General information for g11594.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as histone-arginine N-methyltransferase.
Parent gene
- The parent gene g11594 is located on chr_1: 17391241..17394921 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11594 | g11594.t1 | TSS | g11594.t1 | 17390503 | 17390503 |
| chr_1 | g11594 | g11594.t1 | isoform | g11594.t1 | 17390576 | 17394921 |
| chr_1 | g11594 | g11594.t1 | exon | g11594.t1.exon1 | 17390576 | 17390653 |
| chr_1 | g11594 | g11594.t1 | cds | g11594.t1.CDS1 | 17390576 | 17390653 |
| chr_1 | g11594 | g11594.t1 | exon | g11594.t1.exon2 | 17390712 | 17390817 |
| chr_1 | g11594 | g11594.t1 | cds | g11594.t1.CDS2 | 17390712 | 17390817 |
| chr_1 | g11594 | g11594.t1 | exon | g11594.t1.exon3 | 17390876 | 17392273 |
| chr_1 | g11594 | g11594.t1 | cds | g11594.t1.CDS3 | 17390876 | 17392273 |
| chr_1 | g11594 | g11594.t1 | exon | g11594.t1.exon4 | 17392348 | 17394683 |
| chr_1 | g11594 | g11594.t1 | cds | g11594.t1.CDS4 | 17392348 | 17394683 |
| chr_1 | g11594 | g11594.t1 | exon | g11594.t1.exon5 | 17394736 | 17394921 |
| chr_1 | g11594 | g11594.t1 | cds | g11594.t1.CDS5 | 17394736 | 17394921 |
| chr_1 | g11594 | g11594.t1 | TTS | g11594.t1 | 17394977 | 17394977 |
Sequences
>g11594.t1 Gene=g11594 Length=4104
ATGGAGAGGAAAACAAGATCAGGAAAAATTGTTTCATCATCACCATCAGTTGAACCAAAA
GTTGCTGCTCCTGGAAAACGAGGACGAAAAAAGAAGAACGAAGTGACAGAAAATGCAGCC
GAACAAACAATTCAACAAGACCAAACAACACAACATCCCACAAGACGTAGTATGAGAGGA
AAAAATGTTAGTCATTCTGACATCTCTCTAAATGAATCAACTGCATCAACTCAAATACAA
GAAGAAGAAAACAGTAACATTAGTGCAATATCGATCACTATTAATGATGATGACAATAAG
AGTATAAATGAAGAAAAATCCTCTCTAGAAAATGTAACATCTGAAATAATGATGAAAACC
CTGGAAATAAAATTAGTTGATTGCTGTTTGCAAGAGAAAGAGAGTGTTCATGAAATAGCT
ATGGATATTGATAATCAACTAAAAAATAAAGAGACTGTAAAAGAAGAAGAGGTGAAGGAG
GAAAAAATTATAGTATTAAATGAAACAATTATCGATGAGCAAATTAATGAAATTATTACA
ATAAATGAGAATATCAAACAAGAATCTGTAGTAAAACATGATGAGGACAAACCAATTAAT
GAACTCATAGATATAGCAAAATTAGAAAAAATTGATATTGCAAAAGAGACACTTACATCT
GATAAAAATGAAGCTACAGTATCAGAAGAAACTTTAGTATGCTCTAAAATAAAGGAAGAA
AATGCAATAGTGGAAATAAAACAAGACATACAAGAATCTTATGAAGAAGTATCTTTTTTA
AGACGATCACGTAGACTCAAAAGTATTTATTCTGAAATACCTCCTCAAATACAAGAAACA
TCAGTTTCTAATATAAAAGATCAAGTTAATATGTCACCTGATGCAGCAATAAAAATTAAA
AACATCACTAAAAAATCTCATGAGATTGAAGATGAAAAACTTTCAAATGATGATATTAAA
TTGATAGATCCAAAATCAGAACATGCTGAAATTAAAAATGAAAACCTAAATGAGAAACAA
ATACCATATGAAAAATCTCTAACATTAGAGGACTTACAATGTGACCCACGTCTTAGTCAA
TTTGTAACAATTAAAGACAACATTTATATTAAGTCTTCAGATAAAGTTATATGCAAAGTG
AATAAGACAATGAAATGTGATTGTACAATAACTGAAGAGGACTTGAAAAATGGTGAAATG
GGTTGCAGATACAATTGTATCAATCGACTTCTGTTTATTGAATGTAGCTCAAAATGCAGA
