General information for g12729.t8
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Aldo-keto reductase family 1 member B10.
Parent gene
- The parent gene g12729 is located on chr_1: 25509348..25510528 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12729 | g12729.t8 | TTS | g12729.t8 | 25509130 | 25509130 |
| chr_1 | g12729 | g12729.t8 | isoform | g12729.t8 | 25509348 | 25510528 |
| chr_1 | g12729 | g12729.t8 | exon | g12729.t8.exon1 | 25509348 | 25509652 |
| chr_1 | g12729 | g12729.t8 | cds | g12729.t8.CDS1 | 25509348 | 25509652 |
| chr_1 | g12729 | g12729.t8 | exon | g12729.t8.exon2 | 25509705 | 25510281 |
| chr_1 | g12729 | g12729.t8 | cds | g12729.t8.CDS2 | 25509705 | 25510281 |
| chr_1 | g12729 | g12729.t8 | exon | g12729.t8.exon3 | 25510469 | 25510528 |
| chr_1 | g12729 | g12729.t8 | cds | g12729.t8.CDS3 | 25510469 | 25510528 |
| chr_1 | g12729 | g12729.t8 | TSS | g12729.t8 | 25510605 | 25510605 |
Sequences
>g12729.t8 Gene=g12729 Length=942
ATGACAACTATTACATTAAATAATGGAAAAGAATTTCCAGTTGTTGGTTTTGGTAATAAA
GCACCGTCTGGAGTTGTAATTCAAGCTGTAAAAGATGCAATTGATGCTGGATATCGTCAT
ATTGATTGTGCTCACATTTATGGTAATGAGCATGAAGTTGGTGAAGCAATTAATGCAAAA
ATCGCTGAAGGTATCGTCAAGCGTGAAGATCTTTTTATAGTTTCAAAACTTTGGAGTTGT
TTTCATGAAGCAAAAGAAGTTAAGCCAGCACTTGAACATTCATTGAAGCAACTAAATTTA
GACTATCTTGACTTGTACCTCATTCATTGGCCTATTTGTTATCAAAAGTCTAATGAACTT
TGCCCAACAAATGAAGCTGGTGAAATTCTCTATGGAAATACTGATATTCTTGACACTTAT
CGTGCAATGGAAGAACTTGTTGATGCTGGATTGACTAAAAGTATTGGAATTTCAAATTTT
AATATCAAACAAGTAGAGCACATCACTAAAAATGCTCGCATTCAACCAGTCACCAATCAA
GTTGAATGCCATCCATATTTGTTGAACAAAAAATTATCTGATTTCTGCAAGAGCAAGAAT
ATTGTCATCACCGCTTATGCACCACTTGGATCACCAGCTAGACCATGGGCAACGCCAGAT
GATCGTATTCTTTTAAAAGAACCGAAATTATTAGAAATTGCCGAAAAGCACAAAAAGACA
CCAGCACAAGTTTTAATTCGATTCCAAATTCAGCTTGGTCATGTTGCCATTCCTAAGTCA
GTTACAAAGGATCGCATAATCAGCAATTTTGATGTCTTTAACTTTACTTTGAGTGACAGT
GACATGAATGATTTGCAAAGCTTTGGACATGTTGAACGTGTATTCACAATTTCTCGTGAT
AAGGATCATCCAAATTATCCCTTTAATGATGAAGAAGCTTGA
>g12729.t8 Gene=g12729 Length=313
MTTITLNNGKEFPVVGFGNKAPSGVVIQAVKDAIDAGYRHIDCAHIYGNEHEVGEAINAK
IAEGIVKREDLFIVSKLWSCFHEAKEVKPALEHSLKQLNLDYLDLYLIHWPICYQKSNEL
CPTNEAGEILYGNTDILDTYRAMEELVDAGLTKSIGISNFNIKQVEHITKNARIQPVTNQ
VECHPYLLNKKLSDFCKSKNIVITAYAPLGSPARPWATPDDRILLKEPKLLEIAEKHKKT
PAQVLIRFQIQLGHVAIPKSVTKDRIISNFDVFNFTLSDSDMNDLQSFGHVERVFTISRD
KDHPNYPFNDEEA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g12729.t8 | Gene3D | G3DSA:3.20.20.100 | - | 1 | 312 | 1.2E-128 |
| 2 | g12729.t8 | PANTHER | PTHR11732:SF294 | ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 | 3 | 310 | 2.3E-119 |
| 3 | g12729.t8 | PANTHER | PTHR11732 | ALDO/KETO REDUCTASE | 3 | 310 | 2.3E-119 |
| 14 | g12729.t8 | PIRSF | PIRSF000097 | AKR | 1 | 312 | 3.5E-123 |
| 7 | g12729.t8 | PRINTS | PR00069 | Aldo-keto reductase signature | 33 | 57 | 8.9E-60 |
| 5 | g12729.t8 | PRINTS | PR00069 | Aldo-keto reductase signature | 93 | 111 | 8.9E-60 |
| 4 | g12729.t8 | PRINTS | PR00069 | Aldo-keto reductase signature | 143 | 160 | 8.9E-60 |
| 8 | g12729.t8 | PRINTS | PR00069 | Aldo-keto reductase signature | 177 | 206 | 8.9E-60 |
| 6 | g12729.t8 | PRINTS | PR00069 | Aldo-keto reductase signature | 224 | 248 | 8.9E-60 |
| 1 | g12729.t8 | Pfam | PF00248 | Aldo/keto reductase family | 26 | 287 | 2.1E-53 |
| 11 | g12729.t8 | ProSitePatterns | PS00798 | Aldo/keto reductase family signature 1. | 37 | 54 | - |
| 10 | g12729.t8 | ProSitePatterns | PS00062 | Aldo/keto reductase family signature 2. | 143 | 160 | - |
| 12 | g12729.t8 | ProSitePatterns | PS00063 | Aldo/keto reductase family putative active site signature. | 257 | 272 | - |
| 9 | g12729.t8 | SUPERFAMILY | SSF51430 | NAD(P)-linked oxidoreductase | 2 | 290 | 7.99E-94 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0047834 | D-threo-aldose 1-dehydrogenase activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
