General information for g12729.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member B10.
Parent gene
- The parent gene g12729 is located on chr_1: 25509348..25510528 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12729 | g12729.t3 | TTS | g12729.t3 | 25509130 | 25509130 |
| chr_1 | g12729 | g12729.t3 | isoform | g12729.t3 | 25509348 | 25510528 |
| chr_1 | g12729 | g12729.t3 | exon | g12729.t3.exon1 | 25509348 | 25509652 |
| chr_1 | g12729 | g12729.t3 | cds | g12729.t3.CDS1 | 25509348 | 25509652 |
| chr_1 | g12729 | g12729.t3 | exon | g12729.t3.exon2 | 25509705 | 25510281 |
| chr_1 | g12729 | g12729.t3 | cds | g12729.t3.CDS2 | 25509705 | 25510281 |
| chr_1 | g12729 | g12729.t3 | exon | g12729.t3.exon3 | 25510477 | 25510528 |
| chr_1 | g12729 | g12729.t3 | cds | g12729.t3.CDS3 | 25510477 | 25510506 |
| chr_1 | g12729 | g12729.t3 | TSS | g12729.t3 | 25510605 | 25510605 |
Sequences
>g12729.t3 Gene=g12729 Length=934
ATGACAACTATTACATTAAATAATGGAAAAGAATTTCCAGTTGTTGGTTTTGGCACCGTC
TGGAGTTGTAATTCAAGCTGTAAAAGATGCAATTGATGCTGGATATCGTCATATTGATTG
TGCTCACATTTATGGTAATGAGCATGAAGTTGGTGAAGCAATTAATGCAAAAATCGCTGA
AGGTATCGTCAAGCGTGAAGATCTTTTTATAGTTTCAAAACTTTGGAGTTGTTTTCATGA
AGCAAAAGAAGTTAAGCCAGCACTTGAACATTCATTGAAGCAACTAAATTTAGACTATCT
TGACTTGTACCTCATTCATTGGCCTATTTGTTATCAAAAGTCTAATGAACTTTGCCCAAC
AAATGAAGCTGGTGAAATTCTCTATGGAAATACTGATATTCTTGACACTTATCGTGCAAT
GGAAGAACTTGTTGATGCTGGATTGACTAAAAGTATTGGAATTTCAAATTTTAATATCAA
ACAAGTAGAGCACATCACTAAAAATGCTCGCATTCAACCAGTCACCAATCAAGTTGAATG
CCATCCATATTTGTTGAACAAAAAATTATCTGATTTCTGCAAGAGCAAGAATATTGTCAT
CACCGCTTATGCACCACTTGGATCACCAGCTAGACCATGGGCAACGCCAGATGATCGTAT
TCTTTTAAAAGAACCGAAATTATTAGAAATTGCCGAAAAGCACAAAAAGACACCAGCACA
AGTTTTAATTCGATTCCAAATTCAGCTTGGTCATGTTGCCATTCCTAAGTCAGTTACAAA
GGATCGCATAATCAGCAATTTTGATGTCTTTAACTTTACTTTGAGTGACAGTGACATGAA
TGATTTGCAAAGCTTTGGACATGTTGAACGTGTATTCACAATTTCTCGTGATAAGGATCA
TCCAAATTATCCCTTTAATGATGAAGAAGCTTGA
>g12729.t3 Gene=g12729 Length=303
MEKNFQLLVLAPSGVVIQAVKDAIDAGYRHIDCAHIYGNEHEVGEAINAKIAEGIVKRED
LFIVSKLWSCFHEAKEVKPALEHSLKQLNLDYLDLYLIHWPICYQKSNELCPTNEAGEIL
YGNTDILDTYRAMEELVDAGLTKSIGISNFNIKQVEHITKNARIQPVTNQVECHPYLLNK
KLSDFCKSKNIVITAYAPLGSPARPWATPDDRILLKEPKLLEIAEKHKKTPAQVLIRFQI
QLGHVAIPKSVTKDRIISNFDVFNFTLSDSDMNDLQSFGHVERVFTISRDKDHPNYPFND
EEA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g12729.t3 | Gene3D | G3DSA:3.20.20.100 | - | 7 | 302 | 4.8E-122 |
| 2 | g12729.t3 | PANTHER | PTHR11732:SF294 | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 | 10 | 300 | 9.2E-117 |
| 3 | g12729.t3 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 10 | 300 | 9.2E-117 |
| 16 | g12729.t3 | PIRSF | PIRSF000097 | AKR | 8 | 302 | 4.6E-117 |
| 4 | g12729.t3 | PRINTS | PR00069 | Aldo-keto reductase signature | 23 | 47 | 6.6E-60 |
| 7 | g12729.t3 | PRINTS | PR00069 | Aldo-keto reductase signature | 83 | 101 | 6.6E-60 |
| 5 | g12729.t3 | PRINTS | PR00069 | Aldo-keto reductase signature | 133 | 150 | 6.6E-60 |
| 6 | g12729.t3 | PRINTS | PR00069 | Aldo-keto reductase signature | 167 | 196 | 6.6E-60 |
| 8 | g12729.t3 | PRINTS | PR00069 | Aldo-keto reductase signature | 214 | 238 | 6.6E-60 |
| 1 | g12729.t3 | Pfam | PF00248 | Aldo/keto reductase family | 16 | 277 | 2.9E-53 |
| 12 | g12729.t3 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 13 | g12729.t3 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 4 | - |
| 14 | g12729.t3 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 5 | 15 | - |
| 15 | g12729.t3 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 16 | 19 | - |
| 11 | g12729.t3 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 303 | - |
| 18 | g12729.t3 | ProSitePatterns | PS00798 | Aldo/keto reductase family signature 1. | 27 | 44 | - |
| 17 | g12729.t3 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 133 | 150 | - |
| 19 | g12729.t3 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 247 | 262 | - |
| 9 | g12729.t3 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 13 | 280 | 5.37E-90 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
