General information for g12611.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aminoacylase-1A.
Parent gene
- The parent gene g12611 is located on chr_1: 24784989..24787293 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12611 | g12611.t1 | TTS | g12611.t1 | 24784552 | 24784552 |
| chr_1 | g12611 | g12611.t1 | isoform | g12611.t1 | 24784700 | 24786951 |
| chr_1 | g12611 | g12611.t1 | exon | g12611.t1.exon1 | 24784700 | 24784904 |
| chr_1 | g12611 | g12611.t1 | cds | g12611.t1.CDS1 | 24784700 | 24784904 |
| chr_1 | g12611 | g12611.t1 | exon | g12611.t1.exon2 | 24784976 | 24785447 |
| chr_1 | g12611 | g12611.t1 | cds | g12611.t1.CDS2 | 24784976 | 24785447 |
| chr_1 | g12611 | g12611.t1 | exon | g12611.t1.exon3 | 24785580 | 24785760 |
| chr_1 | g12611 | g12611.t1 | cds | g12611.t1.CDS3 | 24785580 | 24785760 |
| chr_1 | g12611 | g12611.t1 | exon | g12611.t1.exon4 | 24786316 | 24786569 |
| chr_1 | g12611 | g12611.t1 | cds | g12611.t1.CDS4 | 24786316 | 24786569 |
| chr_1 | g12611 | g12611.t1 | exon | g12611.t1.exon5 | 24786822 | 24786951 |
| chr_1 | g12611 | g12611.t1 | cds | g12611.t1.CDS5 | 24786822 | 24786951 |
| chr_1 | g12611 | g12611.t1 | TSS | g12611.t1 | 24787291 | 24787291 |
Sequences
>g12611.t1 Gene=g12611 Length=1242
ATGGAGTGCAATTTGATTTTGAGAGATGAAGAGAAGAACAAACAATATCAAAATTGGGAA
AATAATGAAGAAATTCAGATTTTTCGCGAATACTTGCGAATACCGACAGTGCATCCAAAC
ATTGATTACCGCGATTGTGTTCGTTTTTTGTTTCGACTCGCTGATGAGATTGGCTTGAGT
GCGAAAATCTTCTATCCCATAGAGAAAAGTAAGCCGGTTGTTGTGCTTACTATGCTTGGC
ACAAATCCAGAACTCAAGTCCATTATTTTAAATTCTCATATGGACGTTGTTCCGGTTTTT
GAAGAATACTGGACTCACAAGCCATTTGATGCTGAAATGGATGAAGAAGGGAGAATTTTT
GCTCGTGGTGCACAAGACATGAAGTGTTGTGGAATGCAATATTTATCAGCACTCAGATAC
TTCAAAAGAAAAAATATACAGTTCAAACGAACAATTCATGTTGTTTTTGTGCCAAATGAA
GAACTAGGTGGTCAAGGTGGAATGGCTGATTTTGTTCATACAACAGAATTCCGAGCTCTT
AATTGTGGATTTTCACTTGATGAAGGAATTGCATCACCAACAGATACATTCAATGTTTTC
TATGCAGAAAGATGTATATGGCACATAATCTTTACAATCAATGGGAATAATGGTCATGGC
GCACTTTTACTAAAAGACACTGCACCAGAAAAGCTTCGTAAAATTTTAGACAGATTTTAT
GACTTTCGCGATACTCAAGTGAAAAAACTATTGGAAAATCCAGATTTGACAATTGGTGAT
GTTACAACTGTTAATATAACAATGATAAATGGCGGTGTACAATTGAACACAGTTCCACCA
GAAATTCGTGTTATGACAGACATTCGTTTAGCTGTTGATGTTGATCATGAACAATTTGAA
AATATGGTAAAAAGCTGGTGCATTGAAGCTGGCAATGTTGAATATGAATTTGATCTCAAA
GATCCCTTCATTCCACCAACAAAACTTGATGAATCAAATATTTATTGGCATGCATTTAAA
TCAGCTGTTAGCGAAGCAAATATAAAAACCAAAGTTCAAGTTTTTCCTGGTGGAACTGAT
TCTCGATATTTGAGAAGCGTCGGAATTCCTGCAATCGGTTTCAGTCCAATGAATAATACT
CCTGTTTTACTTCATGATCATGATGAGTTCCTTCAAGCCGATGTCTACCTCAGAGGAATT
GAAATTTATAAGAAAATTATTAGCAAAGTTGCAAATTGCTAA
>g12611.t1 Gene=g12611 Length=413
MECNLILRDEEKNKQYQNWENNEEIQIFREYLRIPTVHPNIDYRDCVRFLFRLADEIGLS
AKIFYPIEKSKPVVVLTMLGTNPELKSIILNSHMDVVPVFEEYWTHKPFDAEMDEEGRIF
ARGAQDMKCCGMQYLSALRYFKRKNIQFKRTIHVVFVPNEELGGQGGMADFVHTTEFRAL
NCGFSLDEGIASPTDTFNVFYAERCIWHIIFTINGNNGHGALLLKDTAPEKLRKILDRFY
DFRDTQVKKLLENPDLTIGDVTTVNITMINGGVQLNTVPPEIRVMTDIRLAVDVDHEQFE
NMVKSWCIEAGNVEYEFDLKDPFIPPTKLDESNIYWHAFKSAVSEANIKTKVQVFPGGTD
SRYLRSVGIPAIGFSPMNNTPVLLHDHDEFLQADVYLRGIEIYKKIISKVANC
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g12611.t1 | CDD | cd05646 | M20_AcylaseI_like | 21 | 411 | 0.0 |
| 8 | g12611.t1 | Gene3D | G3DSA:3.40.630.10 | Zn peptidases | 15 | 208 | 1.7E-55 |
| 7 | g12611.t1 | Gene3D | G3DSA:3.30.70.360 | - | 209 | 321 | 2.5E-19 |
| 9 | g12611.t1 | Gene3D | G3DSA:3.30.70.1640 | - | 333 | 413 | 5.5E-37 |
| 3 | g12611.t1 | PANTHER | PTHR45892 | AMINOACYLASE-1 | 13 | 412 | 2.2E-161 |
| 4 | g12611.t1 | PANTHER | PTHR45892:SF1 | AMINOACYLASE-1 | 13 | 412 | 2.2E-161 |
| 10 | g12611.t1 | PIRSF | PIRSF036696 | ACY-1 | 14 | 413 | 1.1E-181 |
| 2 | g12611.t1 | Pfam | PF01546 | Peptidase family M20/M25/M40 | 89 | 408 | 1.5E-37 |
| 1 | g12611.t1 | Pfam | PF07687 | Peptidase dimerisation domain | 202 | 308 | 1.4E-10 |
| 12 | g12611.t1 | ProSitePatterns | PS00759 | ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. | 124 | 163 | - |
| 5 | g12611.t1 | SUPERFAMILY | SSF53187 | Zn-dependent exopeptidases | 13 | 411 | 4.59E-57 |
| 6 | g12611.t1 | SUPERFAMILY | SSF55031 | Bacterial exopeptidase dimerisation domain | 207 | 308 | 7.63E-11 |
| 13 | g12611.t1 | TIGRFAM | TIGR01880 | Ac-peptdase-euk: N-acyl-L-amino-acid amidohydrolase | 18 | 412 | 1.2E-170 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016787 | hydrolase activity | MF |
| GO:0006520 | cellular amino acid metabolic process | BP |
| GO:0004046 | aminoacylase activity | MF |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
- This transcript has been annotated with K14677 (aminoacylase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
