Gene loci information

Transcript annotation

  • This transcript has been annotated as Moesin/ezrin/radixin homolog 1.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g13085 g13085.t9 TSS g13085.t9 27865974 27865974
chr_1 g13085 g13085.t9 isoform g13085.t9 27866448 27878596
chr_1 g13085 g13085.t9 exon g13085.t9.exon1 27866448 27866714
chr_1 g13085 g13085.t9 exon g13085.t9.exon2 27866963 27867178
chr_1 g13085 g13085.t9 cds g13085.t9.CDS1 27867167 27867178
chr_1 g13085 g13085.t9 exon g13085.t9.exon3 27871590 27871769
chr_1 g13085 g13085.t9 cds g13085.t9.CDS2 27871590 27871769
chr_1 g13085 g13085.t9 exon g13085.t9.exon4 27876246 27877400
chr_1 g13085 g13085.t9 cds g13085.t9.CDS3 27876246 27877400
chr_1 g13085 g13085.t9 exon g13085.t9.exon5 27878146 27878367
chr_1 g13085 g13085.t9 cds g13085.t9.CDS4 27878146 27878367
chr_1 g13085 g13085.t9 exon g13085.t9.exon6 27878432 27878596
chr_1 g13085 g13085.t9 cds g13085.t9.CDS5 27878432 27878596
chr_1 g13085 g13085.t9 TTS g13085.t9 27878931 27878931

Sequences

>g13085.t9 Gene=g13085 Length=2205
AGTTTTGCTTTGGTCTCTCTCATTGACGGACGGTTGGAGTTTTCGACTTTCACAACATAT
TATTCTGCATTTTTGATTAGTAGGTAATTGTACGACGACGAAGCAATAGTTGCGAATAAA
TACGTGCTGTGTTAAATTATCGTCAGCTACTAAATTGAGAATTTCTTGTTAATTAAAAAA
TATCACAAGTTGAAATTCACAAAAAATAGTTATGGTGAAGAAAAAATGAAACCGTGGCAA
GTGCTTTCCTGTTGATTGTTGTTTGTGATTTATTAATTTTGATATTCTTTTTTAAACGGA
ATATACAAAAATACGATATAAAGTCTCATCACTAGCAGCAGCAGTTCATCGCCACGAAAA
TCGCGAGAGAAACTTTTTACATTAAAAACGAAAATTACGCGATTTCTCAGTTGAATAAAT
AATAAATTTTCAAAGATCCGCAGCTGAATTAAAAAAAAAAACAGAATCATCATGCCAAAA
TCACTAAATGTTCGCGTTACGACGATGGATGCAGAGTTGGAATTTGCCATCCAACAAAGC
ACCACAGGCAAGCAGCTTTTCGATCAAGTTGTTAAGACAATTGGCCTTCGAGAAGTTTGG
