General information for g12834.t6
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Multifunctional protein ADE2.
Parent gene
- The parent gene g12834 is located on chr_1: 26473015..26477102 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g12834 | g12834.t6 | TSS | g12834.t6 | 26471425 | 26471425 |
| chr_1 | g12834 | g12834.t6 | isoform | g12834.t6 | 26472226 | 26473990 |
| chr_1 | g12834 | g12834.t6 | exon | g12834.t6.exon1 | 26472226 | 26472437 |
| chr_1 | g12834 | g12834.t6 | cds | g12834.t6.CDS1 | 26472233 | 26472437 |
| chr_1 | g12834 | g12834.t6 | exon | g12834.t6.exon2 | 26472519 | 26473428 |
| chr_1 | g12834 | g12834.t6 | cds | g12834.t6.CDS2 | 26472519 | 26473015 |
| chr_1 | g12834 | g12834.t6 | exon | g12834.t6.exon3 | 26473493 | 26473667 |
| chr_1 | g12834 | g12834.t6 | exon | g12834.t6.exon4 | 26473723 | 26473846 |
| chr_1 | g12834 | g12834.t6 | exon | g12834.t6.exon5 | 26473923 | 26473990 |
| chr_1 | g12834 | g12834.t6 | TTS | g12834.t6 | NA | NA |
Sequences
>g12834.t6 Gene=g12834 Length=1489
TGATATTATGAGACAAACAACAATTCTCGTCTTTGAAATCCTCGAACGTGCATGGACAGA
GAAAAACTGTGCACTCATTGATATGAAAATTGAATTTGGAGTAGATGAAAACGGCGAAAT
ACTTGTTGCTGATGTGATAGACAGCGATTCATGGCGTTTGTGGCCTTCGGGTGATAAACG
TTTGATGGTCGATAAGCAAGTATACAGAAATTCTAAAAATGATCATTTGGTTGTGATTAT
TATGGGTTCACCTTCTGATAAGGAACACTGTCAAAAAATTGCCAAACATTGTAATGAACT
TGGACTTAATACAGAAATGCGCGTTTCTTCAGCACACAAAGTTACAAAGGGCACACTTCA
AATCATGTCAGAATATGAAGGAATTATCAAAAATCTCGTCTTTATCACAGTTGCTGGTCG
TTCAAACGGACTCGGACCAGTTTTATCTGGCAACACATCTTATCCAGTGATTAACTGTCC
ACCAATCAAAAGTGATACCATGAACATTGACTTGTGGTCTTCAATCAACTTGCCATCCGG
TTTAGGATGTAGCACAGTAATCTATCCAGAAGCCGCAGCACTCAATGCAGCTCAAATTTT
GGGTCTCAGCAACTTCATGATTTGGTCACGACTTAGAGTCAAGATGATTAATAATCTGAT
AAGCTTGAAAAAAGCTGATAAAGAATTGCGTGGAGTCAAGGAAGCTTAAACAATGAATAT
CTTTTTATTTCCTTTTATAATTGCCATAATTTAGAGCTATATTCTTTTATATTTTTTGGT
CTTCAATAAAACATATTTTTATAATAATTTATTTTTTGTTGGTTTTTGTTTGAGAAGAAT
TAGATGATGGTATGGCGCTTGGATCTAGACCAAATTTTTTCATTTCAAGAGCAATATTGA
ATAAATAGTCATAACATTCACATTGTGTTTTTGCTGATTGCCATGATTTTCCCCAAACAT
AAATGCCATGACGTCTTACTAGAACGGCAGACGTTCCTGGATATTCCTTTATTGCGTTAT
ATGAGCTCTCTTCCAAGTCTCTCTCTTGATTTGTATTTTCAATGATCGGAACTACAAGTT
CCTCATCATATCTCAAATAACGATTTAATTCGTAATCGAAAATTTTACCTTAATCATTTC
TTGATGAGTTATTTTAAATTCTTTTTCATAAAGCAATGTAGCCATAACTGCATTAGGTGA
GTGAGTATGAATTACAGAGCCTGCATTTCGCATTTTATACGCGATCATGAAGAGTGGTGT
ACATTGAGATTTTTTCAATTTTTTATAATCAGGTGGTTTTTACCAAATCATCACCATCCA
AATTTTGAATAAATAAATCATCAATTTGAATTCTTTCTTTTTGAACACCAGAAGGCGCAA
TATAAATTTCATCGTCTAATTTGATAGAAATACCCCCACCATTACCGGTAACCCATCCTA
GATCATAGAATTGTTTGCAAAGATCTGGGATTAATTTTCTAGGATGTTC
>g12834.t6 Gene=g12834 Length=233
MRQTTILVFEILERAWTEKNCALIDMKIEFGVDENGEILVADVIDSDSWRLWPSGDKRLM
VDKQVYRNSKNDHLVVIIMGSPSDKEHCQKIAKHCNELGLNTEMRVSSAHKVTKGTLQIM
SEYEGIIKNLVFITVAGRSNGLGPVLSGNTSYPVINCPPIKSDTMNIDLWSSINLPSGLG
CSTVIYPEAAALNAAQILGLSNFMIWSRLRVKMINNLISLKKADKELRGVKEA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g12834.t6 | Gene3D | G3DSA:3.30.470.20 | - | 1 | 72 | 3.6E-26 |
| 13 | g12834.t6 | Gene3D | G3DSA:3.40.50.7700 | - | 73 | 201 | 3.3E-48 |
| 7 | g12834.t6 | Hamap | MF_02045 | Phosphoribosylaminoimidazole carboxylase [purE]. | 73 | 228 | 34.577671 |
| 3 | g12834.t6 | PANTHER | PTHR43599:SF3 | MULTIFUNCTIONAL PROTEIN ADE2 | 1 | 71 | 6.1E-106 |
| 5 | g12834.t6 | PANTHER | PTHR43599 | MULTIFUNCTIONAL PROTEIN ADE2 | 1 | 71 | 6.1E-106 |
| 4 | g12834.t6 | PANTHER | PTHR43599:SF3 | MULTIFUNCTIONAL PROTEIN ADE2 | 69 | 230 | 6.1E-106 |
| 6 | g12834.t6 | PANTHER | PTHR43599 | MULTIFUNCTIONAL PROTEIN ADE2 | 69 | 230 | 6.1E-106 |
| 1 | g12834.t6 | Pfam | PF01259 | SAICAR synthetase | 1 | 71 | 1.0E-18 |
| 2 | g12834.t6 | Pfam | PF00731 | AIR carboxylase | 75 | 212 | 1.6E-35 |
| 11 | g12834.t6 | ProSitePatterns | PS01058 | SAICAR synthetase signature 2. | 23 | 31 | - |
| 10 | g12834.t6 | SMART | SM01001 | AIRC_2 | 73 | 220 | 7.9E-28 |
| 8 | g12834.t6 | SUPERFAMILY | SSF56104 | SAICAR synthase-like | 1 | 74 | 1.31E-19 |
| 9 | g12834.t6 | SUPERFAMILY | SSF52255 | N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) | 74 | 229 | 2.62E-37 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity | MF |
| GO:0006164 | purine nucleotide biosynthetic process | BP |
| GO:0006189 | ‘de novo’ IMP biosynthetic process | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
