General information for g11913.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cytochrome P450 4g1.
Parent gene
- The parent gene g11913 is located on chr_1: 19257262..19259924 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g11913 | g11913.t1 | TSS | g11913.t1 | 19257170 | 19257170 |
| chr_1 | g11913 | g11913.t1 | isoform | g11913.t1 | 19257262 | 19259612 |
| chr_1 | g11913 | g11913.t1 | exon | g11913.t1.exon1 | 19257262 | 19257463 |
| chr_1 | g11913 | g11913.t1 | cds | g11913.t1.CDS1 | 19257262 | 19257463 |
| chr_1 | g11913 | g11913.t1 | exon | g11913.t1.exon2 | 19257526 | 19257690 |
| chr_1 | g11913 | g11913.t1 | cds | g11913.t1.CDS2 | 19257526 | 19257690 |
| chr_1 | g11913 | g11913.t1 | exon | g11913.t1.exon3 | 19257748 | 19258033 |
| chr_1 | g11913 | g11913.t1 | cds | g11913.t1.CDS3 | 19257748 | 19258033 |
| chr_1 | g11913 | g11913.t1 | exon | g11913.t1.exon4 | 19258092 | 19258536 |
| chr_1 | g11913 | g11913.t1 | cds | g11913.t1.CDS4 | 19258092 | 19258536 |
| chr_1 | g11913 | g11913.t1 | exon | g11913.t1.exon5 | 19259031 | 19259612 |
| chr_1 | g11913 | g11913.t1 | cds | g11913.t1.CDS5 | 19259031 | 19259612 |
| chr_1 | g11913 | g11913.t1 | TTS | g11913.t1 | 19259913 | 19259913 |
Sequences
>g11913.t1 Gene=g11913 Length=1680
ATGGCTGTGGAACAAATTGTTCAAAGCAGCATTTTAACATCGCCGCTCGTCCTTCCACTT
TTGGCAATTGCTTTTGTTCTCACAGCAATTCATTTTTGGCAAATGTCAAGAAGACAAAGG
AAAATTGGAGATTTAATTCCTGGTCCGCCAACTATCCCAATTGTAGGAAATGCTCATTTT
TTCTTAAATCTCACAAATCATGAAATGTTTGGCAAAGCGCTTGACATTGTGAATAGTTAT
GGTCATGTCGTTCGTGGTTGGGTTGGTCATAAACTTATAGTTGGACTCTCAGATCCACGT
GATGTTGAATTAATCCTCGGAAGTCATGTTCATATTGATAAATCTGATGAATATAGATTC
TTTAAAGATTGGTTAGGCAATGGATTATTAATTTCAACTGGTGAAAAATGGAGAACTCAT
AGAAAACTTATTGCGCCAGCTTTTCATATGAATGTTCTTAAAAGTTTTATGCCAACATTT
AATGATAACAGTCGATTTGTAATAAAAAAACTCATGAAAGAAGTTGGAAAAGAATTTGAT
TGTCATGATTATATGAGTGAAGCAACTGTTGATATTTTGCTTGAAACAGCAATGGGTTCA
AAAAGAACAAGCGAAAGCGAAGAAGGTTTCAAATATGCAATGGCTGTAATGAAAATGTGC
GACATTCTTCATAAACGTCAATTCAAAATTTTCTCACGCTTTGAGCCTTTCTTCACACTC
ACTGGAATGCGTGAGCAACAAAAGAAATTGCTCGGAATTATTCATGGAATGACACAACGT
GTTTTAAATGAGAAAAAAGATATTTTTGACAAAAATTTAGCAGAAGGAAATTTGCCTTCA
CCTTCTTTGGCTGAAATTATCAAAAATGATGAACAAGTCGATCAAGCAGTTAAAAAAGCA
AAAGCAAAAGCTACTGGACTTCGTGATGATCTCGATGATATTGATGAAAATGATGTAGGA
GAAAAACGAAGATTGGCATTTTTAGATCTTATGATTGAGACATCACATTATAATCCAACA
CAATTATCAAAGGATGAGATTAAGCAGCAAGTGGATACAATCATGTTTGAGGGCCATGAC
ACTTCGGAAAGTTCCACAGCTGCAGGTTCAAGCTTCACACTCTGCATGCTTGGTTGTCAT
CCTGATATTCAAGAAAAAGTTTATGCAGAACAGAAAGCAATCTTTGGTGATTCTGATCGT
GATTGTACCTTTGCTGATACTTTAGAAATGAAATATTTAGAAAGAGTGATTTTTGAAACA
CTAAGATTGTATCCTCCAGTACCATTGATTGCTAGAAAAATCAACCAAGACTTGAAACTT
GCTTCAGTTGACTATGTAATTCCTTCGGGTACAACAATTATTATTGGCACTTACAAAATT
CACCGTAGACCTGATATTTATAATAACCCTGAGAAATTTGATCCTGATAACTTTTTACCA
GAAAGAACTGCAAATCGTCATTATTACAGTTATATTCCTTTCTCAGCTGGACCTCGAAGT
TGTGTCGGACGCAAATATGCGATGCTTAAATTAAAAGTGTTGCTCAGTACAATTATTAGA
AACTTCCATGTTTATAGCACTGTACAAGAGAAAGATTTCAAATTACAAGGCGACATTATC
