General information for g11745.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as histone-arginine N-methyltransferase.
Parent gene
- The parent gene g11745 is located on chr_1: 18214627..18214884 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11745 | g11745.t1 | isoform | g11745.t1 | 18209741 | 18214627 |
| chr_1 | g11745 | g11745.t1 | exon | g11745.t1.exon1 | 18209741 | 18210106 |
| chr_1 | g11745 | g11745.t1 | cds | g11745.t1.CDS1 | 18209741 | 18210106 |
| chr_1 | g11745 | g11745.t1 | exon | g11745.t1.exon2 | 18210165 | 18210659 |
| chr_1 | g11745 | g11745.t1 | cds | g11745.t1.CDS2 | 18210165 | 18210659 |
| chr_1 | g11745 | g11745.t1 | exon | g11745.t1.exon3 | 18210717 | 18211715 |
| chr_1 | g11745 | g11745.t1 | cds | g11745.t1.CDS3 | 18210717 | 18211715 |
| chr_1 | g11745 | g11745.t1 | exon | g11745.t1.exon4 | 18211775 | 18214627 |
| chr_1 | g11745 | g11745.t1 | cds | g11745.t1.CDS4 | 18211775 | 18214627 |
| chr_1 | g11745 | g11745.t1 | TSS | g11745.t1 | 18215010 | 18215010 |
| chr_1 | g11745 | g11745.t1 | TTS | g11745.t1 | NA | NA |
Sequences
>g11745.t1 Gene=g11745 Length=4713
ATGGACACCAATACAGACCAAGAGGATGGCTGTTCGAGTAGTGATTTGGATATCAGCAAT
GATATTAATGGATGTTTAAAGTCTCTCGATGATGATATTGATGGACCTTCAAAACATAAT
ATATCTAATAACGACAATGATGAAAGTTCTTCGAGCAGTTCAAGCAGTTCTAGTAGTAGC
TCGAGTGAGTCATCTTCGTCTTCATCCTCAAAATCTTCTAAAACATCATCATCTCACAAA
AAATCATCAACGAAAGCAAAAGAAAAAAACACTGAAATTAAATATCCATTTCCATCACCT
ACGAAAATTGTTGCAACAACAGATCGAGTTTTGTATCCAGCGAGATTTAATAAAAAGCAA
CAATTAGTGCTTGAAAAAACATCTTCACCTTCTTCTACTCATAAAACACAACATAGATCA
CGTTCACGATCAAGAGGTCCACGAGTTGTTAGAGAATCAGGATACCGCACCGATGGTTCA
GTTTCATCTGATATAAAAAGAAGAAAATCAAGAGCTCCTTCAGCACCACGCTCATCAATA
GTACCAATCGATTTAGATTTAGATTTAGATGTTTTACAACTGAATACAGAACCATCAACT
TCAGTAAAACTAACAAAAAAGAACGTAAATCTAATGGCGCGAAAAAATGATACCAACAAT
AATAATGGCAACGTCTTATCAAGTAGTAAAATGCGACCGTTAGCAATGAATTTAGAATTA
AATAGGCGACTTCTCGAACACAAAATGAATCTTAATGGTCGCAGTGTACCATTTTCTTCA
TCTTCATGTAAATTAGGATTCGGTCTTAAGTCAAGTCAGTCATTTCAAGAATTGACAGCT
ACTTCAAAAGTTATGACGCCTTCATGGACAGCTAATGATGAAAAAAATTCTAAACCTGTT
AAGTATGCAAAATCATTATCGCGAATAGTGATGAAATCACGAAGACTTTCTGTAACAAGT
CGGCCTGCATCAGTTAGAAGTGCAACTTCAACTATATCTCGAATACGACGTGCACCGACA
CCAGCTACAATAAGAAACAATGAATATGTTTTAGCTCAAGTTGTAGAAGTAACTGCCGCT
CTTGCAAAATGCACAATTTCAACGCCAAAAACTTTAAAAACTCAAAAGGTTCATCACAAT
CGTGGTAGTGATAGTAAAAATATACAGAATCATACAGCAAAGAAGAAAAAGACTGCTACT
ACTGTTGCTAAAAGAAGAAGCAAAAAAACATTTGATGATAATGATACAGTGCCTGTTGCT
GAAGATCACAAGTTGCCATTGAAAAAACGTCATTATTTGATTACAGAAGAAAAATCTTGC
AATGTTAAGCGAAAGCGAACCAAAAAATCTCTTCAACCACCGCCGTCAGGAATTTTTGAG
CCTACTGCAAACGTACATGACGATGAAACTTCTCCTCCATCGTCATTTGATGTTATAAAT
ATGATATGTCCAACAATTTCTACAGATACAAAGACAAAAGTTTTCACCAAAACATCAGTA
GTTGATAACATTCTTACTAAATTAGAACCGACAGTAAATAGAAAGAAAAGAAGAAGAGCA
AATAGAACTGGATTTCCAACACCTAAACGACCCAAAAAGAAAATTGTTAATGATAATGCG
AGTGACACATCAAGTGTAATTAAAAAGAGCCAACGAAAAAGAAAGTTTTCACAGCGGGAT
CAGGATAATGAAATACAAGTTATGACCGCTCGACAATTACAACTAAAACAACAAAAAGAA
CTAGAACTGAGACTAATAGAACCAAAGCCAGAAATAAATAGAAATATGAGAGGAAGAGCG
AAATCAGTTTGCCATATTTCAGAGTCAGATTTAGATTCATCATTACCGCCTGTGAAAAGA
AAACGTCGACAAACTATATTTATTGATCAAAAAGAGGAGCAAAAAGATGCAGTACAGCAT
AAATCCAATAATAGATACTTTTTAAATAATTTATCTGAAATTAAACTCAATCAAGCACAA
GTTGATGATGATAAAAAAATAATGATTAAGAAAAAACGTCGACAAACGATACACTCTGAA
AATATTTCACCTCTAAATGAAACTTATCAACAATTAACACATCCTCATCTTAATATTTCT
TCTACTATTGCATCAAAAATAAATAAAAAATCTAAAATTGATGTGAAAAAGGTGCCACCT
AAATTAAATGAATCGATTCCACCTGTGAAGCTTATACCAAAAAATGTTTACAACGGTGAC
ACTCAAAAAAAAGCATTTGTGCCAAGTTTAAAAGGTACAAAATGTCGATGTGCTCCCAAT
CTATGTGGTGAATCATGTTTAAATAGATCGATGTTTATTGAATGTGATGTTTCAATATGC
GGCAAAAATTGTACAAATAGTGTCATACAAACTGGTGGTCTGCTAAATAGGGATGTAGAA
AAATTTCAAACAGAGTACAAAGGCTATGGTGTCCGAACGAAAAAAAATATTAAAAAAAAG
ACTCTCATTTTGGAATATACTGGAGAAGTTTTATTTAAAGAAACTTTTAGACAACGAATG
CAAACAATATATAAAAACGATCAGCATCATTATTGTCTTGAACTAAGTAATGGTTTAGTA
CTTGACGGTCATCGAATGGGATCTTTATGTCGTTTTGTTAATCATTCATGTAAACCAAAC
TGTAGCATGGCTAAAATTTATGTTGATGGTTTACCGAGAATGATATTACAAGCTGAAGAA
GATATAAAAGCAGGAACCGAGCTCAATTATGATTATAAGTTTGATAATTTTGAAGATATG
ACACCACAACAATGCTTTTGTGGTGCTGACACTTGTAGAGGGACATTGAGTGCTGCTCAA
AAGACACCACGACGAATGAGTTTATCATTTAAGGACGGTGAAGTTGTGAAAAAGAATGGA
AGAAAGAGTAAAACAACATCTACTATTCCAAAAGCAAATTCATGTTTCCTCATGAGAAAT
CTTCGTAAAGTAGAAAAACATCATCCAGGACTGATCGCTTACTACCAAAATTTAAAAAAC
GGAATAGAGGAGGTTGATCCTAAAATTGGATTTTCATTTGTATCAAAAACACATGAAAAT
TCTCCACCATCATTAGACCAGCAATTAGTGGACTCACAAACTTCAACTAAAATTGAAGAT
GAGAAAGAAGAGAAATTAAAAGAAAATAATGAATCAGAAGTGCCCATAATTATGAATCAG
CCGCTATCTGAGCAATCACAAGTATTATGGCAGATGTGTGAGCGTTTAGAATCAAGTCAT
GGTGAACAAATTAAGAAAATATCTATCCCCCCTTCTCCCGAAACGGGTCATTCAAATCAC
GATCGAATATCTCTTCCTGTATCTTTTAACGATATAAAACAAAATGTTAAAATGGGCAAT
TATGACTTGAATCCTTTGTTATATCATTACCACATGAAAATTATGCTTGATAATGTTGTA
AAATTTTGGGGTGTAAATTGTGAACAATTTCATACAATGAATACAATTCGTGATGCATAC
AAAATAATACGAACTGAAATGATTGAAGAAGTTAAACGAATATGGGAGGATGAATTACTA
GTTAATGCTATGATGGATAAAGCTGTTAAGAAGCCTGCAAAAAATCGTAAAAAAGTTCAA
GAGAAAAATGATGATGAGGATATTGTTAATTGTCATTGTGGTAGATATTTAGAAGAAGGC
CTAATGATTCAATGTCAAAAATGTCTTACATGGCAGCATGTTGATTGCGCTGGAACAGAT
GGAAAAACTACTGACGATTATCATTGTATCAAATGTGTGCCTCGAGTTGTAGATTTAGAA
ATCATAAAGAAAGGTGAAACAACTGCTGATGGTTATCAATGCTATTTAACATTAATGAGA
GGCAATCTTCAGATTCGTGTTGGAGATGCAGTTTATGTATTAAGAGATATTCCAATAGAT
CCTAAAATTGTTGGTGGTCCAAGACATACATATGAGACAATTGGAAAAGTTAATTATGCC
GAATGTGACATTGTTCGAGTTGAGACTCTCTATAAAGATGCTAATGGACAATCAAAAGTT
CTTGGTCATCATTATTTACGGCCAAATGAAGTTTATCATGAACCTACAAGAAAGTTCTAC