TGTGGAGAATTTTGTGACAATCAACAATTTCAACGATACAATTATGCTCCAGTTTCCGTT
TTTCGGACTGAAAAGAAGGGTTATGGTATTCGGGCTGAAGATGATATTCCAGCAGAAACA
TTTATTATAGAATATGTTGGTGAAGTTCTTAATAATAAGCAGTTTGAGAAGAGAGCAAAA
AAATATTCGAAAGATAAAAATCGACATTATTATTTCATGGCTTTACGTAGTAATGCTGTT
ATCGATGCTACTTCCAAAGGAAATATTTCAAGGTTCATAAATCATTCATGTGATCCTAAT
GCAATGACACAAAAGTGGACTGTAAATGGTGAACTAAGAGTAGGATTTTTCAGTATTCGT
GATATAAATAGAGGTGAAGAAATAACATTTGATTATCAATTTCAACGTTATGGAAAGGAA
GCACAAAAATGCTTTTGTGAATCAGAAAAATGTCGTGGATGGATTGGAGAAAATCCAATG
AGTGATGAAGAAGTAGAAGTTGATGACGCAAAACCTAAGAAAAGTCGTGGAAAGAAAACT
GCACCACGAAAAACAAAAGTTTTTATGGAAATCACAGAAGCAGATGATGACGACGATGAA
GAGAATGATAAAATTGAAAATGATATTGATGAAAATATATCTCCAGAAAAATCTGAAATG
AAAAAAGAACCAGCATCTGAAAAAATAATAAGAAAGACCAAGAAACGTCAAGATATAGAA
GATCTTGAAATTGAAGAAGAAATTAATGATTTAACAAAAACAGGATTGAAAAATAGAGCA
CATACTATCCGACTATCACGTTTAGTAGTAAGAGCAAAAAGCACAGACACACGAAGTCGA
ATTTTGAAAATTTTAATATCAGGTGATATGCCTTGTCGTCGCTTATTTTTGGATTATAAT
GGTCTAAGATTGTTACACAATTGGATGTGTGATATAAGTGTCAAAAGTTCTATACCAGAT
CTTTATTTATGTATGGAAGTTATGAATGCACTTAATATCTTGCCTATAACAAATAAAACT
GTCCTGCGTGAATCTAAAGTCCTAGAAAGAGTTGAAAAATGGAAAAATTTGGATCTTGAA
AAGAAGAAATTAACAAAGGAAGAAAAGAAGCAGGCAAAAGCGGAGAAGAAAAAAAATAAA
GCAGCAAATAAGTTACAACTTGATGAATCAAACAAATCAATGGATGAAGCAACATTATTA
GTTCGAACTTTTGATGTTTTGGAAGAGTTACCGATGATGAAACTAATAGTCAAAGAAACA
GCATCAGAATTACTTGAAAAATGGGAAGTACTCAAAGAAGATTTTAAAATTCCTAAAAAA
CAAAAACAAGAAATTATGATAGAACATGAACGAGAAGCGGGCATGGAAGAATGGCAGGCA
AATAATACCACAGATTCAGCTAATAATGAACGTTATAAAAATAGATTCGGAGAAGATTCT
TTTACTAGTAGTAATAATCGTAATATTTCATCTTCGTATAAGAAAACTTTTGATCCAATG
GAACGACAAAAGAGACGACAAATGTTTGCCATGAGAATGGCTCAAGAAGAAATGGAAAAA
AGAATGAATCTCCTTCATGAAAATAATTGTGCTCTCTTTGGTCTTTCACCTACACTCACG
CATCCATTAAATGTACCGTTTCGAGTGAATAGAGTCACGGGACAGTATTGTAACATTCTT
GGAGCAATTCTACCTATTCCTCCGAATCATCATAATTTCAAATATGAACCTCTTACACTC
TCCACAAATCCCGATGACTACAATCTTCCACCTATTGATCTCCCGGAACATTGGAAATAT
GCTATTGACAAATATGGAAGAATTTATTATTATCATGAAAAAATAAGACAGCCTCAATGG
GAAGCACCAATAAAAATTCTTCCCCTAAATGTAAATTCAGATAGTGATGATCCTAATGAA
ATCGACAGTGATGAATCTGAAACGGAAACAGAAGACTCAGAAGAGGAAGAATTGAGAGAA
CTTCTTGAAATGCTTAAAAAGAAAAAGCAACTAATGACATCTCAGTCTACAACAAACACG
ACTCAGATGGATACTGATGAGGACGACTTGGAAAAAAAAATTATGAATAATATGCTTTCA
AATCCTCCAGATCAGGCTATAAAACTATCACAATTACCTGTTAAAAAGTGTTTGAAAAAG
AAAAGTCGACGTGGATTGAGCACTATGAAGTTTATTCGTCCAAGAACTGAAGAGGATAAA
CTTTATGGTCGTACTGAAACAAGACGTTATAAAGAGCTCAAAGAGAAATTAAGACGTGAT
AAAAAAAGGCGTATGCTTTTGGGTGAGAGTTCTGGAAATATATCAGAAGATGATGATGAG
GAGGAAGATGGTGATGCAACATTAGATGAATCAAGTTTAGTAAAAATGGTCGATGAACTT
GATATTCTAACAAAATCAAAGCAGCTTGATAAAATACGTAAAATTAAAAAAGATGTTGCA
