General information for g12728.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member B1.
Parent gene
- The parent gene g12728 is located on chr_1: 25507881..25508906 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12728 | g12728.t2 | isoform | g12728.t2 | 25505503 | 25508906 |
| chr_1 | g12728 | g12728.t2 | exon | g12728.t2.exon1 | 25505503 | 25505719 |
| chr_1 | g12728 | g12728.t2 | exon | g12728.t2.exon2 | 25507381 | 25507765 |
| chr_1 | g12728 | g12728.t2 | cds | g12728.t2.CDS1 | 25507464 | 25507765 |
| chr_1 | g12728 | g12728.t2 | exon | g12728.t2.exon3 | 25507838 | 25508414 |
| chr_1 | g12728 | g12728.t2 | cds | g12728.t2.CDS2 | 25507838 | 25508153 |
| chr_1 | g12728 | g12728.t2 | exon | g12728.t2.exon4 | 25508839 | 25508906 |
| chr_1 | g12728 | g12728.t2 | TSS | g12728.t2 | 25508972 | 25508972 |
| chr_1 | g12728 | g12728.t2 | TTS | g12728.t2 | NA | NA |
Sequences
>g12728.t2 Gene=g12728 Length=1247
ATGGCAGCACCTACTGTTACTCTCAATAATGGCAAACAATTTCCAATCGTTGGCCTTGGT
AATGAAAATCACCACCTGGTGTTGTTGCTCAAGCTGTAAAAGACGCAATTGATGCTGGCT
ATCGTCATTTTGACGGTGCTCATGTATATGAAAATGAGCATGAAGTTGGTGAAGGAATTA
ATGCTAAAATCGCTGAAGGTGTTATCAAACGTGAAGACGTTTTTGTAACATCAAAATTAT
GGTGCACTTTCCATGACCCAAAGGATGTTCGTGGTGCACTCGAGCATACATTGAAACAAT
TAAATTTAGATTATCTTGACTTGTACCTCATGCATTGGCCTATTTGTTATCAAAAATCAA
CTGAATTGTTCCCAAAGAATGAAGCTGGTGAAATTTTGCACGCTAATTTTGATATTCTTG
ACACTTATCGTGCAATGGAGGAACTTGTTGATGCTGGATTGACTAAAAGTATTGGAATTT
CAAACTTCAATATCAAACAAGTTGAGTACATTACTAAAAATGCTCGCATCCAACCAGTCA
CCAATCAAGTTGAATGCAATCCATATTTACTTAATAAAGAATTAAGTGATTTCTGCAAAA
GTAAAAACATTGTCATCACCGCTTATTCACCTCTTGGTTCACCAGGTCGTCCATGGGCAA
CACCAGATGACCGAGTATTATTAAAAGAACCAAAACTTTTAGAGATCGCTCAGAAGCACA
ATAAAACACCAGCACAAATTTTAATCCGTTACCAAATTCAACGCGGTCACGTTGTCATAC
CGAAATCAGTTACGAAGGATCGCATAATCAGTAATTTTGATGTTTTCAACTTCACATTGA
GCGATTCTGAAATAAAAGATTTGGAAAACTTCAACTATACTGAGCGCATTTGTAGCATGT
CTCAAGATAAACATCATCCAGCTTATCCTTTCAATGACGACGCCTAAAAAATGCACCGCC
TGCCTCTTTTTTGATTGTCTGATTATCAAAAAAATGAAATAAATGTGGAACACACAGTTT
CTTTTCAAATATTCCTGCTTAAATCTATTAACTTCTCGTTCAACTTCATTTTGATGAGCT
TTACGCATTGATTCAAGAGCCTGCAATGTTGCTTGCGTTTCTTCAGCTAGTGCCTGTTCT
TTTTCTTCCAATAATTTTTGTATTTCTGCTTTATGTTTCGCTTCCAAATCCGCTATTTTA
CGTTTATGTGACGACTCAATTGCCACAAGACCTTTCTCACAGAGAAT
>g12728.t2 Gene=g12728 Length=205
MHWPICYQKSTELFPKNEAGEILHANFDILDTYRAMEELVDAGLTKSIGISNFNIKQVEY
ITKNARIQPVTNQVECNPYLLNKELSDFCKSKNIVITAYSPLGSPGRPWATPDDRVLLKE
PKLLEIAQKHNKTPAQILIRYQIQRGHVVIPKSVTKDRIISNFDVFNFTLSDSEIKDLEN
FNYTERICSMSQDKHHPAYPFNDDA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g12728.t2 | Gene3D | G3DSA:3.20.20.100 | - | 1 | 205 | 1.3E-79 |
| 2 | g12728.t2 | PANTHER | PTHR11732:SF294 | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 | 1 | 203 | 1.5E-68 |
| 3 | g12728.t2 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 1 | 203 | 1.5E-68 |
| 4 | g12728.t2 | PRINTS | PR00069 | Aldo-keto reductase signature | 36 | 53 | 6.7E-33 |
| 6 | g12728.t2 | PRINTS | PR00069 | Aldo-keto reductase signature | 70 | 99 | 6.7E-33 |
| 5 | g12728.t2 | PRINTS | PR00069 | Aldo-keto reductase signature | 117 | 141 | 6.7E-33 |
| 1 | g12728.t2 | Pfam | PF00248 | Aldo/keto reductase family | 2 | 180 | 1.1E-30 |
| 8 | g12728.t2 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 36 | 53 | - |
| 9 | g12728.t2 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 150 | 165 | - |
| 7 | g12728.t2 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 1 | 200 | 1.96E-56 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
