General information for g12759.t8
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Hydroxyacylglutathione hydrolase, mitochondrial.
Parent gene
- The parent gene g12759 is located on chr_1: 25816024..25817434 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12759 | g12759.t8 | TTS | g12759.t8 | 25815885 | 25815885 |
| chr_1 | g12759 | g12759.t8 | isoform | g12759.t8 | 25816024 | 25817193 |
| chr_1 | g12759 | g12759.t8 | exon | g12759.t8.exon1 | 25816024 | 25816457 |
| chr_1 | g12759 | g12759.t8 | cds | g12759.t8.CDS1 | 25816024 | 25816457 |
| chr_1 | g12759 | g12759.t8 | exon | g12759.t8.exon2 | 25816531 | 25816826 |
| chr_1 | g12759 | g12759.t8 | cds | g12759.t8.CDS2 | 25816531 | 25816826 |
| chr_1 | g12759 | g12759.t8 | exon | g12759.t8.exon3 | 25816887 | 25817193 |
| chr_1 | g12759 | g12759.t8 | cds | g12759.t8.CDS3 | 25816887 | 25816936 |
| chr_1 | g12759 | g12759.t8 | TSS | g12759.t8 | 25817448 | 25817448 |
Sequences
>g12759.t8 Gene=g12759 Length=1037
ATGATTTCACGGGTTTTTAATTCTATTACAAGCAAATTCTCTCAGTCACAATCATTAACT
GCAGCATATTTTACATGTAAGCTCCCTCAAATTTATTTCTGGAAATTTTTATCAGTTATC
AGTTGTTTATTTATTAATTTCTAAAATTAGATTAGAATTTTTCTATTATCATTATTAAAT
AATCAATTTCATTTAAAGATAAAGCTTGGAGACAAAACGGTTTGAGAGGTACACATAGTT
CACAACAATCTATCAATATGACTGATATGAGTGTTAGAATTTTACCGGCATTGTCAGATA
ACTACATGTATTTGATAATATGCAATAAAACTAAAGAAGCTGCAATTGTAGATCCAGTGA
ACCCGGAAACTGTCATTGAAGCGGTGAAGAATGAGAATGTTGAACTCAAGTCAGTGCTTA
CAACACATCATCATTGGGATCATGCTGGAGGAAACGAAAAACTTCTCTCGCTCTTTGGTA
AACCATTGACAGTTTACGGCGGAGATGACAGAATTGGCGGTCTCAACAAGAAAGTTAAAC
AAGATGACAAGTTCAATATCGGCAATCTGAATGTTAGCTGCATATTCACGCCTTGTCACA
CAAGTCATATTTGTTATTATGTGGAGTCATCGACTGCTGAACAAAAAGCTGTTTTTACGG
GTGATACGCTTTTTCTTGGTGGCTGTGGTCGATTTTTTGAAGGAACGGCTGAACAAATGT
ATTCTGCTTTAATTGAGAAGCTATCAAGTTTGCCTGATGAGACAAAAGTTTTCTGTGGTC
ATGAATATGCACTGGGTAATTTGAAATTTGGAAATCATGTTGAGCCTGATAATAAAGACA
TTTTGGCTAAAATTGAATGGACAAAAGCAAAACGTGATCAAAACGAGCCATCAGTACCAT
CCACAATAGGCGAAGAAAAGCTTATTAATCCATTTATGCGTGTTAATACTGAGTCAGTTC
AGAAATTTGCAAATTCTATTGGAAAACCCATTGATACGATGGCTCATATTCGTAAAGTTA
AAGATTCATTCAAATAA
>g12759.t8 Gene=g12759 Length=259
MTDMSVRILPALSDNYMYLIICNKTKEAAIVDPVNPETVIEAVKNENVELKSVLTTHHHW
DHAGGNEKLLSLFGKPLTVYGGDDRIGGLNKKVKQDDKFNIGNLNVSCIFTPCHTSHICY
YVESSTAEQKAVFTGDTLFLGGCGRFFEGTAEQMYSALIEKLSSLPDETKVFCGHEYALG
NLKFGNHVEPDNKDILAKIEWTKAKRDQNEPSVPSTIGEEKLINPFMRVNTESVQKFANS
IGKPIDTMAHIRKVKDSFK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g12759.t8 | CDD | cd07723 | hydroxyacylglutathione_hydrolase_MBL-fold | 7 | 175 | 0.00000 |
| 7 | g12759.t8 | Gene3D | G3DSA:3.60.15.10 | - | 4 | 259 | 0.00000 |
| 5 | g12759.t8 | Hamap | MF_01374 | Hydroxyacylglutathione hydrolase [gloB]. | 4 | 258 | 34.93394 |
| 3 | g12759.t8 | PANTHER | PTHR11935:SF80 | HYDROXYACYLGLUTATHIONE HYDROLASE, MITOCHONDRIAL | 3 | 259 | 0.00000 |
| 4 | g12759.t8 | PANTHER | PTHR11935 | BETA LACTAMASE DOMAIN | 3 | 259 | 0.00000 |
| 8 | g12759.t8 | PIRSF | PIRSF005457 | Glx | 1 | 258 | 0.00000 |
| 2 | g12759.t8 | Pfam | PF00753 | Metallo-beta-lactamase superfamily | 17 | 175 | 0.00000 |
| 1 | g12759.t8 | Pfam | PF16123 | Hydroxyacylglutathione hydrolase C-terminus | 176 | 258 | 0.00000 |
| 10 | g12759.t8 | SMART | SM00849 | Lactamase_B_5a | 14 | 175 | 0.00000 |
| 6 | g12759.t8 | SUPERFAMILY | SSF56281 | Metallo-hydrolase/oxidoreductase | 4 | 258 | 0.00000 |
| 11 | g12759.t8 | TIGRFAM | TIGR03413 | GSH_gloB: hydroxyacylglutathione hydrolase | 8 | 258 | 0.00000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004416 | hydroxyacylglutathione hydrolase activity | MF |
| GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione | BP |
KEGG
Orthology
- This transcript has been annotated with K01069 (hydroxyacylglutathione hydrolase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed