General information for g11834.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as cAMP-dependent protein kinase type II regulatory subunit.
Parent gene
- The parent gene g11834 is located on chr_1: 18676446..18678716 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11834 | g11834.t3 | isoform | g11834.t3 | 18671600 | 18678716 |
| chr_1 | g11834 | g11834.t3 | exon | g11834.t3.exon1 | 18671600 | 18671999 |
| chr_1 | g11834 | g11834.t3 | TSS | g11834.t3 | 18671608 | 18671608 |
| chr_1 | g11834 | g11834.t3 | exon | g11834.t3.exon2 | 18676361 | 18676659 |
| chr_1 | g11834 | g11834.t3 | cds | g11834.t3.CDS1 | 18676446 | 18676659 |
| chr_1 | g11834 | g11834.t3 | exon | g11834.t3.exon3 | 18676875 | 18677062 |
| chr_1 | g11834 | g11834.t3 | cds | g11834.t3.CDS2 | 18676875 | 18677062 |
| chr_1 | g11834 | g11834.t3 | exon | g11834.t3.exon4 | 18677264 | 18677364 |
| chr_1 | g11834 | g11834.t3 | cds | g11834.t3.CDS3 | 18677264 | 18677364 |
| chr_1 | g11834 | g11834.t3 | exon | g11834.t3.exon5 | 18677502 | 18677827 |
| chr_1 | g11834 | g11834.t3 | cds | g11834.t3.CDS4 | 18677502 | 18677827 |
| chr_1 | g11834 | g11834.t3 | exon | g11834.t3.exon6 | 18677896 | 18678078 |
| chr_1 | g11834 | g11834.t3 | cds | g11834.t3.CDS5 | 18677896 | 18678078 |
| chr_1 | g11834 | g11834.t3 | exon | g11834.t3.exon7 | 18678144 | 18678716 |
| chr_1 | g11834 | g11834.t3 | cds | g11834.t3.CDS6 | 18678144 | 18678274 |
| chr_1 | g11834 | g11834.t3 | TTS | g11834.t3 | 18678712 | 18678712 |
Sequences
>g11834.t3 Gene=g11834 Length=2070
GGGGAAGACAGTAGAAATCGCGTTTAAAAAGTTTCAAGAGGAAATTTTTTTCACTATAAT
ATTTAATGATTTTTTATCGGAAAAATCTTTTTTCGGTTTAATTAGTGAATTTAGTTTGAT
AGCCAGCAGTGGCTATAAGCGATAAAAATCGAAAGTGAAAAATTTTGAGAGCAAATTGTG
CGAGAAAAAATATTTTAAAAATTTCCTGATGGAAAATTAAAATCGAAAAAAAATCGAAGA
GAGTGAGAGTAGAAGCAAAAAAATTAGTCAAAGTGTATAAATTGTGAGAAAATTTAATTT
GAACCATTTGGCATTAAAATTATATCTGAAGTGCTTCACGCCATCGGAACAATCAAAAAA
GTGTGATCTAATTGATAAAAATATCCATATATTTAATAAACATATCGCACAATAAATAAC
TAGGTAAAATAACATCAAAAGCATATAGTTTAGTAAAAAGTGAAAATAATTTCGCTAAAA
GCATCATGTCAAAACAGAAAGTGAAAGTTCCCGATAGCCTTCGAGATGTTTTATTAGAAT
TCTCAATTGCTTACTTGCTTGAACAGCCTGGCGATGTAATTGACTTTGCAGTTGATTTCT
TTACAAAGCTTCAAACAAATCGAGCACAAACAGGGATAAGCATCGGATCAAATCAAAAAC
CAACTACACCAGATGAGAGTATCATTTCACAAGATGAAGAACCTGTTGTTAATCGCTTTG
CTGCGGGTCGACGAAAGTCTGTTTTTGCCGAACAGTATGATCCCGAGGAGGATAACGACG
ATGAAGATAATAACAAGGTCATATTCCCAAAGACAGATGAACAACGTGCCCGCCTTTGTG
ATTCGGTGAAAAATATTTTGCTCTTCCGTGCACTTGATCCAGAGCAGATGAATGAAATTC
TTGACGCAATGTTTGAGAAGAAAGTGAGACCCGATGATACGATTATTCGACAGGGCGACG
ACGGAGATAATTTTTACGTCATTGAGTCTGGAATCTATAATGCTTATGTTGGTGAAGATA
ACAAACATGTGCATACATATGAAAATCGTGGTTCATTTGGAGAATTAGCTTTGCTATACA
ATATGCCACGTGCAGCAACTATTCGAGCAGTAACTGATGGTCAACTGTGGGCATTAGATC
GTCAAACATTCCGACGAATTCTTCTCAAATCAGCATTCAGAAAAAGAAAAATGTACGAAA
CACTCATTAATAGTGTGCCAATGCTTAAAGCTTTACAAAATTATGAACGAATGAATTTGG
CGGATGCTTTAATTCCAAAAGTTTATCAAGAAGGTGAACAAATTATTAAGCAGGGTGATG
CTGCTGACGGTATGTACTTCATTGAGGAAGGAACTGTTTCAATTAAAATTCATCAAGATG
GTGGTGAAACAGAAATTTCAAAATTAGAGAAAGGACAATACTTTGGTGAATTGGCTTTAG
TAACACATAGACCACGCGCTGCATCTGCATATGCTCAAAATACTGTGAAAGTTGCATTTA
TTGATGTTGAAGCATTTGAGCGCTTACTGGGTCCATGCATGGATATTATGAAGCGAAATA
TTGATGATTATGAATCACAGTTATTGAAAATATTTGGCAGCAAATCGAATATTGCCGACA
TTCGATAAAGCGATTTGGTGAAATATATATAAACAAGACGTAAAAACTACAACTCGATTT
ACGATACTGCAAGACAGCAACAAAACAAAATTATAAAAAAATGTGAAAAATTTATTTAAA
AAGCAAATTGAAGAAAATCACAAGTCTTTACATGAATTATTATAATGTGTTCTCGCTGGC
ATTGAACACTAAAAATTGAAATTATATATTTATTTATTTACATAAATGAGACGAAAGAAA
AGCATTGAGAAGAAAATTTGAAAAAAATTTAGTTATGAATTTTTTCATTATACATACATA
CAATACATAGACATATGTTCGCAATATTCATCAAAAAATAATTGAAAATTATCTAGTGAA
AAAAAATCAATATCTAATTTTGATGTGAAATTTAATAGTTTTAACAAGAAGAAAACTGAA
ATAATAGATATTTTAAGAACAACTCCTAAA
>g11834.t3 Gene=g11834 Length=380
MSKQKVKVPDSLRDVLLEFSIAYLLEQPGDVIDFAVDFFTKLQTNRAQTGISIGSNQKPT
TPDESIISQDEEPVVNRFAAGRRKSVFAEQYDPEEDNDDEDNNKVIFPKTDEQRARLCDS
VKNILLFRALDPEQMNEILDAMFEKKVRPDDTIIRQGDDGDNFYVIESGIYNAYVGEDNK
HVHTYENRGSFGELALLYNMPRAATIRAVTDGQLWALDRQTFRRILLKSAFRKRKMYETL
INSVPMLKALQNYERMNLADALIPKVYQEGEQIIKQGDAADGMYFIEEGTVSIKIHQDGG
ETEISKLEKGQYFGELALVTHRPRAASAYAQNTVKVAFIDVEAFERLLGPCMDIMKRNID
DYESQLLKIFGSKSNIADIR
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 18 | g11834.t3 | CDD | cd00038 | CAP_ED | 126 | 237 | 4.58114E-33 |
| 17 | g11834.t3 | CDD | cd00038 | CAP_ED | 246 | 359 | 1.77237E-30 |
| 13 | g11834.t3 | Gene3D | G3DSA:1.20.890.10 | - | 4 | 47 | 9.2E-14 |
| 14 | g11834.t3 | Gene3D | G3DSA:2.60.120.10 | Jelly Rolls | 85 | 227 | 1.7E-53 |
| 15 | g11834.t3 | Gene3D | G3DSA:2.60.120.10 | Jelly Rolls | 228 | 372 | 8.2E-51 |
| 3 | g11834.t3 | PANTHER | PTHR11635 | CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN | 5 | 375 | 2.1E-170 |
| 4 | g11834.t3 | PANTHER | PTHR11635:SF162 | CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT | 5 | 375 | 2.1E-170 |
| 16 | g11834.t3 | PIRSF | PIRSF000548 | PK_regulatory | 28 | 376 | 1.0E-135 |
| 5 | g11834.t3 | PRINTS | PR00103 | cAMP-dependent protein kinase signature | 147 | 161 | 1.0E-24 |
| 9 | g11834.t3 | PRINTS | PR00103 | cAMP-dependent protein kinase signature | 162 | 176 | 1.0E-24 |
| 7 | g11834.t3 | PRINTS | PR00103 | cAMP-dependent protein kinase signature | 311 | 320 | 1.0E-24 |
| 8 | g11834.t3 | PRINTS | PR00103 | cAMP-dependent protein kinase signature | 323 | 334 | 1.0E-24 |
| 6 | g11834.t3 | PRINTS | PR00103 | cAMP-dependent protein kinase signature | 344 | 356 | 1.0E-24 |
| 2 | g11834.t3 | Pfam | PF00027 | Cyclic nucleotide-binding domain | 145 | 227 | 3.4E-20 |
| 1 | g11834.t3 | Pfam | PF00027 | Cyclic nucleotide-binding domain | 265 | 348 | 1.3E-21 |
| 25 | g11834.t3 | ProSitePatterns | PS00888 | Cyclic nucleotide-binding domain signature 1. | 153 | 169 | - |
| 22 | g11834.t3 | ProSitePatterns | PS00889 | Cyclic nucleotide-binding domain signature 2. | 191 | 208 | - |
| 24 | g11834.t3 | ProSitePatterns | PS00888 | Cyclic nucleotide-binding domain signature 1. | 273 | 289 | - |
| 23 | g11834.t3 | ProSitePatterns | PS00889 | Cyclic nucleotide-binding domain signature 2. | 313 | 330 | - |
| 27 | g11834.t3 | ProSiteProfiles | PS50042 | cAMP/cGMP binding motif profile. | 126 | 243 | 39.431 |
| 26 | g11834.t3 | ProSiteProfiles | PS50042 | cAMP/cGMP binding motif profile. | 246 | 365 | 37.84 |
| 19 | g11834.t3 | SMART | SM00394 | akam_3 | 10 | 47 | 0.0027 |
| 21 | g11834.t3 | SMART | SM00100 | cnmp_10 | 126 | 244 | 6.4E-27 |
| 20 | g11834.t3 | SMART | SM00100 | cnmp_10 | 246 | 363 | 3.4E-28 |
| 12 | g11834.t3 | SUPERFAMILY | SSF47391 | Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 3 | 46 | 9.94E-10 |
| 10 | g11834.t3 | SUPERFAMILY | SSF51206 | cAMP-binding domain-like | 108 | 229 | 5.76E-34 |
| 11 | g11834.t3 | SUPERFAMILY | SSF51206 | cAMP-binding domain-like | 240 | 367 | 4.84E-32 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0001932 | regulation of protein phosphorylation | BP |
| GO:0008603 | cAMP-dependent protein kinase regulator activity | MF |
| GO:0005952 | cAMP-dependent protein kinase complex | CC |
KEGG
Orthology
- This transcript has been annotated with K04739 (cAMP-dependent protein kinase regulator)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