ACAAATGAGCTCATGAGAACATCTATTTTTGAATCCATTCCCGTTGATCTTGTCATTGAT
ACATGTTGGGTGCTTGATCCAAATAATTATTTCAAAGGTCGACCAATTAATAGCATTGAA
GAACACGTATACATATGTGAATATAAAGTAGATAAACAAGCACGTGTGTTTAGTGTTACA
AAAAAGAGCAGTCGGCAGCCTATAAGCACCAAGCCGTATGCATTTTACAAATATGAAGAA
TTGCTGAGACAGCGTCGAAATCATTTGCCTCATGATATTGATCACGTAATACCAAAGAAA
TTAAAAAAAGAAATGCAAATGATAAAAAAAGAAGTGAGAACAAGCAGTGAAAGATCTTTG
ATAGACTCGTCAATTATATCTGTGGGAAAAGAACTCATTCATCATCAACCGATTTCAAAA
AAGATTGTTTCAGTGAAACAAAAAGCTGAAAATCTTGAAAATTGCATTAGCAAAATAAAA
TTTCCAACAACCTTTCATAAAAATATAAAGGATTCTCAAACTAACAACACTAAAGAAAAT
GAATTGAAACTGCAAAACAATGAGATTAAGCAAACAAAGGCAAATGCTAGCAGAAAAAAA
ATTCAAAAACGTGGTAGAAAAGGAAAGCGCTAA
>g11745.t1 Gene=g11745 Length=1570
MDTNTDQEDGCSSSDLDISNDINGCLKSLDDDIDGPSKHNISNNDNDESSSSSSSSSSSS
SSESSSSSSSKSSKTSSSHKKSSTKAKEKNTEIKYPFPSPTKIVATTDRVLYPARFNKKQ
QLVLEKTSSPSSTHKTQHRSRSRSRGPRVVRESGYRTDGSVSSDIKRRKSRAPSAPRSSI
VPIDLDLDLDVLQLNTEPSTSVKLTKKNVNLMARKNDTNNNNGNVLSSSKMRPLAMNLEL
NRRLLEHKMNLNGRSVPFSSSSCKLGFGLKSSQSFQELTATSKVMTPSWTANDEKNSKPV
KYAKSLSRIVMKSRRLSVTSRPASVRSATSTISRIRRAPTPATIRNNEYVLAQVVEVTAA
LAKCTISTPKTLKTQKVHHNRGSDSKNIQNHTAKKKKTATTVAKRRSKKTFDDNDTVPVA
EDHKLPLKKRHYLITEEKSCNVKRKRTKKSLQPPPSGIFEPTANVHDDETSPPSSFDVIN
MICPTISTDTKTKVFTKTSVVDNILTKLEPTVNRKKRRRANRTGFPTPKRPKKKIVNDNA
SDTSSVIKKSQRKRKFSQRDQDNEIQVMTARQLQLKQQKELELRLIEPKPEINRNMRGRA
KSVCHISESDLDSSLPPVKRKRRQTIFIDQKEEQKDAVQHKSNNRYFLNNLSEIKLNQAQ
VDDDKKIMIKKKRRQTIHSENISPLNETYQQLTHPHLNISSTIASKINKKSKIDVKKVPP
KLNESIPPVKLIPKNVYNGDTQKKAFVPSLKGTKCRCAPNLCGESCLNRSMFIECDVSIC
GKNCTNSVIQTGGLLNRDVEKFQTEYKGYGVRTKKNIKKKTLILEYTGEVLFKETFRQRM
QTIYKNDQHHYCLELSNGLVLDGHRMGSLCRFVNHSCKPNCSMAKIYVDGLPRMILQAEE
DIKAGTELNYDYKFDNFEDMTPQQCFCGADTCRGTLSAAQKTPRRMSLSFKDGEVVKKNG
RKSKTTSTIPKANSCFLMRNLRKVEKHHPGLIAYYQNLKNGIEEVDPKIGFSFVSKTHEN
SPPSLDQQLVDSQTSTKIEDEKEEKLKENNESEVPIIMNQPLSEQSQVLWQMCERLESSH
GEQIKKISIPPSPETGHSNHDRISLPVSFNDIKQNVKMGNYDLNPLLYHYHMKIMLDNVV
KFWGVNCEQFHTMNTIRDAYKIIRTEMIEEVKRIWEDELLVNAMMDKAVKKPAKNRKKVQ
EKNDDEDIVNCHCGRYLEEGLMIQCQKCLTWQHVDCAGTDGKTTDDYHCIKCVPRVVDLE
IIKKGETTADGYQCYLTLMRGNLQIRVGDAVYVLRDIPIDPKIVGGPRHTYETIGKVNYA
ECDIVRVETLYKDANGQSKVLGHHYLRPNEVYHEPTRKFYTNELMRTSIFESIPVDLVID
TCWVLDPNNYFKGRPINSIEEHVYICEYKVDKQARVFSVTKKSSRQPISTKPYAFYKYEE
LLRQRRNHLPHDIDHVIPKKLKKEMQMIKKEVRTSSERSLIDSSIISVGKELIHHQPISK
KIVSVKQKAENLENCISKIKFPTTFHKNIKDSQTNNTKENELKLQNNEIKQTKANASRKK
IQKRGRKGKR
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g11745.t1 | CDD | cd04717 | BAH_polybromo | 1282 | 1421 | 1.19103E-42 |
| 10 | g11745.t1 | Coils | Coil | Coil | 1535 | 1562 | - |
| 7 | g11745.t1 | Gene3D | G3DSA:2.170.270.10 | SET domain | 693 | 951 | 1.5E-63 |
| 9 | g11745.t1 | Gene3D | G3DSA:3.30.40.10 | Zinc/RING finger domain | 1199 | 1268 | 5.6E-14 |
