATTGATAATGAAAGAAGACAAATTAGTACAACTTCGACATTAAGT
TTGCACAATCATTCAAATGAGAGCATCGACGATGATTCCGATGACTCTAGTCATGCTCCG
TCTGTTGGTTGTTTTTCTTTTGTTGGCACGAGTTCATCAAATGATGGGAAAAAATCAAAG
AATCGATATAAAAAATTTTCTAAACAACATTCTTTAGATCTTGAAAATCGTCAATTATTA
CCAACAACTCCATTAACAATGACAACGCGAAATGCAAATTCTAGAAAAAACAGTACTGAT
CCAAAGAAAAAAATTCAATTTGATGAATTATCGACGGCAAAGACTCGAGTGGATGTAGAT
TTAATGTTCTATAAACGTTTTGAGCAAAGTCTTGACGCAGTTGGTTCACATGAGTTAACT
GAACAAGATACTATTTATATACGAGCCAAACCAAAAAATAAACTTGCTATGAGGCTACAA
AAAAGTCTCGATGCAATCGATTCATATGATATCGATGAAGTTAATACTTGTGAAGAACGA
CCAGAAAAGGTTTATTCAAAATCAATTGATGATCTTTCAACTGGTGGTGACTATCAATGG
CATCGAGGTGGATCACAATTTACATTTGAGTGCTTTCTAAAAAATGGTTCTGCGCGAAAT
GGCTTTGAAAAAGGAAGAAATAATGATAACGAGAATTCCGATGAATGGACAAGAGATGAT
TTCGGATCAAGCAGCCTTCAGTTGTGTGGTTTTCAACCATTGGAACGTGATAAAAAGAAA
TTAGGAATTGTTGAAATGGTTCTTTACAATATGGCGTCATTTTTGGCAAGTTTTGCGACA
GGATTTGATATTCGAATATCAAATTTACAGCATTCACAACCTATAAACCATCCACTGTTG
CAAAATAAAATAATTTCTAATGAGTATGAAATGAATGCACATAATAGTCCCCTCTATAAA
GGCATTTATCCACATGAAAGAGATATTCTGAATGTTGGAAATCCTCATTTAAATAAATTG
TATGGTCTCGAAACTTACCCTTACCATGGTCAAACTAAACAGAAGAACAGAGCATCACTT
AATCAATTGGCTGGATTTCAAAACAATAGAGCTGCAAATAATTTTATGCAGTCAACCACA
TTAACGACAACGAGTGGTTTAGGCTCCAATTTCACTTCTTATACAACTGATCCGATTGAT
GATACGTCTTCAATGAGTAGCTTGATTAGCGAAAATAAGCTTCATCGATTGAACATGAAT
GCAAATGTTGGAGCATCATCTTCGTTTTTGGAAAGTGATTTAAATACTGATGAATATATT
TTAATTCCTGATGGTGAAAATCCACAATTTTTGTCTCCACAAAAAATTTGCTATGGATCT
GATTTTTATGTTTCTAATTCAAAATCATTACAGCAACAGCAACAATTACATTCCAATCCT
TTTGATAACACTCCATTAATGTTGATAAATTCTGGTCCACAAAGTTTCATTGAATTGAGT
AATCAGTATGAAAGTGATATGTTTAGACAAGTTAATTATATGGAGCAAAATATCCCTCAA
CCAACACCACCACAACTTCCACCAAAAACACCAAATCGAACTCCAGTCATGGGAACAAAA
ACGATTCATCGTAGAACGCTTTCAAACACTTCTTCACAGTCACAATTCACAAATAGTAAT
AATAATAGTCGAAATATATATACCAATTCAAGAATCGAAGAGATAGATTATCGTTTTCAT
AATTTTAATATTAATAATGCCATTAATCGTGAACCACTTCAATTTCATTCAGTGCCATAT
AGCTGCAATTTCTCAGATCAGCAACAAATACCAAATCGAATGCGTTTATATGAGAATGTT
AGCCATTTTCAACAAAATCTTCAGTCTATGTCATTACCACCATCACATTGTCAAACACCT
GTAAGAAGATTCGAAACATCAAATTCTCAAGAGCATTATAAGCCAATAATATCATCATCT
AATTCAAATACAGAAAAACGAAAAATGTTTTTTGCAACTGAACCGATGAACGATGAAAGT
TCTAAGACATCAAATGGAAACTGTGATCAAATTTTTATTACTGATGCAAATATAAGTATT
GTCAATACTTCAAAAGTTTCAAGTAGTACTGGCTGTACGCCAACACATTCCACTCCACAA
GATAGTTTTAGTGATGATAGTTCTTACTTGAGCGCATTATCGCGAGTTCGTTTCAGTCCG
GATAATTTTTTAAATGAAACAGTAAATAGCTTTAGTTCAACAAGTCGTATGGCAGTAGCA
AACATGCAACGTGCAATGGTGAGGAGAACAATTGAATTAGAAGAGAGTGACAAATCATAA
>g11582.t1 Gene=g11582 Length=1399
MSEINNELVYGNYSLLDNHQESPLYTAKYDYSAQGEDELDLKVGQIVWVLSKDESISGDY
GWWTGKIGDRVGIFPANYVTNDDLMLKDAHPSEIDYDELDVKEVIGAGGFGEVKRAFFAD
DLVAVKEARHNPELDYNVTRQNVLQEAKLFWTLKHPNIVTLRGVCLKPPKFCLVMEYARG
GSLNRILSSSRRIPPDVLIDWAIQICRGMTYLHNGAPISVIHRDLKSSNVLISESIDDGD
LRGKTLKITDFGLAREAYNTTRMSAAGTYAWMPPEVIKAGTYSKASDVWSYGVLLWELLT
GEIPYKGFDSLSVAYGVAINTLSLPIPKTCPQAWGNLMKSCWEIDSHKRPQFKSILRDLE
VIAESGFKQTPHESFHNMQDCWKKEIAEVLHELRLKEKELRCKEEELTRVQQQQKREQEN
LMKLAQELKNRELDLLGRELKIIMSNAPTPHKRRNKIGTSKLKLLKKAPCQISFPLDFKH
KITVMHTGTADEVNLQKDTPPASPAPTRLRAIALPSDDERDTSSSTTTKGKTWGPSSMSS
QRERGFLPAGNLFRPERLHNLVKSAPNLDNKSRSSTSTSDNNIVLGNNSDFCDSMTVKNS
TASINSHHYTNTNYHSIYYERDLMKIDNERRQISTTSTLSLHNHSNESIDDDSDDSSHAP
SVGCFSFVGTSSSNDGKKSKNRYKKFSKQHSLDLENRQLLPTTPLTMTTRNANSRKNSTD
PKKKIQFDELSTAKTRVDVDLMFYKRFEQSLDAVGSHELTEQDTIYIRAKPKNKLAMRLQ
KSLDAIDSYDIDEVNTCEERPEKVYSKSIDDLSTGGDYQWHRGGSQFTFECFLKNGSARN
GFEKGRNNDNENSDEWTRDDFGSSSLQLCGFQPLERDKKKLGIVEMVLYNMASFLASFAT
GFDIRISNLQHSQPINHPLLQNKIISNEYEMNAHNSPLYKGIYPHERDILNVGNPHLNKL
YGLETYPYHGQTKQKNRASLNQLAGFQNNRAANNFMQSTTLTTTSGLGSNFTSYTTDPID
DTSSMSSLISENKLHRLNMNANVGASSSFLESDLNTDEYILIPDGENPQFLSPQKICYGS
DFYVSNSKSLQQQQQLHSNPFDNTPLMLINSGPQSFIELSNQYESDMFRQVNYMEQNIPQ
PTPPQLPPKTPNRTPVMGTKTIHRRTLSNTSSQSQFTNSNNNSRNIYTNSRIEEIDYRFH
NFNINNAINREPLQFHSVPYSCNFSDQQQIPNRMRLYENVSHFQQNLQSMSLPPSHCQTP
VRRFETSNSQEHYKPIISSSNSNTEKRKMFFATEPMNDESSKTSNGNCDQIFITDANISI
VNTSKVSSSTGCTPTHSTPQDSFSDDSSYLSALSRVRFSPDNFLNETVNSFSSTSRMAVA
NMQRAMVRRTIELEESDKS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 19 | g11582.t1 | CDD | cd14061 | STKc_MLK | 104 | 362 | 1.58306E-164 |
| 18 | g11582.t1 | Coils | Coil | Coil | 386 | 434 | - |
| 16 | g11582.t1 | Gene3D | G3DSA:2.30.30.40 | SH3 Domains | 20 | 83 | 9.2E-20 |
| 15 | g11582.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 90 | 179 | 6.2E-26 |
| 17 | g11582.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 180 | 412 | 1.5E-67 |
| 27 | g11582.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 492 | 543 | - |
| 25 | g11582.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 526 | 543 | - |
| 26 | g11582.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 676 | 723 | - |
| 24 | g11582.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 693 | 715 | - |
| 3 | g11582.t1 | PANTHER | PTHR44329:SF39 | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10 | 22 | 539 | 6.9E-197 |
| 4 | g11582.t1 | PANTHER | PTHR44329 | SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED | 22 | 539 | 6.9E-197 |
| 9 | g11582.t1 | PRINTS | PR00452 | SH3 domain signature | 23 | 33 | 4.9E-6 |
| 11 | g11582.t1 | PRINTS | PR00452 | SH3 domain signature | 37 | 52 | 4.9E-6 |
| 12 | g11582.t1 | PRINTS | PR00452 | SH3 domain signature | 59 | 68 | 4.9E-6 |
| 10 | g11582.t1 | PRINTS | PR00452 | SH3 domain signature | 70 | 82 | 4.9E-6 |
| 8 | g11582.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 175 | 188 | 1.6E-12 |
| 7 | g11582.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 214 | 232 | 1.6E-12 |
| 6 | g11582.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 286 | 308 | 1.6E-12 |
| 5 | g11582.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 330 | 352 | 1.6E-12 |
| 1 | g11582.t1 | Pfam | PF00018 | SH3 domain | 27 | 76 | 1.2E-11 |
| 2 | g11582.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 100 | 359 | 5.9E-64 |
| 23 | g11582.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 105 | 126 | - |
| 22 | g11582.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 220 | 232 | - |
| 28 | g11582.t1 | ProSiteProfiles | PS50002 | Src homology 3 (SH3) domain profile. | 20 | 84 | 24.882 |
| 29 | g11582.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 99 | 375 | 43.637 |
| 20 | g11582.t1 | SMART | SM00326 | SH3_2 | 23 | 83 | 1.1E-18 |
| 21 | g11582.t1 | SMART | SM00220 | serkin_6 | 99 | 362 | 1.7E-65 |
| 14 | g11582.t1 | SUPERFAMILY | SSF50044 | SH3-domain | 22 | 84 | 2.23E-19 |
| 13 | g11582.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 84 | 359 | 1.5E-75 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004709 | MAP kinase kinase kinase activity | MF |
| GO:0005524 | ATP binding | MF |
| GO:0005515 | protein binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K04417 (mitogen-activated protein kinase kinase kinase 9)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
