General information for g11711.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Eye-specific diacylglycerol kinase.
Parent gene
- The parent gene g11711 is located on chr_1: 17988715..17998172 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11711 | g11711.t2 | isoform | g11711.t2 | 17988715 | 17998172 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon1 | 17988715 | 17988902 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS1 | 17988715 | 17988902 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon2 | 17989084 | 17989222 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS2 | 17989084 | 17989222 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon3 | 17989895 | 17990098 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS3 | 17989895 | 17990098 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon4 | 17992414 | 17992543 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS4 | 17992414 | 17992543 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon5 | 17992618 | 17992918 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS5 | 17992618 | 17992918 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon6 | 17992987 | 17993161 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS6 | 17992987 | 17993161 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon7 | 17994314 | 17994482 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS7 | 17994314 | 17994482 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon8 | 17994579 | 17994620 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS8 | 17994579 | 17994620 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon9 | 17994793 | 17994852 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS9 | 17994793 | 17994852 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon10 | 17994920 | 17995155 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS10 | 17994920 | 17995155 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon11 | 17995220 | 17995410 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS11 | 17995220 | 17995410 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon12 | 17995481 | 17995707 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS12 | 17995481 | 17995707 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon13 | 17995768 | 17996149 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS13 | 17995768 | 17996149 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon14 | 17997572 | 17997635 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS14 | 17997572 | 17997635 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon15 | 17997696 | 17998017 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS15 | 17997696 | 17998017 |
| chr_1 | g11711 | g11711.t2 | exon | g11711.t2.exon16 | 17998144 | 17998172 |
| chr_1 | g11711 | g11711.t2 | cds | g11711.t2.CDS16 | 17998144 | 17998172 |
| chr_1 | g11711 | g11711.t2 | TTS | g11711.t2 | 17998740 | 17998740 |
| chr_1 | g11711 | g11711.t2 | TSS | g11711.t2 | NA | NA |
Sequences
>g11711.t2 Gene=g11711 Length=2859
ATGAAATCATCAAAAACTAAAGGAAAACTTGCCAAGCTTATTATAGTTGGATTTGGATTC
AAAACATGTTTTAAATATTATCCAAATGAAAACGATTTATATAACAAAATTAAATGCTAC
GAAAAAAATCATCGAAGGAAAAAAGCTATTCGCTATAGAAACAGAAATGGACTACCATTT
AAGCTCAGAAAACCAGGCGATAATTCAGGAACACGACAAATAAGAAACACACCGGACTGG
ACAGAAAATGCTGTGTCAGGAGATCATTTGTGGGTGCCTACTTCGGTATCAGGAGATTGC
TGTTATATCGGTGATAATGACTGTACTAAACATGGACCAAGAATGAAATGTTCCGCATGT
AAAATTATTGCTCATGCAAGTTGTATATCGATTTTAATGGATCGATCGCAATTAGCATGC
AAACCAACATTTCGTGATGTGGGTGTCCGTCAATATCGAGAACAAACTAGAACTCATCAT
CATTGGATACATCGCCGTACTGAGAAAGGCAAATGTCGTCAGTGTGGAAAGTCTTTACAA
GCGAAATTATCATTTAGTTCAAAGGAGATTGTGGCTTTATCATGTGCCTGGTGCAAATCA
TCATATCATAATAAAGAGGCATGTTTTAATCCACAGCGCATAGGTGAAGAGTGTTCATTA
GGGACTCATTCACGTATAATAGTTCCTCCATCATGGATTGTAAAACTTCCAAAAAGAGGC
AGTTTCAAATCATCACTGCGGAAAACACCAAAAAAGAAAACAGCCGGAAAGAAAAAGTCT
AAAGAGAAAGAGCTGAGAACATTTGTAATAAAACCTATTCCAACACCAAATCTTACGCCT
GTTTTGGTTTTTATAAATCCAAAAAGTGGCGGTAATCAAGGTGCAAAATTACTTCAAAAA
TTCCAATGGCTTCTGAATCCTCGTCAAGTATTTGATTTGACACAAGGTGGACCTAAAATG
GGCTTGGAGTTATTTCGCAAAGTACCAAATTTACGTGTTCTTGCATGCGGTGGAGATGGA
ACTGTTGGATGGGTGCTTTCGGTACTTGATCAAATCAATATTACTCCACCTCCTGCTGTC
GGTGTTTTGCCGCTTGGTACGGGCAATGATTTGGCTCGTCATTTAGGATGGGGTGGCGGT
TATACTGATGAGCCGATTGGAAAAATTCTTTCCAATATTGCAAATTCTGATACGGTATTA
TTAGATCGATGGAATCTCAAAGTAACTCCGAATACAAATGCTACTGATGTATCTGACGGA
AAAGACACTTTACCACTTAGTGTAGTTAACAATTACTTCTCTTTAGGCGTTGATGCTCAT
ATTGCTCTCGAGTTTCACGAAGCCAGAGAGGCTCATCCAGAAAAATTCAATTCTCGATTG
AGAAATAAAATGTTTTATGGGCAAGCAGGCGGAAAGGACTTGCTGAAAAGAAAGTGGAAA
AATCTTGCTGAACTAGTTACTTTGGAGTGTGACGGTAAAGACATAACACCAAAGCTCAAA
GAATTACGTGTTCATGCGATTGTGTTTCTAAATATTGCGAGTTACGGTGGTGGCACGCAT
CCGTGGAATAAATCTGGAGGACAGTTCGAGCCTTCTACAGATGATGGATTGATAGAAGTT
GTTGGTCTCACGACATATCAGTTGCCACTTCTTCAAGCTGGCGGACATGGAACTTGTATA
ATACAATGTCGTTCAGCAAAAATTGTTACATCTAAAACAATTCCAATGCAGGTCGATGGT
GAAGCATGTAAAGTGAAACCATCAATCATTGAATTGTCTCTGCTTAATAAGGCTGTAATG
TTGGCCAAGAAGAAACCGGGGCGAATGAATGTTCAACAAGCAACATTGGAGCCAACAAAT
ATTAATATTTGTCGTATTAAAATGTCCGATTATGAACAGCACCATTATGATAAAGATTCA
CTAAAACAGAGTGCGACATTACTAGGCTCTATAGAAGTTAATCCTTCTTCTGATCTTGAA
GCTGTTCGTGTTATTATAAATAAAATGTCTGAAGAATGCAGTGATGGTTTGAAACTAACA
CCTGACTGGTGTTTTATTGATTCTTGTACTGCTGAACGATGTTTTCGAGTTGATAGAGCG
CAAGAAAATTTACACTATGTTACGGATATTGCATCTGATGTGATTTATGTTTTGGATCAA
GAATGTTCTACTTTACCACAAACGCCTGAAAATGAGAGTCCTGCAAATCTTGTGAATCCC
ATTATATCGAGTATGGAATCTAGTGAATCACATGAAGGAACACCAATGACACCGGGAAAG
AAATTTTTCAATCGTTCTTTGAGTTCTGGACCAAATTCAGGTGGAACTTCATCTTCAAGA
AAAAGCTCACAAGGATCTCAGGGCTCAAATGGAAGTGCACGAAGCTCATTAAATGCCTCA
AAGGAAGACATTGCGGGTAATGGAGAATCAGCTAACTATAAAGCTACACTTTTGGAAAAG
ACAACAGACGCTGTGATAAAAGCTGCTAAAAATGGAGACCTGACATTGCTTAAAGAACTG
CATCAACAAGGCTATTCACTTCTTTCAATTGACACTATGGGTCATACAGCACTTCACCAT
GCAAGCCGATACGGTCATAAAGACATCGTAAGATTTTTAATCGCCTACGCTCCTGATTCA
ATTATCAACATGATTGATAATGAAAAAGGCCAGACGGCTCTTCATAAAGCAGCAGCATTG
AAGCGCAGAAGTATTAGCTATATGCTCGTGGCAGCAGGATCAAATTTACTAATACAAGAC
AACACAGGAAAAACACCAAAAATATTAGCATTGGAAGCCGATGATCATGAGTTGGCGGCT
TATCTTGAAAGTCAAGAACAATTTCACTGTGCGGTTTAA
>g11711.t2 Gene=g11711 Length=952
MKSSKTKGKLAKLIIVGFGFKTCFKYYPNENDLYNKIKCYEKNHRRKKAIRYRNRNGLPF
KLRKPGDNSGTRQIRNTPDWTENAVSGDHLWVPTSVSGDCCYIGDNDCTKHGPRMKCSAC
KIIAHASCISILMDRSQLACKPTFRDVGVRQYREQTRTHHHWIHRRTEKGKCRQCGKSLQ
AKLSFSSKEIVALSCAWCKSSYHNKEACFNPQRIGEECSLGTHSRIIVPPSWIVKLPKRG
SFKSSLRKTPKKKTAGKKKSKEKELRTFVIKPIPTPNLTPVLVFINPKSGGNQGAKLLQK
FQWLLNPRQVFDLTQGGPKMGLELFRKVPNLRVLACGGDGTVGWVLSVLDQINITPPPAV
GVLPLGTGNDLARHLGWGGGYTDEPIGKILSNIANSDTVLLDRWNLKVTPNTNATDVSDG
KDTLPLSVVNNYFSLGVDAHIALEFHEAREAHPEKFNSRLRNKMFYGQAGGKDLLKRKWK
NLAELVTLECDGKDITPKLKELRVHAIVFLNIASYGGGTHPWNKSGGQFEPSTDDGLIEV
VGLTTYQLPLLQAGGHGTCIIQCRSAKIVTSKTIPMQVDGEACKVKPSIIELSLLNKAVM
LAKKKPGRMNVQQATLEPTNINICRIKMSDYEQHHYDKDSLKQSATLLGSIEVNPSSDLE
AVRVIINKMSEECSDGLKLTPDWCFIDSCTAERCFRVDRAQENLHYVTDIASDVIYVLDQ
ECSTLPQTPENESPANLVNPIISSMESSESHEGTPMTPGKKFFNRSLSSGPNSGGTSSSR
KSSQGSQGSNGSARSSLNASKEDIAGNGESANYKATLLEKTTDAVIKAAKNGDLTLLKEL
HQQGYSLLSIDTMGHTALHHASRYGHKDIVRFLIAYAPDSIINMIDNEKGQTALHKAAAL
KRRSISYMLVAAGSNLLIQDNTGKTPKILALEADDHELAAYLESQEQFHCAV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 19 | g11711.t2 | Gene3D | G3DSA:3.40.50.10330 | - | 278 | 395 | 3.0E-13 |
| 17 | g11711.t2 | Gene3D | G3DSA:2.60.200.40 | - | 427 | 592 | 1.1E-13 |
| 18 | g11711.t2 | Gene3D | G3DSA:1.25.40.20 | - | 793 | 952 | 5.0E-23 |
| 16 | g11711.t2 | MobiDBLite | mobidb-lite | consensus disorder prediction | 768 | 804 | - |
| 5 | g11711.t2 | PANTHER | PTHR11255 | DIACYLGLYCEROL KINASE | 82 | 723 | 8.4E-270 |
| 6 | g11711.t2 | PANTHER | PTHR11255:SF93 | EYE-SPECIFIC DIACYLGLYCEROL KINASE | 82 | 723 | 8.4E-270 |
| 4 | g11711.t2 | Pfam | PF00130 | Phorbol esters/diacylglycerol binding domain (C1 domain) | 160 | 218 | 1.3E-9 |
| 3 | g11711.t2 | Pfam | PF00781 | Diacylglycerol kinase catalytic domain | 280 | 390 | 8.6E-30 |
| 2 | g11711.t2 | Pfam | PF00609 | Diacylglycerol kinase accessory domain | 428 | 582 | 3.6E-47 |
| 1 | g11711.t2 | Pfam | PF13637 | Ankyrin repeats (many copies) | 855 | 901 | 2.0E-8 |
| 23 | g11711.t2 | ProSiteProfiles | PS50146 | DAG-kinase catalytic (DAGKc) domain profile. | 276 | 410 | 47.435 |
| 20 | g11711.t2 | ProSiteProfiles | PS50297 | Ankyrin repeat region circular profile. | 820 | 942 | 22.808 |
| 21 | g11711.t2 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 853 | 879 | 9.858 |
| 22 | g11711.t2 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 889 | 921 | 9.938 |
| 14 | g11711.t2 | SMART | SM00109 | c1_12 | 89 | 140 | 1.3 |
| 13 | g11711.t2 | SMART | SM00109 | c1_12 | 159 | 218 | 0.02 |
| 15 | g11711.t2 | SMART | SM00046 | dagk_c4a_7 | 280 | 404 | 1.1E-64 |
| 9 | g11711.t2 | SMART | SM00045 | dagk_c4b_2 | 428 | 582 | 3.2E-83 |
| 11 | g11711.t2 | SMART | SM00248 | ANK_2a | 820 | 849 | 4300.0 |
| 12 | g11711.t2 | SMART | SM00248 | ANK_2a | 853 | 884 | 2.6E-4 |
| 10 | g11711.t2 | SMART | SM00248 | ANK_2a | 889 | 918 | 63.0 |
| 8 | g11711.t2 | SUPERFAMILY | SSF111331 | NAD kinase/diacylglycerol kinase-like | 277 | 599 | 1.31E-53 |
| 7 | g11711.t2 | SUPERFAMILY | SSF48403 | Ankyrin repeat | 821 | 945 | 3.42E-23 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004143 | diacylglycerol kinase activity | MF |
| GO:0007205 | protein kinase C-activating G protein-coupled receptor signaling pathway | BP |
| GO:0003951 | NAD+ kinase activity | MF |
| GO:0007165 | signal transduction | BP |
| GO:0005515 | protein binding | MF |
| GO:0016301 | kinase activity | MF |
| GO:0035556 | intracellular signal transduction | BP |
KEGG
Orthology
- This transcript has been annotated with K00901 (diacylglycerol kinase (ATP))
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
