General information for g12191.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Glucose dehydrogenase.
Parent gene
- The parent gene g12191 is located on chr_1: 21666711..21669535 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12191 | g12191.t1 | TTS | g12191.t1 | 21666552 | 21666552 |
| chr_1 | g12191 | g12191.t1 | isoform | g12191.t1 | 21666711 | 21669535 |
| chr_1 | g12191 | g12191.t1 | exon | g12191.t1.exon1 | 21666711 | 21668240 |
| chr_1 | g12191 | g12191.t1 | cds | g12191.t1.CDS1 | 21666711 | 21668240 |
| chr_1 | g12191 | g12191.t1 | exon | g12191.t1.exon2 | 21668300 | 21668664 |
| chr_1 | g12191 | g12191.t1 | cds | g12191.t1.CDS2 | 21668300 | 21668664 |
| chr_1 | g12191 | g12191.t1 | exon | g12191.t1.exon3 | 21668729 | 21668757 |
| chr_1 | g12191 | g12191.t1 | cds | g12191.t1.CDS3 | 21668729 | 21668757 |
| chr_1 | g12191 | g12191.t1 | exon | g12191.t1.exon4 | 21669375 | 21669535 |
| chr_1 | g12191 | g12191.t1 | cds | g12191.t1.CDS4 | 21669375 | 21669535 |
| chr_1 | g12191 | g12191.t1 | TSS | g12191.t1 | NA | NA |
Sequences
>g12191.t1 Gene=g12191 Length=2085
ATGTTGAATAATTGGATTAAACAAATTGCACTGTTGGTTTTACTTAATTTCTGTTTTTGC
AATTTTATTGACGACTATGTTAGTAAAAAAATCAACATTTTACCACCAAGAACGAAGCCA
ACATCAATTTTCAATAAATTTAAGACTAGATTTACTAAAGCACCCACAACTCCTTCATCA
CTTCCAAATGTTGGTTACATATCTGGCGAATGTGCAGCAAGGAGTGTTGGTGATATTAAT
GATCTTATTAATTCTATGGGTGACACACTCTTAAATCTTCAATGTTCTATCTCATCGTCT
GATCAGTGGCCAGAAGATTACGGTCCAATGGTTCTGCGTAGTGGTAAGACTTTAAAGTTG
TTCTTAAAAGCCAAAGCTCAAAAAATTGAATTGCAAATTATCCAAAAATTCACAGCAAGA
GCATTAGATGACTTTGACTTTATCATAGTTGGAGCTGGAAGTGCGGGTTCTGTTTTAGCA
AGTCGATTAAGTGAGAGAACTGATTGGAAAATTTTGTTGATAGAAGCAGGCCAAAATCCA
CCAATTGAGAGTGAGATCCCAGGCATGTTTTATTCAATATGGAACTCTACGACTTATTCA
TATAGATATTTTGCTGAAAAATCAACAAAGTTCGGTTTAGCTTATAAAAATGCAATTTTT
TATCCAAGCGGAAAAATGTTAGGAGGAACAAGTGGTTTGAACGCAATGCTTTATGTTCGA
GGTGTTCCAAATGACTTTGATAATTGGAATATTAAAGGATGGACATATAATGATGTTTTG
CCATATTTTAAGAAAGCTGAAGGAAACAAAAAATTAAAAAACTCAAAATTTCATGGAATT
GAAGGAAATTTGATTGTTGATGATTATCCAAATGATGAAGCTATAAAAAAGGGAATTTTA
AATGGTATTGAAGAAATAGGCTATAAATCTCTAAATGACATTAATGGCGATGAGCATATT
GGTTTTACTTTGGCTCAAGGAACGCTCGAAAATGGTGAAAGATGCAGCAGTGCAAAAGCT
TATTTGACAAAAGTAAAAAATCGACCAAATTTAAAAGTTATAAAAAATGCAGTTGTCAGC
AAACTGATTGTAAATAGCAATAAAATTGAAGGTGTAATTTTTAATTTAAATGGCAGAACA
TTGACAGCTCGTATGAGAAAAGAAGTCATTTTATCAGCTGGCGTATTTGGAAGTCCAAAA
ATTTTGATGTTGTCAGGAATTGGAAAAAGCAATGACCTTTTGCCTTTTAATATTCCACAA
GTTGTAGATTTGCCAGTTGGTTATAATCTTCAAGACCATGTCATGACAGCAATGAGCTTC
AGTTTTCTTAAATCGGTAGCACCTGATGATAATCCAATCAATTATTATGGTTCATTATTT
ACTTATTTAACACAGAAGACTGGCCTTTATGCTGGTATTGGTTGCTCAAATCTTTTGGGA
TTTATAAGCACACAAAATCTTCCAGTTCCAGACATTGAGTTCATACACATGTGCATTCCT
AAGAAAATGATTAATTACCCTCATCTTTTACAAGAATTCAATTACAACGATGAATTTATA
GCTCAATTTGAAAATTTTAACATGCAAGCACCTGCATTAGCTGGCAATACAATTTTACTT
AGACCAAAATCACGTGGAACTGTCAAACTTCGCAGCTCGAATTTTAATGATCCTCTGGTA
ATTAATCTAAATTTTCTTGAATCTGATGAAGATGTGACAACATTAATTGCTGGAATTCGT
GCTTATAGAAAACTTTTAACAACTAAAGGTTTCAAATCTTATGAAATTGAATACCTCAAA
CCTATTATTCCTGAATGCGATGTATTTCAATTTGATAGCAATGAATATTGGCGTTGTTAT
CTGAAATATTTTTCGACAACAATTTGGCATCCAGTTGGAACTTGTAAAATGGGAAATGAG
GAAGATCAAAGTGCTGTTTTGCTTCCAGATTTAAGTGTTCGTGGTATGAGCGGCTTGCGT
GTAGTCGATGCTAGTGTTATGCCAAATATTGTGAGTGGTCATACAAATGCTGCCACAATA
ATGATTGCTGAAAAGGCTTCAGACATGATAAAGAACGTGTGGTAG
>g12191.t1 Gene=g12191 Length=694
MLNNWIKQIALLVLLNFCFCNFIDDYVSKKINILPPRTKPTSIFNKFKTRFTKAPTTPSS
LPNVGYISGECAARSVGDINDLINSMGDTLLNLQCSISSSDQWPEDYGPMVLRSGKTLKL
FLKAKAQKIELQIIQKFTARALDDFDFIIVGAGSAGSVLASRLSERTDWKILLIEAGQNP
PIESEIPGMFYSIWNSTTYSYRYFAEKSTKFGLAYKNAIFYPSGKMLGGTSGLNAMLYVR
GVPNDFDNWNIKGWTYNDVLPYFKKAEGNKKLKNSKFHGIEGNLIVDDYPNDEAIKKGIL
NGIEEIGYKSLNDINGDEHIGFTLAQGTLENGERCSSAKAYLTKVKNRPNLKVIKNAVVS
KLIVNSNKIEGVIFNLNGRTLTARMRKEVILSAGVFGSPKILMLSGIGKSNDLLPFNIPQ
VVDLPVGYNLQDHVMTAMSFSFLKSVAPDDNPINYYGSLFTYLTQKTGLYAGIGCSNLLG
FISTQNLPVPDIEFIHMCIPKKMINYPHLLQEFNYNDEFIAQFENFNMQAPALAGNTILL
RPKSRGTVKLRSSNFNDPLVINLNFLESDEDVTTLIAGIRAYRKLLTTKGFKSYEIEYLK
PIIPECDVFQFDSNEYWRCYLKYFSTTIWHPVGTCKMGNEEDQSAVLLPDLSVRGMSGLR
VVDASVMPNIVSGHTNAATIMIAEKASDMIKNVW
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g12191.t1 | Gene3D | G3DSA:3.50.50.60 | - | 145 | 691 | 3.2E-162 |
| 8 | g12191.t1 | Gene3D | G3DSA:3.30.560.10 | Glucose Oxidase | 182 | 629 | 3.2E-162 |
| 3 | g12191.t1 | PANTHER | PTHR11552 | GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE | 123 | 691 | 3.0E-170 |
| 14 | g12191.t1 | PIRSF | PIRSF000137 | Alcohol_oxidase | 121 | 694 | 1.8E-139 |
| 1 | g12191.t1 | Pfam | PF00732 | GMC oxidoreductase | 145 | 434 | 3.5E-65 |
| 2 | g12191.t1 | Pfam | PF05199 | GMC oxidoreductase | 542 | 686 | 4.8E-36 |
| 10 | g12191.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 20 | - |
| 11 | g12191.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 7 | - |
| 12 | g12191.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 8 | 15 | - |
| 13 | g12191.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 16 | 20 | - |
| 9 | g12191.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 21 | 694 | - |
| 15 | g12191.t1 | ProSitePatterns | PS00623 | GMC oxidoreductases signature 1. | 224 | 247 | - |
| 5 | g12191.t1 | SUPERFAMILY | SSF51905 | FAD/NAD(P)-binding domain | 143 | 693 | 3.56E-71 |
| 4 | g12191.t1 | SUPERFAMILY | SSF54373 | FAD-linked reductases, C-terminal domain | 429 | 634 | 6.77E-35 |
| 6 | g12191.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 20 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | MF |
| GO:0050660 | flavin adenine dinucleotide binding | MF |
| GO:0055114 | NA | NA |
KEGG
Orthology
- This transcript has been annotated with K15403 (fatty acid omega-hydroxy dehydrogenase [EC:1.1.-.-])
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
