General information for g12610.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aminoacylase-1.
Parent gene
- The parent gene g12610 is located on chr_1: 24782653..24783615 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12610 | g12610.t1 | TTS | g12610.t1 | 24782001 | 24782001 |
| chr_1 | g12610 | g12610.t1 | isoform | g12610.t1 | 24782072 | 24783615 |
| chr_1 | g12610 | g12610.t1 | exon | g12610.t1.exon1 | 24782072 | 24782279 |
| chr_1 | g12610 | g12610.t1 | cds | g12610.t1.CDS1 | 24782072 | 24782279 |
| chr_1 | g12610 | g12610.t1 | exon | g12610.t1.exon2 | 24782336 | 24783245 |
| chr_1 | g12610 | g12610.t1 | cds | g12610.t1.CDS2 | 24782336 | 24783245 |
| chr_1 | g12610 | g12610.t1 | exon | g12610.t1.exon3 | 24783531 | 24783615 |
| chr_1 | g12610 | g12610.t1 | cds | g12610.t1.CDS3 | 24783531 | 24783615 |
| chr_1 | g12610 | g12610.t1 | TSS | g12610.t1 | 24783710 | 24783710 |
Sequences
>g12610.t1 Gene=g12610 Length=1203
ATGAGTGCCTACGAAAGTAATGAAGAAATTCAAATTTTTCGTGAATATCTGAGAATCCCA
AGTGTTCATCCGAACATTGATTATGAACCATGTGTGGAATTTTTAAGACGACAAGCGAGT
GATTTGGATTTAGAATTTCGTGTTGAATATCCAAAAACTGAGAAGAAACCAGTTGTAATT
TTAACATGGATTGGAACTCAACCAGAATTGCCATCGATCATTCTTAATTCTCATATGGAT
GTTGTGCCAGTTTTTGAAGAATTTTGGACTCACAAGCCATTTGATGCTGATATTGATGAA
AATGGAAAAATTTTTGCTCGTGGTTCGCAAGATATGAAATGTGTTGGCACTCAATATTTG
GGTGCATTGAGATACTTCAAGAGAAATAATATTCAATTTAAAAGAACAATCCATGCAACA
TTTTTACCAGAAGAAGAAGTCGGTGGTGTTGAAGGAATGCGTGATTTTATTCATACTGAT
TCGTTTAAAAAATTAAATGCTGGCTTTTCACTTGATGAAGGTATTGCAAGTCCAACTGAT
ACTTTTAATGTCTTTTATGCTGAACGATCAATTTGGCATATTCAATTTGAAATTCCTGGA
AACCCAGGACATGGAAGTTTGCTATTGAAAAATACAGCTGGTGAAAAACTTGAGAAACTT
TTGAATCGCTTTATTGAATTTCGTGATAGTCAAGTGAAACGTTTGGCAGAAAATCCTGAT
CTTCTTATTGGCGATGTTACAACTGTAAATGTTACACAAATTCATGGTGGTGTTCAATCG
AATGTTATCCCTCCAGAATTTAAAATGGTAATCGATGCTCGGCTTGCACTTGATGTCAAT
CATGCTGAATTTGAAAATATGATCAAAAAATGGTGTGAAGAAGCTGGCGAAGGAATTAAA
TTTGATTATGAACAAAAACAACCAAAAGTTGAAGCTACAAAAACTGACAAAAGCAACCCT
TATTTTACTGCATTTAAATCTGCTATTGATGAACTTGGACTTGATATTAAACTTCAAGTC
TTCCCTGGTGGAACTGATTCACGATATTTGAGAGGTGTTGGCATTCCTGCAATTGGTTTC
AGTCCAATGAATAACACACCAGTTTTGCTTCATGATAATGACGAATTTCTTCGTGCTGAT
GTTTATTTGAAAGGAATTGAAATCTACAAGAAAATTATCAGCAATATTGCAAATTTGGAT
TAA
>g12610.t1 Gene=g12610 Length=400
MSAYESNEEIQIFREYLRIPSVHPNIDYEPCVEFLRRQASDLDLEFRVEYPKTEKKPVVI
LTWIGTQPELPSIILNSHMDVVPVFEEFWTHKPFDADIDENGKIFARGSQDMKCVGTQYL
GALRYFKRNNIQFKRTIHATFLPEEEVGGVEGMRDFIHTDSFKKLNAGFSLDEGIASPTD
TFNVFYAERSIWHIQFEIPGNPGHGSLLLKNTAGEKLEKLLNRFIEFRDSQVKRLAENPD
LLIGDVTTVNVTQIHGGVQSNVIPPEFKMVIDARLALDVNHAEFENMIKKWCEEAGEGIK
FDYEQKQPKVEATKTDKSNPYFTAFKSAIDELGLDIKLQVFPGGTDSRYLRGVGIPAIGF
SPMNNTPVLLHDNDEFLRADVYLKGIEIYKKIISNIANLD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g12610.t1 | CDD | cd05646 | M20_AcylaseI_like | 6 | 397 | 0 |
| 8 | g12610.t1 | Gene3D | G3DSA:3.40.630.10 | Zn peptidases | 3 | 193 | 0 |
| 7 | g12610.t1 | Gene3D | G3DSA:3.30.70.360 | - | 194 | 305 | 0 |
| 9 | g12610.t1 | Gene3D | G3DSA:3.30.70.1640 | - | 319 | 399 | 0 |
| 3 | g12610.t1 | PANTHER | PTHR45892 | AMINOACYLASE-1 | 4 | 399 | 0 |
| 4 | g12610.t1 | PANTHER | PTHR45892:SF1 | AMINOACYLASE-1 | 4 | 399 | 0 |
| 11 | g12610.t1 | PIRSF | PIRSF036696 | ACY-1 | 1 | 400 | 0 |
| 2 | g12610.t1 | Pfam | PF01546 | Peptidase family M20/M25/M40 | 74 | 394 | 0 |
| 1 | g12610.t1 | Pfam | PF07687 | Peptidase dimerisation domain | 186 | 297 | 0 |
| 5 | g12610.t1 | SUPERFAMILY | SSF53187 | Zn-dependent exopeptidases | 7 | 398 | 0 |
| 6 | g12610.t1 | SUPERFAMILY | SSF55031 | Bacterial exopeptidase dimerisation domain | 192 | 304 | 0 |
| 10 | g12610.t1 | TIGRFAM | TIGR01880 | Ac-peptdase-euk: N-acyl-L-amino-acid amidohydrolase | 3 | 398 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016787 | hydrolase activity | MF |
| GO:0006520 | cellular amino acid metabolic process | BP |
| GO:0004046 | aminoacylase activity | MF |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
- This transcript has been annotated with K14677 (aminoacylase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
