General information for g12611.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aminoacylase-1A.
Parent gene
- The parent gene g12611 is located on chr_1: 24784989..24787293 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12611 | g12611.t3 | TTS | g12611.t3 | 24784552 | 24784552 |
| chr_1 | g12611 | g12611.t3 | isoform | g12611.t3 | 24784700 | 24786951 |
| chr_1 | g12611 | g12611.t3 | exon | g12611.t3.exon1 | 24784700 | 24784904 |
| chr_1 | g12611 | g12611.t3 | cds | g12611.t3.CDS1 | 24784700 | 24784904 |
| chr_1 | g12611 | g12611.t3 | exon | g12611.t3.exon2 | 24784976 | 24785447 |
| chr_1 | g12611 | g12611.t3 | cds | g12611.t3.CDS2 | 24784976 | 24785447 |
| chr_1 | g12611 | g12611.t3 | exon | g12611.t3.exon3 | 24785580 | 24785760 |
| chr_1 | g12611 | g12611.t3 | cds | g12611.t3.CDS3 | 24785580 | 24785760 |
| chr_1 | g12611 | g12611.t3 | exon | g12611.t3.exon4 | 24786316 | 24786951 |
| chr_1 | g12611 | g12611.t3 | cds | g12611.t3.CDS4 | 24786316 | 24786468 |
| chr_1 | g12611 | g12611.t3 | TSS | g12611.t3 | 24787291 | 24787291 |
Sequences
>g12611.t3 Gene=g12611 Length=1494
ATGGAGTGCAATTTGATTTTGAGAGATGAAGAGAAGAACAAACAATATCAAAATTGGGAA
AATAATGAAGAAATTCAGATTTTTCGCGAATACTTGCGAATACCGACAGTGCATCCAAAC
ATTGATTACCGTAAGTTTGACATATATGACATATGAATGAAAGTAAATTCCCTTACACAC
TTGTCGTGAATGAATTCTATTAATAGTGACACCGAAAATGAGAGAAACAATCAAATCAAA
TCAACAACTTGTTGTCTCCGTCATTTTTCTATTTTTATTACACGCACAATTTAAAATCTT
CTCATCTTTCTGTCAATATGACCTTCAACCTGAAAAATGATCTTTTAATCGCTTTGTTTA
TGTTGATCCTTTTTATTTACAGGCGATTGTGTTCGTTTTTTGTTTCGACTCGCTGATGAG
ATTGGCTTGAGTGCGAAAATCTTCTATCCCATAGAGAAAAGTAAGCCGGTTGTTGTGCTT
ACTATGCTTGGCACAAATCCAGAACTCAAGTCCATTATTTTAAATTCTCATATGGACGTT
GTTCCGGTTTTTGAAGAATACTGGACTCACAAGCCATTTGATGCTGAAATGGATGAAGAA
GGGAGAATTTTTGCTCGTGGTGCACAAGACATGAAGTGTTGTGGAATGCAATATTTATCA
GCACTCAGATACTTCAAAAGAAAAAATATACAGTTCAAACGAACAATTCATGTTGTTTTT
GTGCCAAATGAAGAACTAGGTGGTCAAGGTGGAATGGCTGATTTTGTTCATACAACAGAA
TTCCGAGCTCTTAATTGTGGATTTTCACTTGATGAAGGAATTGCATCACCAACAGATACA
TTCAATGTTTTCTATGCAGAAAGATGTATATGGCACATAATCTTTACAATCAATGGGAAT
AATGGTCATGGCGCACTTTTACTAAAAGACACTGCACCAGAAAAGCTTCGTAAAATTTTA
GACAGATTTTATGACTTTCGCGATACTCAAGTGAAAAAACTATTGGAAAATCCAGATTTG
ACAATTGGTGATGTTACAACTGTTAATATAACAATGATAAATGGCGGTGTACAATTGAAC
ACAGTTCCACCAGAAATTCGTGTTATGACAGACATTCGTTTAGCTGTTGATGTTGATCAT
GAACAATTTGAAAATATGGTAAAAAGCTGGTGCATTGAAGCTGGCAATGTTGAATATGAA
TTTGATCTCAAAGATCCCTTCATTCCACCAACAAAACTTGATGAATCAAATATTTATTGG
CATGCATTTAAATCAGCTGTTAGCGAAGCAAATATAAAAACCAAAGTTCAAGTTTTTCCT
GGTGGAACTGATTCTCGATATTTGAGAAGCGTCGGAATTCCTGCAATCGGTTTCAGTCCA
ATGAATAATACTCCTGTTTTACTTCATGATCATGATGAGTTCCTTCAAGCCGATGTCTAC
CTCAGAGGAATTGAAATTTATAAGAAAATTATTAGCAAAGTTGCAAATTGCTAA
>g12611.t3 Gene=g12611 Length=336
MLGTNPELKSIILNSHMDVVPVFEEYWTHKPFDAEMDEEGRIFARGAQDMKCCGMQYLSA
LRYFKRKNIQFKRTIHVVFVPNEELGGQGGMADFVHTTEFRALNCGFSLDEGIASPTDTF
NVFYAERCIWHIIFTINGNNGHGALLLKDTAPEKLRKILDRFYDFRDTQVKKLLENPDLT
IGDVTTVNITMINGGVQLNTVPPEIRVMTDIRLAVDVDHEQFENMVKSWCIEAGNVEYEF
DLKDPFIPPTKLDESNIYWHAFKSAVSEANIKTKVQVFPGGTDSRYLRSVGIPAIGFSPM
NNTPVLLHDHDEFLQADVYLRGIEIYKKIISKVANC
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g12611.t3 | Gene3D | G3DSA:3.40.630.10 | Zn peptidases | 1 | 131 | 1.7E-41 |
| 8 | g12611.t3 | Gene3D | G3DSA:3.30.70.360 | - | 132 | 244 | 1.7E-19 |
| 10 | g12611.t3 | Gene3D | G3DSA:3.30.70.1640 | - | 256 | 336 | 3.9E-37 |
| 3 | g12611.t3 | PANTHER | PTHR45892 | AMINOACYLASE-1 | 3 | 335 | 3.1E-141 |
| 4 | g12611.t3 | PANTHER | PTHR45892:SF1 | AMINOACYLASE-1 | 3 | 335 | 3.1E-141 |
| 12 | g12611.t3 | PIRSF | PIRSF036696 | ACY-1 | 1 | 336 | 2.4E-155 |
| 2 | g12611.t3 | Pfam | PF01546 | Peptidase family M20/M25/M40 | 12 | 331 | 7.2E-38 |
| 1 | g12611.t3 | Pfam | PF07687 | Peptidase dimerisation domain | 125 | 231 | 9.4E-11 |
| 7 | g12611.t3 | ProSitePatterns | PS00759 | ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. | 47 | 86 | - |
| 5 | g12611.t3 | SUPERFAMILY | SSF53187 | Zn-dependent exopeptidases | 3 | 335 | 1.63E-47 |
| 6 | g12611.t3 | SUPERFAMILY | SSF55031 | Bacterial exopeptidase dimerisation domain | 130 | 231 | 5.08E-11 |
| 11 | g12611.t3 | TIGRFAM | TIGR01880 | Ac-peptdase-euk: N-acyl-L-amino-acid amidohydrolase | 2 | 335 | 9.3E-148 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016787 | hydrolase activity | MF |
| GO:0006520 | cellular amino acid metabolic process | BP |
| GO:0004046 | aminoacylase activity | MF |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
