Gene loci information

Transcript annotation

  • This transcript has been annotated as Putative Aldo-keto reductase family 1 member A1-A.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g12729 g12729.t7 TTS g12729.t7 25509130 25509130
chr_1 g12729 g12729.t7 isoform g12729.t7 25509348 25510528
chr_1 g12729 g12729.t7 exon g12729.t7.exon1 25509348 25509652
chr_1 g12729 g12729.t7 cds g12729.t7.CDS1 25509348 25509652
chr_1 g12729 g12729.t7 exon g12729.t7.exon2 25509705 25510302
chr_1 g12729 g12729.t7 cds g12729.t7.CDS2 25509705 25509915
chr_1 g12729 g12729.t7 exon g12729.t7.exon3 25510487 25510528
chr_1 g12729 g12729.t7 TSS g12729.t7 25510605 25510605

Sequences

>g12729.t7 Gene=g12729 Length=945
ATGACAACTATTACATTAAATAATGGAAAAGAATTTCCAGTTAGTTGAATTTTAATTTTT
TAGGCACCGTCTGGAGTTGTAATTCAAGCTGTAAAAGATGCAATTGATGCTGGATATCGT
CATATTGATTGTGCTCACATTTATGGTAATGAGCATGAAGTTGGTGAAGCAATTAATGCA
AAAATCGCTGAAGGTATCGTCAAGCGTGAAGATCTTTTTATAGTTTCAAAACTTTGGAGT
TGTTTTCATGAAGCAAAAGAAGTTAAGCCAGCACTTGAACATTCATTGAAGCAACTAAAT
TTAGACTATCTTGACTTGTACCTCATTCATTGGCCTATTTGTTATCAAAAGTCTAATGAA
CTTTGCCCAACAAATGAAGCTGGTGAAATTCTCTATGGAAATACTGATATTCTTGACACT
TATCGTGCAATGGAAGAACTTGTTGATGCTGGATTGACTAAAAGTATTGGAATTTCAAAT
TTTAATATCAAACAAGTAGAGCACATCACTAAAAATGCTCGCATTCAACCAGTCACCAAT
CAAGTTGAATGCCATCCATATTTGTTGAACAAAAAATTATCTGATTTCTGCAAGAGCAAG
AATATTGTCATCACCGCTTATGCACCACTTGGATCACCAGCTAGACCATGGGCAACGCCA
GATGATCGTATTCTTTTAAAAGAACCGAAATTATTAGAAATTGCCGAAAAGCACAAAAAG
ACACCAGCACAAGTTTTAATTCGATTCCAAATTCAGCTTGGTCATGTTGCCATTCCTAAG
TCAGTTACAAAGGATCGCATAATCAGCAATTTTGATGTCTTTAACTTTACTTTGAGTGAC
AGTGACATGAATGATTTGCAAAGCTTTGGACATGTTGAACGTGTATTCACAATTTCTCGT
GATAAGGATCATCCAAATTATCCCTTTAATGATGAAGAAGCTTGA

>g12729.t7 Gene=g12729 Length=171
MEELVDAGLTKSIGISNFNIKQVEHITKNARIQPVTNQVECHPYLLNKKLSDFCKSKNIV
ITAYAPLGSPARPWATPDDRILLKEPKLLEIAEKHKKTPAQVLIRFQIQLGHVAIPKSVT
KDRIISNFDVFNFTLSDSDMNDLQSFGHVERVFTISRDKDHPNYPFNDEEA

Protein features from InterProScan

Transcript Database ID Name Start End E.value
10 g12729.t7 Gene3D G3DSA:3.20.20.100 - 1 170 3.3E-66
2 g12729.t7 PANTHER PTHR11732:SF294 ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 1 168 1.7E-60
3 g12729.t7 PANTHER PTHR11732 ALDO/KETO REDUCTASE 1 168 1.7E-60
6 g12729.t7 PRINTS PR00069 Aldo-keto reductase signature 1 18 2.8E-34
5 g12729.t7 PRINTS PR00069 Aldo-keto reductase signature 35 64 2.8E-34
4 g12729.t7 PRINTS PR00069 Aldo-keto reductase signature 82 106 2.8E-34
1 g12729.t7 Pfam PF00248 Aldo/keto reductase family 1 145 2.5E-26
8 g12729.t7 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 1 18 -
9 g12729.t7 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 115 130 -
7 g12729.t7 SUPERFAMILY SSF51430 NAD(P)-linked oxidoreductase 1 153 8.64E-46

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0047834 D-threo-aldose 1-dehydrogenase activity MF
GO:0055114 NA NA
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values