General information for g12728.t11
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member B10.
Parent gene
- The parent gene g12728 is located on chr_1: 25507881..25508906 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12728 | g12728.t11 | TTS | g12728.t11 | 25507381 | 25507381 |
| chr_1 | g12728 | g12728.t11 | isoform | g12728.t11 | 25507382 | 25508906 |
| chr_1 | g12728 | g12728.t11 | exon | g12728.t11.exon1 | 25507382 | 25507765 |
| chr_1 | g12728 | g12728.t11 | cds | g12728.t11.CDS1 | 25507464 | 25507765 |
| chr_1 | g12728 | g12728.t11 | exon | g12728.t11.exon2 | 25507838 | 25508414 |
| chr_1 | g12728 | g12728.t11 | cds | g12728.t11.CDS2 | 25507838 | 25508414 |
| chr_1 | g12728 | g12728.t11 | exon | g12728.t11.exon3 | 25508829 | 25508906 |
| chr_1 | g12728 | g12728.t11 | cds | g12728.t11.CDS3 | 25508829 | 25508906 |
| chr_1 | g12728 | g12728.t11 | TSS | g12728.t11 | 25508972 | 25508972 |
Sequences
>g12728.t11 Gene=g12728 Length=1039
ATGGCAGCACCTACTGTTACTCTCAATAATGGCAAACAATTTCCAATCGTTGGCCTTGGT
AATGAAAAAAATTTGAATTCACCACCTGGTGTTGTTGCTCAAGCTGTAAAAGACGCAATT
GATGCTGGCTATCGTCATTTTGACGGTGCTCATGTATATGAAAATGAGCATGAAGTTGGT
GAAGGAATTAATGCTAAAATCGCTGAAGGTGTTATCAAACGTGAAGACGTTTTTGTAACA
TCAAAATTATGGTGCACTTTCCATGACCCAAAGGATGTTCGTGGTGCACTCGAGCATACA
TTGAAACAATTAAATTTAGATTATCTTGACTTGTACCTCATGCATTGGCCTATTTGTTAT
CAAAAATCAACTGAATTGTTCCCAAAGAATGAAGCTGGTGAAATTTTGCACGCTAATTTT
GATATTCTTGACACTTATCGTGCAATGGAGGAACTTGTTGATGCTGGATTGACTAAAAGT
ATTGGAATTTCAAACTTCAATATCAAACAAGTTGAGTACATTACTAAAAATGCTCGCATC
CAACCAGTCACCAATCAAGTTGAATGCAATCCATATTTACTTAATAAAGAATTAAGTGAT
TTCTGCAAAAGTAAAAACATTGTCATCACCGCTTATTCACCTCTTGGTTCACCAGGTCGT
CCATGGGCAACACCAGATGACCGAGTATTATTAAAAGAACCAAAACTTTTAGAGATCGCT
CAGAAGCACAATAAAACACCAGCACAAATTTTAATCCGTTACCAAATTCAACGCGGTCAC
GTTGTCATACCGAAATCAGTTACGAAGGATCGCATAATCAGTAATTTTGATGTTTTCAAC
TTCACATTGAGCGATTCTGAAATAAAAGATTTGGAAAACTTCAACTATACTGAGCGCATT
TGTAGCATGTCTCAAGATAAACATCATCCAGCTTATCCTTTCAATGACGACGCCTAAAAA
ATGCACCGCCTGCCTCTTTTTTGATTGTCTGATTATCAAAAAAATGAAATAAATGTGGAA
CACACAGTTTCTTTTCAAA
>g12728.t11 Gene=g12728 Length=318
MAAPTVTLNNGKQFPIVGLGNEKNLNSPPGVVAQAVKDAIDAGYRHFDGAHVYENEHEVG
EGINAKIAEGVIKREDVFVTSKLWCTFHDPKDVRGALEHTLKQLNLDYLDLYLMHWPICY
QKSTELFPKNEAGEILHANFDILDTYRAMEELVDAGLTKSIGISNFNIKQVEYITKNARI
QPVTNQVECNPYLLNKELSDFCKSKNIVITAYSPLGSPGRPWATPDDRVLLKEPKLLEIA
QKHNKTPAQILIRYQIQRGHVVIPKSVTKDRIISNFDVFNFTLSDSEIKDLENFNYTERI
CSMSQDKHHPAYPFNDDA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g12728.t11 | Gene3D | G3DSA:3.20.20.100 | - | 2 | 318 | 5.9E-130 |
| 2 | g12728.t11 | PANTHER | PTHR11732:SF294 | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 | 3 | 316 | 1.0E-119 |
| 3 | g12728.t11 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 3 | 316 | 1.0E-119 |
| 14 | g12728.t11 | PIRSF | PIRSF000097 | AKR | 1 | 318 | 5.6E-125 |
| 5 | g12728.t11 | PRINTS | PR00069 | Aldo-keto reductase signature | 39 | 63 | 5.4E-57 |
| 8 | g12728.t11 | PRINTS | PR00069 | Aldo-keto reductase signature | 99 | 117 | 5.4E-57 |
| 6 | g12728.t11 | PRINTS | PR00069 | Aldo-keto reductase signature | 149 | 166 | 5.4E-57 |
| 7 | g12728.t11 | PRINTS | PR00069 | Aldo-keto reductase signature | 183 | 212 | 5.4E-57 |
| 4 | g12728.t11 | PRINTS | PR00069 | Aldo-keto reductase signature | 230 | 254 | 5.4E-57 |
| 1 | g12728.t11 | Pfam | PF00248 | Aldo/keto reductase family | 31 | 293 | 4.1E-53 |
| 11 | g12728.t11 | ProSitePatterns | PS00798 | Aldo/keto reductase family signature 1. | 43 | 60 | - |
| 10 | g12728.t11 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 149 | 166 | - |
| 12 | g12728.t11 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 263 | 278 | - |
| 9 | g12728.t11 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 4 | 312 | 1.22E-96 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K00002 (alcohol dehydrogenase (NADP+))
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
