General information for g13105.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cyclin-dependent kinase 1.
Parent gene
- The parent gene g13105 is located on chr_1: 27987634..27988657 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g13105 | g13105.t1 | TTS | g13105.t1 | 27987386 | 27987386 |
| chr_1 | g13105 | g13105.t1 | isoform | g13105.t1 | 27987634 | 27988657 |
| chr_1 | g13105 | g13105.t1 | exon | g13105.t1.exon1 | 27987634 | 27988390 |
| chr_1 | g13105 | g13105.t1 | cds | g13105.t1.CDS1 | 27987634 | 27988390 |
| chr_1 | g13105 | g13105.t1 | exon | g13105.t1.exon2 | 27988443 | 27988543 |
| chr_1 | g13105 | g13105.t1 | cds | g13105.t1.CDS2 | 27988443 | 27988543 |
| chr_1 | g13105 | g13105.t1 | exon | g13105.t1.exon3 | 27988610 | 27988657 |
| chr_1 | g13105 | g13105.t1 | cds | g13105.t1.CDS3 | 27988610 | 27988657 |
| chr_1 | g13105 | g13105.t1 | TSS | g13105.t1 | 27988744 | 27988744 |
Sequences
>g13105.t1 Gene=g13105 Length=906
ATGGAGGACTTTCAAAAAATTGAGAAGATTGGTGAAGGCACATATGGGGTTGTCTATAAA
GGCAAAAATAAGAAAACTGGCGAGATAGTAGCAATGAAAAAGATACGCCTTGAATCTGAA
GACGAAGGGATTCCTTCTACAGCGATTCGTGAAATTTCGTTATTGAAAGAACTGAAACAT
CCAAATATCGTCTCTTTACAAGACGTTTTAATGGAAGATAGTCGACTGTATTTAATCTTT
GAATTTCTCTCGATGGATCTTAAAAAATACATGGATTCACTGCCCTCAGAAAAGATGTTG
GATACAGAATTAGTTCGAAGCTACATGTATCAAATAACTGCCGCAATTGTTTTTTGCCAT
AGACGACGAGTTTTGCATCGCGATTTGAAACCTCAAAATTTACTTATAAATAAGGATGGT
TTAATAAAGGTAGCTGATTTTGGATTGGGTCGTTCATTTGGGATTCCTGTCCGTAATTAT
ACACATGAGATTGTTACACTTTGGTATCGTGCGCCAGAAGTTTTGCTTGGCTCACAACGC
TATTCATGTCCAGTTGATGTATGGTCTTTAGGATGTATATTCGCTGAAATGGCTACGCGT
AAGCCTCTATTCCAAGGTGATTCCGAAATAGATCAATTATTCCGAATGTTCAGGATTTTG
AAGACACCAACAGATGATATCTGGCCAGGAGTCACACAATTGCCAGATTACAAACCAACA
TTTCCATGCTGGACACAAAACAATCTTGCTCAACATGTCAAAAATATGGATTCAGCTGCA
TTTGATTTATTAAATAAAACTTTGATTTACGATCCAGCTCTTCGCATTTCAGCAAAAGAA
ATGCTTGAACATAAATATTTTGATACAATCGATCGCAGCATCATAAGCTCGATCCCTCTT
CATTAA
>g13105.t1 Gene=g13105 Length=301
MEDFQKIEKIGEGTYGVVYKGKNKKTGEIVAMKKIRLESEDEGIPSTAIREISLLKELKH
PNIVSLQDVLMEDSRLYLIFEFLSMDLKKYMDSLPSEKMLDTELVRSYMYQITAAIVFCH
RRRVLHRDLKPQNLLINKDGLIKVADFGLGRSFGIPVRNYTHEIVTLWYRAPEVLLGSQR
YSCPVDVWSLGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTDDIWPGVTQLPDYKPT
FPCWTQNNLAQHVKNMDSAAFDLLNKTLIYDPALRISAKEMLEHKYFDTIDRSIISSIPL
H
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g13105.t1 | CDD | cd07861 | STKc_CDK1_euk | 3 | 287 | 0.0 |
| 5 | g13105.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 1 | 84 | 1.6E-37 |
| 6 | g13105.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 85 | 296 | 1.5E-71 |
| 2 | g13105.t1 | PANTHER | PTHR24056:SF457 | - | 3 | 290 | 2.1E-125 |
| 3 | g13105.t1 | PANTHER | PTHR24056 | CELL DIVISION PROTEIN KINASE | 3 | 290 | 2.1E-125 |
| 1 | g13105.t1 | Pfam | PF00069 | Protein kinase domain | 4 | 287 | 9.2E-77 |
| 9 | g13105.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 10 | 33 | - |
| 8 | g13105.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 124 | 136 | - |
| 11 | g13105.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 4 | 287 | 48.937 |
| 10 | g13105.t1 | SMART | SM00220 | serkin_6 | 4 | 287 | 5.2E-103 |
| 4 | g13105.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 1 | 290 | 1.35E-100 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K02087 (cyclin-dependent kinase 1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
