Gene loci information

Transcript annotation

  • This transcript has been annotated as Hydroxyacylglutathione hydrolase, mitochondrial.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g12759 g12759.t11 TTS g12759.t11 25815885 25815885
chr_1 g12759 g12759.t11 isoform g12759.t11 25816024 25817434
chr_1 g12759 g12759.t11 exon g12759.t11.exon1 25816024 25816457
chr_1 g12759 g12759.t11 cds g12759.t11.CDS1 25816024 25816457
chr_1 g12759 g12759.t11 exon g12759.t11.exon2 25816528 25816826
chr_1 g12759 g12759.t11 cds g12759.t11.CDS2 25816528 25816826
chr_1 g12759 g12759.t11 exon g12759.t11.exon3 25816887 25816995
chr_1 g12759 g12759.t11 cds g12759.t11.CDS3 25816887 25816995
chr_1 g12759 g12759.t11 exon g12759.t11.exon4 25817118 25817251
chr_1 g12759 g12759.t11 cds g12759.t11.CDS4 25817118 25817193
chr_1 g12759 g12759.t11 exon g12759.t11.exon5 25817373 25817434
chr_1 g12759 g12759.t11 TSS g12759.t11 25817448 25817448

Sequences

>g12759.t11 Gene=g12759 Length=1038
TTTGTTTACATTGAAATTTTCTTGTAATAAAATATTAATTTTAAAGTGTTTTAAAACTAA
AATTGAAATCTTTTTCAGATAAGCTATCAACAATTTAATATCATTAAGTGCGATTATTAG
ATGATTTCACGGGTTTTTAATTCTATTACAAGCAAATTCTCTCAGTCACAATCATTAACT
GCAGCATATTTTACATATAAAGCTTGGAGACAAAACGGTTTGAGAGGTACACATAGTTCA
CAACAATCTATCAATATGACTGATATGAGTGTTAGAATTTTACCGGCATTGTCAGATAAC
TACATGTATTTGATAATATGCAATAAAACTAAAGAAGCTGCAATTGTAGATCCAGTGAAC
CCGGAAACTGTCATTGAAGCGGTGAAGAATGAGAATGTTGAACTCAAGTCAGTGCTTACA
ACACATCATCATTGGGATCATGCTGGAGGAAACGAAAAACTTCTCTCGCTCTTTGGTAAA
CCATTGACAGTTTACGGCGGAGATGACAGAATTGGCGGTCTCAACAAGAAAGTTAAACAA
GATGACAAGTTCAATATCGGCAATCTGAATGTTAGCTGCATATTCACGCCTTGTCACACA
AGTGGTCATATTTGTTATTATGTGGAGTCATCGACTGCTGAACAAAAAGCTGTTTTTACG
GGTGATACGCTTTTTCTTGGTGGCTGTGGTCGATTTTTTGAAGGAACGGCTGAACAAATG
TATTCTGCTTTAATTGAGAAGCTATCAAGTTTGCCTGATGAGACAAAAGTTTTCTGTGGT
CATGAATATGCACTGGGTAATTTGAAATTTGGAAATCATGTTGAGCCTGATAATAAAGAC
ATTTTGGCTAAAATTGAATGGACAAAAGCAAAACGTGATCAAAACGAGCCATCAGTACCA
TCCACAATAGGCGAAGAAAAGCTTATTAATCCATTTATGCGTGTTAATACTGAGTCAGTT
CAGAAATTTGCAAATTCTATTGGAAAACCCATTGATACGATGGCTCATATTCGTAAAGTT
AAAGATTCATTCAAATAA

>g12759.t11 Gene=g12759 Length=305
MISRVFNSITSKFSQSQSLTAAYFTYKAWRQNGLRGTHSSQQSINMTDMSVRILPALSDN
YMYLIICNKTKEAAIVDPVNPETVIEAVKNENVELKSVLTTHHHWDHAGGNEKLLSLFGK
PLTVYGGDDRIGGLNKKVKQDDKFNIGNLNVSCIFTPCHTSGHICYYVESSTAEQKAVFT
GDTLFLGGCGRFFEGTAEQMYSALIEKLSSLPDETKVFCGHEYALGNLKFGNHVEPDNKD
ILAKIEWTKAKRDQNEPSVPSTIGEEKLINPFMRVNTESVQKFANSIGKPIDTMAHIRKV
KDSFK

Protein features from InterProScan

Transcript Database ID Name Start End E.value
9 g12759.t11 CDD cd07723 hydroxyacylglutathione_hydrolase_MBL-fold 52 221 0.00000
7 g12759.t11 Gene3D G3DSA:3.60.15.10 - 49 305 0.00000
5 g12759.t11 Hamap MF_01374 Hydroxyacylglutathione hydrolase [gloB]. 49 304 36.64601
3 g12759.t11 PANTHER PTHR11935:SF80 HYDROXYACYLGLUTATHIONE HYDROLASE, MITOCHONDRIAL 39 305 0.00000
4 g12759.t11 PANTHER PTHR11935 BETA LACTAMASE DOMAIN 39 305 0.00000
8 g12759.t11 PIRSF PIRSF005457 Glx 44 304 0.00000
2 g12759.t11 Pfam PF00753 Metallo-beta-lactamase superfamily 62 221 0.00000
1 g12759.t11 Pfam PF16123 Hydroxyacylglutathione hydrolase C-terminus 222 304 0.00000
10 g12759.t11 SMART SM00849 Lactamase_B_5a 59 221 0.00000
6 g12759.t11 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase 49 304 0.00000
11 g12759.t11 TIGRFAM TIGR03413 GSH_gloB: hydroxyacylglutathione hydrolase 53 304 0.00000

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0004416 hydroxyacylglutathione hydrolase activity MF
GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione BP

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values