General information for g1239.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Soluble guanylate cyclase 89Da.
Parent gene
- The parent gene g1239 is located on chr_3: 9070002..9075276 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g1239 | g1239.t1 | isoform | g1239.t1 | 9070002 | 9075276 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon1 | 9070002 | 9070043 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS1 | 9070002 | 9070043 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon2 | 9071800 | 9071999 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS2 | 9071800 | 9071999 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon3 | 9072056 | 9072249 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS3 | 9072056 | 9072249 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon4 | 9072338 | 9072510 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS4 | 9072338 | 9072510 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon5 | 9072685 | 9072775 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS5 | 9072685 | 9072775 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon6 | 9073494 | 9073660 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS6 | 9073494 | 9073660 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon7 | 9073727 | 9074022 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS7 | 9073727 | 9074022 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon8 | 9074085 | 9074679 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS8 | 9074085 | 9074679 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon9 | 9074856 | 9075032 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS9 | 9074856 | 9075032 |
| chr_3 | g1239 | g1239.t1 | exon | g1239.t1.exon10 | 9075157 | 9075276 |
| chr_3 | g1239 | g1239.t1 | cds | g1239.t1.CDS10 | 9075157 | 9075276 |
| chr_3 | g1239 | g1239.t1 | TSS | g1239.t1 | NA | NA |
| chr_3 | g1239 | g1239.t1 | TTS | g1239.t1 | NA | NA |
Sequences
>g1239.t1 Gene=g1239 Length=2055
ATGTATGGAATGCTTCTTGAATCGGTTCAACATTTTGTTCAGCTTGAGTTTGGTGAACGT
GTTTGGAATCGAGCATTGATTGCAACACAATGCAAGCACAATGTATTCAATACACATCAG
CAATATCCTGATAGTTTAATTCCTGACTTGGCTGCAGCTTTAGCTGAAATAACTGGCAAA
CAATATGATTATTTTATGATATTTTTTGGAAGATGTTTTGTGAGATTTTTTAGTAATTTT
GGTTATGATGAAATGATTCGAGCAACTGGACGATATTTCTGTGATTTTCTACAATCAGTT
GATAACATTCATTTACAAATGCGTTTTACATATCGCAAAATGAAGTCGCCATCAATGCAA
GTCACTGATATCGATCAAAATGGAGCGACACTAATCTATCGAAGTAATCGTACAGGTTTT
TCTAAGTATCTCATGGGCCAATTGATGGAGATTGCGAAGGAAATTTACGATTCCGATTTG
AAAGTTCGCATCGTTGATTCAATTAATGATTCAGCCGGTGGTACAGCTGGTCCGATTGAA
TTATCATCAAAATCAGCATTGAAATCTGTCGTTGTGAAGTTTCGTCTTGATTTCGATAAT
GCCGAATATGTTGAAAACTGCATGAGAATGAAAAGTCATCCATCTCAATTGTCTTTGAAA
CCTGTTACTACTGAAATGCTTTTAGAGCTCTTTCCATTCGGTATGATCTTAAATAATGAG
ATGAAAATTGTGGCTGCTGGCAACAATTTAATTGAGTCTTGGAGCTCAAACAATGATAAT
AAACATCCTAATGAGTTGATTGGAAGTAAAATCACGAAGTACTTTAAATTACGTCGACCA
ACTGGTATTGTGTTTGACTTCACAAATGTTACGCAGCTACAAGCCGTTTTATTTGAAATT
CAATTGATTCGATCAAAAAATTCGGCATCAGCCAAAGGATTAGTGAGAACTGAATCTGGA
AAGAATTTTAGACCGATAAGCAGTAGTGGTGGAAATTCGGATGGTATTGATAATGAAGGT
GATACTGTTGCTATTGTAAATGAAGTAGGAACTTCATTGAATTTTAAAAGACGTGGATCT
CAAGGAATTAAAAGTATTTTGCTTAAAGGTGAAATGAGATTCTTAAAAGAGATCAATATG
CTTGTATTCTTATGCAGTCCACTCATAAACAACTTGGATGAAATGAGTGAAATGAGTTTA
TTTCTTAATGATCTCAACTTTCATGGTCTTAGTCGTGAAATGGTTTTCTCAGGTTTTAAA
CATTATTCTCGTCTTGATTTAATGTGTGAAAGAGAAGAACAAAGAGCTGAAGAGTTGGAA
ACTTCACTATCATTAGCTGATTCATGGAAAAAGCAAGGTGATGAACTTTTATATTCAATG
ATTCCACGATCAGTTGCTGATCGAATTAAAAATGGACAAGACCCGCTTGCAACATGTCAA
TCATTTGAAGAAGTTACAGTAATTTTTGCTGAAATTCAAGAACAATCTTATGCATCTGAT
GCAATTCAATCAGCAATGAATACTGTAAATACATTGAATGCAGCATTTTCAGCATTTGAT
GAATTAATTCAATCACCAATGGCGTATAAAGTTGAGACAGTAGGAAAAGTTTACATGGCT
GTTAGTGGTGCGCCTGATGTGAATCCTTTACATATGCAAACAGTTGCTGATTTATCACTT
CAAATGCTATATTCAATTAAAAATTTAAATATCGAAGGTGTTTCTGTTAAAATTGGATTT
CATACTGGTCCGGTTGTTGCTGGAATAGTTGGTTTAAAAGTTCCTCGCTATTGTCTTTTT
GGTGATACTGTCAATACAGCTAGTCGAATGGAAAGCAGCAGTGAATCAAATAAAATTCAA
GTCTCAGGCCAAACTGCTAAAAAATTGAAGAAATTAGGATATAAATTAACATATCGTGGT
CTTGTTACTGTAAAAGGAAAAGGTGAAATGGAAACTTTTTGGCTAGATGAAGGACCCAAT
GAAGATTATGCCTCACGTAAAAGAAGTGGCAGCGGACTGAAAAATAAAATCAAGAATATG
CTGAATGGAAATTAA
>g1239.t1 Gene=g1239 Length=684
MYGMLLESVQHFVQLEFGERVWNRALIATQCKHNVFNTHQQYPDSLIPDLAAALAEITGK
QYDYFMIFFGRCFVRFFSNFGYDEMIRATGRYFCDFLQSVDNIHLQMRFTYRKMKSPSMQ
VTDIDQNGATLIYRSNRTGFSKYLMGQLMEIAKEIYDSDLKVRIVDSINDSAGGTAGPIE
LSSKSALKSVVVKFRLDFDNAEYVENCMRMKSHPSQLSLKPVTTEMLLELFPFGMILNNE
MKIVAAGNNLIESWSSNNDNKHPNELIGSKITKYFKLRRPTGIVFDFTNVTQLQAVLFEI
QLIRSKNSASAKGLVRTESGKNFRPISSSGGNSDGIDNEGDTVAIVNEVGTSLNFKRRGS
QGIKSILLKGEMRFLKEINMLVFLCSPLINNLDEMSEMSLFLNDLNFHGLSREMVFSGFK
HYSRLDLMCEREEQRAEELETSLSLADSWKKQGDELLYSMIPRSVADRIKNGQDPLATCQ
SFEEVTVIFAEIQEQSYASDAIQSAMNTVNTLNAAFSAFDELIQSPMAYKVETVGKVYMA
VSGAPDVNPLHMQTVADLSLQMLYSIKNLNIEGVSVKIGFHTGPVVAGIVGLKVPRYCLF
GDTVNTASRMESSSESNKIQVSGQTAKKLKKLGYKLTYRGLVTVKGKGEMETFWLDEGPN
EDYASRKRSGSGLKNKIKNMLNGN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g1239.t1 | CDD | cd07302 | CHD | 484 | 655 | 8.26723E-46 |
| 12 | g1239.t1 | Coils | Coil | Coil | 422 | 442 | - |
| 11 | g1239.t1 | Gene3D | G3DSA:3.90.1520.10 | - | 1 | 179 | 3.3E-53 |
| 10 | g1239.t1 | Gene3D | G3DSA:3.30.450.260 | - | 222 | 319 | 1.7E-9 |
| 9 | g1239.t1 | Gene3D | G3DSA:3.30.450.260 | - | 341 | 405 | 1.9E-8 |
| 8 | g1239.t1 | Gene3D | G3DSA:3.30.70.1230 | Adenylyl Cyclase | 474 | 658 | 1.6E-57 |
| 16 | g1239.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 665 | 684 | - |
| 4 | g1239.t1 | PANTHER | PTHR45655 | GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 | 1 | 655 | 9.0E-244 |
| 5 | g1239.t1 | PANTHER | PTHR45655:SF5 | SOLUBLE GUANYLATE CYCLASE 89DA-RELATED | 1 | 655 | 9.0E-244 |
| 1 | g1239.t1 | Pfam | PF07700 | Haem-NO-binding | 2 | 163 | 2.3E-55 |
| 2 | g1239.t1 | Pfam | PF07701 | Heme NO binding associated | 221 | 468 | 1.1E-62 |
| 3 | g1239.t1 | Pfam | PF00211 | Adenylate and Guanylate cyclase catalytic domain | 480 | 656 | 2.5E-52 |
| 15 | g1239.t1 | ProSitePatterns | PS00452 | Guanylate cyclase signature. | 588 | 611 | - |
| 17 | g1239.t1 | ProSiteProfiles | PS50125 | Guanylate cyclase domain profile. | 486 | 611 | 37.508 |
| 14 | g1239.t1 | SMART | SM00044 | cyc_6 | 448 | 646 | 5.9E-52 |
| 6 | g1239.t1 | SUPERFAMILY | SSF111126 | Ligand-binding domain in the NO signalling and Golgi transport | 1 | 205 | 6.28E-51 |
| 7 | g1239.t1 | SUPERFAMILY | SSF55073 | Nucleotide cyclase | 480 | 655 | 8.63E-47 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006182 | cGMP biosynthetic process | BP |
| GO:0020037 | heme binding | MF |
| GO:0016849 | phosphorus-oxygen lyase activity | MF |
| GO:0009190 | cyclic nucleotide biosynthetic process | BP |
| GO:0035556 | intracellular signal transduction | BP |
| GO:0004383 | guanylate cyclase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K01769 (guanylate cyclase, other)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed