General information for g12044.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Tyramine beta-hydroxylase.
Parent gene
- The parent gene g12044 is located on chr_1: 20645917..20647558 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12044 | g12044.t1 | isoform | g12044.t1 | 20642856 | 20645917 |
| chr_1 | g12044 | g12044.t1 | exon | g12044.t1.exon1 | 20642856 | 20642931 |
| chr_1 | g12044 | g12044.t1 | cds | g12044.t1.CDS1 | 20642856 | 20642931 |
| chr_1 | g12044 | g12044.t1 | exon | g12044.t1.exon2 | 20645035 | 20645261 |
| chr_1 | g12044 | g12044.t1 | cds | g12044.t1.CDS2 | 20645035 | 20645261 |
| chr_1 | g12044 | g12044.t1 | exon | g12044.t1.exon3 | 20645555 | 20645681 |
| chr_1 | g12044 | g12044.t1 | cds | g12044.t1.CDS3 | 20645555 | 20645681 |
| chr_1 | g12044 | g12044.t1 | exon | g12044.t1.exon4 | 20645751 | 20645917 |
| chr_1 | g12044 | g12044.t1 | cds | g12044.t1.CDS4 | 20645751 | 20645917 |
| chr_1 | g12044 | g12044.t1 | TSS | g12044.t1 | NA | NA |
| chr_1 | g12044 | g12044.t1 | TTS | g12044.t1 | NA | NA |
Sequences
>g12044.t1 Gene=g12044 Length=597
ATGATTGTGGTTATAGCTCTACTAATGTGTCTTGCGGTCATTTGCGATGGGAAATTTCAT
AGACATCGAGTCCCAAATATCACACCAAACCAAATGCACCAGATTACTTTAGATCCCGTT
GAAAAAGTAAAACTCACTTGGATGGTAGATTGGCCAGAGAAGAATGTTTTCTTTCAAGTG
AAAAATGGCATCAATGACAAATTTAGCTGGTTTGCAGTGGGATTTTCTCGTCGCGGTGAT
TTTGCTCGAACTGACTTTTGCATATTTCAAAAGGAGGAGAACGACAGAATCGATACTAAT
ATTGATGCTTGGTCGAGTAAAGATGGTCGAGAAATTATTATCGATCGACAGCAAGATTGT
ATAAGTATAGCTCGAACGAACAAAGATGAAATTGCATTTAGGAGAAAATTTGACACTTGC
GACGAGGAAGATTTTAATTTTCACGAGGGAACAATGTTTATATATTGGATGCGAGGCGAA
GAACCATTAGATTTCGTAGATGAAAGTATACCAATGCCTGATTTGTCTGAGGAAAACTTT
GGAATGTCACACGTGCAGCTATTAAGAGCTGATTCCATAAGTATACCAGAAAAGTAA
>g12044.t1 Gene=g12044 Length=198
MIVVIALLMCLAVICDGKFHRHRVPNITPNQMHQITLDPVEKVKLTWMVDWPEKNVFFQV
KNGINDKFSWFAVGFSRRGDFARTDFCIFQKEENDRIDTNIDAWSSKDGREIIIDRQQDC
ISIARTNKDEIAFRRKFDTCDEEDFNFHEGTMFIYWMRGEEPLDFVDESIPMPDLSEENF
GMSHVQLLRADSISIPEK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g12044.t1 | CDD | cd09631 | DOMON_DOH | 35 | 165 | 1.26336E-15 |
| 2 | g12044.t1 | PANTHER | PTHR10157 | DOPAMINE BETA HYDROXYLASE RELATED | 28 | 194 | 1.9E-33 |
| 3 | g12044.t1 | PANTHER | PTHR10157:SF29 | DOPAMINE BETA-HYDROXYLASE | 28 | 194 | 1.9E-33 |
| 1 | g12044.t1 | Pfam | PF03351 | DOMON domain | 42 | 159 | 1.6E-16 |
| 8 | g12044.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 17 | - |
| 9 | g12044.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 1 | - |
| 10 | g12044.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 2 | 13 | - |
| 11 | g12044.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 14 | 17 | - |
| 7 | g12044.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 18 | 198 | - |
| 6 | g12044.t1 | ProSiteProfiles | PS50836 | DOMON domain profile. | 41 | 159 | 16.159 |
| 4 | g12044.t1 | SMART | SM00664 | DOMON_3 | 70 | 159 | 1.7E-4 |
| 5 | g12044.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 17 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004500 | dopamine beta-monooxygenase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