CTCAAGAGGACTGACGGTTTCCGAATTAAACTTGAGCAACGAAAGACAAAGGCCACATAA
>g11913.t1 Gene=g11913 Length=559
MAVEQIVQSSILTSPLVLPLLAIAFVLTAIHFWQMSRRQRKIGDLIPGPPTIPIVGNAHF
FLNLTNHEMFGKALDIVNSYGHVVRGWVGHKLIVGLSDPRDVELILGSHVHIDKSDEYRF
FKDWLGNGLLISTGEKWRTHRKLIAPAFHMNVLKSFMPTFNDNSRFVIKKLMKEVGKEFD
CHDYMSEATVDILLETAMGSKRTSESEEGFKYAMAVMKMCDILHKRQFKIFSRFEPFFTL
TGMREQQKKLLGIIHGMTQRVLNEKKDIFDKNLAEGNLPSPSLAEIIKNDEQVDQAVKKA
KAKATGLRDDLDDIDENDVGEKRRLAFLDLMIETSHYNPTQLSKDEIKQQVDTIMFEGHD
TSESSTAAGSSFTLCMLGCHPDIQEKVYAEQKAIFGDSDRDCTFADTLEMKYLERVIFET
LRLYPPVPLIARKINQDLKLASVDYVIPSGTTIIIGTYKIHRRPDIYNNPEKFDPDNFLP
ERTANRHYYSYIPFSAGPRSCVGRKYAMLKLKVLLSTIIRNFHVYSTVQEKDFKLQGDII
LKRTDGFRIKLEQRKTKAT
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g11913.t1 | Coils | Coil | Coil | 297 | 317 | - |
| 2 | g11913.t1 | PANTHER | PTHR24291:SF106 | CYTOCHROME P450 4G1-RELATED | 9 | 553 | 4.8E-258 |
| 3 | g11913.t1 | PANTHER | PTHR24291 | CYTOCHROME P450 FAMILY 4 | 9 | 553 | 4.8E-258 |
| 6 | g11913.t1 | PRINTS | PR00463 | E-class P450 group I signature | 77 | 96 | 4.2E-21 |
| 5 | g11913.t1 | PRINTS | PR00463 | E-class P450 group I signature | 370 | 396 | 4.2E-21 |
| 13 | g11913.t1 | PRINTS | PR00385 | P450 superfamily signature | 379 | 392 | 2.9E-9 |
| 4 | g11913.t1 | PRINTS | PR00463 | E-class P450 group I signature | 414 | 432 | 4.2E-21 |
| 11 | g11913.t1 | PRINTS | PR00385 | P450 superfamily signature | 415 | 426 | 2.9E-9 |
| 8 | g11913.t1 | PRINTS | PR00463 | E-class P450 group I signature | 456 | 480 | 4.2E-21 |
| 7 | g11913.t1 | PRINTS | PR00463 | E-class P450 group I signature | 491 | 501 | 4.2E-21 |
| 12 | g11913.t1 | PRINTS | PR00385 | P450 superfamily signature | 492 | 501 | 2.9E-9 |
| 9 | g11913.t1 | PRINTS | PR00463 | E-class P450 group I signature | 501 | 524 | 4.2E-21 |
| 10 | g11913.t1 | PRINTS | PR00385 | P450 superfamily signature | 501 | 512 | 2.9E-9 |
| 1 | g11913.t1 | Pfam | PF00067 | Cytochrome P450 | 47 | 549 | 2.0E-100 |
| 17 | g11913.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 11 | - |
| 18 | g11913.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 12 | 33 | - |
| 16 | g11913.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 34 | 559 | - |
| 20 | g11913.t1 | ProSitePatterns | PS00086 | Cytochrome P450 cysteine heme-iron ligand signature. | 494 | 503 | - |
| 14 | g11913.t1 | SUPERFAMILY | SSF48264 | Cytochrome P450 | 46 | 554 | 3.27E-108 |
| 19 | g11913.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 12 | 34 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0020037 | heme binding | MF |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | MF |
| GO:0005506 | iron ion binding | MF |
| GO:0055114 | NA | NA |
KEGG
Orthology
- This transcript has been annotated with K15001 (cytochrome P450 family 4 [EC:1.14.-.-])
Pathway
This gene does not belong to any pathways.
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed