General information for g12101.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as IQ motif and SEC7 domain-containing protein 1.
Parent gene
- The parent gene g12101 is located on chr_1: 20937721..20938129 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12101 | g12101.t1 | isoform | g12101.t1 | 20923087 | 20938129 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon1 | 20923087 | 20923451 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS1 | 20923087 | 20923451 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon2 | 20923513 | 20923896 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS2 | 20923513 | 20923896 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon3 | 20923962 | 20924433 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS3 | 20923962 | 20924433 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon4 | 20924498 | 20925749 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS4 | 20924498 | 20925749 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon5 | 20925830 | 20926099 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS5 | 20925830 | 20926099 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon6 | 20926243 | 20926620 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS6 | 20926243 | 20926620 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon7 | 20937721 | 20937796 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS7 | 20937721 | 20937796 |
| chr_1 | g12101 | g12101.t1 | exon | g12101.t1.exon8 | 20938123 | 20938129 |
| chr_1 | g12101 | g12101.t1 | cds | g12101.t1.CDS8 | 20938123 | 20938129 |
| chr_1 | g12101 | g12101.t1 | TSS | g12101.t1 | 20938548 | 20938548 |
| chr_1 | g12101 | g12101.t1 | TTS | g12101.t1 | NA | NA |
Sequences
>g12101.t1 Gene=g12101 Length=3204
ATGGAAGACCACAAGAAAAACTCATCTAAAATCGACAATATAAAGAGCTCATCGGCAGCA
GTCGAGCACAGCAAAAAATCTAGTTTGCCACAAACTTCGGACCGTCCACTGTGTTCGACC
ACTGGGAGCTTTAACACATCAACAGAACAATATTCATTTGAAAATCAATCCTCGTCGTCA
TCGTTTGGTTCTGAGTCTCATCATCATCACCACCATCATCATCATCATCAGCATGTAATC
GACAGTCATTTAAGCTACGATATCGAAGATGACATCATTAATATGGACGATGACGAAAGT
AATCACAGTTATGTATATTTACAATCACAGCAACATTATACACCGCCACCAGTAGAATTT
CAAGAAGGTTCAACTCCCCAACATCAACCATCATTAATCAAAAAAGGTTCCATTATGAGA
AATAATCCTGAGTTAATGAAACGCAATCGTCAAAATAATTCAAGTTATGAGCTGTCACAA
GATCTCTTGGATAAGCAAATTGAATTGCTTGAAAGAAAGTATGGTGGAATTAGAGCGCGA
AAAGCAGCAATATGTATTCAACGCGCCTTCCGTCACTACAAGATGGTTAAGAAATTTGCT
TCAATCACAGCAATGGCGAAAGCAGATAAACGCATCTCAAATCGTTGCAGTATGCAGTCA
TTAATAAGTGTAGGAGAACAAGAGTCTAGTGATTTGGGAATAAGCCAAGCTGGACAAAAA
GTTTGTGCAATAATATCAGCAACTCCTCCCGGACAACCACGACCATCTGCCAATCGAGCC
GTATCATTTCGTGAACGTCGAAATGTGCTAGATTCGAATTTCAATCAAGTTGCGGTGAAA
CGACAGCCACTTTCACAAAGTAATTTTCAACAGCAACATCCGTCACAGTCATCACAGCCT
CCTCATTCACATGCATATGTTAATTTATTACACTCACAAGATCAGCAGTACAATAACTAT
CAAAATTATCATAGTCATAATAACAGCAACAATAATAACTATGCAAGCAACAATAGCTCA
CTTAATAGTTCATCATTACATCAATACGAATTAAATATTTCATCGAGTTCTGCAAATACG
ACAATGAACTCATCGTGGAATTCTTATAGCAACAGTCCAAATGCTTCACTTATTGCTCAG
CAACAGTACTATGTTAGACCGAGAACATCGAGTATTTCAAACAAAAAAGTTCCACCAGAA
GTTCCTAAACGAACTAGTAGCATACAACCACCACCACAAAGTACACCGCCACAGAAATAT
CCGCCGCAAGCTTATGCCGTACAACAATCGTCAAGGAGTCATCATCATCATCACCATCAC
CATCATCATCATGCTCAAATGAAAGCAGTTGCACATTCACAACAACAATTCTATAAAACA
GAAAATGGAAATCATTCATCGCCAGATTCTCTATCATTATCTTCCAATTCTCCAGTTCCA
AATCACTCTCACTCTCATTGGCAAAATCAGACATCAATTGAACAACAAACACAACATATA
TTACACCAACAATACATTTTAGAGCAGAAGCACATTCAACAGCAATTGATTCAACAACAA
AATGAAATTCAACTCCAAGCAAAGCTATCAGAGACTATTCGTAAACGCCAATATCGTATT
GGATTGAATTTATTCAATAAGAAACCCGAAAAAGGTATAACATACCTTATGCACAAAAAT
TTCCTTGAAAATTCACCGCATGCGGTATCAAAGTTTTTGATATCACGAAAAGGTTTATCA
CGACAAATGATTGGTGAATATTTGGGAAATCTTCAACAGCCATTTAATATGGCAGTGTTG
GAATATTTTGTCGAAGAAATGGATTGCTCTGGCTTGCCAATAGACGTAGCTTTGAGAAAA
TTCCAATCATATTTTCGAATGCCAGGTGAGGCGCAAAAAATAGAACGTTTAATGGAAGTC
TTTTCACATCGTTATGCTGTATGTAATCCTGATGTTGTTGCAAAATTGAGATCTCCTGAT
ACGATATTTGTATTGGCATTTGCAATTATTATGTTAAATACAGATCTACATACGCCAAAT
ATTAAAGCTGATCGTCGCATGAAATGTGAAGATTTTATAAAGAATCTTCGAGGAATAGAT
GATTGCATGGATATCGATAAAAATATTTTGGTTGGCATCTATGAACGAATTAAAGAGTCT
GAATTTAAAACAGCATCAGATCACGTTACACAAGTTATGAAAGTGCAAAAAACTATTGTT
GGTAAAAAGTTGAATTTGGCAGTTCCACATCGTCGATTAGTTTGTTATTGTCGATTATAT
GAGATTGACATAAATAAGAAGGAGCGTCAAGGTTTACATCAGCGTGAAGTTTTTCTGTTC
AATGATTTGCTTGTGGTGACGAAGATTTTAACAAAAAAGAAAGCATCAGTGACGTATACA
TTTAGAAATTCCTTTTCACTTGTGGGATTGGTTGTAACACTCTTAGATGTGCCAAATTAT
CCTTTTTGCATTCGTCTATCACAGAAGGCTGACAAAAAGATTCTTGCCACATTCAATGCA
CGCAATGAGCATGATCGTTGTAAATTTGCAGATGATTTGCGTGAATCTATTGCAGAAATG
GACGAAATGGAGTCTATTCGTATTGAAATGGAACTTGAAAGACAAATGAAAGCAACACGA
TGTGTAGGGAATGGAATGAATAATAATAATGTAGAGAACCGAGATAGTGGTGTTGGTGAT
ATTGAGGCACTTGAATTTACAACAACTTCAAAGTCCTCCTCATTCGATACAAAATCAAAT
TCGGGTAATGACATTCAAAATGGACAATTGAAGCGTGGCGGTGCGCTAAGTAATTCTCTA
CTCGATATTCATGATCAATTTGGTAATGAATGTCGTCAGAGACGTGGAAGTGTCGGTTCA
TTAGATAGTGGAATGTCAATATCTTTTCAATCAAATTCTACTAATAATAATAATGCTTCC
AATTGCAAAAATCCTGAAAGCTCAACAACATCTACTACAAATATAAATACTTATGTATCA
ACTCAAACAAGTGCGATAGTACAACGTCAGCCGTCGCAGCAACAGCATGCTAATGGTAAT
AGTCACCCAATGATGATTCCTCCACTGCTTCCAAATAGTGCATTATATCAGTACAATAAT
GATCAAATGGTACATATGCATGAATTATATGAGGAACACACTCATACTCGTTCACATGTT
GATGGACGATCAACGGATGTTTAA
>g12101.t1 Gene=g12101 Length=1067
MEDHKKNSSKIDNIKSSSAAVEHSKKSSLPQTSDRPLCSTTGSFNTSTEQYSFENQSSSS
SFGSESHHHHHHHHHHQHVIDSHLSYDIEDDIINMDDDESNHSYVYLQSQQHYTPPPVEF
QEGSTPQHQPSLIKKGSIMRNNPELMKRNRQNNSSYELSQDLLDKQIELLERKYGGIRAR
KAAICIQRAFRHYKMVKKFASITAMAKADKRISNRCSMQSLISVGEQESSDLGISQAGQK
VCAIISATPPGQPRPSANRAVSFRERRNVLDSNFNQVAVKRQPLSQSNFQQQHPSQSSQP
PHSHAYVNLLHSQDQQYNNYQNYHSHNNSNNNNYASNNSSLNSSSLHQYELNISSSSANT
TMNSSWNSYSNSPNASLIAQQQYYVRPRTSSISNKKVPPEVPKRTSSIQPPPQSTPPQKY
PPQAYAVQQSSRSHHHHHHHHHHHAQMKAVAHSQQQFYKTENGNHSSPDSLSLSSNSPVP
NHSHSHWQNQTSIEQQTQHILHQQYILEQKHIQQQLIQQQNEIQLQAKLSETIRKRQYRI
GLNLFNKKPEKGITYLMHKNFLENSPHAVSKFLISRKGLSRQMIGEYLGNLQQPFNMAVL
EYFVEEMDCSGLPIDVALRKFQSYFRMPGEAQKIERLMEVFSHRYAVCNPDVVAKLRSPD
TIFVLAFAIIMLNTDLHTPNIKADRRMKCEDFIKNLRGIDDCMDIDKNILVGIYERIKES
EFKTASDHVTQVMKVQKTIVGKKLNLAVPHRRLVCYCRLYEIDINKKERQGLHQREVFLF
NDLLVVTKILTKKKASVTYTFRNSFSLVGLVVTLLDVPNYPFCIRLSQKADKKILATFNA
RNEHDRCKFADDLRESIAEMDEMESIRIEMELERQMKATRCVGNGMNNNNVENRDSGVGD
IEALEFTTTSKSSSFDTKSNSGNDIQNGQLKRGGALSNSLLDIHDQFGNECRQRRGSVGS
LDSGMSISFQSNSTNNNNASNCKNPESSTTSTTNINTYVSTQTSAIVQRQPSQQQHANGN
SHPMMIPPLLPNSALYQYNNDQMVHMHELYEEHTHTRSHVDGRSTDV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g12101.t1 | CDD | cd00171 | Sec7 | 534 | 722 | 2.12468E-78 |
| 11 | g12101.t1 | CDD | cd13318 | PH_IQSEC | 749 | 875 | 1.55472E-69 |
| 9 | g12101.t1 | Gene3D | G3DSA:1.10.220.20 | - | 492 | 608 | 1.6E-32 |
| 8 | g12101.t1 | Gene3D | G3DSA:1.10.1000.11 | - | 609 | 726 | 1.2E-44 |
| 7 | g12101.t1 | Gene3D | G3DSA:2.30.29.30 | - | 742 | 876 | 1.8E-51 |
| 13 | g12101.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 81 | - |
| 17 | g12101.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 12 | 63 | - |
| 15 | g12101.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 389 | 490 | - |
| 19 | g12101.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 404 | 419 | - |
| 18 | g12101.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 431 | 448 | - |
| 16 | g12101.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 449 | 490 | - |
| 14 | g12101.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 971 | 992 | - |
| 3 | g12101.t1 | PANTHER | PTHR10663:SF342 | FI21420P1 | 144 | 981 | 4.5E-213 |
| 4 | g12101.t1 | PANTHER | PTHR10663 | GUANYL-NUCLEOTIDE EXCHANGE FACTOR | 144 | 981 | 4.5E-213 |
| 1 | g12101.t1 | Pfam | PF01369 | Sec7 domain | 534 | 722 | 5.4E-62 |
| 2 | g12101.t1 | Pfam | PF16453 | PH domain | 742 | 875 | 9.2E-58 |
| 20 | g12101.t1 | ProSiteProfiles | PS50096 | IQ motif profile. | 179 | 208 | 6.504 |
| 21 | g12101.t1 | ProSiteProfiles | PS50190 | SEC7 domain profile. | 534 | 720 | 40.555 |
| 12 | g12101.t1 | SMART | SM00222 | sec7_5 | 531 | 722 | 9.7E-82 |
| 6 | g12101.t1 | SUPERFAMILY | SSF48425 | Sec7 domain | 533 | 723 | 7.59E-65 |
| 5 | g12101.t1 | SUPERFAMILY | SSF50729 | PH domain-like | 731 | 865 | 1.8E-17 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
| GO:0032012 | regulation of ARF protein signal transduction | BP |
| GO:0005085 | guanyl-nucleotide exchange factor activity | MF |
KEGG
Orthology
- This transcript has been annotated with K12495 (IQ motif and SEC7 domain-containing protein)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
