General information for g11762.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Dual specificity protein kinase TTK.
Parent gene
- The parent gene g11762 is located on chr_1: 18273912..18275105 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11762 | g11762.t1 | TSS | g11762.t1 | 18273612 | 18273612 |
| chr_1 | g11762 | g11762.t1 | isoform | g11762.t1 | 18273673 | 18275085 |
| chr_1 | g11762 | g11762.t1 | exon | g11762.t1.exon1 | 18273673 | 18273770 |
| chr_1 | g11762 | g11762.t1 | cds | g11762.t1.CDS1 | 18273673 | 18273770 |
| chr_1 | g11762 | g11762.t1 | exon | g11762.t1.exon2 | 18273830 | 18273904 |
| chr_1 | g11762 | g11762.t1 | cds | g11762.t1.CDS2 | 18273830 | 18273904 |
| chr_1 | g11762 | g11762.t1 | exon | g11762.t1.exon3 | 18273966 | 18275085 |
| chr_1 | g11762 | g11762.t1 | cds | g11762.t1.CDS3 | 18273966 | 18275085 |
| chr_1 | g11762 | g11762.t1 | TTS | g11762.t1 | 18275217 | 18275217 |
Sequences
>g11762.t1 Gene=g11762 Length=1293
ATGTCATTATTTTTTCCCAAACGCATAAGTGAATTAACAACAATTGATTCAGATCTTGAA
ACTCCAGAAAAATCAAAAAACAAAAACTCAACAAGGAATACAGCTATCTTTCCAAAAAGA
ATTAATGATATCAAAGAATCAGATTCTGAGAATGATGAAGAAGAAGAAGACAAATTAAAT
TGTGCGATACTAAATGACTCTTTTGTGCTAACAATTGAGAATCTTTCAACAATTGAGAAA
GATCCCACGAAGCAACCTATGATGCAACAGCAGCAACCTAAAATTCTTTTTCGAACGCCT
ATTACCAGACCATTTCCTTCATCTTCCATAATTGGATCGCAATTAGATCCAAAGCTACTC
TCTTCAATTCAGAAAATGTCATCTATTAAAGAGTCAATTATTAGAGAGAAACCAAAGGAA
AACTGTATAATTATCAACAAAATTGAGTATGAAATTGATAAAAAAATTGGTGCTGGTGGT
TCATCAACAGTTTTCCTCGCTCGAGGTTGTAAATCAGGAAAAGAATGTGCTATAAAATTG
GTAAATTTAGATGGAGATCCACAAGTTATTGAAGGATATTTAAATGAAACAAAGCTTCTC
GCAAGGCTGCAAGGCAATATTAATGTAATTGCATTGTACGACTATTGTCATTTGCCAGAT
AAGAAAATTCTTTACATGGTAATGGAAAAAGGAGAATCAGATCTACATAAAATATTGCAA
AAATACACTTCACATATACCTTTATTTACGTTAATGAATTATTGGCATCAAATGTTGCAA
GCAGTGAATTTTATTCATGAGAATGGAATAATTCATAGTGATTTGAAACCTGCTAATTTT
TTGGCTGTAGGTGATAGGTTAAAATTAATTGATTTCGGAATTGCTTCAAGTATTGCAATT
GATTCTACATCAATAATTAAATTCTCACAGGCAGGAACTTTCAATTATATTTCACCTGAA
GCACTTATTGATACATCAAACGAAGATAGTCCATCTACACATCAACCGAAAATTCGACTT
TCAACAAAATCAGATGTATGGTCACTCGGTTGCATTTTGTATTTGCTTCTTTACATGAAA
ACTCCATTTTCCCATATTAAGAATCTACATCAAAAAATTCAAGCTATAACGAATCCTCAA
ACAACAATAAACTATCCTACATTACCGAATTATTATCCTGAAATGTTACTTTGTATGCTG
AAAAAATGTTTAATTCATAATCCAAAAGAGCGTTCATCTGTATCCGATCTTCTTAAATAT
CCTTTTCATATGATTATTCCTGTAGAACAATAG
>g11762.t1 Gene=g11762 Length=430
MSLFFPKRISELTTIDSDLETPEKSKNKNSTRNTAIFPKRINDIKESDSENDEEEEDKLN
CAILNDSFVLTIENLSTIEKDPTKQPMMQQQQPKILFRTPITRPFPSSSIIGSQLDPKLL
SSIQKMSSIKESIIREKPKENCIIINKIEYEIDKKIGAGGSSTVFLARGCKSGKECAIKL
VNLDGDPQVIEGYLNETKLLARLQGNINVIALYDYCHLPDKKILYMVMEKGESDLHKILQ
KYTSHIPLFTLMNYWHQMLQAVNFIHENGIIHSDLKPANFLAVGDRLKLIDFGIASSIAI
DSTSIIKFSQAGTFNYISPEALIDTSNEDSPSTHQPKIRLSTKSDVWSLGCILYLLLYMK
TPFSHIKNLHQKIQAITNPQTTINYPTLPNYYPEMLLCMLKKCLIHNPKERSSVSDLLKY
PFHMIIPVEQ
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 5 | g11762.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 143 | 232 | 1.1E-19 |
| 6 | g11762.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 233 | 425 | 3.6E-44 |
| 12 | g11762.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 16 | 57 | - |
| 2 | g11762.t1 | PANTHER | PTHR22974 | MIXED LINEAGE PROTEIN KINASE | 50 | 422 | 3.9E-114 |
| 3 | g11762.t1 | PANTHER | PTHR22974:SF21 | DUAL SPECIFICITY PROTEIN KINASE TTK | 50 | 422 | 3.9E-114 |
| 1 | g11762.t1 | Pfam | PF00069 | Protein kinase domain | 150 | 422 | 1.5E-51 |
| 8 | g11762.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 345 | - |
| 9 | g11762.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 346 | 363 | - |
| 7 | g11762.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 364 | 430 | - |
| 10 | g11762.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 156 | 179 | - |
| 13 | g11762.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 150 | 423 | 39.241 |
| 11 | g11762.t1 | SMART | SM00220 | serkin_6 | 150 | 423 | 6.0E-64 |
| 4 | g11762.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 149 | 423 | 5.13E-65 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0007093 | mitotic cell cycle checkpoint signaling | BP |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | MF |
| GO:0051304 | chromosome separation | BP |
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K08866 (serine/threonine-protein kinase TTK/MPS1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
