General information for g11762.t46
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Dual specificity protein kinase TTK.
Parent gene
- The parent gene g11762 is located on chr_1: 18273912..18275105 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11762 | g11762.t46 | TSS | g11762.t46 | 18273612 | 18273612 |
| chr_1 | g11762 | g11762.t46 | isoform | g11762.t46 | 18273673 | 18275085 |
| chr_1 | g11762 | g11762.t46 | exon | g11762.t46.exon1 | 18273673 | 18273904 |
| chr_1 | g11762 | g11762.t46 | exon | g11762.t46.exon2 | 18273966 | 18275085 |
| chr_1 | g11762 | g11762.t46 | cds | g11762.t46.CDS1 | 18274051 | 18275085 |
| chr_1 | g11762 | g11762.t46 | TTS | g11762.t46 | 18275217 | 18275217 |
Sequences
>g11762.t46 Gene=g11762 Length=1352
ATGTCATTATTTTTTCCCAAACGCATAAGTGAATTAACAACAATTGATTCAGATCTTGAA
ACTCCAGAAAAATCAAAAAACAAAAACTCAACAAGGAAGTATGTAAAACAAAATACGATA
CTTTTTAGAAATCACAAATATTAAATTTAAATTTCAGTACAGCTATCTTTCCAAAAAGAA
TTAATGATATCAAAGAATCAGATTCTGAGAATGATGAAGAAGAAGAAGACAAATTAAATT
GTGCGATACTAAATGACTCTTTTGTGCTAACAATTGAGAATCTTTCAACAATTGAGAAAG
ATCCCACGAAGCAACCTATGATGCAACAGCAGCAACCTAAAATTCTTTTTCGAACGCCTA
TTACCAGACCATTTCCTTCATCTTCCATAATTGGATCGCAATTAGATCCAAAGCTACTCT
CTTCAATTCAGAAAATGTCATCTATTAAAGAGTCAATTATTAGAGAGAAACCAAAGGAAA
ACTGTATAATTATCAACAAAATTGAGTATGAAATTGATAAAAAAATTGGTGCTGGTGGTT
CATCAACAGTTTTCCTCGCTCGAGGTTGTAAATCAGGAAAAGAATGTGCTATAAAATTGG
TAAATTTAGATGGAGATCCACAAGTTATTGAAGGATATTTAAATGAAACAAAGCTTCTCG
CAAGGCTGCAAGGCAATATTAATGTAATTGCATTGTACGACTATTGTCATTTGCCAGATA
AGAAAATTCTTTACATGGTAATGGAAAAAGGAGAATCAGATCTACATAAAATATTGCAAA
AATACACTTCACATATACCTTTATTTACGTTAATGAATTATTGGCATCAAATGTTGCAAG
CAGTGAATTTTATTCATGAGAATGGAATAATTCATAGTGATTTGAAACCTGCTAATTTTT
TGGCTGTAGGTGATAGGTTAAAATTAATTGATTTCGGAATTGCTTCAAGTATTGCAATTG
ATTCTACATCAATAATTAAATTCTCACAGGCAGGAACTTTCAATTATATTTCACCTGAAG
CACTTATTGATACATCAAACGAAGATAGTCCATCTACACATCAACCGAAAATTCGACTTT
CAACAAAATCAGATGTATGGTCACTCGGTTGCATTTTGTATTTGCTTCTTTACATGAAAA
CTCCATTTTCCCATATTAAGAATCTACATCAAAAAATTCAAGCTATAACGAATCCTCAAA
CAACAATAAACTATCCTACATTACCGAATTATTATCCTGAAATGTTACTTTGTATGCTGA
AAAAATGTTTAATTCATAATCCAAAAGAGCGTTCATCTGTATCCGATCTTCTTAAATATC
CTTTTCATATGATTATTCCTGTAGAACAATAG
>g11762.t46 Gene=g11762 Length=344
MMQQQQPKILFRTPITRPFPSSSIIGSQLDPKLLSSIQKMSSIKESIIREKPKENCIIIN
KIEYEIDKKIGAGGSSTVFLARGCKSGKECAIKLVNLDGDPQVIEGYLNETKLLARLQGN
INVIALYDYCHLPDKKILYMVMEKGESDLHKILQKYTSHIPLFTLMNYWHQMLQAVNFIH
ENGIIHSDLKPANFLAVGDRLKLIDFGIASSIAIDSTSIIKFSQAGTFNYISPEALIDTS
NEDSPSTHQPKIRLSTKSDVWSLGCILYLLLYMKTPFSHIKNLHQKIQAITNPQTTINYP
TLPNYYPEMLLCMLKKCLIHNPKERSSVSDLLKYPFHMIIPVEQ
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g11762.t46 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 57 | 146 | 7.2E-20 |
| 8 | g11762.t46 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 147 | 339 | 2.1E-44 |
| 2 | g11762.t46 | PANTHER | PTHR22974 | MIXED LINEAGE PROTEIN KINASE | 47 | 336 | 4.4E-113 |
| 3 | g11762.t46 | PANTHER | PTHR22974:SF21 | DUAL SPECIFICITY PROTEIN KINASE TTK | 47 | 336 | 4.4E-113 |
| 1 | g11762.t46 | Pfam | PF00069 | Protein kinase domain | 64 | 336 | 7.3E-52 |
| 6 | g11762.t46 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 70 | 93 | - |
| 9 | g11762.t46 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 64 | 337 | 39.241 |
| 5 | g11762.t46 | SMART | SM00220 | serkin_6 | 64 | 337 | 6.0E-64 |
| 4 | g11762.t46 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 63 | 337 | 2.43E-65 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0007093 | mitotic cell cycle checkpoint signaling | BP |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | MF |
| GO:0051304 | chromosome separation | BP |
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K08866 (serine/threonine-protein kinase TTK/MPS1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