| 8 | g11745.t1 | Gene3D | G3DSA:2.30.30.490 | - | 1269 | 1569 | 2.3E-37 |
| 18 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 27 | 98 | - |
| 22 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 39 | 79 | - |
| 26 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 122 | 177 | - |
| 23 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 372 | 411 | - |
| 28 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 377 | 391 | - |
| 19 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 511 | 562 | - |
| 24 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 512 | 529 | - |
| 17 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1017 | 1034 | - |
| 21 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1017 | 1050 | - |
| 27 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1035 | 1050 | - |
| 25 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1544 | 1570 | - |
| 20 | g11745.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1556 | 1570 | - |
| 3 | g11745.t1 | PANTHER | PTHR46147:SF3 | HISTONE-LYSINE N-METHYLTRANSFERASE ASH1 | 21 | 1558 | 3.3E-177 |
| 4 | g11745.t1 | PANTHER | PTHR46147 | HISTONE-LYSINE N-METHYLTRANSFERASE ASH1 | 21 | 1558 | 3.3E-177 |
| 1 | g11745.t1 | Pfam | PF00856 | SET domain | 808 | 912 | 1.4E-14 |
| 2 | g11745.t1 | Pfam | PF01426 | BAH domain | 1285 | 1419 | 8.2E-13 |
| 16 | g11745.t1 | ProSitePatterns | PS01359 | Zinc finger PHD-type signature. | 1211 | 1252 | - |
| 29 | g11745.t1 | ProSiteProfiles | PS51215 | AWS domain profile. | 750 | 793 | 10.5 |
| 31 | g11745.t1 | ProSiteProfiles | PS50280 | SET domain profile. | 797 | 913 | 15.281 |
| 32 | g11745.t1 | ProSiteProfiles | PS50868 | Post-SET domain profile. | 921 | 937 | 9.314 |
| 30 | g11745.t1 | ProSiteProfiles | PS51038 | BAH domain profile. | 1283 | 1421 | 14.734 |
| 14 | g11745.t1 | SMART | SM00570 | shorttest3 | 750 | 794 | 0.0084 |
| 15 | g11745.t1 | SMART | SM00317 | set_7 | 797 | 919 | 5.4E-33 |
| 12 | g11745.t1 | SMART | SM00249 | PHD_3 | 1210 | 1253 | 1.6E-6 |
| 13 | g11745.t1 | SMART | SM00439 | BAH_4 | 1283 | 1421 | 1.7E-20 |
| 5 | g11745.t1 | SUPERFAMILY | SSF82199 | SET domain | 727 | 934 | 1.44E-52 |
| 6 | g11745.t1 | SUPERFAMILY | SSF57903 | FYVE/PHD zinc finger | 1202 | 1257 | 4.65E-12 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005634 | nucleus | CC |
| GO:0005515 | protein binding | MF |
| GO:0003682 | chromatin binding | MF |
| GO:0018024 | histone-lysine N-methyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K06101 ([histone H3]-lysine4 N-trimethyltransferase ASH1L)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
