General information for g12728.t13
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member B10.
Parent gene
- The parent gene g12728 is located on chr_1: 25507881..25508906 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12728 | g12728.t13 | TTS | g12728.t13 | 25507381 | 25507381 |
| chr_1 | g12728 | g12728.t13 | isoform | g12728.t13 | 25507382 | 25508906 |
| chr_1 | g12728 | g12728.t13 | exon | g12728.t13.exon1 | 25507382 | 25507765 |
| chr_1 | g12728 | g12728.t13 | cds | g12728.t13.CDS1 | 25507464 | 25507765 |
| chr_1 | g12728 | g12728.t13 | exon | g12728.t13.exon2 | 25507838 | 25508414 |
| chr_1 | g12728 | g12728.t13 | cds | g12728.t13.CDS2 | 25507838 | 25508414 |
| chr_1 | g12728 | g12728.t13 | exon | g12728.t13.exon3 | 25508843 | 25508906 |
| chr_1 | g12728 | g12728.t13 | cds | g12728.t13.CDS3 | 25508843 | 25508878 |
| chr_1 | g12728 | g12728.t13 | TSS | g12728.t13 | 25508972 | 25508972 |
Sequences
>g12728.t13 Gene=g12728 Length=1025
ATGGCAGCACCTACTGTTACTCTCAATAATGGCAAACAATTTCCAATCGTTGGCCTTGGT
AATGTCACCACCTGGTGTTGTTGCTCAAGCTGTAAAAGACGCAATTGATGCTGGCTATCG
TCATTTTGACGGTGCTCATGTATATGAAAATGAGCATGAAGTTGGTGAAGGAATTAATGC
TAAAATCGCTGAAGGTGTTATCAAACGTGAAGACGTTTTTGTAACATCAAAATTATGGTG
CACTTTCCATGACCCAAAGGATGTTCGTGGTGCACTCGAGCATACATTGAAACAATTAAA
TTTAGATTATCTTGACTTGTACCTCATGCATTGGCCTATTTGTTATCAAAAATCAACTGA
ATTGTTCCCAAAGAATGAAGCTGGTGAAATTTTGCACGCTAATTTTGATATTCTTGACAC
TTATCGTGCAATGGAGGAACTTGTTGATGCTGGATTGACTAAAAGTATTGGAATTTCAAA
CTTCAATATCAAACAAGTTGAGTACATTACTAAAAATGCTCGCATCCAACCAGTCACCAA
TCAAGTTGAATGCAATCCATATTTACTTAATAAAGAATTAAGTGATTTCTGCAAAAGTAA
AAACATTGTCATCACCGCTTATTCACCTCTTGGTTCACCAGGTCGTCCATGGGCAACACC
AGATGACCGAGTATTATTAAAAGAACCAAAACTTTTAGAGATCGCTCAGAAGCACAATAA
AACACCAGCACAAATTTTAATCCGTTACCAAATTCAACGCGGTCACGTTGTCATACCGAA
ATCAGTTACGAAGGATCGCATAATCAGTAATTTTGATGTTTTCAACTTCACATTGAGCGA
TTCTGAAATAAAAGATTTGGAAAACTTCAACTATACTGAGCGCATTTGTAGCATGTCTCA
AGATAAACATCATCCAGCTTATCCTTTCAATGACGACGCCTAAAAAATGCACCGCCTGCC
TCTTTTTTGATTGTCTGATTATCAAAAAAATGAAATAAATGTGGAACACACAGTTTCTTT
TCAAA
>g12728.t13 Gene=g12728 Length=304
MANNFQSLALVMSPPGVVAQAVKDAIDAGYRHFDGAHVYENEHEVGEGINAKIAEGVIKR
EDVFVTSKLWCTFHDPKDVRGALEHTLKQLNLDYLDLYLMHWPICYQKSTELFPKNEAGE
ILHANFDILDTYRAMEELVDAGLTKSIGISNFNIKQVEYITKNARIQPVTNQVECNPYLL
NKELSDFCKSKNIVITAYSPLGSPGRPWATPDDRVLLKEPKLLEIAQKHNKTPAQILIRY
QIQRGHVVIPKSVTKDRIISNFDVFNFTLSDSEIKDLENFNYTERICSMSQDKHHPAYPF
NDDA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g12728.t13 | Gene3D | G3DSA:3.20.20.100 | - | 6 | 304 | 3.6E-124 |
| 2 | g12728.t13 | PANTHER | PTHR11732:SF294 | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 | 7 | 302 | 3.3E-116 |
| 3 | g12728.t13 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 7 | 302 | 3.3E-116 |
| 16 | g12728.t13 | PIRSF | PIRSF000097 | AKR | 7 | 304 | 6.5E-119 |
| 8 | g12728.t13 | PRINTS | PR00069 | Aldo-keto reductase signature | 25 | 49 | 4.5E-57 |
| 6 | g12728.t13 | PRINTS | PR00069 | Aldo-keto reductase signature | 85 | 103 | 4.5E-57 |
| 5 | g12728.t13 | PRINTS | PR00069 | Aldo-keto reductase signature | 135 | 152 | 4.5E-57 |
| 4 | g12728.t13 | PRINTS | PR00069 | Aldo-keto reductase signature | 169 | 198 | 4.5E-57 |
| 7 | g12728.t13 | PRINTS | PR00069 | Aldo-keto reductase signature | 216 | 240 | 4.5E-57 |
| 1 | g12728.t13 | Pfam | PF00248 | Aldo/keto reductase family | 18 | 279 | 6.3E-53 |
| 12 | g12728.t13 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 13 | g12728.t13 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 4 | - |
| 14 | g12728.t13 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 5 | 12 | - |
| 15 | g12728.t13 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 13 | 19 | - |
| 11 | g12728.t13 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 304 | - |
| 18 | g12728.t13 | ProSitePatterns | PS00798 | Aldo/keto reductase family signature 1. | 29 | 46 | - |
| 17 | g12728.t13 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 135 | 152 | - |
| 19 | g12728.t13 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 249 | 264 | - |
| 9 | g12728.t13 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 14 | 298 | 7.07E-92 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
