General information for g12451.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Kynureninase.
Parent gene
- The parent gene g12451 is located on chr_1: 23797231..23798851 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12451 | g12451.t1 | isoform | g12451.t1 | 23797231 | 23798851 |
| chr_1 | g12451 | g12451.t1 | exon | g12451.t1.exon1 | 23797231 | 23798392 |
| chr_1 | g12451 | g12451.t1 | cds | g12451.t1.CDS1 | 23797231 | 23798392 |
| chr_1 | g12451 | g12451.t1 | exon | g12451.t1.exon2 | 23798805 | 23798851 |
| chr_1 | g12451 | g12451.t1 | cds | g12451.t1.CDS2 | 23798805 | 23798851 |
| chr_1 | g12451 | g12451.t1 | TSS | g12451.t1 | NA | NA |
| chr_1 | g12451 | g12451.t1 | TTS | g12451.t1 | NA | NA |
Sequences
>g12451.t1 Gene=g12451 Length=1209
ATGAGTTACAAAATTCTACCGTTACAGACAAACAGACAAGAAAGAAATAAATTTCAAATT
CCTCTAAATACAATTTATTTTTGTGGAAATTCTCTTGGTCTCTGTCCAATTGAATCAGAA
AAAGTTGTAAATCAAATTATACAAGAATGGGAACAAAATCACATTCATTCATGGAACCTT
GCGATTCAATTGCCATTAAAAGTTGGTAATAAAATTGGAAAATTGATCGGTGCAGAAGAA
AATGAAACAATTATTGCCGATTCAACTTCAATAAATCTTTTTAAATGCCTCGGAACTTCA
ATTGCAATTCAAAAAATTAAAAATCCTAATCGTCGTTCAATTTTGTTAGATCGTGAAAAT
TTCTCAAATGACTTGGGTCTCCTTAAACTTCTTTCAACTGATGAATATAAAGTTCGCTAT
TTTGATGACGAAAATCAACTCGAAGATTTTTTAAATGATGATGTTGTATGCATTTTGCTA
TCACATGTAAATTATCATCATGGTAAATTATACAATATAAAAAAAATTACTGAAATGGTG
CACAAAGTTGATGCTTTCATCATTTGGGATCTGTGTCATTCAGTTGGTTCTGTTCCAATC
AACTTGACTGAAGTTAATGCTGATTTTGCAGTTGGTTGTACTGATAAATATTTAAATAGC
AGTCCAGGGGCTCCTGCATTTATTTATGTTAATAAAAAACATCAAAATGTCACTTGGCAA
CCACTGACTGGTTGGCTTGGTCATCAATCACCTTTTAAAATGTCAAAAGATTATGAACCT
ATAGTAGGAATCAAAAATTTTCTTGTTGGAACGCCAGAAGTTTTGCCAATTTCAATTATT
GATTGTAGTGTTGAAATTACACTTGATGCTGGCATGCAACTGATTAGAAAAAAATCATTA
GCTCTTGGTGATCTTTTTATTTTTCTTATGACTGAAAAATGTCCATCATTCAAGCTTGTT
ACACCATTTGAATATGAAAAAAGAGAAAGTCATTTGAGTTATCAACATGAAAATGCAAAT
GAAATCAGCAAATGGATGAGAAAACGAAATATTTATAGTGATTTTATTTCTCCTGATATT
CTTATATTTGCAATGACTCCTTTATATACAAAATTTGTTGATATTTGGAATGCAATTGAA
AATATTTCGGATATTGTTAAAAATGTTGAATCAAAAAATTTTGATGAAAGTTGTGTTAGT
TTAAATTGA
>g12451.t1 Gene=g12451 Length=402
MSYKILPLQTNRQERNKFQIPLNTIYFCGNSLGLCPIESEKVVNQIIQEWEQNHIHSWNL
AIQLPLKVGNKIGKLIGAEENETIIADSTSINLFKCLGTSIAIQKIKNPNRRSILLDREN
FSNDLGLLKLLSTDEYKVRYFDDENQLEDFLNDDVVCILLSHVNYHHGKLYNIKKITEMV
HKVDAFIIWDLCHSVGSVPINLTEVNADFAVGCTDKYLNSSPGAPAFIYVNKKHQNVTWQ
PLTGWLGHQSPFKMSKDYEPIVGIKNFLVGTPEVLPISIIDCSVEITLDAGMQLIRKKSL
ALGDLFIFLMTEKCPSFKLVTPFEYEKRESHLSYQHENANEISKWMRKRNIYSDFISPDI
LIFAMTPLYTKFVDIWNAIENISDIVKNVESKNFDESCVSLN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 5 | g12451.t1 | Gene3D | G3DSA:3.90.1150.10 | Aspartate Aminotransferase | 13 | 385 | 0 |
| 6 | g12451.t1 | Gene3D | G3DSA:3.40.640.10 | - | 36 | 292 | 0 |
| 2 | g12451.t1 | PANTHER | PTHR14084 | KYNURENINASE | 23 | 392 | 0 |
| 3 | g12451.t1 | PANTHER | PTHR14084:SF0 | KYNURENINASE | 23 | 392 | 0 |
| 8 | g12451.t1 | PIRSF | PIRSF038800 | KYNU | 6 | 394 | 0 |
| 1 | g12451.t1 | Pfam | PF00266 | Aminotransferase class-V | 67 | 337 | 0 |
| 4 | g12451.t1 | SUPERFAMILY | SSF53383 | PLP-dependent transferases | 13 | 388 | 0 |
| 7 | g12451.t1 | TIGRFAM | TIGR01814 | kynureninase: kynureninase | 12 | 386 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0030429 | kynureninase activity | MF |
| GO:0006569 | tryptophan catabolic process | BP |
| GO:0003824 | catalytic activity | MF |
| GO:0030170 | pyridoxal phosphate binding | MF |
| GO:0005737 | cytoplasm | CC |
| GO:0009435 | NAD biosynthetic process | BP |
KEGG
Orthology
- This transcript has been annotated with K01556 (kynureninase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed