General information for g11586.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Apoptosis-inducing factor 3.
Parent gene
- The parent gene g11586 is located on chr_1: 17359964..17361576 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11586 | g11586.t1 | isoform | g11586.t1 | 17356174 | 17359964 |
| chr_1 | g11586 | g11586.t1 | exon | g11586.t1.exon1 | 17356174 | 17356357 |
| chr_1 | g11586 | g11586.t1 | cds | g11586.t1.CDS1 | 17356174 | 17356357 |
| chr_1 | g11586 | g11586.t1 | exon | g11586.t1.exon2 | 17356614 | 17358239 |
| chr_1 | g11586 | g11586.t1 | cds | g11586.t1.CDS2 | 17356614 | 17358239 |
| chr_1 | g11586 | g11586.t1 | exon | g11586.t1.exon3 | 17358301 | 17359964 |
| chr_1 | g11586 | g11586.t1 | cds | g11586.t1.CDS3 | 17358301 | 17359964 |
| chr_1 | g11586 | g11586.t1 | TSS | g11586.t1 | NA | NA |
| chr_1 | g11586 | g11586.t1 | TTS | g11586.t1 | NA | NA |
Sequences
>g11586.t1 Gene=g11586 Length=3474
ATGGGAGCTGTGTGCTGTAAAACGTGCAGAACTATAAAATCAGTCAATAATGAAATTAGC
AATCATCAAACACATATTACTGTTCCAATAGTTAAAATTGCATCACCTTCTTTAAATTCA
ACTCCCATAAATAATATAGCAGCAGCATCTCATGTTTCAACACTTCAAAATGCAGTTGAG
CAAAGTAATCAGCCATTAACTTTCATGAATGAAAGCGTCAATAAAGATGAAAAAGAAAAC
TTTCTCGAAAAAGTTGTTTGTCATCAATCCGACTTAGATGAAAACGAAATGAATGAAATT
GATTTTGGCAATAATCAAAAGATATTGCTAATAAAACAAAATGGGAAATTTTATGCAACT
GGCTCAGAATGTGCACACAATGGAGCACCATTAGTTATGGGTTCATTGGGAGATAAAAGA
ATAAGATGTCCATGGCATGGTGCATGCTTCAATATTGAAACTGGTGATATTGAAGACTTC
CCTGGATTGGACAGTATCCCATGTTACAAAGTAAATGTTGATGAAAGCGGTCAAGTTAAA
ATTCGAGCTCGAAAAACACATCTTGAACAACAAAAGGTCATTAAACCTATGACAAAATAT
GACTCCAAAAACAGTCGAAAGTTTGTCATCATTGGAGGTGGTGTAAGTGGCGCAACTTGT
GCGGAAGTTTTACGCCAAAATGGCTTCACGGGGAAAATAATAATAATTTGTAAGGAAGCT
TATTTACCTTATGACCGTACAGAAATAAGCCGGAACCTTGATAGTAAAATAGAGAATATA
CAGCTGAGATCACAAAGCTTTTATGATGAAAATAACATCGAAATAATTTTGTCGTCAGAA
GTTTTATCTCTAGATTCATCTTCAAAACATTTAAAACTTTCAAATGAAAAAGAACTAAAT
TATGATAAAGTTTATATTGCTACTGGAACAAGAGCAAGAAAACCGAAAATTTCTGGTATT
CATCTTAAAAATATATTTACTCTGCGAACATTATTTGATGCTTCGGAAATTGAATCTAAG
CTTAATAACAAGAGTCATTTAATCATTCTTGGCTCAAGTTTTCTTGCATTAGAATTGGCT
TCTTATTGTCATAATAGAGTAGCGAAGACAACAATCATAAGTAATGCATCTTTACCATTA
GTGGAAACATTTGGTGAACAAGTTGGAAACAAAATGCTTGAATTACTTAAATCAAAAAAT
ATTAAAGTTTTTTTGGAATGCGAAATCAAAGCATTTGTGGGTATTAATCAAGAAAATCAT
TTGAGTGCTATAAAATTATCAAATGGCGAGTTTTTGAAAGCTGATCTATGTATTATTGCA
GTCGGGTCTAAATTCAACACAAAGTTCTTAGCTAACAGTGGTATTTTGGTAAACAAAAAT
GGCTCAATCGATACAAATGTTTATATGCAAACTAACAACATAGATGTTTATGCCGGTGGT
GATATTGCCAACTCTCCTATTTATTACAACAATAACGAGCGTGAAATCATTTGTCATTAT
TCGGTAGCACAAAACCATGGAAGAGTAGCTGCACTTAACATGTTGGGAATTAGTACGAAA
GTCAAAACCCTTCCTTATTTCTATACATTGCTTTTTGATAATTGTATCACTTACGTTGGC
TATAGAAAACCATCTAGAGTTTTCATACAAAATAGTACTGATGATTTTAAATTTTCTGCT
TTTTATTTTGACAATGATGATAATGTTGTAGGCATAATTTCATTTCAACCAAATAAATTA
ACCTCGGATTATGCTGAAAAGTTGCAACAAGGATCTAAAATCACTCGAAAGGACTTAAAT
CAATTGTTCGGTATCGTTGTTGAATCAACAGAACCCTTGATAAAGGAAAAGACATTAAGT
GAAGATTTTATTGAGGAGAGCATTTGTGACATAAATGACATAGCTGAAAATGAAATGAAA
GAATTTGTCATTGATAATGATAAGAAAATATTGTTAGTAAAGCAAGAAGGTCGTATTCAT
GCTATTGGTTCCGAATGTTCACATTATGGAGCACCATTAGTTATGGGTTCATTGGGAGAA
GGAAGAATAAGATGTCCATGGCATGGTGCATGCTTCAATATTGAAACTGGTGATATTGAA
GACTTCCCTGGATTGGACAGTATCCCATGTTATCAAGTAATAATCGAAGAGCGTGATGTA
CGCGTAAAAGCAAAAAAATCTATTATTAGAGGCAAGCAAAAAATAATCAAACCAATGGCA
CATTATGATACAAAAAGTGGACTAATTTTTGTGATCATTGGAGGTGGTGCAAGTGGAGCA
ACTTGTGCAGAGATGCTTCGTCAGAATGGTTTCATGGGTCGTATAATTATGATTTGTAAA
GAGTCCTATCTTCCCTACGACCGAATTAAAGTGAGTAAATTTCTTGACAGTAAGATAGAA
GACATACAACTTCGTTCCCAAGCGTTTTATGATGAGCACCACATAGAGTTGATGCTAAAT
ATAGAGGCAACAGATGTTGATGCGAAACTGAAGGAAATTACTCTCAGCTGCGGAAATAAA
TTAAAATATGATAAGCTGTTTGTAGCCAGTGGCTGTCGAGCAAAATATTTAAAAATTCCG
GGAAGTCATTTGCATAATATCTTCACTTTAAGAACACTTGATGATGCAAAACAGATTCAC
TCGAAACTGGATACCGGAAGTCATGTTGTGATTGTTGGTTCAAGTTTCATCGCATTAGAG
ACAGCTACTTATTGTGTGAGTCGTGTTGCCAAAGTGACCATTATTGGACGTAGTTCGAAA
CCGCTGATAGAAACGTTTGGTGAAATAATTGGTGGAAGGATTATGGAATATTTCAAATCA
AAAAAAGTCGAATTCATTATGGAAGCAGAATTGAAAAACTTCTTAGGAAATCATAAAGAA
CTTGAACGTATAGAATTAATAGACGGTAGAACGATTTGGGCTGATGTTTGTATTGTTGCA
ATCGGATCTCGTCCAAATACTGAGTTTTTAGCCAGGAGTGGATTAAAAATTAATTATGAT
GGTTCAATTGACACAAATGAATTCTTAGAGACAAACGTTCGCGATATATATATTGGAGGA
GATATCGCTAATAGTCCAATATTTACTTACTACAATAAGCGTGCATGTATACAGCATTAT
GCTTTGGCACAATATCACGGAAAAATAGCTGCACTTAATATGATTGGCACACGAACGGAA
CTAAGATCAGTGCCTTATTTTTTTACTCTTCTATTTGACTATTGCTTCACTTTCACAGGT
TATGGTCGTGATATTTCTGAAATATTTGTCGACGGAGATTTAGATGAATTTAAATTTGCT
GCATTTTATTTCGATGAAGAACAAAATGTTGTTGGTATGTCATCATGTCAACCAGATAAA
GGAATATCAGATTTTGCTGAAAAATTAGCACAAGGATTTTGTTATCATCGTGATGATATT
GAATGGGCAATTGAATTAGAGGAAGAAGGTATTCAAGATGGAATTCAAATTTGA
>g11586.t1 Gene=g11586 Length=1157
MGAVCCKTCRTIKSVNNEISNHQTHITVPIVKIASPSLNSTPINNIAAASHVSTLQNAVE
QSNQPLTFMNESVNKDEKENFLEKVVCHQSDLDENEMNEIDFGNNQKILLIKQNGKFYAT
GSECAHNGAPLVMGSLGDKRIRCPWHGACFNIETGDIEDFPGLDSIPCYKVNVDESGQVK
IRARKTHLEQQKVIKPMTKYDSKNSRKFVIIGGGVSGATCAEVLRQNGFTGKIIIICKEA
YLPYDRTEISRNLDSKIENIQLRSQSFYDENNIEIILSSEVLSLDSSSKHLKLSNEKELN
YDKVYIATGTRARKPKISGIHLKNIFTLRTLFDASEIESKLNNKSHLIILGSSFLALELA
SYCHNRVAKTTIISNASLPLVETFGEQVGNKMLELLKSKNIKVFLECEIKAFVGINQENH
LSAIKLSNGEFLKADLCIIAVGSKFNTKFLANSGILVNKNGSIDTNVYMQTNNIDVYAGG
DIANSPIYYNNNEREIICHYSVAQNHGRVAALNMLGISTKVKTLPYFYTLLFDNCITYVG
YRKPSRVFIQNSTDDFKFSAFYFDNDDNVVGIISFQPNKLTSDYAEKLQQGSKITRKDLN
QLFGIVVESTEPLIKEKTLSEDFIEESICDINDIAENEMKEFVIDNDKKILLVKQEGRIH
AIGSECSHYGAPLVMGSLGEGRIRCPWHGACFNIETGDIEDFPGLDSIPCYQVIIEERDV
RVKAKKSIIRGKQKIIKPMAHYDTKSGLIFVIIGGGASGATCAEMLRQNGFMGRIIMICK
ESYLPYDRIKVSKFLDSKIEDIQLRSQAFYDEHHIELMLNIEATDVDAKLKEITLSCGNK
LKYDKLFVASGCRAKYLKIPGSHLHNIFTLRTLDDAKQIHSKLDTGSHVVIVGSSFIALE
TATYCVSRVAKVTIIGRSSKPLIETFGEIIGGRIMEYFKSKKVEFIMEAELKNFLGNHKE
LERIELIDGRTIWADVCIVAIGSRPNTEFLARSGLKINYDGSIDTNEFLETNVRDIYIGG
DIANSPIFTYYNKRACIQHYALAQYHGKIAALNMIGTRTELRSVPYFFTLLFDYCFTFTG
YGRDISEIFVDGDLDEFKFAAFYFDEEQNVVGMSSCQPDKGISDFAEKLAQGFCYHRDDI
EWAIELEEEGIQDGIQI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 33 | g11586.t1 | CDD | cd03478 | Rieske_AIFL_N | 85 | 179 | 0.000 |
| 32 | g11586.t1 | CDD | cd03478 | Rieske_AIFL_N | 629 | 722 | 0.000 |
| 28 | g11586.t1 | Gene3D | G3DSA:2.102.10.10 | - | 83 | 193 | 0.000 |
| 27 | g11586.t1 | Gene3D | G3DSA:3.50.50.60 | - | 209 | 515 | 0.000 |
| 26 | g11586.t1 | Gene3D | G3DSA:3.50.50.60 | - | 314 | 441 | 0.000 |
| 29 | g11586.t1 | Gene3D | G3DSA:2.102.10.10 | - | 624 | 734 | 0.000 |
| 25 | g11586.t1 | Gene3D | G3DSA:3.50.50.60 | - | 751 | 1054 | 0.000 |
| 24 | g11586.t1 | Gene3D | G3DSA:3.50.50.60 | - | 856 | 981 | 0.000 |
| 6 | g11586.t1 | PANTHER | PTHR43557 | APOPTOSIS-INDUCING FACTOR 1 | 84 | 599 | 0.000 |
| 8 | g11586.t1 | PANTHER | PTHR43557:SF7 | APOPTOSIS-INDUCING FACTOR MITOCHONDRIA-ASSOCIATED 4 | 84 | 599 | 0.000 |
| 5 | g11586.t1 | PANTHER | PTHR43557 | APOPTOSIS-INDUCING FACTOR 1 | 626 | 1132 | 0.000 |
| 7 | g11586.t1 | PANTHER | PTHR43557:SF7 | APOPTOSIS-INDUCING FACTOR MITOCHONDRIA-ASSOCIATED 4 | 626 | 1132 | 0.000 |
| 17 | g11586.t1 | PRINTS | PR00411 | Pyridine nucleotide disulphide reductase class-I signature | 749 | 771 | 0.000 |
| 11 | g11586.t1 | PRINTS | PR00368 | FAD-dependent pyridine nucleotide reductase signature | 750 | 769 | 0.000 |
| 9 | g11586.t1 | PRINTS | PR00368 | FAD-dependent pyridine nucleotide reductase signature | 843 | 861 | 0.000 |
| 12 | g11586.t1 | PRINTS | PR00368 | FAD-dependent pyridine nucleotide reductase signature | 888 | 906 | 0.000 |
| 16 | g11586.t1 | PRINTS | PR00411 | Pyridine nucleotide disulphide reductase class-I signature | 888 | 913 | 0.000 |
| 13 | g11586.t1 | PRINTS | PR00368 | FAD-dependent pyridine nucleotide reductase signature | 974 | 990 | 0.000 |
| 15 | g11586.t1 | PRINTS | PR00411 | Pyridine nucleotide disulphide reductase class-I signature | 975 | 989 | 0.000 |
| 10 | g11586.t1 | PRINTS | PR00368 | FAD-dependent pyridine nucleotide reductase signature | 1001 | 1023 | 0.000 |
| 14 | g11586.t1 | PRINTS | PR00411 | Pyridine nucleotide disulphide reductase class-I signature | 1016 | 1023 | 0.000 |
| 1 | g11586.t1 | Pfam | PF00355 | Rieske [2Fe-2S] domain | 85 | 169 | 0.000 |
| 3 | g11586.t1 | Pfam | PF07992 | Pyridine nucleotide-disulphide oxidoreductase | 207 | 507 | 0.000 |
| 2 | g11586.t1 | Pfam | PF00355 | Rieske [2Fe-2S] domain | 628 | 711 | 0.000 |
| 4 | g11586.t1 | Pfam | PF07992 | Pyridine nucleotide-disulphide oxidoreductase | 751 | 1034 | 0.000 |
| 30 | g11586.t1 | ProSiteProfiles | PS51296 | Rieske [2Fe-2S] iron-sulfur domain profile. | 84 | 180 | 22.456 |
| 31 | g11586.t1 | ProSiteProfiles | PS51296 | Rieske [2Fe-2S] iron-sulfur domain profile. | 626 | 722 | 23.008 |
| 18 | g11586.t1 | SUPERFAMILY | SSF50022 | ISP domain | 84 | 181 | 0.000 |
| 23 | g11586.t1 | SUPERFAMILY | SSF51905 | FAD/NAD(P)-binding domain | 207 | 486 | 0.000 |
| 21 | g11586.t1 | SUPERFAMILY | SSF55424 | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 521 | 599 | 0.000 |
| 19 | g11586.t1 | SUPERFAMILY | SSF50022 | ISP domain | 628 | 722 | 0.000 |
| 22 | g11586.t1 | SUPERFAMILY | SSF51905 | FAD/NAD(P)-binding domain | 751 | 1080 | 0.000 |
| 20 | g11586.t1 | SUPERFAMILY | SSF55424 | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 1059 | 1140 | 0.000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0051537 | 2 iron, 2 sulfur cluster binding | MF |
| GO:0050660 | flavin adenine dinucleotide binding | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K22747 (apoptosis-inducing factor 3)
Pathway
This gene does not belong to any pathways.
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed