General information for g11722.t4
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Phosphatidylinositol 3-kinase catalytic subunit type 3.
Parent gene
- The parent gene g11722 is located on chr_1: 18076751..18077285 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11722 | g11722.t4 | isoform | g11722.t4 | 18074050 | 18076124 |
| chr_1 | g11722 | g11722.t4 | exon | g11722.t4.exon1 | 18074050 | 18075512 |
| chr_1 | g11722 | g11722.t4 | cds | g11722.t4.CDS1 | 18074050 | 18075512 |
| chr_1 | g11722 | g11722.t4 | exon | g11722.t4.exon2 | 18075572 | 18076124 |
| chr_1 | g11722 | g11722.t4 | cds | g11722.t4.CDS2 | 18075572 | 18075839 |
| chr_1 | g11722 | g11722.t4 | TSS | g11722.t4 | NA | NA |
| chr_1 | g11722 | g11722.t4 | TTS | g11722.t4 | NA | NA |
Sequences
>g11722.t4 Gene=g11722 Length=2016
GAAAACCTAGTTGAAAAAAAACATCATCGATTGGCACGTTCAGCTCGTTCAGGTTTATCT
GATCGCGATGCAAAGCCAACCGCTCAAATTAGAGATCAACTACACTCACTTGTGCATAGA
TCACCAACATTTCAATTAAACAGTGAAGAACAGGATTTGATATGGAAATATAGATTTTAT
TTAAGCACTCAAAAGAAGGCGCTTACAAAATTTCTTAAATGTATTAATTGGCAAACATCT
GCAGAAGTAAGACAAGCTCTTAATCTTCTGGACTTATGGGCACCAATGGATGTTGAAGAT
GCTCTTGAATTATTGAGTCCGAATTTTCAACATCCAGCTGTTAGGCGATATGCGATAACA
CGTCTAAAGCAGTCACAGGATGATGATTTACTTCTCTATTTACTTCAGCTTGTACAAGCA
TTAAAATATGAAAATTTTGATGATATTTTTGAATGGCGTCGACGTGTTATGAATGAAAAA
GACATTTTAAAATCGATTGATGATAACAATTCCACTACTAACGATCAAAGTTCAATTTCT
GATTCCATAATGGCTCAATCTATGACATCTCAACAATTTTTAAATGAATCAGAAGAAATA
ATTGTACCACCTTTAAATCAACAATCTATCATGTCAAGTTCAATATTTTATGATCAACAA
AATGATAATATAAGTGATCAACCGAGAATTGATGATTCTAATAATGATGTAACATCAGAT
ATTTCAAATACTTTGATGAATTCAAAAAGTTCATATATTTGTGATTTAGCAACATTTTTA
ATTCAAAGAGCATGTAAAAATCCAACACTCGCTAATTTTTTCTATTGGTATTTGTTGATA
GAATGTGAAGATCATGAAACTGTTAGAAAAAAAGACGAAAGAGTGCGAGAGATGTATGAA
AATGTGCAAAAAATTTTCCTTAAAACTCTGGAAATGGGTAATACAGATTTGAAAATCATT
CATTCTAATTTGATGAAACAAAAATGCTTTATTGAAAATTTGGTCAAACTAGTGAAATTA
GTTGCAAAAGACTCTGGCAATAGAAAGAAGAAGACAGAAAAATTTCAACAATTGTTGTGT
GATTCAGATGAATTTAAAATTAATTTCACAAGCTTTGAACCATTACCGCTTCCACTTAAT
CCAGAAATATTTATAAAAGGCATCGTAACATCAAAAGTCTCACTTTTCAAATCAGCCTTA
ATGCCAGCAAAATTAACATTCCTTACGACTAATGATACAGAATATGTTGCAATTTTTAAA
AATGGCGATGATTTACGTCAGGATCAACTCATTTTACAAATGATTACTCTCATGGATAAG
TTACTAAGAAAAGAAAATTTAGATTTAAAGCTTACTCCATATCGGGTATTAGCATTATCA
TCTAAACATGGCTTTATGCAATATATTGAATCTATAACAGTTGCGGAGGCACTCAAAACA
GAAGGAACAATATTGAATTTTTTTAAAAAGCATAATCCTTGTGATACATCCTTGTATGGC
ATTCAATCTGAAGTTATGGATACATATATAAAAAGTTGTGCCGGTTATTGTGTCATTACA
TACTTGCTAGGTGTCGGTGATAGACATTTGGATAATTTACTTTTAACTAAAAATGGAAAT
CTATTTCATATAGATTTTGGATATATTTTAGGACGAGATCCGAAACCTCTTCCTCCACCT
ATGAAATTAAGCAAGGAGATGGTCGATGCTATGGGAGGAATAAATTCTGATCATTATCAT
GAGTTTAGGAAACAATGTTATACAGCTTTTCTTCATCTTCGACGACATGCAAATGTCATG
TTAAATTTATTTTCACTTATGACAGATGCTTCAGTTCCCGATATTGCATTAGAACCTGAT
AAAGCAGTAAAGAAAGTAGAAGATAATCTTAAATTGAATTTAACAGATGAAGAGGCAGTT
CAACATTTACAAAATCTTTTAGATGTTTCTCTTTCTGCTGTTATGCCTGCATTAGTTGAA
CAAATACATAAATTAGCTCAATATTGGAGAACATAA
>g11722.t4 Gene=g11722 Length=576
MDVEDALELLSPNFQHPAVRRYAITRLKQSQDDDLLLYLLQLVQALKYENFDDIFEWRRR
VMNEKDILKSIDDNNSTTNDQSSISDSIMAQSMTSQQFLNESEEIIVPPLNQQSIMSSSI
FYDQQNDNISDQPRIDDSNNDVTSDISNTLMNSKSSYICDLATFLIQRACKNPTLANFFY
WYLLIECEDHETVRKKDERVREMYENVQKIFLKTLEMGNTDLKIIHSNLMKQKCFIENLV
KLVKLVAKDSGNRKKKTEKFQQLLCDSDEFKINFTSFEPLPLPLNPEIFIKGIVTSKVSL
FKSALMPAKLTFLTTNDTEYVAIFKNGDDLRQDQLILQMITLMDKLLRKENLDLKLTPYR
VLALSSKHGFMQYIESITVAEALKTEGTILNFFKKHNPCDTSLYGIQSEVMDTYIKSCAG
YCVITYLLGVGDRHLDNLLLTKNGNLFHIDFGYILGRDPKPLPPPMKLSKEMVDAMGGIN
SDHYHEFRKQCYTAFLHLRRHANVMLNLFSLMTDASVPDIALEPDKAVKKVEDNLKLNLT
DEEAVQHLQNLLDVSLSAVMPALVEQIHKLAQYWRT
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g11722.t4 | CDD | cd00896 | PI3Kc_III | 229 | 572 | 0.0 |
| 7 | g11722.t4 | Gene3D | G3DSA:3.30.1010.10 | - | 220 | 375 | 3.8E-55 |
| 8 | g11722.t4 | Gene3D | G3DSA:1.10.1070.11 | - | 376 | 576 | 3.0E-83 |
| 3 | g11722.t4 | PANTHER | PTHR10048 | PHOSPHATIDYLINOSITOL KINASE | 1 | 569 | 1.4E-162 |
| 4 | g11722.t4 | PANTHER | PTHR10048:SF7 | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 | 1 | 569 | 1.4E-162 |
| 2 | g11722.t4 | Pfam | PF00613 | Phosphoinositide 3-kinase family, accessory domain (PIK domain) | 2 | 205 | 6.6E-31 |
| 1 | g11722.t4 | Pfam | PF00454 | Phosphatidylinositol 3- and 4-kinase | 382 | 520 | 9.6E-36 |
| 11 | g11722.t4 | ProSitePatterns | PS00915 | Phosphatidylinositol 3- and 4-kinases signature 1. | 324 | 338 | - |
| 10 | g11722.t4 | ProSitePatterns | PS00916 | Phosphatidylinositol 3- and 4-kinases signature 2. | 417 | 437 | - |
| 15 | g11722.t4 | ProSiteProfiles | PS51545 | PIK helical domain profile. | 1 | 207 | 21.124 |
| 14 | g11722.t4 | ProSiteProfiles | PS50290 | Phosphatidylinositol 3- and 4-kinases family profile. | 320 | 574 | 80.721 |
| 12 | g11722.t4 | SMART | SM00145 | pi3k_hr2_4 | 1 | 224 | 3.5E-11 |
| 13 | g11722.t4 | SMART | SM00146 | pi3k_hr1_6 | 321 | 573 | 2.3E-103 |
| 5 | g11722.t4 | SUPERFAMILY | SSF48371 | ARM repeat | 1 | 206 | 5.75E-33 |
| 6 | g11722.t4 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 228 | 572 | 8.5E-85 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016301 | kinase activity | MF |
| GO:0048015 | phosphatidylinositol-mediated signaling | BP |
| GO:0046854 | phosphatidylinositol phosphate biosynthetic process | BP |
KEGG
Orthology
- This transcript has been annotated with K00914 (phosphatidylinositol 3-kinase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