GAGTCACCTACATTAGATCATTCGAAATTAAAAAAGGGAAAAACCACACTTACATCATTA
GATCAAGCTCAAATAAAACGACAATTCAGAGATGAAATCAAAGAAGAAATAATGAAATTT
TTACAACCGTATCGTGAAGAGACCTGTGTTAATGGAAAAATTACTTCACAAGAAGATTTC
ATTAGTTTAGTCAATAAGCTTACATTTTCTGTTTTAACAAAAGAATCCAAGCATTGTGCA
CAGTCGAATAGCATTTTAAAAGCAACTGATTCTGTGAAAGGCAAAACTAAGGAATATATT
AAAAAATATATGGCTAAATTTGAAGGATCATATTTGAGGAAATCTGATGAGCAAGATTAT
GCAAATATTTTAAACAGAATGTAA
>g11594.t1 Gene=g11594 Length=1367
MERKTRSGKIVSSSPSVEPKVAAPGKRGRKKKNEVTENAAEQTIQQDQTTQHPTRRSMRG
KNVSHSDISLNESTASTQIQEEENSNISAISITINDDDNKSINEEKSSLENVTSEIMMKT
LEIKLVDCCLQEKESVHEIAMDIDNQLKNKETVKEEEVKEEKIIVLNETIIDEQINEIIT
INENIKQESVVKHDEDKPINELIDIAKLEKIDIAKETLTSDKNEATVSEETLVCSKIKEE
NAIVEIKQDIQESYEEVSFLRRSRRLKSIYSEIPPQIQETSVSNIKDQVNMSPDAAIKIK
NITKKSHEIEDEKLSNDDIKLIDPKSEHAEIKNENLNEKQIPYEKSLTLEDLQCDPRLSQ
FVTIKDNIYIKSSDKVICKVNKTMKCDCTITEEDLKNGEMGCRYNCINRLLFIECSSKCR
CGEFCDNQQFQRYNYAPVSVFRTEKKGYGIRAEDDIPAETFIIEYVGEVLNNKQFEKRAK
KYSKDKNRHYYFMALRSNAVIDATSKGNISRFINHSCDPNAMTQKWTVNGELRVGFFSIR
DINRGEEITFDYQFQRYGKEAQKCFCESEKCRGWIGENPMSDEEVEVDDAKPKKSRGKKT
APRKTKVFMEITEADDDDDEENDKIENDIDENISPEKSEMKKEPASEKIIRKTKKRQDIE
DLEIEEEINDLTKTGLKNRAHTIRLSRLVVRAKSTDTRSRILKILISGDMPCRRLFLDYN
GLRLLHNWMCDISVKSSIPDLYLCMEVMNALNILPITNKTVLRESKVLERVEKWKNLDLE
KKKLTKEEKKQAKAEKKKNKAANKLQLDESNKSMDEATLLVRTFDVLEELPMMKLIVKET
ASELLEKWEVLKEDFKIPKKQKQEIMIEHEREAGMEEWQANNTTDSANNERYKNRFGEDS
FTSSNNRNISSSYKKTFDPMERQKRRQMFAMRMAQEEMEKRMNLLHENNCALFGLSPTLT
HPLNVPFRVNRVTGQYCNILGAILPIPPNHHNFKYEPLTLSTNPDDYNLPPIDLPEHWKY
AIDKYGRIYYYHEKIRQPQWEAPIKILPLNVNSDSDDPNEIDSDESETETEDSEEEELRE
LLEMLKKKKQLMTSQSTTNTTQMDTDEDDLEKKIMNNMLSNPPDQAIKLSQLPVKKCLKK
KSRRGLSTMKFIRPRTEEDKLYGRTETRRYKELKEKLRRDKKRRMLLGESSGNISEDDDE
EEDGDATLDESSLVKMVDELDILTKSKQLDKIRKIKKDVAESPTLDHSKLKKGKTTLTSL
DQAQIKRQFRDEIKEEIMKFLQPYREETCVNGKITSQEDFISLVNKLTFSVLTKESKHCA
QSNSILKATDSVKGKTKEYIKKYMAKFEGSYLRKSDEQDYANILNRM
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g11594.t1 | CDD | cd19172 | SET_SETD2 | 435 | 576 | 3.71855E-92 |
| 15 | g11594.t1 | CDD | cd00201 | WW | 1015 | 1043 | 2.17289E-5 |
| 13 | g11594.t1 | Coils | Coil | Coil | 777 | 804 | - |
| 12 | g11594.t1 | Coils | Coil | Coil | 1071 | 1095 | - |
| 9 | g11594.t1 | Gene3D | G3DSA:2.170.270.10 | SET domain | 324 | 599 | 1.9E-85 |
| 10 | g11594.t1 | Gene3D | G3DSA:2.20.70.10 | - | 999 | 1045 | 5.9E-7 |
| 11 | g11594.t1 | Gene3D | G3DSA:1.10.1740.100 | - | 1249 | 1359 | 4.4E-30 |
| 27 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 82 | - |
| 25 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 38 | 82 | - |
| 21 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 583 | 649 | - |
| 20 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 612 | 627 | - |
| 24 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 628 | 649 | - |
| 22 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1051 | 1077 | - |
| 26 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1057 | 1077 | - |
| 28 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1184 | 1209 | - |
| 23 | g11594.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1193 | 1207 | - |
| 5 | g11594.t1 | PANTHER | PTHR46711 | HISTONE-LYSINE N-METHYLTRANSFERASE SETD2 | 381 | 777 | 2.5E-137 |
| 4 | g11594.t1 | PANTHER | PTHR46711 | HISTONE-LYSINE N-METHYLTRANSFERASE SETD2 | 1012 | 1043 | 2.5E-137 |
| 6 | g11594.t1 | PANTHER | PTHR46711 | HISTONE-LYSINE N-METHYLTRANSFERASE SETD2 | 1242 | 1357 | 2.5E-137 |
| 3 | g11594.t1 | Pfam | PF17907 | AWS domain | 399 | 432 | 4.0E-10 |
| 2 | g11594.t1 | Pfam | PF00856 | SET domain | 447 | 552 | 4.8E-21 |
| 1 | g11594.t1 | Pfam | PF08236 | SRI (Set2 Rpb1 interacting) domain | 1263 | 1347 | 4.7E-14 |
| 29 | g11594.t1 | ProSiteProfiles | PS51215 | AWS domain profile. | 381 | 434 | 15.106 |
| 30 | g11594.t1 | ProSiteProfiles | PS50280 | SET domain profile. | 436 | 553 | 20.929 |
| 32 | g11594.t1 | ProSiteProfiles | PS50868 | Post-SET domain profile. | 560 | 576 | 9.167 |
| 31 | g11594.t1 | ProSiteProfiles | PS50020 | WW/rsp5/WWP domain profile. | 1012 | 1045 | 12.176 |
| 18 | g11594.t1 | SMART | SM00570 | shorttest3 | 381 | 435 | 9.8E-14 |
| 19 | g11594.t1 | SMART | SM00317 | set_7 | 436 | 559 | 8.0E-48 |
| 16 | g11594.t1 | SMART | SM00508 | PostSET_3 | 560 | 576 | 6.6E-4 |
| 17 | g11594.t1 | SMART | SM00456 | ww_5 | 1013 | 1045 | 8.6E-6 |
| 7 | g11594.t1 | SUPERFAMILY | SSF82199 | SET domain | 354 | 573 | 5.1E-70 |
| 8 | g11594.t1 | SUPERFAMILY | SSF51045 | WW domain | 1011 | 1046 | 1.78E-7 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005634 | nucleus | CC |
| GO:0010452 | histone H3-K36 methylation | BP |
| GO:0006355 | regulation of transcription, DNA-templated | BP |
| GO:0097198 | histone H3-K36 trimethylation | BP |
| GO:0005694 | chromosome | CC |
| GO:0034968 | histone lysine methylation | BP |
| GO:0016279 | protein-lysine N-methyltransferase activity | MF |
| GO:0005515 | protein binding | MF |
| GO:0046975 | histone methyltransferase activity (H3-K36 specific) | MF |
| GO:0018024 | histone-lysine N-methyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K11423 ([histone H3]-lysine36 N-trimethyltransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
