General information for g11594.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as histone-arginine N-methyltransferase.
Parent gene
- The parent gene g11594 is located on chr_1: 17391241..17394921 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11594 | g11594.t2 | TSS | g11594.t2 | 17391065 | 17391065 |
| chr_1 | g11594 | g11594.t2 | isoform | g11594.t2 | 17391241 | 17393135 |
| chr_1 | g11594 | g11594.t2 | exon | g11594.t2.exon1 | 17391241 | 17392273 |
| chr_1 | g11594 | g11594.t2 | cds | g11594.t2.CDS1 | 17391562 | 17392273 |
| chr_1 | g11594 | g11594.t2 | exon | g11594.t2.exon2 | 17392348 | 17393135 |
| chr_1 | g11594 | g11594.t2 | cds | g11594.t2.CDS2 | 17392348 | 17393135 |
| chr_1 | g11594 | g11594.t2 | TTS | g11594.t2 | 17393147 | 17393147 |
Sequences
>g11594.t2 Gene=g11594 Length=1821
AATATCAAACAAGAATCTGTAGTAAAACATGATGAGGACAAACCAATTAATGAACTCATA
GATATAGCAAAATTAGAAAAAATTGATATTGCAAAAGAGACACTTACATCTGATAAAAAT
GAAGCTACAGTATCAGAAGAAACTTTAGTATGCTCTAAAATAAAGGAAGAAAATGCAATA
GTGGAAATAAAACAAGACATACAAGAATCTTATGAAGAAGTATCTTTTTTAAGACGATCA
CGTAGACTCAAAAGTATTTATTCTGAAATACCTCCTCAAATACAAGAAACATCAGTTTCT
AATATAAAAGATCAAGTTAATATGTCACCTGATGCAGCAATAAAAATTAAAAACATCACT
AAAAAATCTCATGAGATTGAAGATGAAAAACTTTCAAATGATGATATTAAATTGATAGAT
CCAAAATCAGAACATGCTGAAATTAAAAATGAAAACCTAAATGAGAAACAAATACCATAT
GAAAAATCTCTAACATTAGAGGACTTACAATGTGACCCACGTCTTAGTCAATTTGTAACA
ATTAAAGACAACATTTATATTAAGTCTTCAGATAAAGTTATATGCAAAGTGAATAAGACA
ATGAAATGTGATTGTACAATAACTGAAGAGGACTTGAAAAATGGTGAAATGGGTTGCAGA
TACAATTGTATCAATCGACTTCTGTTTATTGAATGTAGCTCAAAATGCAGATGTGGAGAA
TTTTGTGACAATCAACAATTTCAACGATACAATTATGCTCCAGTTTCCGTTTTTCGGACT
GAAAAGAAGGGTTATGGTATTCGGGCTGAAGATGATATTCCAGCAGAAACATTTATTATA
GAATATGTTGGTGAAGTTCTTAATAATAAGCAGTTTGAGAAGAGAGCAAAAAAATATTCG
AAAGATAAAAATCGACATTATTATTTCATGGCTTTACGTAGTAATGCTGTTATCGATGCT
ACTTCCAAAGGAAATATTTCAAGGTTCATAAATCATTCATGTGATCCTAATGCAATGACA
CAAAAGTGGACTGTAAATGGTGAACTAAGAGTAGGATTTTTCAGTATTCGTGATATAAAT
AGAGGTGAAGAAATAACATTTGATTATCAATTTCAACGTTATGGAAAGGAAGCACAAAAA
TGCTTTTGTGAATCAGAAAAATGTCGTGGATGGATTGGAGAAAATCCAATGAGTGATGAA
GAAGTAGAAGTTGATGACGCAAAACCTAAGAAAAGTCGTGGAAAGAAAACTGCACCACGA
AAAACAAAAGTTTTTATGGAAATCACAGAAGCAGATGATGACGACGATGAAGAGAATGAT
AAAATTGAAAATGATATTGATGAAAATATATCTCCAGAAAAATCTGAAATGAAAAAAGAA
CCAGCATCTGAAAAAATAATAAGAAAGACCAAGAAACGTCAAGATATAGAAGATCTTGAA
ATTGAAGAAGAAATTAATGATTTAACAAAAACAGGATTGAAAAATAGAGCACATACTATC
CGACTATCACGTTTAGTAGTAAGAGCAAAAAGCACAGACACACGAAGTCGAATTTTGAAA
ATTTTAATATCAGGTGATATGCCTTGTCGTCGCTTATTTTTGGATTATAATGGTCTAAGA
TTGTTACACAATTGGATGTGTGATATAAGTGTCAAAAGTTCTATACCAGATCTTTATTTA
TGTATGGAAGTTATGAATGCACTTAATATCTTGCCTATAACAAATAAAACTGTCCTGCGT
GAATCTAAAGTCCTAGAAAGAGTTGAAAAATGGAAAAATTTGGATCTTGAAAAGAAGAAA
TTAACAAAGGAAGAAAAGAAG
>g11594.t2 Gene=g11594 Length=500
MSPDAAIKIKNITKKSHEIEDEKLSNDDIKLIDPKSEHAEIKNENLNEKQIPYEKSLTLE
DLQCDPRLSQFVTIKDNIYIKSSDKVICKVNKTMKCDCTITEEDLKNGEMGCRYNCINRL
LFIECSSKCRCGEFCDNQQFQRYNYAPVSVFRTEKKGYGIRAEDDIPAETFIIEYVGEVL
NNKQFEKRAKKYSKDKNRHYYFMALRSNAVIDATSKGNISRFINHSCDPNAMTQKWTVNG
ELRVGFFSIRDINRGEEITFDYQFQRYGKEAQKCFCESEKCRGWIGENPMSDEEVEVDDA
KPKKSRGKKTAPRKTKVFMEITEADDDDDEENDKIENDIDENISPEKSEMKKEPASEKII
RKTKKRQDIEDLEIEEEINDLTKTGLKNRAHTIRLSRLVVRAKSTDTRSRILKILISGDM
PCRRLFLDYNGLRLLHNWMCDISVKSSIPDLYLCMEVMNALNILPITNKTVLRESKVLER
VEKWKNLDLEKKKLTKEEKK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g11594.t2 | CDD | cd19172 | SET_SETD2 | 145 | 286 | 1.17309E-95 |
| 6 | g11594.t2 | Coils | Coil | Coil | 492 | 500 | - |
| 5 | g11594.t2 | Gene3D | G3DSA:2.170.270.10 | SET domain | 35 | 309 | 3.6E-86 |
| 12 | g11594.t2 | MobiDBLite | mobidb-lite | consensus disorder prediction | 293 | 359 | - |
| 13 | g11594.t2 | MobiDBLite | mobidb-lite | consensus disorder prediction | 322 | 337 | - |
| 11 | g11594.t2 | MobiDBLite | mobidb-lite | consensus disorder prediction | 338 | 359 | - |
| 3 | g11594.t2 | PANTHER | PTHR46711 | HISTONE-LYSINE N-METHYLTRANSFERASE SETD2 | 71 | 487 | 8.6E-119 |
| 2 | g11594.t2 | Pfam | PF17907 | AWS domain | 109 | 142 | 1.2E-10 |
| 1 | g11594.t2 | Pfam | PF00856 | SET domain | 157 | 262 | 1.3E-21 |
| 14 | g11594.t2 | ProSiteProfiles | PS51215 | AWS domain profile. | 91 | 144 | 15.106 |
| 15 | g11594.t2 | ProSiteProfiles | PS50280 | SET domain profile. | 146 | 263 | 20.929 |
| 16 | g11594.t2 | ProSiteProfiles | PS50868 | Post-SET domain profile. | 270 | 286 | 9.167 |
| 9 | g11594.t2 | SMART | SM00570 | shorttest3 | 91 | 145 | 9.8E-14 |
| 10 | g11594.t2 | SMART | SM00317 | set_7 | 146 | 269 | 8.0E-48 |
| 8 | g11594.t2 | SMART | SM00508 | PostSET_3 | 270 | 286 | 6.6E-4 |
| 4 | g11594.t2 | SUPERFAMILY | SSF82199 | SET domain | 64 | 283 | 7.06E-71 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016279 | protein-lysine N-methyltransferase activity | MF |
| GO:0005634 | nucleus | CC |
| GO:0010452 | histone H3-K36 methylation | BP |
| GO:0005515 | protein binding | MF |
| GO:0046975 | histone methyltransferase activity (H3-K36 specific) | MF |
| GO:0097198 | histone H3-K36 trimethylation | BP |
| GO:0018024 | histone-lysine N-methyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K11423 ([histone H3]-lysine36 N-trimethyltransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed