General information for g12046.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Tyramine beta-hydroxylase.
Parent gene
- The parent gene g12046 is located on chr_1: 20647717..20648990 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12046 | g12046.t1 | isoform | g12046.t1 | 20647717 | 20648990 |
| chr_1 | g12046 | g12046.t1 | exon | g12046.t1.exon1 | 20647717 | 20647830 |
| chr_1 | g12046 | g12046.t1 | cds | g12046.t1.CDS1 | 20647717 | 20647830 |
| chr_1 | g12046 | g12046.t1 | exon | g12046.t1.exon2 | 20647893 | 20648244 |
| chr_1 | g12046 | g12046.t1 | cds | g12046.t1.CDS2 | 20647893 | 20648244 |
| chr_1 | g12046 | g12046.t1 | exon | g12046.t1.exon3 | 20648335 | 20648638 |
| chr_1 | g12046 | g12046.t1 | cds | g12046.t1.CDS3 | 20648335 | 20648638 |
| chr_1 | g12046 | g12046.t1 | exon | g12046.t1.exon4 | 20648702 | 20648990 |
| chr_1 | g12046 | g12046.t1 | cds | g12046.t1.CDS4 | 20648702 | 20648990 |
| chr_1 | g12046 | g12046.t1 | TSS | g12046.t1 | NA | NA |
| chr_1 | g12046 | g12046.t1 | TTS | g12046.t1 | NA | NA |
Sequences
>g12046.t1 Gene=g12046 Length=1059
ATGGAAGTGTTTCACTGTGAAACAGATGCTGACGTCGAGATTCCATTATATGAGGGAAAT
TGTGATTTGATGCCTGAGGAAGCGAGAGTATGCAGTCGAGTTATGGCATTATGGGCAATG
GGTGCTGCAAAATTTACTTATCCCAAAGATGCTGGCTTGCCATTTGGTGGTCGCGATTAT
AATCCATATATTCGTTTAGAAATGCATTATAACAATCCAAATTTAATATCTGGTGTAATT
GATGGTTCAGGAATGAGAATTAAATATATTGACAAATTAAGAAAATACGATGCTGCTGTT
ATGGAATTAGGACTTGAATATACCGATAAAATGGCAATACCACCGGGTCAATTAGCATTT
CCTTTGAGTGGTTATTGTATAGCTGAATGCACAAAAATAGCATTACCTGAGACAGGCATA
ACAGTTTTCGGTTCACAACTTCACACCCACTTGCGAGGCGTAAGAGTCATGACAAGGCAT
TTTCGTGACGGAAAAGAATTGACGGAACTCAATCGTGATGATTTTTACTTAAATCATTTT
CAAGAAATTCGTCATTTATGGAGAAAACCAGTCATTCTTCCAGGCGATGCTCTTGTTACA
ACGTGTTTTTATGATACCAGAGGCTATCAGAATGCAACATTAGGTGGATTTTCAATTCAA
GATGAAATGTGTGTCAACTACATTCATTATTATCCTGCAACTGAATTAGAACTTTGTAAA
AGCTCTGTATCTGAAAAGACTCTTGCTGATTACTTTGAATTCATGAAAAAAAAGGACCAT
CAAAAAATCGATATTCGTAAAGGACGTGCAGCAAGTTATCGAGCGATAGAATGGACTTTA
CCGCATGTAAATGAGCTTTTTACAATGTACACGAATGAACCATTGAGTATGCAGTGTAAC
CGCAGTGATGGTTATCGATTTGAAGGTTATAATTGGGAAGGAGCGCCAATAACGGAAGTT
CCGATTCAACCGCCACAACCGTATACATCTTGTTCACGTGGAGGCAAATCTCTTCAAAAT
AGCGATGATTGTGACATGTTTGGCATGTGCATTTACTAA
>g12046.t1 Gene=g12046 Length=352
MEVFHCETDADVEIPLYEGNCDLMPEEARVCSRVMALWAMGAAKFTYPKDAGLPFGGRDY
NPYIRLEMHYNNPNLISGVIDGSGMRIKYIDKLRKYDAAVMELGLEYTDKMAIPPGQLAF
PLSGYCIAECTKIALPETGITVFGSQLHTHLRGVRVMTRHFRDGKELTELNRDDFYLNHF
QEIRHLWRKPVILPGDALVTTCFYDTRGYQNATLGGFSIQDEMCVNYIHYYPATELELCK
SSVSEKTLADYFEFMKKKDHQKIDIRKGRAASYRAIEWTLPHVNELFTMYTNEPLSMQCN
RSDGYRFEGYNWEGAPITEVPIQPPQPYTSCSRGGKSLQNSDDCDMFGMCIY
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g12046.t1 | Gene3D | G3DSA:2.60.120.310 | - | 1 | 98 | 0 |
| 11 | g12046.t1 | Gene3D | G3DSA:2.60.120.230 | - | 104 | 262 | 0 |
| 3 | g12046.t1 | PANTHER | PTHR10157 | DOPAMINE BETA HYDROXYLASE RELATED | 1 | 312 | 0 |
| 4 | g12046.t1 | PANTHER | PTHR10157:SF29 | DOPAMINE BETA-HYDROXYLASE | 1 | 312 | 0 |
| 6 | g12046.t1 | PRINTS | PR00767 | Dopamine-beta-monooxygenase signature | 34 | 53 | 0 |
| 7 | g12046.t1 | PRINTS | PR00767 | Dopamine-beta-monooxygenase signature | 98 | 115 | 0 |
| 5 | g12046.t1 | PRINTS | PR00767 | Dopamine-beta-monooxygenase signature | 286 | 306 | 0 |
| 2 | g12046.t1 | Pfam | PF01082 | Copper type II ascorbate-dependent monooxygenase, N-terminal domain | 1 | 75 | 0 |
| 1 | g12046.t1 | Pfam | PF03712 | Copper type II ascorbate-dependent monooxygenase, C-terminal domain | 96 | 252 | 0 |
| 8 | g12046.t1 | SUPERFAMILY | SSF49742 | PHM/PNGase F | 1 | 94 | 0 |
| 9 | g12046.t1 | SUPERFAMILY | SSF49742 | PHM/PNGase F | 94 | 257 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005507 | copper ion binding | MF |
| GO:0004497 | monooxygenase activity | MF |
| GO:0003824 | catalytic activity | MF |
| GO:0055114 | NA | NA |
| GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen | MF |
| GO:0004500 | dopamine beta-monooxygenase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K00503 (dopamine beta-monooxygenase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