TTCTTCGGTCTTCAGTATACAGATCCGAAAGGCGATTTGACATGGATTAAACTTTATAAG
AAGGTGATGAGTCAAGATATTCAAAAGACGGATCCATTGCAGTTCAAATTCCGTGCAAAG
TTCTATCCAGAAGATGTTGCCGAAGAGCTCATTCAGGATATTACACTTCGACTGTTTTAT
TTGCAAGTTAAGAATGCAATTTTGTCTGATGAAATTTACTGTCCGCCCGAAACTTCAGTA
CTTCTTGCATCATATGCCGTTCAAGCGCGTCATGGTGATTTCAATAAAGGAACACATGGC
CCTGGTTTCTTAGTAAACGATAGATTACTTCCACAACGCGTCATCGATCAGCATAAAATG
TCGAAAGACGAATGGGAAACTTCTATAATTACTTGGTGGCAAGAACATCGTGGCATGTTG
CGCGAAGACGCAATGATGGAATATTTGAAAATTGCTCAGGATTTAGAGATGTATGGTGTC
AATTACTTTGAAATTCGCAATAAAAAAGGAACCGAATTATATCTTGGAGTCGATGCGTTG
GGTTTGAACATTTATGAAAAAGACGATAAACTGACGCCTAAAATTGGCTTCCCATGGTCA
GAAATTCGTAATATATCATTTAATGATAAGAAATTCATCATCAAACCTATTGACAAGAAG
GCGCCAGATTTTGTCTTCTTCGCACCACGTGTTCGTATCAATAAGCGCATTCTTGCACTG
TGTATGGGTAATCATGAGCTTTATATGCGTCGTAGAAAACCTGATACCATCGATGTTCAG
CAAATGAAGGCACAAGCTCGTGAAGAAAAGAATGCTAAACAGCAAGAGCGTGAAAAACTT
CAATTGGCACTTGCAGCAAGAGAACGTGCAGAAAAGAAACAGCAAGAGTACGAAGATCGC
TTACGTACAATGCAAGAAGAAATCAATCGTTCACAAGCTAACTTAATGGAAGCTCAAGAG
ATGATAAGACGTTTAGAAGAGCAGTTAAAACAATTGCAGCTATCGAAAGATGAACTTGAG
CAGCGTCAGAATGAATTGCAAGAAATGCTTACTCGTTTGGAAGAAAGCAAAAACATGGAA
GCAGCAGAACGTCAGAAATTGGAAGAAGAAATTTCTGCAAAACAAATCGAAGTGGCCAAG
ATTCAAGAAGAAGTCGAAGCAAAGGATTCCGAAACAAGACGATTACAAGAAGAGGTTGAA
GAAGCACGCCGCAAACAGCAAGAAGCAGCTGCAGCACTTTTGGCAGCTACACAAACACCT
AAACATCATCATTTGGCTGAAGATGAAAATGGAGATGATGATGATATGACGAATGGAGAT
AATGGATCTGGTGGCGGAGATGTATCAAGAGATTTAGATACAGATATGGATATCAAAGAT
CCAATTGAAGATAGACGTACATTAGCTGAACGTAATGAAAGATTACACGATCAATTGAAG
GCATTAAAACAAGATTTGGCACAATCTCGTGACGATACAAAAGAGACTGCCAATGATAAA
ATCCATAGAGAAAATGTACGTCAGGGACGTGACAAATATAAGACATTGCGTGAAATAAGA
AAAGGAAACACCAAACGTCGTGTGGATCAGTTTGAAAACATGTAA

>g13085.t9 Gene=g13085 Length=577
MPKSLNVRVTTMDAELEFAIQQSTTGKQLFDQVVKTIGLREVWFFGLQYTDPKGDLTWIK
LYKKVMSQDIQKTDPLQFKFRAKFYPEDVAEELIQDITLRLFYLQVKNAILSDEIYCPPE
TSVLLASYAVQARHGDFNKGTHGPGFLVNDRLLPQRVIDQHKMSKDEWETSIITWWQEHR
GMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTELYLGVDALGLNIYEKDDKLTPKIGF
PWSEIRNISFNDKKFIIKPIDKKAPDFVFFAPRVRINKRILALCMGNHELYMRRRKPDTI
DVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQQEYEDRLRTMQEEINRSQANLME
AQEMIRRLEEQLKQLQLSKDELEQRQNELQEMLTRLEESKNMEAAERQKLEEEISAKQIE
VAKIQEEVEAKDSETRRLQEEVEEARRKQQEAAAALLAATQTPKHHHLAEDENGDDDDMT
NGDNGSGGGDVSRDLDTDMDIKDPIEDRRTLAERNERLHDQLKALKQDLAQSRDDTKETA
NDKIHRENVRQGRDKYKTLREIRKGNTKRRVDQFENM

Protein features from InterProScan

Transcript Database ID Name Start End E.value
32 g13085.t9 CDD cd17187 FERM_F1_ERM 5 87 1.27933E-51
31 g13085.t9 CDD cd14473 FERM_B-lobe 98 198 1.42937E-29
33 g13085.t9 CDD cd13194 FERM_C_ERM 200 296 4.07954E-71
28 g13085.t9 Coils Coil Coil 302 455 -
29 g13085.t9 Coils Coil Coil 508 542 -
23 g13085.t9 Gene3D G3DSA:3.10.20.90 - 4 82 2.9E-37
27 g13085.t9 Gene3D G3DSA:1.20.80.10 - 83 199 5.1E-39
24 g13085.t9 Gene3D G3DSA:2.30.29.30 - 201 299 8.3E-47
26 g13085.t9 Gene3D G3DSA:1.20.5.450 - 300 487 2.5E-76
25 g13085.t9 Gene3D G3DSA:1.25.40.1020 - 496 577 6.9E-36
38 g13085.t9 MobiDBLite mobidb-lite consensus disorder prediction 429 553 -
39 g13085.t9 MobiDBLite mobidb-lite consensus disorder prediction 429 450 -
40 g13085.t9 MobiDBLite mobidb-lite consensus disorder prediction 493 553 -
5 g13085.t9 PANTHER PTHR23281:SF18 MOESIN/EZRIN/RADIXIN HOMOLOG 1 1 577 4.3E-279
6 g13085.t9 PANTHER PTHR23281 MERLIN/MOESIN/EZRIN/RADIXIN 1 577 4.3E-279
30 g13085.t9 PIRSF PIRSF002305 ERM 1 577 6.8E-281
16 g13085.t9 PRINTS PR00661 ERM family signature 17 36 1.5E-87
10 g13085.t9 PRINTS PR00935 Band 4.1 protein family signature 37 49 9.6E-29
12 g13085.t9 PRINTS PR00661 ERM family signature 69 88 1.5E-87
8 g13085.t9 PRINTS PR00935 Band 4.1 protein family signature 104 117 9.6E-29
15 g13085.t9 PRINTS PR00661 ERM family signature 113 134 1.5E-87
9 g13085.t9 PRINTS PR00935 Band 4.1 protein family signature 117 137 9.6E-29
17 g13085.t9 PRINTS PR00661 ERM family signature 159 176 1.5E-87
7 g13085.t9 PRINTS PR00935 Band 4.1 protein family signature 186 202 9.6E-29
11 g13085.t9 PRINTS PR00661 ERM family signature 209 229 1.5E-87
18 g13085.t9 PRINTS PR00661 ERM family signature 284 303 1.5E-87
14 g13085.t9 PRINTS PR00661 ERM family signature 532 553 1.5E-87
13 g13085.t9 PRINTS PR00661 ERM family signature 554 575 1.5E-87
4 g13085.t9 Pfam PF09379 FERM N-terminal domain 9 68 9.0E-15
3 g13085.t9 Pfam PF00373 FERM central domain 93 206 3.3E-24
2 g13085.t9 Pfam PF09380 FERM C-terminal PH-like domain 210 298 1.1E-25
1 g13085.t9 Pfam PF00769 Ezrin/radixin/moesin family 331 577 2.3E-70
37 g13085.t9 ProSitePatterns PS00660 FERM domain signature 1. 58 88 -
36 g13085.t9 ProSitePatterns PS00661 FERM domain signature 2. 176 205 -
41 g13085.t9 ProSiteProfiles PS50057 FERM domain profile. 5 295 81.393
35 g13085.t9 SMART SM00295 B41_5 1 206 6.0E-81
34 g13085.t9 SMART SM01196 FERM_C_3 210 299 3.8E-36
21 g13085.t9 SUPERFAMILY SSF54236 Ubiquitin-like 2 87 1.32E-24
22 g13085.t9 SUPERFAMILY SSF47031 Second domain of FERM 89 198 4.06E-38
19 g13085.t9 SUPERFAMILY SSF50729 PH domain-like 199 342 3.38E-41
20 g13085.t9 SUPERFAMILY SSF48678 Moesin tail domain 496 577 1.96E-27

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005856 cytoskeleton CC
GO:0003779 actin binding MF
GO:0008092 cytoskeletal protein binding MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values