General information for g11711.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Eye-specific diacylglycerol kinase.
Parent gene
- The parent gene g11711 is located on chr_1: 17988715..17998172 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11711 | g11711.t1 | isoform | g11711.t1 | 17983858 | 17998172 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon1 | 17983858 | 17983893 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS1 | 17983858 | 17983893 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon2 | 17983967 | 17985069 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS2 | 17983967 | 17985069 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon3 | 17989084 | 17989222 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS3 | 17989084 | 17989222 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon4 | 17989895 | 17990098 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS4 | 17989895 | 17990098 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon5 | 17992414 | 17992543 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS5 | 17992414 | 17992543 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon6 | 17992618 | 17992918 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS6 | 17992618 | 17992918 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon7 | 17992987 | 17993161 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS7 | 17992987 | 17993161 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon8 | 17994314 | 17994482 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS8 | 17994314 | 17994482 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon9 | 17994579 | 17994620 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS9 | 17994579 | 17994620 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon10 | 17994793 | 17994852 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS10 | 17994793 | 17994852 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon11 | 17994920 | 17995155 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS11 | 17994920 | 17995155 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon12 | 17995220 | 17995410 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS12 | 17995220 | 17995410 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon13 | 17995481 | 17995707 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS13 | 17995481 | 17995707 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon14 | 17995768 | 17996149 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS14 | 17995768 | 17996149 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon15 | 17997572 | 17997635 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS15 | 17997572 | 17997635 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon16 | 17997696 | 17998017 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS16 | 17997696 | 17998017 |
| chr_1 | g11711 | g11711.t1 | exon | g11711.t1.exon17 | 17998144 | 17998172 |
| chr_1 | g11711 | g11711.t1 | cds | g11711.t1.CDS17 | 17998144 | 17998172 |
| chr_1 | g11711 | g11711.t1 | TTS | g11711.t1 | 17998740 | 17998740 |
| chr_1 | g11711 | g11711.t1 | TSS | g11711.t1 | NA | NA |
Sequences
>g11711.t1 Gene=g11711 Length=3810
ATGAAGACACAAGGTAGTCTTGAAGTACCTAAGCAGGTCCGTTCAGCATCATTCGATGAA
ATTAAATTAGAGTCACAACGAGCAACTCAATACTTACTTAATAATCAATCATCAACCGAT
TCGCAATCTGCATTACTCACCGTTCCCAGTAATCAAAGATCACGAAGCTTTGATTCAGCT
GGTATTGAATCACCAGATGCAAATGCATCTTTTCTTGATATTCCAAGACAGCGCTTTCGA
CGAAAGTCTAGCGCAAAAGCGTCATTATGTATACATTGTCAATATGTTGAGGAGCAAAGA
AAACGTGGAAGTACTGCAGGTTTTTATTTCGATGCTCAAGAATTTAAGTCTCTTACATAT
TCAAATTCATCCTCATCATCATCGTCTGAAAGTGAAAGCGAAAATAGCAATGAAGTTAAA
TGCAGCGACAATGAGAATTTAGATGTAGAACCAGAAGATGAGATAGATATAGATCACTAC
TTTCAAACTCCTAATACTCTTTTACTACCTTCACCATGTAGCATTACGTTTACACTTTCA
CCAACGAATTGTGATTACCCAGCCTTTCCCCTATCATTGGGCACCGTTCAGCCCAATAGT
TCACCAGTGTTGCCTTCAACACCTCCCGTATTTCCACCATCACCAACAATTGAATTTTCT
CACGATCTCGATGAAATTGAAATTCCCGGTCCACGACAACGTCGACGCTCAATATCGAGA
CAAGAAGCCATTTTTGTAGAGCCAACAGGTTCATCACTTGAAAACGTGTCAAATACACCA
GAAACAGAAGAGCAGCAAACGAATGAAATAGAAAGAACAAAAAAAGAAAATGATGAAAGT
GAAAGAAGACATTCAGATGTACCAAAGGCATCAGAACCATTTGTTCGTGATATTTTTCTG
ACTGTGCCTGATTTGAAACGAGATCGTGCAGCATCTGTTGACTCATGTTTCACAAAAGTC
TCATCGGCAGCAAAAACTGAAGAAGTACAACCGCCTGAAGGAGACCTTAATTTGCTTACC
GTACCAAATAGCGGAGCAGTACGATCTCGTAGTGTAGACATTGTTCTTCCAACTGAACAA
CAAGCACGGTATAAAGCACTTGCTTTAGCTGGACCAGCTAATAATATCTATAACAAAGGA
AAACCAGGCGATAATTCAGGAACACGACAAATAAGAAACACACCGGACTGGACAGAAAAT
GCTGTGTCAGGAGATCATTTGTGGGTGCCTACTTCGGTATCAGGAGATTGCTGTTATATC
GGTGATAATGACTGTACTAAACATGGACCAAGAATGAAATGTTCCGCATGTAAAATTATT
GCTCATGCAAGTTGTATATCGATTTTAATGGATCGATCGCAATTAGCATGCAAACCAACA
TTTCGTGATGTGGGTGTCCGTCAATATCGAGAACAAACTAGAACTCATCATCATTGGATA
CATCGCCGTACTGAGAAAGGCAAATGTCGTCAGTGTGGAAAGTCTTTACAAGCGAAATTA
TCATTTAGTTCAAAGGAGATTGTGGCTTTATCATGTGCCTGGTGCAAATCATCATATCAT
AATAAAGAGGCATGTTTTAATCCACAGCGCATAGGTGAAGAGTGTTCATTAGGGACTCAT
TCACGTATAATAGTTCCTCCATCATGGATTGTAAAACTTCCAAAAAGAGGCAGTTTCAAA
TCATCACTGCGGAAAACACCAAAAAAGAAAACAGCCGGAAAGAAAAAGTCTAAAGAGAAA
GAGCTGAGAACATTTGTAATAAAACCTATTCCAACACCAAATCTTACGCCTGTTTTGGTT
TTTATAAATCCAAAAAGTGGCGGTAATCAAGGTGCAAAATTACTTCAAAAATTCCAATGG
CTTCTGAATCCTCGTCAAGTATTTGATTTGACACAAGGTGGACCTAAAATGGGCTTGGAG
TTATTTCGCAAAGTACCAAATTTACGTGTTCTTGCATGCGGTGGAGATGGAACTGTTGGA
TGGGTGCTTTCGGTACTTGATCAAATCAATATTACTCCACCTCCTGCTGTCGGTGTTTTG
CCGCTTGGTACGGGCAATGATTTGGCTCGTCATTTAGGATGGGGTGGCGGTTATACTGAT
GAGCCGATTGGAAAAATTCTTTCCAATATTGCAAATTCTGATACGGTATTATTAGATCGA
TGGAATCTCAAAGTAACTCCGAATACAAATGCTACTGATGTATCTGACGGAAAAGACACT
TTACCACTTAGTGTAGTTAACAATTACTTCTCTTTAGGCGTTGATGCTCATATTGCTCTC
GAGTTTCACGAAGCCAGAGAGGCTCATCCAGAAAAATTCAATTCTCGATTGAGAAATAAA
ATGTTTTATGGGCAAGCAGGCGGAAAGGACTTGCTGAAAAGAAAGTGGAAAAATCTTGCT
GAACTAGTTACTTTGGAGTGTGACGGTAAAGACATAACACCAAAGCTCAAAGAATTACGT
GTTCATGCGATTGTGTTTCTAAATATTGCGAGTTACGGTGGTGGCACGCATCCGTGGAAT
AAATCTGGAGGACAGTTCGAGCCTTCTACAGATGATGGATTGATAGAAGTTGTTGGTCTC
ACGACATATCAGTTGCCACTTCTTCAAGCTGGCGGACATGGAACTTGTATAATACAATGT
CGTTCAGCAAAAATTGTTACATCTAAAACAATTCCAATGCAGGTCGATGGTGAAGCATGT
AAAGTGAAACCATCAATCATTGAATTGTCTCTGCTTAATAAGGCTGTAATGTTGGCCAAG
AAGAAACCGGGGCGAATGAATGTTCAACAAGCAACATTGGAGCCAACAAATATTAATATT
TGTCGTATTAAAATGTCCGATTATGAACAGCACCATTATGATAAAGATTCACTAAAACAG
AGTGCGACATTACTAGGCTCTATAGAAGTTAATCCTTCTTCTGATCTTGAAGCTGTTCGT
GTTATTATAAATAAAATGTCTGAAGAATGCAGTGATGGTTTGAAACTAACACCTGACTGG
TGTTTTATTGATTCTTGTACTGCTGAACGATGTTTTCGAGTTGATAGAGCGCAAGAAAAT
TTACACTATGTTACGGATATTGCATCTGATGTGATTTATGTTTTGGATCAAGAATGTTCT
ACTTTACCACAAACGCCTGAAAATGAGAGTCCTGCAAATCTTGTGAATCCCATTATATCG
AGTATGGAATCTAGTGAATCACATGAAGGAACACCAATGACACCGGGAAAGAAATTTTTC
AATCGTTCTTTGAGTTCTGGACCAAATTCAGGTGGAACTTCATCTTCAAGAAAAAGCTCA
CAAGGATCTCAGGGCTCAAATGGAAGTGCACGAAGCTCATTAAATGCCTCAAAGGAAGAC
ATTGCGGGTAATGGAGAATCAGCTAACTATAAAGCTACACTTTTGGAAAAGACAACAGAC
GCTGTGATAAAAGCTGCTAAAAATGGAGACCTGACATTGCTTAAAGAACTGCATCAACAA
GGCTATTCACTTCTTTCAATTGACACTATGGGTCATACAGCACTTCACCATGCAAGCCGA
TACGGTCATAAAGACATCGTAAGATTTTTAATCGCCTACGCTCCTGATTCAATTATCAAC
ATGATTGATAATGAAAAAGGCCAGACGGCTCTTCATAAAGCAGCAGCATTGAAGCGCAGA
AGTATTAGCTATATGCTCGTGGCAGCAGGATCAAATTTACTAATACAAGACAACACAGGA
AAAACACCAAAAATATTAGCATTGGAAGCCGATGATCATGAGTTGGCGGCTTATCTTGAA
AGTCAAGAACAATTTCACTGTGCGGTTTAA
>g11711.t1 Gene=g11711 Length=1269
MKTQGSLEVPKQVRSASFDEIKLESQRATQYLLNNQSSTDSQSALLTVPSNQRSRSFDSA
GIESPDANASFLDIPRQRFRRKSSAKASLCIHCQYVEEQRKRGSTAGFYFDAQEFKSLTY
SNSSSSSSSESESENSNEVKCSDNENLDVEPEDEIDIDHYFQTPNTLLLPSPCSITFTLS
PTNCDYPAFPLSLGTVQPNSSPVLPSTPPVFPPSPTIEFSHDLDEIEIPGPRQRRRSISR
QEAIFVEPTGSSLENVSNTPETEEQQTNEIERTKKENDESERRHSDVPKASEPFVRDIFL
TVPDLKRDRAASVDSCFTKVSSAAKTEEVQPPEGDLNLLTVPNSGAVRSRSVDIVLPTEQ
QARYKALALAGPANNIYNKGKPGDNSGTRQIRNTPDWTENAVSGDHLWVPTSVSGDCCYI
GDNDCTKHGPRMKCSACKIIAHASCISILMDRSQLACKPTFRDVGVRQYREQTRTHHHWI
HRRTEKGKCRQCGKSLQAKLSFSSKEIVALSCAWCKSSYHNKEACFNPQRIGEECSLGTH
SRIIVPPSWIVKLPKRGSFKSSLRKTPKKKTAGKKKSKEKELRTFVIKPIPTPNLTPVLV
FINPKSGGNQGAKLLQKFQWLLNPRQVFDLTQGGPKMGLELFRKVPNLRVLACGGDGTVG
WVLSVLDQINITPPPAVGVLPLGTGNDLARHLGWGGGYTDEPIGKILSNIANSDTVLLDR
WNLKVTPNTNATDVSDGKDTLPLSVVNNYFSLGVDAHIALEFHEAREAHPEKFNSRLRNK
MFYGQAGGKDLLKRKWKNLAELVTLECDGKDITPKLKELRVHAIVFLNIASYGGGTHPWN
KSGGQFEPSTDDGLIEVVGLTTYQLPLLQAGGHGTCIIQCRSAKIVTSKTIPMQVDGEAC
KVKPSIIELSLLNKAVMLAKKKPGRMNVQQATLEPTNINICRIKMSDYEQHHYDKDSLKQ
SATLLGSIEVNPSSDLEAVRVIINKMSEECSDGLKLTPDWCFIDSCTAERCFRVDRAQEN
LHYVTDIASDVIYVLDQECSTLPQTPENESPANLVNPIISSMESSESHEGTPMTPGKKFF
NRSLSSGPNSGGTSSSRKSSQGSQGSNGSARSSLNASKEDIAGNGESANYKATLLEKTTD
AVIKAAKNGDLTLLKELHQQGYSLLSIDTMGHTALHHASRYGHKDIVRFLIAYAPDSIIN
MIDNEKGQTALHKAAALKRRSISYMLVAAGSNLLIQDNTGKTPKILALEADDHELAAYLE
SQEQFHCAV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g11711.t1 | Coils | Coil | Coil | 263 | 283 | - |
| 11 | g11711.t1 | Gene3D | G3DSA:3.40.50.10330 | - | 595 | 712 | 4.3E-13 |
| 9 | g11711.t1 | Gene3D | G3DSA:2.60.200.40 | - | 744 | 909 | 1.7E-13 |
| 10 | g11711.t1 | Gene3D | G3DSA:1.25.40.20 | - | 1110 | 1269 | 7.4E-23 |
| 22 | g11711.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 34 | 62 | - |
| 24 | g11711.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 121 | 135 | - |
| 25 | g11711.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 121 | 145 | - |
| 26 | g11711.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 230 | 289 | - |
| 23 | g11711.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 244 | 264 | - |
| 21 | g11711.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 265 | 289 | - |
| 20 | g11711.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1085 | 1121 | - |
| 5 | g11711.t1 | PANTHER | PTHR11255 | DIACYLGLYCEROL KINASE | 399 | 1040 | 8.2E-270 |
| 6 | g11711.t1 | PANTHER | PTHR11255:SF93 | EYE-SPECIFIC DIACYLGLYCEROL KINASE | 399 | 1040 | 8.2E-270 |
| 4 | g11711.t1 | Pfam | PF00130 | Phorbol esters/diacylglycerol binding domain (C1 domain) | 477 | 535 | 1.8E-9 |
| 3 | g11711.t1 | Pfam | PF00781 | Diacylglycerol kinase catalytic domain | 597 | 707 | 1.3E-29 |
| 2 | g11711.t1 | Pfam | PF00609 | Diacylglycerol kinase accessory domain | 745 | 898 | 5.5E-47 |
| 1 | g11711.t1 | Pfam | PF13637 | Ankyrin repeats (many copies) | 1172 | 1218 | 2.9E-8 |
| 30 | g11711.t1 | ProSiteProfiles | PS50146 | DAG-kinase catalytic (DAGKc) domain profile. | 593 | 727 | 47.435 |
| 27 | g11711.t1 | ProSiteProfiles | PS50297 | Ankyrin repeat region circular profile. | 1137 | 1259 | 22.808 |
| 28 | g11711.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 1170 | 1196 | 9.858 |
| 29 | g11711.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 1206 | 1238 | 9.938 |
| 17 | g11711.t1 | SMART | SM00109 | c1_12 | 406 | 457 | 1.3 |
| 18 | g11711.t1 | SMART | SM00109 | c1_12 | 476 | 535 | 0.02 |
| 19 | g11711.t1 | SMART | SM00046 | dagk_c4a_7 | 597 | 721 | 1.1E-64 |
| 13 | g11711.t1 | SMART | SM00045 | dagk_c4b_2 | 745 | 899 | 3.2E-83 |
| 15 | g11711.t1 | SMART | SM00248 | ANK_2a | 1137 | 1166 | 4300.0 |
| 16 | g11711.t1 | SMART | SM00248 | ANK_2a | 1170 | 1201 | 2.6E-4 |
| 14 | g11711.t1 | SMART | SM00248 | ANK_2a | 1206 | 1235 | 63.0 |
| 8 | g11711.t1 | SUPERFAMILY | SSF111331 | NAD kinase/diacylglycerol kinase-like | 594 | 916 | 2.18E-53 |
| 7 | g11711.t1 | SUPERFAMILY | SSF48403 | Ankyrin repeat | 1138 | 1262 | 5.13E-23 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004143 | diacylglycerol kinase activity | MF |
| GO:0007205 | protein kinase C-activating G protein-coupled receptor signaling pathway | BP |
| GO:0003951 | NAD+ kinase activity | MF |
| GO:0007165 | signal transduction | BP |
| GO:0005515 | protein binding | MF |
| GO:0016301 | kinase activity | MF |
| GO:0035556 | intracellular signal transduction | BP |
KEGG
Orthology
- This transcript has been annotated with K00901 (diacylglycerol kinase (ATP))
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
